Objective:Human diphyllobothriosis is a global fish-borne zoonosis affecting approximately 20 million people.This study reports the first human case of Dibothriocephalus dendriticus(D.dendriticus)in China and explores...Objective:Human diphyllobothriosis is a global fish-borne zoonosis affecting approximately 20 million people.This study reports the first human case of Dibothriocephalus dendriticus(D.dendriticus)in China and explores its epidemiological and phylogenetic implications.Methods:Morphological features of eggs and proglottids were examined.The mitochondrial cox1 gene was sequenced for species identification.Phylogenetic analysis and epidemiological data were analyzed to trace the infection source.Results:The expelled tapeworm measured 50 cm in length and 0.7 cm in width.The gravid proglottid was longer than wide,with a centrally positioned uterus.Eggs measured 63.29±1.17×48.31±0.94μm(n=15)and had an operculum.The cox1 gene(PQ169609)showed 99.87%homology with D.dendriticus(AM412738.2).Morphological and molecular analyses confirmed the parasite as D.dendriticus.Consumption of raw salmon in Hong Kong Special Administrative Region(May 2023)and raw trout in Beijing Municipality(August 2022)were identified as potential infection sources.Phylogenetic analysis linked the strain to one from UK fish(KY552870),suggesting a common origin.Conclusion:This study reports the first human case of D.dendriticus in China.It highlights the emerging threat of D.dendriticus amid globalization and rising fish consumption.Strengthening food safety measures is essential to reducing infection risk.展开更多
The International Health Regulations(IHR)of the republic of South Africa confirmed 20 human monkeypox(mpox)cases including the death of 3 individuals to the World Health Organization(WHO)between 8 May and 2 July 2024....The International Health Regulations(IHR)of the republic of South Africa confirmed 20 human monkeypox(mpox)cases including the death of 3 individuals to the World Health Organization(WHO)between 8 May and 2 July 2024.All the cases were men aged between 17 and 43 years and 11 were men who have sex with men.Out of these cases,15 cases were living with un-managed or recently diagnosed HIV infection.All these cases were symptomatic with extensive skin lesions and required hospitalization.This sudden incidence of mpox cases without any prior history of international travel,high prevalence of HIV and high case fatality ratio,suggests that the community transmission is still prevalent.Rise of mpox cases in vulnerable groups in South Africa has the potential for increased health impact in people living in neighboring countries and has the risk of cross border and international spread.Due to this reason,national health authorities in South Africa have initiated various response measures with the support from the WHO to control this infection[1].展开更多
Human living environment interacts with human behaviors.Environment to some degree determines human behaviors which in return reshape and sustain the dynamic environment.Taking Richard Jefferies' The Acorn Gathere...Human living environment interacts with human behaviors.Environment to some degree determines human behaviors which in return reshape and sustain the dynamic environment.Taking Richard Jefferies' The Acorn Gatherer as a case study,this paper makes an argument that the behaviors of the villagers in the story can be more adequately interpreted in view of the backward countryside environment,and the same is true with the author Richard Jefferies' non-interference in the omniscient third-person point of view in writing the story.It is Richard Jefferies' family environment that makes up his viewpoint of writing,reflecting his critical loving of the countryside,where lives boom and conventions are extremely followed.展开更多
This study assesses the causes and prevention measures of rabies through epidemiological investigation and analysis. A field epidemiological survey was conducted to investigate a case of rabies by fox bite. The onset ...This study assesses the causes and prevention measures of rabies through epidemiological investigation and analysis. A field epidemiological survey was conducted to investigate a case of rabies by fox bite. The onset of symptoms began 50 days after the bite. The patient did not receive standard treatment, rabies vaccination, or rabies immunoglobulin injection. The fox was killed on the spot. Saliva and pre-death blood samples were collected at different periods, and only blood RT-PCR tests yielded positive results. Wild fox bite is a major risk factor of rabies infection in Xinjiang Province, China.展开更多
Human rights issues are practical political issues in the realm of international relations. Publicizing hu man rights to the rest of the wold i： one key means of spreading the tru image of a rising and responsibl l...Human rights issues are practical political issues in the realm of international relations. Publicizing hu man rights to the rest of the wold i： one key means of spreading the tru image of a rising and responsibl large country. Effective publicit3 regarding human rights developmen can help China win undersandin and respect from the internationa community for China＇s human rightt policies, show the image of a demo cratic, progressive, civilized ant open large country, and create favor. able global public opinion for China Since the Communist Party of Chin （CPC） attaches great importance tc publicity regarding key human right, issues of economic and social signifi. cance in China and of international concern as well, it has organizec relevant press conferences and corn. piled white papers on human rights. White papers are important means fol China to publicize its human right, progress to the rest of the world anc are important windows by which foreign countries can understanc China＇s policies, principled stand, and achievements related to humar rights. Based on a review of Chinese government white papers, this article discusses the work, function and modes of human rights publicity.展开更多
BACKGROUND Necrolytic acral erythema(NAE) is a rare dermatological disorder,which is associated with hepatitis C virus(HCV) infection or zinc deficiency.It is characterized by erythematous or violaceous lesions occurr...BACKGROUND Necrolytic acral erythema(NAE) is a rare dermatological disorder,which is associated with hepatitis C virus(HCV) infection or zinc deficiency.It is characterized by erythematous or violaceous lesions occurring primarily in the lower extremities.The treatment includes systemic steroids and oral zinc supplementation.We report a case of NAE in a 66-year-old human immunodeficiency virus(HIV)/HCV co-infected woman with NAE.NAE is rarely reported in co-infected patients and the exact mechanisms of pathogenesis are still unclear.CASE SUMMARY A 66-year-old HIV/HCV co-infected female patient presented with painless,nonpruritic rash of extremities for one week and underwent extensive work-up for possible rheumatologic disorders including vasculitis and cryoglobulinemia.Punch skin biopsies of right and left thigh revealed thickened parakeratotic stratum corneum most consistent with NAE.Patient was started on prednisone and zinc supplementation with resolution of the lesions and improvement of rash.CONCLUSION Clinicians should maintain high clinical suspicion for early recognition of NAE in patients with rash and HCV.展开更多
基金Supported by the Three-Year Initiative Plan for Strengthening Public Health System Construction in Shanghai(2023-2025)Key Discipline Project(GWVI-11.1-12)the National Parasite Resource Center(NPRC-2019-194-30).
