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A methodology for aircraft mission effectiveness evaluation and design space exploration based on virtual operational test
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作者 Hu LIU Qiang GUO +2 位作者 Yongliang TIAN Kangwen SUN Chenxuan ZHAO 《Chinese Journal of Aeronautics》 2025年第2期92-110,共19页
The early involvement of test and evaluation can significantly reduce the cost of modifying issues and errors found in the later stages of aircraft development and design process.This paper presents a methodology for ... The early involvement of test and evaluation can significantly reduce the cost of modifying issues and errors found in the later stages of aircraft development and design process.This paper presents a methodology for aircraft mission effectiveness evaluation and design space exploration based on Virtual Operational Test(VOT),incorporating Virtual Open Scenario(VOS)and User in Scenarios(UIS)concepts.By employing modeling and simulation technologies in the early stages of aircraft development and design,a virtual environment can be constructed,allowing aircraft users to participate more closely and conveniently in the design process.Virtual tests conducted by users within the mission context provide data on mission effectiveness and critical user feedback.This paper outlines the main components of the virtual operational test process and related conceptual methods,and discusses an open support system framework that supports VOT.The effectiveness and adaptability of the method are demonstrated through two case studies:a beyond-visual-range air combat scenario and a helicopter ground attack scenario.These case studies demonstrate the evaluation of aircraft mission effectiveness and the sensitivity analysis and optimization of design and operational parameters based on VOT. 展开更多
关键词 Virtual operational test Effectiveness evaluation User in scenarios System of systems Virtual simulation Design space exploration
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Efficient CO_(2) Desorption Catalysts:From Material Design to Kinetics Analysis and Application Evaluation
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作者 Lei Xing Zhen Chen +3 位作者 Guoxiong Zhan Zhoulan Huang Lidong Wang Junhua Li 《Engineering》 2025年第6期251-259,共9页
Catalytic amine-solvent regeneration has been validated as an energy-saving strategy for CO_(2) chemisorption by boosting reaction kinetics under mild conditions.The upscale performance evaluation and longterm durabil... Catalytic amine-solvent regeneration has been validated as an energy-saving strategy for CO_(2) chemisorption by boosting reaction kinetics under mild conditions.The upscale performance evaluation and longterm durability are indispensable steps for industrial application but have been scarcely reported thus far.Here,we report a ZrO_(2)/Al_(2)O_(3) pack catalyst that possesses strong metal oxide-support interactions,a porous structure,active and stable Zr-O-Al coordination,promoted proton transfer and a 40.7% decrease in the energy activation of carbamate decomposition,which significantly accelerates CO_(2) desorption kinetics.The upscale experiment and cost evaluation based on industrial flue gas revealed that the use of packing catalysts can reduce energy consumption by 27.56% and optimize the overall cost by 10.49%.The active sites present excellent stability in alkaline solvents.This work is the first to investigate the ability of high-technology readiness(technology readiness level at 6(TRL 6))for catalytic aminesolvent regeneration,providing valuable insights for potential applications involving efficient CO_(2) capture with catalyst assistance. 展开更多
关键词 CO_(2)capture Catalytic CO_(2)desorption Upscale evaluation Process simulation Technical economics
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Training effectiveness evaluation of helicopter emergency relief based on virtual simulation 被引量:11
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作者 Xue SUN Hu LIU +1 位作者 Guanghui WU Yaoming ZHOU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2018年第10期2000-2012,共13页
Helicopters are playing an increasingly important part in emergency relief, such as earthquake rescue, firefighting and medical transport. With the development of virtual simulation technology, virtual simulation-base... Helicopters are playing an increasingly important part in emergency relief, such as earthquake rescue, firefighting and medical transport. With the development of virtual simulation technology, virtual simulation-based training is widely used in the training of the helicopter crew especially for the dangerous and costly missions mentioned above. A complete training effectiveness evaluation method is proposed to evaluate the trainees' training effect based on virtual simulation in this paper. A key to this method is regarding the complicated process as a discrete event-activity flow system and establishing the evaluation indicator system. Then expert group and Analytical Network Process(ANP) are applied to determine the weight of indicators. When the training data are processed, there is a novel attempt to apply Fuzzy Comprehensive Evaluation(FCE) model to calculate the two categories of indicators. Eventually, an experiment and the analysis were carried out to validate the evaluation method. 展开更多
