A series of monomethoxy poly（ethylene glycol） （mPEG） grafted copolyglutamates （PmPEGs） were synthesized through ring-opening polymerization （ROP） followed by click chemistry. Supramolecular hydrogels based on ...A series of monomethoxy poly（ethylene glycol） （mPEG） grafted copolyglutamates （PmPEGs） were synthesized through ring-opening polymerization （ROP） followed by click chemistry. Supramolecular hydrogels based on polymer inclusion complexes （ICs） between PmPEG and α-cyclodextriri （α-CD） were prepared in aqueous solution. The rheological measurements indicated their gelation properties were affected by several factors including the mPEG length, graft density and the sample concentration. These hydrogels displayed thermo-sensitive gel-sol transition under appropriate conditions due to the reversible mPEG and α-CD inclusion complexation. These hydrogels also showed pH-sensitive behavior due to the deprotonate of carboxylic acid side groups. The ICs formation of a channel-type crystalline structure induced gelation mechanism was verified by various techniques. In vitro cytotoxicity assays demonstrated that the supramolecular hydrogels are nontoxic and cytocompatible.展开更多
A series of novel six-coordinated terpyridine zinc complexes,containing ammonium salts and thymine fragment at the two terminals,have been designed and synthesized,which can function as highly sensitive visualized sen...A series of novel six-coordinated terpyridine zinc complexes,containing ammonium salts and thymine fragment at the two terminals,have been designed and synthesized,which can function as highly sensitive visualized sensors for melamine detection via selective metallo-hydrogel formation.After fully characterization by various techniques,the complementary triple-hydrogen-bonding between the thymine fragment and melamine,as well as π-π stacking interactions may be responsible for the selective metallo-hydrogel formation.In light of the possible interference aroused by milk ingredients(proteins,peptides and amino acids) and legal/illegal additives(urine,sugars and vitamins),a series of control experiments are therefore involved.To our delight,this visual recognition is highly selective,no gelation was observed with the selected milk ingredients or additives.Remarkably,this new developed protocol enables convenient and highly selective visual recognition of melamine at a concentration as low as 10 ppm in raw milk without any tedious pretreatment.展开更多
基金financially supported by the National Natural Science Fund for Distinguished Young Scholars(No.51225306)the National Natural Science Foundation of China(No.21434008)
文摘A series of monomethoxy poly（ethylene glycol） （mPEG） grafted copolyglutamates （PmPEGs） were synthesized through ring-opening polymerization （ROP） followed by click chemistry. Supramolecular hydrogels based on polymer inclusion complexes （ICs） between PmPEG and α-cyclodextriri （α-CD） were prepared in aqueous solution. The rheological measurements indicated their gelation properties were affected by several factors including the mPEG length, graft density and the sample concentration. These hydrogels displayed thermo-sensitive gel-sol transition under appropriate conditions due to the reversible mPEG and α-CD inclusion complexation. These hydrogels also showed pH-sensitive behavior due to the deprotonate of carboxylic acid side groups. The ICs formation of a channel-type crystalline structure induced gelation mechanism was verified by various techniques. In vitro cytotoxicity assays demonstrated that the supramolecular hydrogels are nontoxic and cytocompatible.
基金Financial support from the State General Administration of the People’s Republic of China for Quality Supervision and Inspection and Quarantine (No.2016QK122)Shanghai Institute of Quality Inspection and Technical Research+1 种基金the National Natural Science Foundation of China (Nos.21572036 and 21861132002)the Department of Chemistry,Fudan University
文摘A series of novel six-coordinated terpyridine zinc complexes,containing ammonium salts and thymine fragment at the two terminals,have been designed and synthesized,which can function as highly sensitive visualized sensors for melamine detection via selective metallo-hydrogel formation.After fully characterization by various techniques,the complementary triple-hydrogen-bonding between the thymine fragment and melamine,as well as π-π stacking interactions may be responsible for the selective metallo-hydrogel formation.In light of the possible interference aroused by milk ingredients(proteins,peptides and amino acids) and legal/illegal additives(urine,sugars and vitamins),a series of control experiments are therefore involved.To our delight,this visual recognition is highly selective,no gelation was observed with the selected milk ingredients or additives.Remarkably,this new developed protocol enables convenient and highly selective visual recognition of melamine at a concentration as low as 10 ppm in raw milk without any tedious pretreatment.
