Objective To explore and quantify the association of hot night exposure during the sperm development period(0–90 lag days) with semen quality.Methods A total of 6,640 male sperm donors from 6 human sperm banks in Chi...Objective To explore and quantify the association of hot night exposure during the sperm development period(0–90 lag days) with semen quality.Methods A total of 6,640 male sperm donors from 6 human sperm banks in China during 2014–2020were recruited in this multicenter study.Two indices(i.e.,hot night excess [HNE] and hot night duration[HND]) were used to estimate the heat intensity and duration during nighttime.Linear mixed models were used to examine the association between hot nights and semen quality parameters.Results The exposure-response relationship revealed that HNE and HND during 0–90 days before semen collection had a significantly inverse association with sperm motility.Specifically,a 1 ℃ increase in HNE was associated with decreased sperm progressive motility of 0.0090(95% confidence interval[CI]:–0.0147,–0.0033) and decreased total motility of 0.0094(95% CI:–0.0160,–0.0029).HND was significantly associated with reduced sperm progressive motility and total motility of 0.0021(95% CI:–0.0040,–0.0003) and 0.0023(95% CI:–0.0043,–0.0002),respectively.Consistent results were observed at different temperature thresholds on hot nights.Conclusion Our findings highlight the need to mitigate nocturnal heat exposure during spermatogenesis to maintain optimal semen quality.展开更多
The construction of human settlements plays a vital role in achieving sustainable development goals.With the growing population,both urban and rural planning—as well as the development of human settlements—on the Qi...The construction of human settlements plays a vital role in achieving sustainable development goals.With the growing population,both urban and rural planning—as well as the development of human settlements—on the Qinghai-Tibet Plateau in China have received increasing attention.This study proposed a comprehensive framework to assess the quality of human settlements and identify their limiting factors of Nyingchi City,southeastern Qinghai-Tibet Plateau of China.The framework integrated a region-specific evaluation system tailored to the plateau’s unique characteristics and utilized multi-source data collected through field-based questionnaires and remote sensing.Analytical methods employed include the Criteria Importance Through Intercriteria Correlation(CRITIC)weighting method,difference analysis for evaluating spatial and categorical variations,and a novel approach introduced in this study for identifying limiting factors.In August 2021,a questionnaire-based survey was conducted in the southeastern Qinghai-Tibet Plateau,yielding 823 valid responses.The average evaluation score for human settlement quality(HSQ)was(6.96±0.94),indicating that settlement conditions were approaching the satisfaction threshold.Notably,the score for the health dimension was(6.28±1.41),reflecting relatively underdeveloped health services in the region.From the perspective of spatial patterns,despite its favorable natural conditions,the HSQ in Medog County was relatively backward,reflecting uncoordinated development that warrants attention.Significant differences were observed in the perceptions of human settlements among different groups in terms of ethnicity,income,and educational background.Low ratings for income and employment conditions represented a major limitation to the local HSQ.The development of human settlements in the southeastern Qinghai-Tibet Plateau still needs further promotion due to population disparities and the challenges of creating a healthy environment in high-altitude regions.The results are valuable for improving human settlements in plateau regions,which can help make targeted policy recommendations.展开更多
Objective:To implement humanized quality care in critical respiratory failure nursing,observe the effect,and analyze the satisfaction.Methods:80 patients with severe respiratory failure were divided into 40 cases per ...Objective:To implement humanized quality care in critical respiratory failure nursing,observe the effect,and analyze the satisfaction.Methods:80 patients with severe respiratory failure were divided into 40 cases per group(admitted from February 2022 to December 2023)by double-blind method,the control group performed routine care,and the observation group was given humanized quality care.Results:After the nursing care,two respiratory function indexes of the observation group were lower than those of the control group,and two pulmonary function indexes were higher than those of the control group(P<0.05);regarding the complication situation,the incidence rate of the observation group was lower(P<0.05);regarding the nursing care satisfaction situation,the observation group had a higher level of total satisfaction(P<0.05).Conclusion:The application of a humanized quality nursing intervention model in the care of critical respiratory failure can actively improve patients’respiratory status and lung function,reduce complications,and satisfy patients.展开更多