关键词 Analytical network process Emergency relief Fuzzy comprehensive evaluation HELICOPTER Training effectiveness evaluation Virtual simulation
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Evaluation Model of Design for Operation and Architecture of Hierarchical Virtual Simulation for Flight Vehicle Design 被引量:6
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作者 LIU Hua TIAN Yongliang +2 位作者 ZHANG Chaoying YIN Jiao SUN Yijie 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2012年第2期216-226,共11页
In order to take requirements for commercial operations or military missions into better consideration in new flight vehicle design, a tri-hierarchical task classification model of "design for operation" is proposed... In order to take requirements for commercial operations or military missions into better consideration in new flight vehicle design, a tri-hierarchical task classification model of "design for operation" is proposed, which takes basic man-object interaction task, complex collaborative operation and large-scale joint operation into account. The corresponding general architecture of evaluation criteria is also depicted. Then a virtual simulation-based approach to implement the evaluations at three hierarchy levels is mainly analyzed with a detailed example, which validates the feasibility and effectiveness of evaluation architecture. Finally, extending the virtual simulation architecture from design to operation training is discussed. 展开更多
关键词 flight vehicle design operation virtual simulation TRAINING evaluation model
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Evaluation and scenario simulation for forest ecological security in China 被引量:6
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作者 Qin Zhang Guangyu Wang +4 位作者 Feng Mi Xuanchang Zhang Lianzhen Xu Yufang Zhang Xiaoli Jiang 《Journal of Forestry Research》 SCIE CAS CSCD 2019年第5期1651-1666,共16页
Continuously growing populations and rapid economic development have led to the excessive use of forest resources,and the forest ecosystem is threatened.In response,forest ecological security(FES)has attracted attenti... Continuously growing populations and rapid economic development have led to the excessive use of forest resources,and the forest ecosystem is threatened.In response,forest ecological security(FES)has attracted attention.In this study,an integrated dynamic simulation model was constructed using the system dynamic method,and it was used to evaluate the FES in China from 1999 to 2014.A scenario analysis was then used to evaluate the changes in the FES under five forestry policy scenarios for the 2015–2050 period,including the baseline,afforestation policy,harvesting policies,management policy,investment policy,and a policy mix.The results showed that the evaluation values of the FES increased during the period from 1999 to 2002,the period from 2004 to 2010 and the year 2014,and they decreased in 2003 and during the period from 2011 to 2013.During the 2015–2050 simulation period,the FES improved continuously.In particular,China would enter a new stage when the economic systems,social systems and ecosystems were in harmony after 2040.To improve the FES and the current status of the FES,a scenario analysis showed the most suitable scenario to be Scenario 5 from 2015 to 2020 and Scenario 2 from 2021 to 2050.To relieve pressure,the most suitable scenario would be Scenario 5 from 2015 to 2040 and from 2046 to 2050,and the most suitable scenario would be Scenario 4 for 2041–2045.A policy mix(Scenario 5)would be most efficient under current conditions,while the effects of all the benefits of the forestry policies would weaken over the long term.The integrated method can be regarded as a decision support tool to help policy makers understand FES and promulgate a reasonable forestry policy. 展开更多
关键词 DYNAMIC change TREND FOREST ECOLOGICAL security Integrated evaluation method System DYNAMIC model POLICY simulation
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An experimental analysis of situation awareness for cockpit display interface evaluation based on flight simulation 被引量:26
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作者 Wei Hengyang Zhuang Damin +1 位作者 Wanyan Xiaoru Wang Qun 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2013年第4期884-889,共6页
