Objective:Human diphyllobothriosis is a global fish-borne zoonosis affecting approximately 20 million people.This study reports the first human case of Dibothriocephalus dendriticus(D.dendriticus)in China and explores...Objective:Human diphyllobothriosis is a global fish-borne zoonosis affecting approximately 20 million people.This study reports the first human case of Dibothriocephalus dendriticus(D.dendriticus)in China and explores its epidemiological and phylogenetic implications.Methods:Morphological features of eggs and proglottids were examined.The mitochondrial cox1 gene was sequenced for species identification.Phylogenetic analysis and epidemiological data were analyzed to trace the infection source.Results:The expelled tapeworm measured 50 cm in length and 0.7 cm in width.The gravid proglottid was longer than wide,with a centrally positioned uterus.Eggs measured 63.29±1.17×48.31±0.94μm(n=15)and had an operculum.The cox1 gene(PQ169609)showed 99.87%homology with D.dendriticus(AM412738.2).Morphological and molecular analyses confirmed the parasite as D.dendriticus.Consumption of raw salmon in Hong Kong Special Administrative Region(May 2023)and raw trout in Beijing Municipality(August 2022)were identified as potential infection sources.Phylogenetic analysis linked the strain to one from UK fish(KY552870),suggesting a common origin.Conclusion:This study reports the first human case of D.dendriticus in China.It highlights the emerging threat of D.dendriticus amid globalization and rising fish consumption.Strengthening food safety measures is essential to reducing infection risk.展开更多
This study assesses the causes and prevention measures of rabies through epidemiological investigation and analysis. A field epidemiological survey was conducted to investigate a case of rabies by fox bite. The onset ...This study assesses the causes and prevention measures of rabies through epidemiological investigation and analysis. A field epidemiological survey was conducted to investigate a case of rabies by fox bite. The onset of symptoms began 50 days after the bite. The patient did not receive standard treatment, rabies vaccination, or rabies immunoglobulin injection. The fox was killed on the spot. Saliva and pre-death blood samples were collected at different periods, and only blood RT-PCR tests yielded positive results. Wild fox bite is a major risk factor of rabies infection in Xinjiang Province, China.展开更多
Human living environment interacts with human behaviors.Environment to some degree determines human behaviors which in return reshape and sustain the dynamic environment.Taking Richard Jefferies' The Acorn Gathere...Human living environment interacts with human behaviors.Environment to some degree determines human behaviors which in return reshape and sustain the dynamic environment.Taking Richard Jefferies' The Acorn Gatherer as a case study,this paper makes an argument that the behaviors of the villagers in the story can be more adequately interpreted in view of the backward countryside environment,and the same is true with the author Richard Jefferies' non-interference in the omniscient third-person point of view in writing the story.It is Richard Jefferies' family environment that makes up his viewpoint of writing,reflecting his critical loving of the countryside,where lives boom and conventions are extremely followed.展开更多
Human rights issues are practical political issues in the realm of international relations. Publicizing hu man rights to the rest of the wold i： one key means of spreading the tru image of a rising and responsibl l...Human rights issues are practical political issues in the realm of international relations. Publicizing hu man rights to the rest of the wold i： one key means of spreading the tru image of a rising and responsibl large country. Effective publicit3 regarding human rights developmen can help China win undersandin and respect from the internationa community for China＇s human rightt policies, show the image of a demo cratic, progressive, civilized ant open large country, and create favor. able global public opinion for China Since the Communist Party of Chin （CPC） attaches great importance tc publicity regarding key human right, issues of economic and social signifi. cance in China and of international concern as well, it has organizec relevant press conferences and corn. piled white papers on human rights. White papers are important means fol China to publicize its human right, progress to the rest of the world anc are important windows by which foreign countries can understanc China＇s policies, principled stand, and achievements related to humar rights. Based on a review of Chinese government white papers, this article discusses the work, function and modes of human rights publicity.展开更多