While quality assessment is essential for testing, optimizing, benchmarking, monitoring, and inspecting related systems and services, it also plays an essential role in the design of virtually all visual signal proces...While quality assessment is essential for testing, optimizing, benchmarking, monitoring, and inspecting related systems and services, it also plays an essential role in the design of virtually all visual signal processing and communication algorithms, as well as various related decision-making processes. In this paper, we first provide an overview of recently derived quality assessment approaches for traditional visual signals (i.e., 2D images/videos), with highlights for new trends (such as machine learning approaches). On the other hand, with the ongoing development of devices and multimedia services, newly emerged visual signals (e.g., mobile/3D videos) are becoming more and more popular. This work focuses on recent progresses of quality metrics, which have been reviewed for the newly emerged forms of visual signals, which include scalable and mobile videos, High Dynamic Range (HDR) images, image segmentation results, 3D images/videos, and retargeted images.展开更多
Human life quality requires both industrial/agricultural fast development and high environmental quality.However,the two aspects are conflicted as some contaminants are accidentally released into the environment,poten...Human life quality requires both industrial/agricultural fast development and high environmental quality.However,the two aspects are conflicted as some contaminants are accidentally released into the environment,potentially harmful to human health even at extra-low concentrations.展开更多
Increasing Chinese urbanization and industrialization has prompted greater attention to the study of human settlement and the human-land relationship in the fields of geography, architecture, and urban planning. We us...Increasing Chinese urbanization and industrialization has prompted greater attention to the study of human settlement and the human-land relationship in the fields of geography, architecture, and urban planning. We used bibliometric methods and statistical software to review 180 articles on human settlement in 16 Chinese geographical journals. We found that Chinese geographical human settlement research is characterized by the following：（1） Most research focuses on human settlement extension, valuation indicators, models for urban and rural settlements, theoretical exploration and the planning practices of single-factor, human settlement and complex, geographical livability in macro-scale, urban settlement differentiation and ideal patterns in medium scale, the comprehensive evaluation of settlement environment, and the planning of community units in micro-scale, community settlements; socio-cultural investigation and warnings about advancing human settlement.（2） No progress has been made in synthesizing and integrating method systems. PSR models and DPSIR models are used for targeting mechanisms, while the standard settlement evaluation system was composed of physical ＆ economic indicators by questionnaire surveys. On the other hand, spatial clustering based on GIS has been a frequent focus in recent years. Pioneering research on human settlement and theoretical systems within the context of China＇s urbanization and industrialization will provide guidance on the sustainability of Chinese cities and regions. The following five aspects require greater attention：（1） Natural suitability research on human settlement, and a survey of human settlement demands to reflect the range of different demands concerning ecologically suitable settlements in urban environments, the corresponding valuation indicators, systems, and evolution, and the impact of the residents＇ socio-economic attributes.（2） Spatial-temporal evaluation and sustainability research on urban and rural human settlement at various scales, focusing on evolution and spatial differen-tiation at various scales such as city clusters and comparisons between cities, within the cities and communities.（3） Development of theory and technology for human settlement evolution research, including detection technology and methods, data mining measures, and forecasting and emulation of regional and urban human settlement evolution processes, mechanisms and patterns.（4） Research on the control of human settlement that focuses on optimization, patterns, and policies for effective management and development.（5） Estimating the human settlement system service value and establishing suitable human settlement systems, including social, economic, cultural and ecological service values.展开更多
Swimming is excellent exercise and offers many health benefits. However, the ＂chlorine smell＂ in swimming pools may be a turn-off for some people. Although this smell is often thought to be of chlorine, it actually ...Swimming is excellent exercise and offers many health benefits. However, the ＂chlorine smell＂ in swimming pools may be a turn-off for some people. Although this smell is often thought to be of chlorine, it actually comes from volatile compounds that are produced from unintended reactions between disinfectants （e.g., chlorine） and organic matter in the water （Li and Blatchley, 2007; Zwiener et al., 2007; Schmalz et al., 2011; Daiber et al., 2016）. Body fluids, such as sweat and urine, are among the sources of this organic matter that contribute to the formation of disinfection byproducts （DBPs） （Richardson et al., 2007; Arnaud, 2016; Tang et al., 2016）.展开更多