Aircraft cockpit display interface (CDI) is one of the most important human-machine interfaces for information perceiving. During the process of aircraft design, situation awareness (SA) is frequently considered t... Aircraft cockpit display interface (CDI) is one of the most important human-machine interfaces for information perceiving. During the process of aircraft design, situation awareness (SA) is frequently considered to improve the design, as the CDI must provide enough SA for the pilot to maintain the flight safety. In order to study the SA in the pilot-aircraft system, a cockpit flight simulation environment is built up, which includes a virtual instrument panel, a flight visual display and the corresponding control system. Based on the simulation environment, a human-in-the-loop experiment is designed to measure the SA by the situation awareness global assessment technique (SAGAT). Through the experiment, the SA degrees and heart rate (HR) data of the subjects are obtained, and the SA levels under different CDI designs are analyzed. The results show that analyzing the SA can serve as an objective way to evaluate the design of CDI, which could be proved from the consistent HR data. With this method, evaluations of the CDI design are performed in the experimental flight simulation environment, and optimizations could be guided through the analysis. 展开更多
关键词 Cockpit display interface Design evaluation Flight simulation Heart rate SAGAT Situation awareness
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Comparison of delay compensation methods for real-time hybrid simulation using frequency-domain evaluation index 被引量:3
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作者 Xu Weijie Guo Tong Chen Cheng 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2016年第1期129-143,共15页
The delay compensation method plays an essential role in maintaining the stability and achieving accurate real-time hybrid simulation results. The effectiveness of various compensation methods in different test scenar... The delay compensation method plays an essential role in maintaining the stability and achieving accurate real-time hybrid simulation results. The effectiveness of various compensation methods in different test scenarios, however, needs to be quantitatively evaluated. In this study, four compensation methods (i.e., the polynomial extrapolation, the linear acceleration extrapolation, the inverse compensation and the adaptive inverse compensation) are selected and compared experimentally using a frequency evaluation index (FEI) method. The effectiveness of the FEI method is first verified through comparison with the discrete transfer fimction approach for compensation methods assuming constant delay. Incomparable advantage is further demonstrated for the FEI method when applied to adaptive compensation methods, where the discrete transfer function approach is difficult to implement. Both numerical simulation and laboratory tests with predefined displacements are conducted using sinusoidal signals and random signals as inputs. Findings from numerical simulation and experimental results demonstrate that the FEI method is an efficient and effective approach to compare the performance of different compensation methods, especially for those requiring adaptation of compensation parameters. 展开更多
关键词 real-time hybrid simulation frequency domain evaluation index delay compensation methods
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Evaluation of the applicability of climate forecast system reanalysis weather data for hydrologic simulation: A case study in the Bahe River Basin of the Qinling Mountains, China 被引量:6
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作者 胡胜 邱海军 +5 位作者 杨冬冬 曹明明 宋进喜 吴江 黄晨璐 高宇 《Journal of Geographical Sciences》 SCIE CSCD 2017年第5期546-564,共19页
In recent years, global reanalysis weather data has been widely used in hydrological modeling around the world, but the results of simulations vary greatly. To consider the applicability of Climate Forecast System Rea... In recent years, global reanalysis weather data has been widely used in hydrological modeling around the world, but the results of simulations vary greatly. To consider the applicability of Climate Forecast System Reanalysis(CFSR) data in the hydrologic simulation of watersheds, the Bahe River Basin was used as a case study. Two types of weather data(conventional weather data and CFSR weather data) were considered to establish a Soil and Water Assessment Tool(SWAT) model, which was used to simulate runoff from 2001 to 2012 in the basin at annual and monthly scales. The effect of both datasets on the simulation was assessed using regression analysis, Nash-Sutcliffe Efficiency(NSE), and Percent Bias(PBIAS). A CFSR weather data correction method was proposed. The main results were as follows.(1) The CFSR climate data was applicable for hydrologic simulation in the Bahe River Basin(R^2 of the simulated results above 0.50, NSE above 0.33, and |PBIAS| below 14.8. Although the quality of the CFSR weather data is not perfect, it achieved a satisfactory hydrological simulation after rainfall data correction.(2) The simulated streamflow using the CFSR data was higher than the observed streamflow, which was likely because the estimation of daily rainfall data by CFSR weather data resulted in more rainy days and stronger rainfall intensity than was actually observed. Therefore, the data simulated a higher base flow and flood peak discharge in terms of the water balance, except for some individual years.(3) The relation between the CFSR rainfall data(x) and the observed rainfall data(y) could berepresented by a power exponent equation: y=1.4789x0.8875(R2=0.98,P〈0.001). There was a slight variation between the fitted equations for each station. The equation provides a theoretical basis for the correction of CFSR rainfall data. 展开更多
