AIM:To detect the expression of huCdc7 in colorectal cancer.METHODS:The mRNA and protein expression of huCdc7 in 39 colorectal cancer tissue specimens and matched tumor-adjacent normal colorectal tissue specimens was ...AIM:To detect the expression of huCdc7 in colorectal cancer.METHODS:The mRNA and protein expression of huCdc7 in 39 colorectal cancer tissue specimens and matched tumor-adjacent normal colorectal tissue specimens was detected by reverse transcription-polymerase chain reaction and immunohistochemistry,respectively.RESULTS:The relative expression level of huCdc7 mRNA in colorectal cancer was significantly higher than that in tumor-adjacent normal colorectal tissues(0.03675 ± 1.00 vs 0.01199 ± 0.44,P < 0.05).huCdc7-positive cells displayed brown granules in the nucleus.Tumor tissues contained many huCdc7-positive cells,whereas normal colorectal tissues contained very few positive cells.CONCLUSION:huCdc7 may play an important role in the development and progression of colorectal cancer.展开更多
文摘AIM:To detect the expression of huCdc7 in colorectal cancer.METHODS:The mRNA and protein expression of huCdc7 in 39 colorectal cancer tissue specimens and matched tumor-adjacent normal colorectal tissue specimens was detected by reverse transcription-polymerase chain reaction and immunohistochemistry,respectively.RESULTS:The relative expression level of huCdc7 mRNA in colorectal cancer was significantly higher than that in tumor-adjacent normal colorectal tissues(0.03675 ± 1.00 vs 0.01199 ± 0.44,P < 0.05).huCdc7-positive cells displayed brown granules in the nucleus.Tumor tissues contained many huCdc7-positive cells,whereas normal colorectal tissues contained very few positive cells.CONCLUSION:huCdc7 may play an important role in the development and progression of colorectal cancer.
