Computed tomography (CT), magnetic resonance imaging (MRI), and ultrasonography are essential in clinical imaging for anatomical and functional assessment. However, they lack sensitivity to low-abundance molecular act...Computed tomography (CT), magnetic resonance imaging (MRI), and ultrasonography are essential in clinical imaging for anatomical and functional assessment. However, they lack sensitivity to low-abundance molecular activity. Although positron emission tomography (PET) offers high molecular sensitivity and real-time in vivo quantification, its use is limited by ionizing radiation and short tracer half-life. Magnetic particle imaging (MPI) has recently emerged as a promising alternative, capable of directly mapping the three-dimensional (3D) distribution of superparamagnetic iron oxide nanoparticles (SPIONs) with high sensitivity and spatiotemporal resolution and without ionizing radiation or depth-dependent signal loss. These features make MPI ideal for long-term dynamic cell tracking in radiation-sensitive scenarios. However, developing MPI methods designed for human-scale applications remains challenging. In this perspective, we focus on optimizing system architecture, spatial encoding strategies, and nanoparticle design to enhance resolution, sensitivity, and field of view in MPI and discuss its clinical potential in cell tracking, tumor detection, vascular and neurological disease diagnostics, surgical navigation, multimodal imaging, and magnetically guided hyperthermia.展开更多
The development of the magnetic manipulating system is essential for applications of magnetically actuated miniature robots in biomedical practice,such as targeted therapy and precise surgery.However,the workspaces of...The development of the magnetic manipulating system is essential for applications of magnetically actuated miniature robots in biomedical practice,such as targeted therapy and precise surgery.However,the workspaces of existing magnetic manipulating systems for miniature robots are mostly insufficient to manipulate miniature robots inside human bodies.The present study proposes an innovative electromagnets-based manipulating system,TrinityMag,which can produce dynamic three-dimensional(3D)magnetic fields in a human-scale spherical workspace with a 2.6 m diameter.The magnetic field of a single electromagnet is simulated,and a new calibration technic is designed based on deep learning networks.Then,the arrangement of three electromagnets is optimized to produce maximal 3D arbitrary magnetic fields with limited currents.Moreover,a target-tracking algorithm is developed so that the TrinityMag can track the miniature robot in real time.Finally,the TrinityMag is validated in experiments to manipulate a soft millirobot to move in human-scale tortuous tracks with two types of locomotions.The maximum speed of the soft millirobot reaches 11.05 body length/s.Our work contributes to a significant increment in the workspace of the electromagnets-based manipulating system for miniature robots.We further expect that the TrinityMag could push the applications of miniature robots from laboratory to clinical practice.展开更多
基金supported by the National Key Research and Development Program of China under Grant No.2022YFB3203803the National Natural Science Foundation of China under Grant Nos.62027901,62471372,and 62071362+2 种基金the Natural Science Foundation of Chongqing under Grant No.CSTB2023NSCQ-MSX0955the Science and Technology Program of Guangzhou No.2023B03J1255the Fundamental Research Funds for the Central Universities No.ZYTS25100.
文摘Computed tomography (CT), magnetic resonance imaging (MRI), and ultrasonography are essential in clinical imaging for anatomical and functional assessment. However, they lack sensitivity to low-abundance molecular activity. Although positron emission tomography (PET) offers high molecular sensitivity and real-time in vivo quantification, its use is limited by ionizing radiation and short tracer half-life. Magnetic particle imaging (MPI) has recently emerged as a promising alternative, capable of directly mapping the three-dimensional (3D) distribution of superparamagnetic iron oxide nanoparticles (SPIONs) with high sensitivity and spatiotemporal resolution and without ionizing radiation or depth-dependent signal loss. These features make MPI ideal for long-term dynamic cell tracking in radiation-sensitive scenarios. However, developing MPI methods designed for human-scale applications remains challenging. In this perspective, we focus on optimizing system architecture, spatial encoding strategies, and nanoparticle design to enhance resolution, sensitivity, and field of view in MPI and discuss its clinical potential in cell tracking, tumor detection, vascular and neurological disease diagnostics, surgical navigation, multimodal imaging, and magnetically guided hyperthermia.
基金supported by the National Key Research and Development Program of China(Grant No.2023YFB4705300)the National Natural Science Foundation of China(Grant No.U22A2064)+2 种基金Shenzhen Science and Technology Program(Grant Nos.JCYJ20220818101611025,RCJC20231-211085926038)the Guangdong Basic and Applied Basic Research Foundation(Grant No.2022B1515120010)the SIAT-CUHK Joint Laboratory of Robotics and Intelligent Systems。
文摘The development of the magnetic manipulating system is essential for applications of magnetically actuated miniature robots in biomedical practice,such as targeted therapy and precise surgery.However,the workspaces of existing magnetic manipulating systems for miniature robots are mostly insufficient to manipulate miniature robots inside human bodies.The present study proposes an innovative electromagnets-based manipulating system,TrinityMag,which can produce dynamic three-dimensional(3D)magnetic fields in a human-scale spherical workspace with a 2.6 m diameter.The magnetic field of a single electromagnet is simulated,and a new calibration technic is designed based on deep learning networks.Then,the arrangement of three electromagnets is optimized to produce maximal 3D arbitrary magnetic fields with limited currents.Moreover,a target-tracking algorithm is developed so that the TrinityMag can track the miniature robot in real time.Finally,the TrinityMag is validated in experiments to manipulate a soft millirobot to move in human-scale tortuous tracks with two types of locomotions.The maximum speed of the soft millirobot reaches 11.05 body length/s.Our work contributes to a significant increment in the workspace of the electromagnets-based manipulating system for miniature robots.We further expect that the TrinityMag could push the applications of miniature robots from laboratory to clinical practice.