关键词 CFSR weather data hydrologic simulation applicability evaluation SWAT model Bahe River Basin
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Probability estimation based on grey system theory for simulation evaluation 被引量:5
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作者 Jianmin Wang Jinbo Wang +1 位作者 Tao Zhang Yunjie Wu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2016年第4期871-877,共7页
In the evaluation of some simulation systems, only small samples data are gotten due to the limited conditions. In allusion to the evaluation problem of small sample data, an interval estimation approach with the impr... In the evaluation of some simulation systems, only small samples data are gotten due to the limited conditions. In allusion to the evaluation problem of small sample data, an interval estimation approach with the improved grey confidence degree is proposed.On the basis of the definition of grey distance, three kinds of definition of the grey weight for every sample element in grey estimated value are put forward, and then the improved grey confidence degree is designed. In accordance with the new concept, the grey interval estimation for small sample data is deduced. Furthermore,the bootstrap method is applied for more accurate grey confidence interval. Through resampling of the bootstrap, numerous small samples with the corresponding confidence intervals can be obtained. Then the final confidence interval is calculated from the union of these grey confidence intervals. In the end, the simulation system evaluation using the proposed method is conducted. The simulation results show that the reasonable confidence interval is acquired, which demonstrates the feasibility and effectiveness of the proposed method. 展开更多
关键词 small sample interval estimation simulation system evaluation probability grey system theory
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Simulation Evaluation Study of System Reliability Based on Improved BayesBootstrap Method 被引量:1
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作者 何成铭 滕尚儒 杜海东 《Journal of Donghua University(English Edition)》 EI CAS 2015年第6期970-973,共4页
For the disadvantages of analyzing system reliability using common Bayes method,an evaluation method based on improved Bayes-Bootstrap method is presented.Firstly,the data obliteration problem existing in traditional ... For the disadvantages of analyzing system reliability using common Bayes method,an evaluation method based on improved Bayes-Bootstrap method is presented.Firstly,the data obliteration problem existing in traditional Bayes method is analyzed,then an improved sampling arithmetic is proposed on the foundation of an experience function.Finally,effectiveness of this method is proved by an example.The simulating result shows that this method is more accurate than common Bayes method. 展开更多
关键词 Bayes-Bootstrap RELIABILITY simulation evaluation
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Numerical Simulation Analysis and Ecological Evaluation on Wind Environment of Dwelling Groups in Severe Cold Regions 被引量:1
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作者 Hong Jin Teng Shao 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2014年第5期15-19,共5页
The wind environment around residential building groups is increasingly concerned,while the dwelling groups as the elementary unit of planning design,its quality of surrounding wind environment will directly affect pe... The wind environment around residential building groups is increasingly concerned,while the dwelling groups as the elementary unit of planning design,its quality of surrounding wind environment will directly affect people's life. This study based on the climatic conditions of severe cold regions,selects four dwellings groups with different openings scale and position as the research objects,and then simulates and analyzes the wind speed distribution characteristics of each pattern. Meanwhile,it extracts the wind speed values of one hundred points of each pattern and applies the coefficient of uniformity method to the ecological evaluation. It has been found that grouping pattern of buildings has a dramatic effect on the resulting airflow behavior. Configurations that contain a T-shaped central space with small opened side can effectively prevent and contain airflow in the site offer. The interactive influence between layout of dwelling groups and wind environment are explored,so as to provide basis for the planning design of dwelling groups. 展开更多
关键词 dwelling groups wind environment numerical simulation ecological evaluation
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A Sound Quality Objective Evaluation Method Based on Auditory Peripheral Simulation Model 被引量:1
