Natural damming of rivers by mass movements is a very common and potentially dangerous phenomena which has been documented all over the world. In this paper, a two-layer model of Savage-Hutter type is presented to sim...Natural damming of rivers by mass movements is a very common and potentially dangerous phenomena which has been documented all over the world. In this paper, a two-layer model of Savage-Hutter type is presented to simulate the dynamic procedure for the intrusion of landslide into rivers. The two-layer shallow water system is derived by depth averaging the incompressible Navier-Stokes equations with the hydrostatic assumption. A high order accuracy scheme based on the finite volume method is proposed to solve the presented model equations. Several numerical tests are performed to verify the realiability and feasibility of the proposed model. The numerical results indicate that the proposed method can be competent for simulating the dynamic process of landslide intrusion into the river. The interaction effect between both layers has a significant impact on the landslide movement, water fluctuation and wave propagation.展开更多
Hutter et al.1 first reported that a bone marrow transplant using stem cells derived from a donor with homozygous CCR5 delta32 gene mutation remained HIV-positive but virus-free(below the limits of detection)after hal...Hutter et al.1 first reported that a bone marrow transplant using stem cells derived from a donor with homozygous CCR5 delta32 gene mutation remained HIV-positive but virus-free(below the limits of detection)after halting antiretroviral therapy.Since this observation in 2009,mutation of the CCR5 gene has become an important target in the prevention and treatment of HIV infection.The CRISPR-Cas9 system,which has been called the biggest biotech discovery in the history of molecular biology,can be used for precise genome engineering with the aim of treating genetic disorders.Currently,the application of gene-editing tools,such as CRISPR-Cas9,for genetic engineering of embryos for use in assisted reproduction is prohibited in much of Europe,the United States,and China.2–3.展开更多
基金Financial support from the National Science Fund for Distinguished Young Scholars (Grant No.41225011)the NSFC (Grant No. 41272346)+1 种基金the Information technology project of the Department of transportation (2014364J03090)the STS project of Chinese Academy of Sciences (project No. KFJ-EW-STS-094)
文摘Natural damming of rivers by mass movements is a very common and potentially dangerous phenomena which has been documented all over the world. In this paper, a two-layer model of Savage-Hutter type is presented to simulate the dynamic procedure for the intrusion of landslide into rivers. The two-layer shallow water system is derived by depth averaging the incompressible Navier-Stokes equations with the hydrostatic assumption. A high order accuracy scheme based on the finite volume method is proposed to solve the presented model equations. Several numerical tests are performed to verify the realiability and feasibility of the proposed model. The numerical results indicate that the proposed method can be competent for simulating the dynamic process of landslide intrusion into the river. The interaction effect between both layers has a significant impact on the landslide movement, water fluctuation and wave propagation.
基金supported by the National Natural Science Foundation of China (81772369)supported by the CAMS Innovation Fund for Medical Sciences (CIFMS,2017-I2M-3-001)
文摘Hutter et al.1 first reported that a bone marrow transplant using stem cells derived from a donor with homozygous CCR5 delta32 gene mutation remained HIV-positive but virus-free(below the limits of detection)after halting antiretroviral therapy.Since this observation in 2009,mutation of the CCR5 gene has become an important target in the prevention and treatment of HIV infection.The CRISPR-Cas9 system,which has been called the biggest biotech discovery in the history of molecular biology,can be used for precise genome engineering with the aim of treating genetic disorders.Currently,the application of gene-editing tools,such as CRISPR-Cas9,for genetic engineering of embryos for use in assisted reproduction is prohibited in much of Europe,the United States,and China.2–3.
