Baker's yeast mediated reduction of acenaphthenequinone within 4-10 h afforded mono-hydroxyacenaphthenone mainly with low enantioselectivity,the substrate and mono-hydroxyacenaphthenone product almost converted to...Baker's yeast mediated reduction of acenaphthenequinone within 4-10 h afforded mono-hydroxyacenaphthenone mainly with low enantioselectivity,the substrate and mono-hydroxyacenaphthenone product almost converted to dihydroxyacenaphthene after 48 h.By control of the reaction time and in the presence of DMF as co-solvent,the reduction of 6-substituted acenaphthenequinones under vigorous agitation afforded the corresponding 2-hydroxyacenaphthenones in 24-84%yields with 10-93%ee.展开更多
Regio- and enantioselective reduction of substituted acenaphthenequinones were conducted under mild reaction conditions using plant enzymatic systems. A screening of 15 plants allowed the selection of two suitable pla...Regio- and enantioselective reduction of substituted acenaphthenequinones were conducted under mild reaction conditions using plant enzymatic systems. A screening of 15 plants allowed the selection of two suitable plants fulfilling enantiocomple- mentarity. The （＋）- and （-）-mono hydroxyacenaphthenones were achieved with high conversion and good enantiomeric purity using peach （Prunus persica （L.） Batsch., conversion 98%, 71% ee） and carrot （Daucus carota L., conversion 95%, 81% ee）, respectively.展开更多
基金the National Key Project for Basic Research(No.2003CB114400)Technology Foundationof Shanghai(No.04DZ05605)for financial support.
文摘Baker's yeast mediated reduction of acenaphthenequinone within 4-10 h afforded mono-hydroxyacenaphthenone mainly with low enantioselectivity,the substrate and mono-hydroxyacenaphthenone product almost converted to dihydroxyacenaphthene after 48 h.By control of the reaction time and in the presence of DMF as co-solvent,the reduction of 6-substituted acenaphthenequinones under vigorous agitation afforded the corresponding 2-hydroxyacenaphthenones in 24-84%yields with 10-93%ee.
基金the Program for Changjiang Scholars,the Innovative Research Team in University(No.IRT0711)the Technology Foundation of Shanghai(No.04DZ05605)for financial support of the research.
文摘Regio- and enantioselective reduction of substituted acenaphthenequinones were conducted under mild reaction conditions using plant enzymatic systems. A screening of 15 plants allowed the selection of two suitable plants fulfilling enantiocomple- mentarity. The （＋）- and （-）-mono hydroxyacenaphthenones were achieved with high conversion and good enantiomeric purity using peach （Prunus persica （L.） Batsch., conversion 98%, 71% ee） and carrot （Daucus carota L., conversion 95%, 81% ee）, respectively.