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作者 Yinhan Gao~1,Jun Xie~2,Jie Liang~1,Xin Chang~3,Baojun Wu~2 1.Experimental Centre of Testing Science,Jilin University,Changchun 130022,P.R.China 2.College of Instrumentation & Electrical Engineering,Jilin University,Changchun 130061,P.R.China 3.Laboratory of Applications and Computations in Electromagnetics and Optics,Department of Electrical Engineering, University of Washington,WA 98195-2500,USA 《Journal of Bionic Engineering》 SCIE EI CSCD 2010年第2期199-208,共10页
Based on auditory peripheral simulation model, a new Sound Quality Objective Evaluation (SQOE) method is presented,which can be used to model and analyze the impacts of head, shoulder and other parts of human body on ... Based on auditory peripheral simulation model, a new Sound Quality Objective Evaluation (SQOE) method is presented,which can be used to model and analyze the impacts of head, shoulder and other parts of human body on sound wave trans-mission.This method employs the artificial head technique, in which the head related transfer function was taken into account tothe outer ear simulation phase.First, a bionic artificial head was designed as the outer ear model with considering the outersound field in view of theory and physical explanations.Then the auditory peripheral simulation model was built, which mimicsthe physiological functions of the human hearing, simulating the acoustic signal transfer process and conversion mechanismsfrom the free field to the peripheral auditory system.Finally, performance comparison was made between the proposed SQOEmethod and ArtemiS software, and the verifications of subjective and objective related analysis were made.Results show thatthe proposed method was economical, simple, and with good evaluation quality. 展开更多
关键词 sound quality objective evaluation auditory peripheral simulation model artificial head head related transfer function
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Evaluation of the Arctic Sea-Ice Simulation on SODA3 Datasets 被引量:1
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作者 Zhicheng GE Xuezhu WANG Xidong WANG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第12期2302-2317,共16页
This study evaluates the Arctic sea-ice simulation of the SODA3 dataset driven by different atmospheric forcing fields and explores the errors of the Arctic sea-ice simulation caused by the forcing field.We find that ... This study evaluates the Arctic sea-ice simulation of the SODA3 dataset driven by different atmospheric forcing fields and explores the errors of the Arctic sea-ice simulation caused by the forcing field.We find that the SODA3 data driven by different forcing fields represent a significant systematical error in the simulation of Arctic sea-ice concentration,showing a low concentration of thick ice and a high concentration of thin ice.In terms of sea-ice extent,the SODA3 data from different versions well characterize the interannual variability and declining trend in the observed data,but they overestimate the overall Arctic sea-ice extent,which is related to excessive simulation of ice in the sea-ice margin.Compared to observations,all the chosen SODA3 reanalysis versions driven by different atmospheric forcing generally tend to underestimate the Arctic sea-ice thickness,especially for thick ice in the multi-year sea-ice regions.Inaccurate simulations of Arctic sea-ice transport may partly explain the error in SODA3 sea-ice thickness in multi-year sea-ice areas.The results of different SDOA3 versions differ greatly in the Beaufort Sea,the Fram Strait,and the Central Arctic Sea.The difference in sea-ice thickness among different SODA3 versions is primarily due to the thermodynamic contribution,which may come from the diversity of atmospheric forcing fields.Our work provides a reference for using SODA3 data to study Arctic sea ice. 展开更多
关键词 Arctic sea-ice SODA3 simulation and evaluation sources of model error
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Numerical simulation of drop weight impact sensitivity evaluation criteria for pressed PBXs 被引量:1
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作者 Hong-zheng Duan Yan-qing Wu +1 位作者 Kun Yang Feng-lei Huang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第1期76-90,共15页
A thorough understanding of drop-weight impacted responses for polymer-bonded explosives(PBXs)is significant to evaluate their impact sensitivity.The characteristics of the drop-weight impacted pressed PBXs including ... A thorough understanding of drop-weight impacted responses for polymer-bonded explosives(PBXs)is significant to evaluate their impact sensitivity.The characteristics of the drop-weight impacted pressed PBXs including deforming,fracturing,forming a local high-temperature region and igniting,were simulated using a coupled mechanical-thermo-chemical model integrating micro-defects evolution.A novel evaluation method for impact sensitivity is established using the relation between the input kinetic energy and the output energy due to deformation,crushing energy,local hot spot energy and ignition.The effects of impact velocity on sensitivity were analyzed and the critical local ignition impact velocity is determined as 4.0-4.5 m/s.The simulated results show that shear-crack friction heating is the dominant ignition mechanism.The region along the boundary of PBXs sample is the most hazardous regions where ignition first occur.The propagation of stress wave in PBXs causes shear-crack hotspot and bulk temperature exhibiting an approximate 45°direction evolution path,which is the main reason that dominated damage-ignition region transits from the boundary to the central of sample. 展开更多