In this paper some selected items of changes in the human resources in Polish agriculture at the beginning of 2 Ist century were presented, especially the questions of employment and education of the rural areas popul...In this paper some selected items of changes in the human resources in Polish agriculture at the beginning of 2 Ist century were presented, especially the questions of employment and education of the rural areas population, including farmers. The employment, as the first of the issues, was presented against the changes in the EU and the stable but non-revolutionary character of changes in Polish agriculture was underlined. To illustrate the connections between the process of changes in agriculture and the level of education some statistic data were shown. The disproportion in education level between the urban and the rural population was exposed with the emphasis on poor education of the farmers. The author also discussed the further prospects of human resources changes in the rural area to 2035. At the same time the importance of education in the process of raising the standard of life and work of people in the rural areas was stressed.展开更多
This paper mainly discusses leadership soft skills, which comprise of collaboration or teamwork, communication skills, initiative, leadership ability, people development or coaching, personal effectiveness or personal...This paper mainly discusses leadership soft skills, which comprise of collaboration or teamwork, communication skills, initiative, leadership ability, people development or coaching, personal effectiveness or personal mastery, planning and organizing, and presentation skills. Leaders need to be masters of soft skills because leadership is determined by those who can demonstrate their ability to drive an organization toward excellence and results. The aim of this paper is to contribute to the body of knowledge and literature in leadership soft skills for educational leaders in higher education institutions. In addition, this paper also provides exposure to administrators to understand the importance of leadership soft skills besides highlighting the two relevant models. Furthermore, it also provides an advantage to administrators in developing high quality interpersonal relationships with the people who they associate with in promoting positive working environment. Leadership soft skills can be seen as providing a vital contribution for organizations and administrators in the process of developing of quality human resource.展开更多
Declining female fertility is a health issue that has received broad global attention.Oocyte quality is the key limiting factor of female fertility,and key processes affecting oocyte quality involve the secretion of a...Declining female fertility is a health issue that has received broad global attention.Oocyte quality is the key limiting factor of female fertility,and key processes affecting oocyte quality involve the secretion of and response to hormones,ovarian function,oogenesis,oocyte maturation,and meiosis.However,compared with other species,the research and understanding of human oocyte quality and human reproductive health is limited.This review highlights our current understanding of the physiological factors and pathological factors related to human oocyte quality and discusses potential treatments.In terms of physiology,we discuss the regulation of the hypothalamic-pituitary-gonadal axis,granulosa cells,key subcellular structures,maternal mRNA homeostasis,the extracellular matrix,the maternal microenvironment,and multi-omics resources related to human oocyte quality.In terms of pathology,we review hypothalamic-pituitary-gonadal defects,ovarian dysfunction(including premature ovarian insufficiency and polycystic ovary syndrome),human oocyte development defects,and aging.In terms of the pathological aspects of human oocyte development and quality defects,nearly half of the reported pathogenic genes are involved in meiosis,while the remainder are involved in maternal mRNA regulation,the subcortical maternal complex,zona pellucida formation,ion channels,protein transport,and mitochondrial function.Furthermore,we outline the emerging scientific prospects and challenges for future explorations of the biological mechanisms behind infertility and the development of clinical treatments.This review seeks to deepen our understanding of the mechanisms regulating human oocyte quality and to provide novel insights into clinical female infertility characterized by defects in oocyte quality and oocyte development.展开更多
