Lutein was nano-encapsuled with hydroxypropylmethyl cellulose phthalate （HPMCP） to maintain its bioactivity and to avoid thermal/light degradation. Supercritical antisolvent precipitation was applied to prepare lute...Lutein was nano-encapsuled with hydroxypropylmethyl cellulose phthalate （HPMCP） to maintain its bioactivity and to avoid thermal/light degradation. Supercritical antisolvent precipitation was applied to prepare lutein/HPMCP nano-capsule. The effects of several operating parameters on the yield, lutein loading, encapsulation efficiency, particle size and particle size distribution of the nanocapsule were investigated. The mean diameter of nanocapsules ranged from 163 nm to 219 nm under appropriate experimental conditions. The result of scanning electron microscope showed that the nanocapsules were nearly spherical. The highest yield reached 95.35% when the initial concentration of lutein was saturated. The highest lutein loading of 15.80% and encapsulation efficiency of 88,41% were obtained under the conditions of 11 MPa, 40℃ and CHPMCP： Clutein= 5：1. The results may promote the application of lutein in food industry.展开更多
Water penetration into HPMC matrices may be observed when they are brought into contact withwater.The effects of HPMC substitute type on the water penetration are concentrated on the initially short time.which is cons...Water penetration into HPMC matrices may be observed when they are brought into contact withwater.The effects of HPMC substitute type on the water penetration are concentrated on the initially short time.which is considered to be the time for HPMC to form a hydrogel.After hydrogel is formed,the water penetration rateis identical.The effect of HPMC on water penetration depends on its molecular weight.When a drug is added intoHPMC matrix,the ability of water penetration into matrix is weakened.As the water penetrates,a considerableswelling of the HPMC matrix is also observed,axial swelling is greater than radial swelling,and the swelling ofmatrix is mainly produced by HPMC.High HPMC level produces large swelling of matrix.Linear relations existbetween water penetration,matrix swelling and drug release.展开更多
Calcium carbonate crystallization was performed in hydrogel of hydroxypropylmethyl cellulose (HPMC). Results showed that the polyhydroxy functionalities in HPMC gel network facilitated the nucleation of aragonite whic...Calcium carbonate crystallization was performed in hydrogel of hydroxypropylmethyl cellulose (HPMC). Results showed that the polyhydroxy functionalities in HPMC gel network facilitated the nucleation of aragonite which was not found in experiment without HPMC hydrogel and in experiment using methylcellulose (MC) hydrogel as template. On the other hand, due to the unique assembly of the macromolecules in HPMC hydrogel network, which was different from other hydrogels used in some previous reports, particular crystal morphology, corncob-like CaCO_3, was obtained for the first time.展开更多
基金Supported by the National High Technology Research and Development Program of China(2007AA10Z350)
文摘Lutein was nano-encapsuled with hydroxypropylmethyl cellulose phthalate （HPMCP） to maintain its bioactivity and to avoid thermal/light degradation. Supercritical antisolvent precipitation was applied to prepare lutein/HPMCP nano-capsule. The effects of several operating parameters on the yield, lutein loading, encapsulation efficiency, particle size and particle size distribution of the nanocapsule were investigated. The mean diameter of nanocapsules ranged from 163 nm to 219 nm under appropriate experimental conditions. The result of scanning electron microscope showed that the nanocapsules were nearly spherical. The highest yield reached 95.35% when the initial concentration of lutein was saturated. The highest lutein loading of 15.80% and encapsulation efficiency of 88,41% were obtained under the conditions of 11 MPa, 40℃ and CHPMCP： Clutein= 5：1. The results may promote the application of lutein in food industry.
文摘Water penetration into HPMC matrices may be observed when they are brought into contact withwater.The effects of HPMC substitute type on the water penetration are concentrated on the initially short time.which is considered to be the time for HPMC to form a hydrogel.After hydrogel is formed,the water penetration rateis identical.The effect of HPMC on water penetration depends on its molecular weight.When a drug is added intoHPMC matrix,the ability of water penetration into matrix is weakened.As the water penetrates,a considerableswelling of the HPMC matrix is also observed,axial swelling is greater than radial swelling,and the swelling ofmatrix is mainly produced by HPMC.High HPMC level produces large swelling of matrix.Linear relations existbetween water penetration,matrix swelling and drug release.
基金the Teaching and Research Award Program for Outstanding Young Teachers in Higher Education Institutions of Ministry of Education, China (Grant No. 2002-123)the Key Research Project of Ministry of Education, China (Grant No. 02041)
文摘Calcium carbonate crystallization was performed in hydrogel of hydroxypropylmethyl cellulose (HPMC). Results showed that the polyhydroxy functionalities in HPMC gel network facilitated the nucleation of aragonite which was not found in experiment without HPMC hydrogel and in experiment using methylcellulose (MC) hydrogel as template. On the other hand, due to the unique assembly of the macromolecules in HPMC hydrogel network, which was different from other hydrogels used in some previous reports, particular crystal morphology, corncob-like CaCO_3, was obtained for the first time.