关键词 Polymer-bonded explosives(PBXs) Drop weight impact Numerical simulation Sensitivity evaluation criterion Hotspot mechanism
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Urban Development Boundary Simulation Based on“Double Evaluation”and FLUS Model 被引量:4
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作者 Xuchen JIANG Meng WANG +3 位作者 Gang XU Bingwang FANG Kun QIN Rui XIAO 《Journal of Geodesy and Geoinformation Science》 2022年第2期7-18,共12页
The delimitation of urban development boundaries plays an important role in optimizing the nation land space.“Double evaluation”is one of the important means to study and predict the scale of new construction land i... The delimitation of urban development boundaries plays an important role in optimizing the nation land space.“Double evaluation”is one of the important means to study and predict the scale of new construction land in the future and to determine the spatial distribution of urban construction land.This study combines the“double evaluation”with the FLUS(Future Land-Use Simulation)model to study the delimitation of the urban development boundary of Yichang.The results show that:(1)the“double evaluation”method comprehensively considers the carrying capacity of the resource environmental bear and the suitability of urban development;(2)the FLUS model can better couple the“double evaluation”method for Land Use/Land Cover(LULC)suitability evaluation,Land Use/land Cover Change(LUCC)simulation and urban development boundary delineation,and the overall accuracy of the simulation reaches 96%;(3)according to the requirements of relevant national policies,this study divides the urban development boundary of the study area into concentrated construction areas,elastic development areas and special purpose areas.This function-based division can meet the requirements of urban flexible development,ecological protection and urban safety.This research combines the FLUS model,which is widely used in the simulation of LUCC,with the double evaluation method used in China’s new round of land and space planning to obtain the result of the urban development boundary.This result is consistent with the existing plan of the study area. 展开更多
关键词 urban development boundaries double evaluation FLUS(Future Land-Use simulation)model land spatial layout optimization
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Design of Simulation System for Effectiveness Evaluation of Future Airspace Window Shooting 被引量:1
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作者 LU Da-qing WU An-bo +1 位作者 BAI Gai-chao TU Yi 《Computer Aided Drafting,Design and Manufacturing》 2013年第2期40-43,共4页
Future Airspace Window Shooting is a newly developed technology, which needs effectiveness evaluation before widely used. Future airspace window shooting technology, simulation system development principles and softwa... Future Airspace Window Shooting is a newly developed technology, which needs effectiveness evaluation before widely used. Future airspace window shooting technology, simulation system development principles and software chosen to develop the simulation system are introduced in the first. And then the overall design of the system, realization of the system and effectiveness evaluation through simulation are discussed in detail. Through the simulation, it is known that the FAW shooting has more superior performance when facing maneuvering targets. 展开更多
关键词 future airspace window fire control combat simulation effectiveness evaluation VIRTOOLS
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An Efficient Simulation Tool of Performance Evaluation for Communication Networks
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作者 Wang Xinmiao Guan Rongsheng +1 位作者 Yan Puliu Li Gang 《Wuhan University Journal of Natural Sciences》 CAS 1997年第1期57-60,共4页
We provide an efficient simulation tool for performance evaluation in communication networks. Not only the general simulation functions-which can be found in some old simulation tools, but also the perturbation functi... We provide an efficient simulation tool for performance evaluation in communication networks. Not only the general simulation functions-which can be found in some old simulation tools, but also the perturbation function module via the Standard Clock (SC) approach-in which more than 2 perturbation simulation event paths can be constructed parallelly based on a single nominal simulation event path is included in this simulation software platform. 展开更多
关键词 simulation performance evaluation perturbation analysis standard clock
