Phenome has become a consensus as the next innovation source of biomedicine.As the global network dedicated to largescale research efforts on human phenome and promoting the Human Phenome Project,the Board of Internat...Phenome has become a consensus as the next innovation source of biomedicine.As the global network dedicated to largescale research efforts on human phenome and promoting the Human Phenome Project,the Board of International Human Phenome Consortium(IHPC)plays an essential role to guide the strategy and implementation of international human phenome project and to ensure coordination across the IHPC members.The 4th International Human Phenome Consortium Board Meeting was held virtually on December 13,2022.During the meeting,the keynote speeches highlighted the latest advancements in phenomics.The construction and discoveries of the first human phenome Atlas had shown promising potential in limb development,disease prevention,and early diagnosis.Combining genome-phenome sequencing,analysis,and wellness coaching enhanced individual wellness.Phenomics trajectories from healthy to diseased states and recovery provided insight into the metabolic risk spaces associated with COVID-19.Board members from Ghana,Malaysia,India,and Russia presented their own plans and research progress.The IHPC Board deliberated on the“Framework Guidelines for Human Phenome-related Measurements”and“Proposal of the PhenoBank Initiative”.The meeting also featured a presentation of the annual report of the IHPC Journal Phenomics.Laboratory coordination,interoperable databases,and standard-ized platforms were productively discussed,which would enable concerted research efforts of the Human Phenome Project.展开更多
Imaging-derived phenotypes(IDPs)have been increasingly used in population-based cohort studies in recent years.As widely reported,magnetic resonance imaging(MRI)is an important imaging modality for assessing the anato...Imaging-derived phenotypes(IDPs)have been increasingly used in population-based cohort studies in recent years.As widely reported,magnetic resonance imaging(MRI)is an important imaging modality for assessing the anatomical structure and function of the brain with high resolution and excellent soft-tissue contrast.The purpose of this article was to describe the imaging protocol of the brain MRI in the China Phenobank Project(CHPP).Each participant underwent a 30-min brain MRI scan as part of a 2-h whole-body imaging protocol in CHPP.The brain imaging sequences included T1-magnetization that prepared rapid gradient echo,T2 fuid-attenuated inversion-recovery,magnetic resonance angiography,difusion MRI,and resting-state functional MRI.The detailed descriptions of image acquisition,interpretation,and post-processing were provided in this article.The measured IDPs included volumes of brain subregions,cerebral vessel geometrical parameters,microstructural tracts,and function connectivity metrics.展开更多
基金Funding Shanghai Soft Science Research Project(21692101800,21692102400,22692102000)Shanghai Municipal Science and Technology International Partnership Project(20490780100).
文摘Phenome has become a consensus as the next innovation source of biomedicine.As the global network dedicated to largescale research efforts on human phenome and promoting the Human Phenome Project,the Board of International Human Phenome Consortium(IHPC)plays an essential role to guide the strategy and implementation of international human phenome project and to ensure coordination across the IHPC members.The 4th International Human Phenome Consortium Board Meeting was held virtually on December 13,2022.During the meeting,the keynote speeches highlighted the latest advancements in phenomics.The construction and discoveries of the first human phenome Atlas had shown promising potential in limb development,disease prevention,and early diagnosis.Combining genome-phenome sequencing,analysis,and wellness coaching enhanced individual wellness.Phenomics trajectories from healthy to diseased states and recovery provided insight into the metabolic risk spaces associated with COVID-19.Board members from Ghana,Malaysia,India,and Russia presented their own plans and research progress.The IHPC Board deliberated on the“Framework Guidelines for Human Phenome-related Measurements”and“Proposal of the PhenoBank Initiative”.The meeting also featured a presentation of the annual report of the IHPC Journal Phenomics.Laboratory coordination,interoperable databases,and standard-ized platforms were productively discussed,which would enable concerted research efforts of the Human Phenome Project.
基金the Shanghai Municipal Science and Technology Major Project(No.2017SHZDZX01).
文摘Imaging-derived phenotypes(IDPs)have been increasingly used in population-based cohort studies in recent years.As widely reported,magnetic resonance imaging(MRI)is an important imaging modality for assessing the anatomical structure and function of the brain with high resolution and excellent soft-tissue contrast.The purpose of this article was to describe the imaging protocol of the brain MRI in the China Phenobank Project(CHPP).Each participant underwent a 30-min brain MRI scan as part of a 2-h whole-body imaging protocol in CHPP.The brain imaging sequences included T1-magnetization that prepared rapid gradient echo,T2 fuid-attenuated inversion-recovery,magnetic resonance angiography,difusion MRI,and resting-state functional MRI.The detailed descriptions of image acquisition,interpretation,and post-processing were provided in this article.The measured IDPs included volumes of brain subregions,cerebral vessel geometrical parameters,microstructural tracts,and function connectivity metrics.