BACKGROUND Necrolytic acral erythema(NAE) is a rare dermatological disorder,which is associated with hepatitis C virus(HCV) infection or zinc deficiency.It is characterized by erythematous or violaceous lesions occurr...BACKGROUND Necrolytic acral erythema(NAE) is a rare dermatological disorder,which is associated with hepatitis C virus(HCV) infection or zinc deficiency.It is characterized by erythematous or violaceous lesions occurring primarily in the lower extremities.The treatment includes systemic steroids and oral zinc supplementation.We report a case of NAE in a 66-year-old human immunodeficiency virus(HIV)/HCV co-infected woman with NAE.NAE is rarely reported in co-infected patients and the exact mechanisms of pathogenesis are still unclear.CASE SUMMARY A 66-year-old HIV/HCV co-infected female patient presented with painless,nonpruritic rash of extremities for one week and underwent extensive work-up for possible rheumatologic disorders including vasculitis and cryoglobulinemia.Punch skin biopsies of right and left thigh revealed thickened parakeratotic stratum corneum most consistent with NAE.Patient was started on prednisone and zinc supplementation with resolution of the lesions and improvement of rash.CONCLUSION Clinicians should maintain high clinical suspicion for early recognition of NAE in patients with rash and HCV.展开更多
The International Health Regulations(IHR)of the republic of South Africa confirmed 20 human monkeypox(mpox)cases including the death of 3 individuals to the World Health Organization(WHO)between 8 May and 2 July 2024....The International Health Regulations(IHR)of the republic of South Africa confirmed 20 human monkeypox(mpox)cases including the death of 3 individuals to the World Health Organization(WHO)between 8 May and 2 July 2024.All the cases were men aged between 17 and 43 years and 11 were men who have sex with men.Out of these cases,15 cases were living with un-managed or recently diagnosed HIV infection.All these cases were symptomatic with extensive skin lesions and required hospitalization.This sudden incidence of mpox cases without any prior history of international travel,high prevalence of HIV and high case fatality ratio,suggests that the community transmission is still prevalent.Rise of mpox cases in vulnerable groups in South Africa has the potential for increased health impact in people living in neighboring countries and has the risk of cross border and international spread.Due to this reason,national health authorities in South Africa have initiated various response measures with the support from the WHO to control this infection[1].展开更多
Objective To survey avian influenza A viruses(AIVs) in the environment and explore the reasons for the surge in human H7 N9 cases.Methods A total of 1,045 samples were collected from routine surveillance on poultry-re...Objective To survey avian influenza A viruses(AIVs) in the environment and explore the reasons for the surge in human H7 N9 cases.Methods A total of 1,045 samples were collected from routine surveillance on poultry-related environments and 307 samples from human H7 N9 cases-exposed environments in Henan from 2016 to2017. The nucleic acids of influenza A(Flu A), H5, H7, and H9 subtypes were detected by real-time polymerase chain reaction.Results A total of 27 H7 N9 cases were confirmed in Henan from 2016 to 2017, 24 had a history of live poultry exposure, and 15 had H7 N9 virus detected in the related live poultry markets(LPMs). About 96%(264/275) Flu A positive-environmental samples were from LPMs. H9 was the main AIV subtype(10.05%) from routine surveillance sites with only 1 H7-positive sample, whereas 21.17% samples were H7-positive in H7 N9 cases-exposed environments. Samples from H7 N9 cases-exposed LPMs(47.56%)had much higher AIVs positive rates than those from routine surveillance sites(12.34%). The H7+H9 combination of mixed infection was 78.18%(43/55) of H7-positive samples and 41.34%(43/104) of H9-positive samples.Conclusion The contamination status of AIVs in poultry-related environments is closely associated with the incidence of human infection caused by AIVs. Therefore, systematic surveillance of AIVs in LPMs in China is essential for the detection of novel reassortant viruses and their potential for interspecies transmission.展开更多