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Synthesis,biochemical evaluation and computational simulations of new cytochrome bc1 complex inhibitors based on N-(4-aryloxyphenyl)phthalimides
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作者 Hua Cheng Yan Fu +6 位作者 Qing Chang Ni Zhang Mengwei Bu Yan Niu Qiongyou Wu Cheng Chen Francis Verpoort 《Chinese Chemical Letters》 SCIE CAS CSCD 2018年第12期1897-1900,共4页
The cytochrome bc1complex(the bc1complex or complex Ⅲ) is an attractive target for the discovery of numerous pharmaceuticals and pesticides. In order to identify new lead structures for this target, a new series of m... The cytochrome bc1complex(the bc1complex or complex Ⅲ) is an attractive target for the discovery of numerous pharmaceuticals and pesticides. In order to identify new lead structures for this target, a new series of molecules, N-(4-aryloxyphenyl)phthalimides, were designed and synthesized in a straightforward manner. Our design strategy was to introduce a 4-aryloxyphenyl group, a fragment which exhibited promising bc1complex-inhibiting properties, into the aryl group of the valuable N-arylphthalimide backbone. Afterward, the biochemical evaluation of the newly synthesized compounds was carried out,and the results implied that several compounds demonstrated good activities against succinatecytochrome reductase(SCR, a mixture of mitochondrial complex Ⅱ and the bc1complex). Further studies confirmed that 3e’, a representative compound in this paper, was identified as an inhibitor of the bc1complex. Furthermore, computational simulations were also performed to better understand binding of 3e’ to the enzyme complex, which indicated that 3e’ should bind to the Qosite of the bc1complex.Consequently, we harbor the idea that this paper can provide a solid platform for synthesis and discovery of other bc1complex inhibitors. 展开更多
关键词 Cytochrome bc_1 complex Inhibitor N-(4-Aryloxyphenyl)phthalimide SYNTHESIS Biochemical evaluation Computational simulation
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Surgical simulation and evaluation in anterior cruciate ligament reconstruction with image-free navigation
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作者 王田苗 《High Technology Letters》 EI CAS 2009年第1期32-37,共6页
A surgical simulation and evaluation method in the anterior cruciate ligament(ACL)reconstructionwith image-free navigation was presented.Firstly,video tracking module,bone surface reconstructionmodule and virtual simu... A surgical simulation and evaluation method in the anterior cruciate ligament(ACL)reconstructionwith image-free navigation was presented.Firstly,video tracking module,bone surface reconstructionmodule and virtual simulation module of this system were discussed.Secondly,the coordinate relations ofseveral surgery objects(including surgical instrument,anatomical,camera and screen)in the surgicalenvironment,the tracking based on MicronTracker with two cameras and the bone surface real-time recon-struction based on the Delaunay algorithm were introduced in detail.Finally,experiments of anisometrymeasurement and virtual simulation on two plastics were carried out to verify the validity of the proposedmethod.The anisometry value of reconstructed ACL was 8.970039mm.The effectiveness of ACL recon-struction has been proved by preliminary evaluation trials. 展开更多
关键词 MicronTracker monitoring anisometry ACL reconstruction virtual simulation evaluation
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Reliability Evaluation of Distribution Systems under <i>μ</i>Grid-Tied and Islanded <i>μ</i>Grid Modes Using Monte Carlo Simulation
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作者 Ahmed R. Abul’Wafa A. T. M. Taha 《Smart Grid and Renewable Energy》 2014年第3期52-62,共11页
Reliability evaluation of distribution networks under grid-tied and islanded μ grid modes is presented. The Monte Carlo simulation (MCS) algorithm is applied to a modified RBTS Bus 2 distribution network. The network... Reliability evaluation of distribution networks under grid-tied and islanded μ grid modes is presented. The Monte Carlo simulation (MCS) algorithm is applied to a modified RBTS Bus 2 distribution network. The network includes three types of distributed energy resources, namely, solar photovoltaic (PV), wind turbine (WT), and diesel turbine generator (DTG). These distributed generators contribute to supply part of the load during grid-connected mode, but supply 100% of the load in the islanded μ grid mode. A storage system is included to decrease the peak load since the peak of the output power of the PV’s and the peak load do not match time wise in most load profiles. The impact of implementing renewable distributed generation, storage systems, and conventional generation on the reliability of distribution network is studied. This study shows that the penetration of distributed generations can improve the reliability indices of the distribution network. 展开更多
关键词 Reliability evaluation MONTE Carlo simulation Distributed Generations
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