目的:研究糖化血红蛋白(HbAlc)水平对妊娠期糖尿病(GDM)孕妇妊娠结局的影响。方法:112例妊娠期糖尿病孕妇作为GDM组、再根据妊娠24~28周时GDM患者空腹血清HbAlc水平分为高水平组(HbAlc≥6.5%,n=43)和低水平组(HbAlc<6.5%,n=69),选取...目的:研究糖化血红蛋白(HbAlc)水平对妊娠期糖尿病(GDM)孕妇妊娠结局的影响。方法:112例妊娠期糖尿病孕妇作为GDM组、再根据妊娠24~28周时GDM患者空腹血清HbAlc水平分为高水平组(HbAlc≥6.5%,n=43)和低水平组(HbAlc<6.5%,n=69),选取同期产检的95例正常孕妇作为对照组;比较对照组和GDM组孕妇妊娠24~28周时空腹HbAlc水平,GDM组孕妇给予以糖尿病饮食及运动指导干预,两周时再次检测HbAlc水平;分析不同HbAlc水平GDM孕妇早产、剖宫产、羊水过多、妊娠期高血压发生率、分娩孕周和产前体质指数(BMI),比较新生儿出生后1 min Apgar≤7分、巨大儿、低血糖、高胆红素血症患儿及新生儿体质量。结果:妊娠24~28周时,GDM组HbAlc水平高于对照组(t=9.95,P<0.05);妊娠24~28周时,两组GDM孕妇给予饮食及运动干预,HbAlc水平降低,与干预前比较,差异有统计学意义(t=9.66,P<0.05);干预后,HbAlc高水平GDM孕妇HbAlc恢复正常比例低于低水平GDM孕妇(χ~2=4.57,P=0.033);HbAlc高水平组GDM孕妇分娩时孕周比低水平组短,但早产、剖宫产、羊水过多及妊娠期高血压的发生率均高于低水平组孕妇(P<0.05);GDM高水平组新生儿体质量、新生儿出生后1 min Apgar≤7分、巨大儿、低血糖及高胆红素血症发生率显著高于低水平组(P<0.05)。结论:高表达HbAlc的GDM孕妇的妊娠期结局较差,新生儿的并发症发生率变高,可将HbAlc的监测作为血糖控制及避免产后新生儿并发症的重要指标。展开更多
For a period of two years, a survey of 110 parturitions of Labrador breed bitches was carried out in Rosario City to determine the average number of puppies per litter, percentage of dystocia of all parturitions, perc...For a period of two years, a survey of 110 parturitions of Labrador breed bitches was carried out in Rosario City to determine the average number of puppies per litter, percentage of dystocia of all parturitions, percentage of males and females born and causes of dystocia, as well as the incidence of clinically detectable congenital pathologies. Over a total of 110 parturitions ninety three （84.5%） parturitions were normal and 17 （15.5%） were dystocic ones, it was established that atony 1 was the most numerous cause of dystocia （53%）, followed by atony 2 （23%）, dystocia by fetal disorders （6%）, hydramnios （6%）, uterine rupture （6%） and vagina fibrous band （6%）. The whole puppies born was 866, 7.9 puppies per litter, if comparison between normal parturitions and dystocic ones is made, numbers are 7.05 and 8.02 respectively. When sex evaluation percentage is made 51.5% are males and 48.5% are females. When viability of puppies born is calculated it is established that in ones born by normal parturition perinatal death was 9.3%, while in those born by dystocia it was 10.9%. Among clinically verifiable congenital disorders low weight at birth was the most frequent congenital alteration, followed by cleft palate, lethal congenital edema or walrus syndrome and hare lip.展开更多
文摘目的:研究糖化血红蛋白(HbAlc)水平对妊娠期糖尿病(GDM)孕妇妊娠结局的影响。方法:112例妊娠期糖尿病孕妇作为GDM组、再根据妊娠24~28周时GDM患者空腹血清HbAlc水平分为高水平组(HbAlc≥6.5%,n=43)和低水平组(HbAlc<6.5%,n=69),选取同期产检的95例正常孕妇作为对照组;比较对照组和GDM组孕妇妊娠24~28周时空腹HbAlc水平,GDM组孕妇给予以糖尿病饮食及运动指导干预,两周时再次检测HbAlc水平;分析不同HbAlc水平GDM孕妇早产、剖宫产、羊水过多、妊娠期高血压发生率、分娩孕周和产前体质指数(BMI),比较新生儿出生后1 min Apgar≤7分、巨大儿、低血糖、高胆红素血症患儿及新生儿体质量。结果:妊娠24~28周时,GDM组HbAlc水平高于对照组(t=9.95,P<0.05);妊娠24~28周时,两组GDM孕妇给予饮食及运动干预,HbAlc水平降低,与干预前比较,差异有统计学意义(t=9.66,P<0.05);干预后,HbAlc高水平GDM孕妇HbAlc恢复正常比例低于低水平GDM孕妇(χ~2=4.57,P=0.033);HbAlc高水平组GDM孕妇分娩时孕周比低水平组短,但早产、剖宫产、羊水过多及妊娠期高血压的发生率均高于低水平组孕妇(P<0.05);GDM高水平组新生儿体质量、新生儿出生后1 min Apgar≤7分、巨大儿、低血糖及高胆红素血症发生率显著高于低水平组(P<0.05)。结论:高表达HbAlc的GDM孕妇的妊娠期结局较差,新生儿的并发症发生率变高,可将HbAlc的监测作为血糖控制及避免产后新生儿并发症的重要指标。
文摘For a period of two years, a survey of 110 parturitions of Labrador breed bitches was carried out in Rosario City to determine the average number of puppies per litter, percentage of dystocia of all parturitions, percentage of males and females born and causes of dystocia, as well as the incidence of clinically detectable congenital pathologies. Over a total of 110 parturitions ninety three （84.5%） parturitions were normal and 17 （15.5%） were dystocic ones, it was established that atony 1 was the most numerous cause of dystocia （53%）, followed by atony 2 （23%）, dystocia by fetal disorders （6%）, hydramnios （6%）, uterine rupture （6%） and vagina fibrous band （6%）. The whole puppies born was 866, 7.9 puppies per litter, if comparison between normal parturitions and dystocic ones is made, numbers are 7.05 and 8.02 respectively. When sex evaluation percentage is made 51.5% are males and 48.5% are females. When viability of puppies born is calculated it is established that in ones born by normal parturition perinatal death was 9.3%, while in those born by dystocia it was 10.9%. Among clinically verifiable congenital disorders low weight at birth was the most frequent congenital alteration, followed by cleft palate, lethal congenital edema or walrus syndrome and hare lip.