BACKGROUND The current case report describes successful phacoemulsification with the aid of perioperative topical ascorbic acid(AA) in two patients with corneal endothelial disorders to prevent postoperative corneal e...BACKGROUND The current case report describes successful phacoemulsification with the aid of perioperative topical ascorbic acid(AA) in two patients with corneal endothelial disorders to prevent postoperative corneal endothelial decompensation.CASE SUMMARY Two eyes of two patients underwent phacoemulsification with pre-existing corneal endothelial disorders including Fuchs corneal endothelial dystrophy(Patient 1) and endotheliitis(Patient 2). Topical AA was applied to both patients at least one month before and after with a frequency of four times per day. After the surgery, both eyes improved best-corrected visual acuity(BCVA) and there was limited human corneal endothelial cell loss without signs of corneal endothelial decompensation, such as deteriorated BCVA or persistent corneal edema during the follow-up of at least two years.CONCLUSION Perioperative administration of topical AA may be an alternative therapy to the triple procedure in patients expecting to undergo cataract surgery.展开更多
AIM:To investigate the correlation between human epidermal growth factor receptor(HER-2) protein expression and colorectal cancer(CRC) using a casecontrol study and meta-analysis.METHODS:Tumor tissue specimens from 16...AIM:To investigate the correlation between human epidermal growth factor receptor(HER-2) protein expression and colorectal cancer(CRC) using a casecontrol study and meta-analysis.METHODS:Tumor tissue specimens from 162 CRC patients were selected for the case group.Fifty cases were randomly selected,and normal CRC tissue at least 10 cm away from the tumor margins of these cases was used to generate the control group.The expression of the HER-2 protein in the 162 CRC tissue samples and the 50 adjacent normal mucosa tissue samples was detected via immunohistochemistry.The experimental data were analyzed using SPSS 18.0software,and R software version 3.1.0 was utilized for further verification.RESULTS:The expression of HER-2 protein in the 162 CRC tissue samples was significantly higher than in the normal tissue specimens.The data showed that the expression of HER-2 in CRC was related to the Dukes' stage,the depth of invasion and lymph node metastasis.The HER-2-positive patients had lower 3-and 5-year OS rates than the HER-2-negative patients,but there was no significant difference.However,there was a statistically significant difference in the 3- and5-year disease-free survival(DFS) rates of HER-2-positive and HER-2-negative patients.The results of the meta-analysis showed that the expression of HER-2in CRC patients was statistically significantly increased over that of healthy people.The 3-year DFS rate in HER-2-positive patients was markedly lower than that in HER-2-negative patients.CONCLUSION:Down-regulation of HER-2 expression might be a dependable strategy for CRC therapy.展开更多
基金Supported by the Three-Year Initiative Plan for Strengthening Public Health System Construction in Shanghai(2023-2025)Key Discipline Project(GWVI-11.1-12)the National Parasite Resource Center(NPRC-2019-194-30).
文摘Objective:Human diphyllobothriosis is a global fish-borne zoonosis affecting approximately 20 million people.This study reports the first human case of Dibothriocephalus dendriticus(D.dendriticus)in China and explores its epidemiological and phylogenetic implications.Methods:Morphological features of eggs and proglottids were examined.The mitochondrial cox1 gene was sequenced for species identification.Phylogenetic analysis and epidemiological data were analyzed to trace the infection source.Results:The expelled tapeworm measured 50 cm in length and 0.7 cm in width.The gravid proglottid was longer than wide,with a centrally positioned uterus.Eggs measured 63.29±1.17×48.31±0.94μm(n=15)and had an operculum.The cox1 gene(PQ169609)showed 99.87%homology with D.dendriticus(AM412738.2).Morphological and molecular analyses confirmed the parasite as D.dendriticus.Consumption of raw salmon in Hong Kong Special Administrative Region(May 2023)and raw trout in Beijing Municipality(August 2022)were identified as potential infection sources.Phylogenetic analysis linked the strain to one from UK fish(KY552870),suggesting a common origin.Conclusion:This study reports the first human case of D.dendriticus in China.It highlights the emerging threat of D.dendriticus amid globalization and rising fish consumption.Strengthening food safety measures is essential to reducing infection risk.