Heavy metals are widely concerning because of their toxicity,persistence,non-degradation and bioaccumulation ability.Iluman health ambient water quality criteria(AWQC)are specific levels of chemicals that can occur in...Heavy metals are widely concerning because of their toxicity,persistence,non-degradation and bioaccumulation ability.Iluman health ambient water quality criteria(AWQC)are specific levels of chemicals that can occur in water without harming human health.At present,most countries do not consider the effects of aquatic vegetables in deriving human health AWQC.Therefore,the intake of aquatic vegetables(Brasenia schreberi)was added to the derivation of human health AWQC and a health risk assessment for 13 heavy metals in Taihu Lake.The human health AWQC(consumption of water,fish and aquatic vegetables)values of 13 heavy metals ranged from 0.04(Cd)to 710.87μg/L(Sn),and the intake of B.schreberi had a very significant effect on the human health AWQC for Cu,with a more than 62-fold difference.The hazard quotients of As(2.8),Cd(1.6),Cr(1.4)and Cu(4.86)were higher than the safe level(HQ=1),indicating that As,Cd,Cr and Cu in Taihu Lake posed a significant health risk.Sensitivity analysis showed that the contribution rate of B.schreberi intake to the human health risk from Cu was 91.6%,and all results indicated that the risk of Cu in B.schreberi to human health should be of particular concern.This study adds the consideration of aquatic vegetable consumption to the traditional method of human health AWQC derivation and risk assessments for the first time,and this approach can promote the development of risk assessments and water quality criteria.展开更多
This study assesses the effect of human capital expansion on China's export product quality.It employs the difference-in-differences(DID)framework based on a quasi-natural experiment investigating the 1999 higher ...This study assesses the effect of human capital expansion on China's export product quality.It employs the difference-in-differences(DID)framework based on a quasi-natural experiment investigating the 1999 higher education enrollment expansion as the exogenous policy shock.The empirical results confirm that human capital expansion appreciably improved the quality of China's export products.Human capital expansion promoted the transformation and upgrading of old products and the development of new products in term of intensive margin;it strengthened the endowment advantages of incumbent high-quality export enterprises while preventing low-quality enterprises from entering the market through price competition on the extensive margin.This prevented quality decline.Further,the study reveals that the improvement effect driven by human capital came from both innovation-induced and managerial efficiency improvement channels and was more prominent for large or foreign-funded enterprises in the eastern region.Our findings highlight the role of human capital in China's remarkable export performance from an endogenous growth perspective.展开更多
This thesis appraises the human resources in developed regions, relatively developed regions, moderately developed regions and underdeveloped regions in China by means of comprehensive fuzzy assessment of human resour...This thesis appraises the human resources in developed regions, relatively developed regions, moderately developed regions and underdeveloped regions in China by means of comprehensive fuzzy assessment of human resources quality. Then the interrelationship between regional economic development and human resources quality is analysed. The results can be of some value for decision making.展开更多
As AI technology advances rapidly,concerns are growing about whether humans will eventually be replaced by machines.Optimists argue that human beings possess unique qualities and we should not make ourselves renji,or...As AI technology advances rapidly,concerns are growing about whether humans will eventually be replaced by machines.Optimists argue that human beings possess unique qualities and we should not make ourselves renji,or“machine-like people.”The term comes from rm(meaning“human”)andjY(“machine”).Originally,it was used in online gaming to refer to Al-controlled characters,such as NPCs(non-player characters),designed to play alongside real players or help them hone their skills.展开更多
基金funded by the Guangdong Provincial Natural Science Foundation of China(No.2022A1515011517).
文摘Objective To explore and quantify the association of hot night exposure during the sperm development period(0–90 lag days) with semen quality.Methods A total of 6,640 male sperm donors from 6 human sperm banks in China during 2014–2020were recruited in this multicenter study.Two indices(i.e.,hot night excess [HNE] and hot night duration[HND]) were used to estimate the heat intensity and duration during nighttime.Linear mixed models were used to examine the association between hot nights and semen quality parameters.Results The exposure-response relationship revealed that HNE and HND during 0–90 days before semen collection had a significantly inverse association with sperm motility.Specifically,a 1 ℃ increase in HNE was associated with decreased sperm progressive motility of 0.0090(95% confidence interval[CI]:–0.0147,–0.0033) and decreased total motility of 0.0094(95% CI:–0.0160,–0.0029).HND was significantly associated with reduced sperm progressive motility and total motility of 0.0021(95% CI:–0.0040,–0.0003) and 0.0023(95% CI:–0.0043,–0.0002),respectively.Consistent results were observed at different temperature thresholds on hot nights.Conclusion Our findings highlight the need to mitigate nocturnal heat exposure during spermatogenesis to maintain optimal semen quality.
