Methylene blue(MB)is an FDA(Food and Drug Administration)-approved contrast agent with donor−acceptor(D−A)structure integrated with carbonyl-containing nitrogen-heterocycles.MB can be converted into MBH(protonated MB)...Methylene blue(MB)is an FDA(Food and Drug Administration)-approved contrast agent with donor−acceptor(D−A)structure integrated with carbonyl-containing nitrogen-heterocycles.MB can be converted into MBH(protonated MB)by protonation,which not only induces the fluorescence emission redshifted from the first near-infrared window(NIR-I,650−950 nm)to the second near-infrared window(NIR-II,1000−1700 nm)but also achieves ACQ-to-AIE conversion.MB has been successfully demonstrated in hyperacidemia imaging with an extremely low pH value(<1).展开更多
基金supported by National Key R&D Programs(China)(2021YFA0910001,2023YFA0915400)Guangdong Provincial Key Area R&D Program(2020B111-1540001)+7 种基金Shenzhen Basic Research(key project)(China)(JCYJ20210324120011030,JCYJ20210324115804013,and JCYJ20200109114616534)the Shenzhen Science and Technology Program(KQTD20210811090115019)the Major Instrumentation Development Program of the Chinese Academy of Sciences(Project Number:ZDKYYQ20220008)Shenzhen-Macao Technology Plan(SGDX202011030928-0301)Technological Cooperation Projects(China)(2020-A0505100047)Guangdong Basic and Applied Basic Research Fund Project(China)(2021A1515110699)Zhuhai Innovation and Entrepreneurship Team Project(ZH011104-05180056PWC)All animal experiments were performed under the protocols approved by the Animal Care and Use Committee(Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences)(Serial number:SIAT-IACUC-210701-YYS-GP-A1974).
文摘Methylene blue(MB)is an FDA(Food and Drug Administration)-approved contrast agent with donor−acceptor(D−A)structure integrated with carbonyl-containing nitrogen-heterocycles.MB can be converted into MBH(protonated MB)by protonation,which not only induces the fluorescence emission redshifted from the first near-infrared window(NIR-I,650−950 nm)to the second near-infrared window(NIR-II,1000−1700 nm)but also achieves ACQ-to-AIE conversion.MB has been successfully demonstrated in hyperacidemia imaging with an extremely low pH value(<1).