文摘This study assesses the causes and prevention measures of rabies through epidemiological investigation and analysis. A field epidemiological survey was conducted to investigate a case of rabies by fox bite. The onset of symptoms began 50 days after the bite. The patient did not receive standard treatment, rabies vaccination, or rabies immunoglobulin injection. The fox was killed on the spot. Saliva and pre-death blood samples were collected at different periods, and only blood RT-PCR tests yielded positive results. Wild fox bite is a major risk factor of rabies infection in Xinjiang Province, China.
文摘Human living environment interacts with human behaviors.Environment to some degree determines human behaviors which in return reshape and sustain the dynamic environment.Taking Richard Jefferies' The Acorn Gatherer as a case study,this paper makes an argument that the behaviors of the villagers in the story can be more adequately interpreted in view of the backward countryside environment,and the same is true with the author Richard Jefferies' non-interference in the omniscient third-person point of view in writing the story.It is Richard Jefferies' family environment that makes up his viewpoint of writing,reflecting his critical loving of the countryside,where lives boom and conventions are extremely followed.
文摘Human rights issues are practical political issues in the realm of international relations. Publicizing hu man rights to the rest of the wold i： one key means of spreading the tru image of a rising and responsibl large country. Effective publicit3 regarding human rights developmen can help China win undersandin and respect from the internationa community for China＇s human rightt policies, show the image of a demo cratic, progressive, civilized ant open large country, and create favor. able global public opinion for China Since the Communist Party of Chin （CPC） attaches great importance tc publicity regarding key human right, issues of economic and social signifi. cance in China and of international concern as well, it has organizec relevant press conferences and corn. piled white papers on human rights. White papers are important means fol China to publicize its human right, progress to the rest of the world anc are important windows by which foreign countries can understanc China＇s policies, principled stand, and achievements related to humar rights. Based on a review of Chinese government white papers, this article discusses the work, function and modes of human rights publicity.
文摘BACKGROUND Necrolytic acral erythema(NAE) is a rare dermatological disorder,which is associated with hepatitis C virus(HCV) infection or zinc deficiency.It is characterized by erythematous or violaceous lesions occurring primarily in the lower extremities.The treatment includes systemic steroids and oral zinc supplementation.We report a case of NAE in a 66-year-old human immunodeficiency virus(HIV)/HCV co-infected woman with NAE.NAE is rarely reported in co-infected patients and the exact mechanisms of pathogenesis are still unclear.CASE SUMMARY A 66-year-old HIV/HCV co-infected female patient presented with painless,nonpruritic rash of extremities for one week and underwent extensive work-up for possible rheumatologic disorders including vasculitis and cryoglobulinemia.Punch skin biopsies of right and left thigh revealed thickened parakeratotic stratum corneum most consistent with NAE.Patient was started on prednisone and zinc supplementation with resolution of the lesions and improvement of rash.CONCLUSION Clinicians should maintain high clinical suspicion for early recognition of NAE in patients with rash and HCV.
文摘The International Health Regulations(IHR)of the republic of South Africa confirmed 20 human monkeypox(mpox)cases including the death of 3 individuals to the World Health Organization(WHO)between 8 May and 2 July 2024.All the cases were men aged between 17 and 43 years and 11 were men who have sex with men.Out of these cases,15 cases were living with un-managed or recently diagnosed HIV infection.All these cases were symptomatic with extensive skin lesions and required hospitalization.This sudden incidence of mpox cases without any prior history of international travel,high prevalence of HIV and high case fatality ratio,suggests that the community transmission is still prevalent.Rise of mpox cases in vulnerable groups in South Africa has the potential for increased health impact in people living in neighboring countries and has the risk of cross border and international spread.Due to this reason,national health authorities in South Africa have initiated various response measures with the support from the WHO to control this infection[1].