基金Under the auspices of the Second Tibetan Plateau Scientific Expedition and Research Program(STEP,No.2019QZKK0608)。
文摘The construction of human settlements plays a vital role in achieving sustainable development goals.With the growing population,both urban and rural planning—as well as the development of human settlements—on the Qinghai-Tibet Plateau in China have received increasing attention.This study proposed a comprehensive framework to assess the quality of human settlements and identify their limiting factors of Nyingchi City,southeastern Qinghai-Tibet Plateau of China.The framework integrated a region-specific evaluation system tailored to the plateau’s unique characteristics and utilized multi-source data collected through field-based questionnaires and remote sensing.Analytical methods employed include the Criteria Importance Through Intercriteria Correlation(CRITIC)weighting method,difference analysis for evaluating spatial and categorical variations,and a novel approach introduced in this study for identifying limiting factors.In August 2021,a questionnaire-based survey was conducted in the southeastern Qinghai-Tibet Plateau,yielding 823 valid responses.The average evaluation score for human settlement quality(HSQ)was(6.96±0.94),indicating that settlement conditions were approaching the satisfaction threshold.Notably,the score for the health dimension was(6.28±1.41),reflecting relatively underdeveloped health services in the region.From the perspective of spatial patterns,despite its favorable natural conditions,the HSQ in Medog County was relatively backward,reflecting uncoordinated development that warrants attention.Significant differences were observed in the perceptions of human settlements among different groups in terms of ethnicity,income,and educational background.Low ratings for income and employment conditions represented a major limitation to the local HSQ.The development of human settlements in the southeastern Qinghai-Tibet Plateau still needs further promotion due to population disparities and the challenges of creating a healthy environment in high-altitude regions.The results are valuable for improving human settlements in plateau regions,which can help make targeted policy recommendations.
文摘Objective:To implement humanized quality care in critical respiratory failure nursing,observe the effect,and analyze the satisfaction.Methods:80 patients with severe respiratory failure were divided into 40 cases per group(admitted from February 2022 to December 2023)by double-blind method,the control group performed routine care,and the observation group was given humanized quality care.Results:After the nursing care,two respiratory function indexes of the observation group were lower than those of the control group,and two pulmonary function indexes were higher than those of the control group(P<0.05);regarding the complication situation,the incidence rate of the observation group was lower(P<0.05);regarding the nursing care satisfaction situation,the observation group had a higher level of total satisfaction(P<0.05).Conclusion:The application of a humanized quality nursing intervention model in the care of critical respiratory failure can actively improve patients’respiratory status and lung function,reduce complications,and satisfy patients.
基金partially supported by the Research Grants Council of the Hong Kong SAR, China (Project CUHK 415712)the Ministry of Education Academic Research Fund (AcRF) Tier 2 in Singapore under Grant No. T208B1218
文摘While quality assessment is essential for testing, optimizing, benchmarking, monitoring, and inspecting related systems and services, it also plays an essential role in the design of virtually all visual signal processing and communication algorithms, as well as various related decision-making processes. In this paper, we first provide an overview of recently derived quality assessment approaches for traditional visual signals (i.e., 2D images/videos), with highlights for new trends (such as machine learning approaches). On the other hand, with the ongoing development of devices and multimedia services, newly emerged visual signals (e.g., mobile/3D videos) are becoming more and more popular. This work focuses on recent progresses of quality metrics, which have been reviewed for the newly emerged forms of visual signals, which include scalable and mobile videos, High Dynamic Range (HDR) images, image segmentation results, 3D images/videos, and retargeted images.
基金supported by National Natural Science Foundation of China(No.U21A20290)。
文摘Human life quality requires both industrial/agricultural fast development and high environmental quality.However,the two aspects are conflicted as some contaminants are accidentally released into the environment,potentially harmful to human health even at extra-low concentrations.