文摘Objective:Human diphyllobothriosis is a global fish-borne zoonosis affecting approximately 20 million people.This study reports the first human case of Dibothriocephalus dendriticus(D.dendriticus)in China and explores its epidemiological and phylogenetic implications.Methods:Morphological features of eggs and proglottids were examined.The mitochondrial cox1 gene was sequenced for species identification.Phylogenetic analysis and epidemiological data were analyzed to trace the infection source.Results:The expelled tapeworm measured 50 cm in length and 0.7 cm in width.The gravid proglottid was longer than wide,with a centrally positioned uterus.Eggs measured 63.29±1.17×48.31±0.94μm(n=15)and had an operculum.The cox1 gene(PQ169609)showed 99.87%homology with D.dendriticus(AM412738.2).Morphological and molecular analyses confirmed the parasite as D.dendriticus.Consumption of raw salmon in Hong Kong Special Administrative Region(May 2023)and raw trout in Beijing Municipality(August 2022)were identified as potential infection sources.Phylogenetic analysis linked the strain to one from UK fish(KY552870),suggesting a common origin.Conclusion:This study reports the first human case of D.dendriticus in China.It highlights the emerging threat of D.dendriticus amid globalization and rising fish consumption.Strengthening food safety measures is essential to reducing infection risk.
文摘The International Health Regulations(IHR)of the republic of South Africa confirmed 20 human monkeypox(mpox)cases including the death of 3 individuals to the World Health Organization(WHO)between 8 May and 2 July 2024.All the cases were men aged between 17 and 43 years and 11 were men who have sex with men.Out of these cases,15 cases were living with un-managed or recently diagnosed HIV infection.All these cases were symptomatic with extensive skin lesions and required hospitalization.This sudden incidence of mpox cases without any prior history of international travel,high prevalence of HIV and high case fatality ratio,suggests that the community transmission is still prevalent.Rise of mpox cases in vulnerable groups in South Africa has the potential for increased health impact in people living in neighboring countries and has the risk of cross border and international spread.Due to this reason,national health authorities in South Africa have initiated various response measures with the support from the WHO to control this infection[1].
文摘Human living environment interacts with human behaviors.Environment to some degree determines human behaviors which in return reshape and sustain the dynamic environment.Taking Richard Jefferies' The Acorn Gatherer as a case study,this paper makes an argument that the behaviors of the villagers in the story can be more adequately interpreted in view of the backward countryside environment,and the same is true with the author Richard Jefferies' non-interference in the omniscient third-person point of view in writing the story.It is Richard Jefferies' family environment that makes up his viewpoint of writing,reflecting his critical loving of the countryside,where lives boom and conventions are extremely followed.
文摘This study assesses the causes and prevention measures of rabies through epidemiological investigation and analysis. A field epidemiological survey was conducted to investigate a case of rabies by fox bite. The onset of symptoms began 50 days after the bite. The patient did not receive standard treatment, rabies vaccination, or rabies immunoglobulin injection. The fox was killed on the spot. Saliva and pre-death blood samples were collected at different periods, and only blood RT-PCR tests yielded positive results. Wild fox bite is a major risk factor of rabies infection in Xinjiang Province, China.
文摘Human rights issues are practical political issues in the realm of international relations. Publicizing hu man rights to the rest of the wold i： one key means of spreading the tru image of a rising and responsibl large country. Effective publicit3 regarding human rights developmen can help China win undersandin and respect from the internationa community for China＇s human rightt policies, show the image of a demo cratic, progressive, civilized ant open large country, and create favor. able global public opinion for China Since the Communist Party of Chin （CPC） attaches great importance tc publicity regarding key human right, issues of economic and social signifi. cance in China and of international concern as well, it has organizec relevant press conferences and corn. piled white papers on human rights. White papers are important means fol China to publicize its human right, progress to the rest of the world anc are important windows by which foreign countries can understanc China＇s policies, principled stand, and achievements related to humar rights. Based on a review of Chinese government white papers, this article discusses the work, function and modes of human rights publicity.
文摘BACKGROUND Necrolytic acral erythema(NAE) is a rare dermatological disorder,which is associated with hepatitis C virus(HCV) infection or zinc deficiency.It is characterized by erythematous or violaceous lesions occurring primarily in the lower extremities.The treatment includes systemic steroids and oral zinc supplementation.We report a case of NAE in a 66-year-old human immunodeficiency virus(HIV)/HCV co-infected woman with NAE.NAE is rarely reported in co-infected patients and the exact mechanisms of pathogenesis are still unclear.CASE SUMMARY A 66-year-old HIV/HCV co-infected female patient presented with painless,nonpruritic rash of extremities for one week and underwent extensive work-up for possible rheumatologic disorders including vasculitis and cryoglobulinemia.Punch skin biopsies of right and left thigh revealed thickened parakeratotic stratum corneum most consistent with NAE.Patient was started on prednisone and zinc supplementation with resolution of the lesions and improvement of rash.CONCLUSION Clinicians should maintain high clinical suspicion for early recognition of NAE in patients with rash and HCV.