基金supported by Henan Department of Science and Technology Project [182102310235]Henan Medical Science and Technology Research Project [201702269]Henan Natural Science Foundation [182300410384]
文摘Objective To survey avian influenza A viruses(AIVs) in the environment and explore the reasons for the surge in human H7 N9 cases.Methods A total of 1,045 samples were collected from routine surveillance on poultry-related environments and 307 samples from human H7 N9 cases-exposed environments in Henan from 2016 to2017. The nucleic acids of influenza A(Flu A), H5, H7, and H9 subtypes were detected by real-time polymerase chain reaction.Results A total of 27 H7 N9 cases were confirmed in Henan from 2016 to 2017, 24 had a history of live poultry exposure, and 15 had H7 N9 virus detected in the related live poultry markets(LPMs). About 96%(264/275) Flu A positive-environmental samples were from LPMs. H9 was the main AIV subtype(10.05%) from routine surveillance sites with only 1 H7-positive sample, whereas 21.17% samples were H7-positive in H7 N9 cases-exposed environments. Samples from H7 N9 cases-exposed LPMs(47.56%)had much higher AIVs positive rates than those from routine surveillance sites(12.34%). The H7+H9 combination of mixed infection was 78.18%(43/55) of H7-positive samples and 41.34%(43/104) of H9-positive samples.Conclusion The contamination status of AIVs in poultry-related environments is closely associated with the incidence of human infection caused by AIVs. Therefore, systematic surveillance of AIVs in LPMs in China is essential for the detection of novel reassortant viruses and their potential for interspecies transmission.
基金Supported by the Chang Gung Memorial Hospital,No.CMRPG3F1471~2 and No.CMRPG3G0031~3the Ministry of Science and Technology No.MOST106-2314-B-182A-042-34 and No.MOST 107-2314-B-182A-088-MY3
文摘BACKGROUND The current case report describes successful phacoemulsification with the aid of perioperative topical ascorbic acid(AA) in two patients with corneal endothelial disorders to prevent postoperative corneal endothelial decompensation.CASE SUMMARY Two eyes of two patients underwent phacoemulsification with pre-existing corneal endothelial disorders including Fuchs corneal endothelial dystrophy(Patient 1) and endotheliitis(Patient 2). Topical AA was applied to both patients at least one month before and after with a frequency of four times per day. After the surgery, both eyes improved best-corrected visual acuity(BCVA) and there was limited human corneal endothelial cell loss without signs of corneal endothelial decompensation, such as deteriorated BCVA or persistent corneal edema during the follow-up of at least two years.CONCLUSION Perioperative administration of topical AA may be an alternative therapy to the triple procedure in patients expecting to undergo cataract surgery.
文摘AIM:To investigate the correlation between human epidermal growth factor receptor(HER-2) protein expression and colorectal cancer(CRC) using a casecontrol study and meta-analysis.METHODS:Tumor tissue specimens from 162 CRC patients were selected for the case group.Fifty cases were randomly selected,and normal CRC tissue at least 10 cm away from the tumor margins of these cases was used to generate the control group.The expression of the HER-2 protein in the 162 CRC tissue samples and the 50 adjacent normal mucosa tissue samples was detected via immunohistochemistry.The experimental data were analyzed using SPSS 18.0software,and R software version 3.1.0 was utilized for further verification.RESULTS:The expression of HER-2 protein in the 162 CRC tissue samples was significantly higher than in the normal tissue specimens.The data showed that the expression of HER-2 in CRC was related to the Dukes' stage,the depth of invasion and lymph node metastasis.The HER-2-positive patients had lower 3-and 5-year OS rates than the HER-2-negative patients,but there was no significant difference.However,there was a statistically significant difference in the 3- and5-year disease-free survival(DFS) rates of HER-2-positive and HER-2-negative patients.The results of the meta-analysis showed that the expression of HER-2in CRC patients was statistically significantly increased over that of healthy people.The 3-year DFS rate in HER-2-positive patients was markedly lower than that in HER-2-negative patients.CONCLUSION:Down-regulation of HER-2 expression might be a dependable strategy for CRC therapy.