基金National Natural Science Foundation of China,No.41230632,No.41301110,No.41501119 Zhejiang Provincial Natural Science Foundation of China,No.LY16D010008,No.Y14D010007
文摘Increasing Chinese urbanization and industrialization has prompted greater attention to the study of human settlement and the human-land relationship in the fields of geography, architecture, and urban planning. We used bibliometric methods and statistical software to review 180 articles on human settlement in 16 Chinese geographical journals. We found that Chinese geographical human settlement research is characterized by the following：（1） Most research focuses on human settlement extension, valuation indicators, models for urban and rural settlements, theoretical exploration and the planning practices of single-factor, human settlement and complex, geographical livability in macro-scale, urban settlement differentiation and ideal patterns in medium scale, the comprehensive evaluation of settlement environment, and the planning of community units in micro-scale, community settlements; socio-cultural investigation and warnings about advancing human settlement.（2） No progress has been made in synthesizing and integrating method systems. PSR models and DPSIR models are used for targeting mechanisms, while the standard settlement evaluation system was composed of physical ＆ economic indicators by questionnaire surveys. On the other hand, spatial clustering based on GIS has been a frequent focus in recent years. Pioneering research on human settlement and theoretical systems within the context of China＇s urbanization and industrialization will provide guidance on the sustainability of Chinese cities and regions. The following five aspects require greater attention：（1） Natural suitability research on human settlement, and a survey of human settlement demands to reflect the range of different demands concerning ecologically suitable settlements in urban environments, the corresponding valuation indicators, systems, and evolution, and the impact of the residents＇ socio-economic attributes.（2） Spatial-temporal evaluation and sustainability research on urban and rural human settlement at various scales, focusing on evolution and spatial differen-tiation at various scales such as city clusters and comparisons between cities, within the cities and communities.（3） Development of theory and technology for human settlement evolution research, including detection technology and methods, data mining measures, and forecasting and emulation of regional and urban human settlement evolution processes, mechanisms and patterns.（4） Research on the control of human settlement that focuses on optimization, patterns, and policies for effective management and development.（5） Estimating the human settlement system service value and establishing suitable human settlement systems, including social, economic, cultural and ecological service values.
文摘Swimming is excellent exercise and offers many health benefits. However, the ＂chlorine smell＂ in swimming pools may be a turn-off for some people. Although this smell is often thought to be of chlorine, it actually comes from volatile compounds that are produced from unintended reactions between disinfectants （e.g., chlorine） and organic matter in the water （Li and Blatchley, 2007; Zwiener et al., 2007; Schmalz et al., 2011; Daiber et al., 2016）. Body fluids, such as sweat and urine, are among the sources of this organic matter that contribute to the formation of disinfection byproducts （DBPs） （Richardson et al., 2007; Arnaud, 2016; Tang et al., 2016）.
文摘In this paper some selected items of changes in the human resources in Polish agriculture at the beginning of 2 Ist century were presented, especially the questions of employment and education of the rural areas population, including farmers. The employment, as the first of the issues, was presented against the changes in the EU and the stable but non-revolutionary character of changes in Polish agriculture was underlined. To illustrate the connections between the process of changes in agriculture and the level of education some statistic data were shown. The disproportion in education level between the urban and the rural population was exposed with the emphasis on poor education of the farmers. The author also discussed the further prospects of human resources changes in the rural area to 2035. At the same time the importance of education in the process of raising the standard of life and work of people in the rural areas was stressed.
文摘This paper mainly discusses leadership soft skills, which comprise of collaboration or teamwork, communication skills, initiative, leadership ability, people development or coaching, personal effectiveness or personal mastery, planning and organizing, and presentation skills. Leaders need to be masters of soft skills because leadership is determined by those who can demonstrate their ability to drive an organization toward excellence and results. The aim of this paper is to contribute to the body of knowledge and literature in leadership soft skills for educational leaders in higher education institutions. In addition, this paper also provides exposure to administrators to understand the importance of leadership soft skills besides highlighting the two relevant models. Furthermore, it also provides an advantage to administrators in developing high quality interpersonal relationships with the people who they associate with in promoting positive working environment. Leadership soft skills can be seen as providing a vital contribution for organizations and administrators in the process of developing of quality human resource.
基金supported by the National Natural Science Foundation of China(82325021,82288102,32130029,82371662,82422033,and 82271685)the Project of the Shanghai MunicipalScience and Technology Commission(23QA1401800)+1 种基金the Fund ofFudan University and Cao’ejiang Basic Research(24FCB01)the New Cornerstone Science Foundation through the XPLORERPRIZE.Lei Wang is a SANS Exploration Scholar.
文摘Declining female fertility is a health issue that has received broad global attention.Oocyte quality is the key limiting factor of female fertility,and key processes affecting oocyte quality involve the secretion of and response to hormones,ovarian function,oogenesis,oocyte maturation,and meiosis.However,compared with other species,the research and understanding of human oocyte quality and human reproductive health is limited.This review highlights our current understanding of the physiological factors and pathological factors related to human oocyte quality and discusses potential treatments.In terms of physiology,we discuss the regulation of the hypothalamic-pituitary-gonadal axis,granulosa cells,key subcellular structures,maternal mRNA homeostasis,the extracellular matrix,the maternal microenvironment,and multi-omics resources related to human oocyte quality.In terms of pathology,we review hypothalamic-pituitary-gonadal defects,ovarian dysfunction(including premature ovarian insufficiency and polycystic ovary syndrome),human oocyte development defects,and aging.In terms of the pathological aspects of human oocyte development and quality defects,nearly half of the reported pathogenic genes are involved in meiosis,while the remainder are involved in maternal mRNA regulation,the subcortical maternal complex,zona pellucida formation,ion channels,protein transport,and mitochondrial function.Furthermore,we outline the emerging scientific prospects and challenges for future explorations of the biological mechanisms behind infertility and the development of clinical treatments.This review seeks to deepen our understanding of the mechanisms regulating human oocyte quality and to provide novel insights into clinical female infertility characterized by defects in oocyte quality and oocyte development.
基金This work was supported by the National Science and Technology Project of Water Pollution Control and Abatement of China(Grant No.2017ZX07301002-02)the Project of Chinese Research Academy of Environmental Sciences(Grant No.2020YSKY-007)the National Natural Science Foundation of China(Grant No.41521003).
文摘Heavy metals are widely concerning because of their toxicity,persistence,non-degradation and bioaccumulation ability.Iluman health ambient water quality criteria(AWQC)are specific levels of chemicals that can occur in water without harming human health.At present,most countries do not consider the effects of aquatic vegetables in deriving human health AWQC.Therefore,the intake of aquatic vegetables(Brasenia schreberi)was added to the derivation of human health AWQC and a health risk assessment for 13 heavy metals in Taihu Lake.The human health AWQC(consumption of water,fish and aquatic vegetables)values of 13 heavy metals ranged from 0.04(Cd)to 710.87μg/L(Sn),and the intake of B.schreberi had a very significant effect on the human health AWQC for Cu,with a more than 62-fold difference.The hazard quotients of As(2.8),Cd(1.6),Cr(1.4)and Cu(4.86)were higher than the safe level(HQ=1),indicating that As,Cd,Cr and Cu in Taihu Lake posed a significant health risk.Sensitivity analysis showed that the contribution rate of B.schreberi intake to the human health risk from Cu was 91.6%,and all results indicated that the risk of Cu in B.schreberi to human health should be of particular concern.This study adds the consideration of aquatic vegetable consumption to the traditional method of human health AWQC derivation and risk assessments for the first time,and this approach can promote the development of risk assessments and water quality criteria.
基金This study is supported by the Projects of National Natural Science Foundation of China(Nos.72163016 and 71963017).
文摘This study assesses the effect of human capital expansion on China's export product quality.It employs the difference-in-differences(DID)framework based on a quasi-natural experiment investigating the 1999 higher education enrollment expansion as the exogenous policy shock.The empirical results confirm that human capital expansion appreciably improved the quality of China's export products.Human capital expansion promoted the transformation and upgrading of old products and the development of new products in term of intensive margin;it strengthened the endowment advantages of incumbent high-quality export enterprises while preventing low-quality enterprises from entering the market through price competition on the extensive margin.This prevented quality decline.Further,the study reveals that the improvement effect driven by human capital came from both innovation-induced and managerial efficiency improvement channels and was more prominent for large or foreign-funded enterprises in the eastern region.Our findings highlight the role of human capital in China's remarkable export performance from an endogenous growth perspective.
基金This paper is funded by National Science Fund. No:79770 0 81
文摘This thesis appraises the human resources in developed regions, relatively developed regions, moderately developed regions and underdeveloped regions in China by means of comprehensive fuzzy assessment of human resources quality. Then the interrelationship between regional economic development and human resources quality is analysed. The results can be of some value for decision making.
文摘As AI technology advances rapidly,concerns are growing about whether humans will eventually be replaced by machines.Optimists argue that human beings possess unique qualities and we should not make ourselves renji,or“machine-like people.”The term comes from rm(meaning“human”)andjY(“machine”).Originally,it was used in online gaming to refer to Al-controlled characters,such as NPCs(non-player characters),designed to play alongside real players or help them hone their skills.
