Oncology Research Editorial Office Published:19 January 2026 The published article titled“miR-202 Promotes Cell Apoptosis in Esophageal Squamous Cell Carcinoma by Targeting HSF2”has been retracted from Oncology Rese...Oncology Research Editorial Office Published:19 January 2026 The published article titled“miR-202 Promotes Cell Apoptosis in Esophageal Squamous Cell Carcinoma by Targeting HSF2”has been retracted from Oncology Research,Vol.25,No.2,2017,pp.215-223.DOI:10.3727/096504016X14732772150541 URL:https://www.techscience.com/or/v25n2/56800.展开更多
Heat stress reduces theanine content in tea plants,but the underlying molecular mechanism remains unclear.In this study,a temperature gradient treatment(20℃,25℃,30℃,and 35℃)was performed to unveil the effect of he...Heat stress reduces theanine content in tea plants,but the underlying molecular mechanism remains unclear.In this study,a temperature gradient treatment(20℃,25℃,30℃,and 35℃)was performed to unveil the effect of heat stress on biosynthesis and accumulation of theanine.We found that heat stress induced metabolic changes,characterized by decreased theanine content and increased catechin levels.In addition,heat stress up-regulated the expression of the class B heat shock transcription factor gene CsHSFB2c,while significantly suppressing the transcription of key theanine biosynthetic genes CsTS1 and CsGS1.Functional studies showed that silencing CsHSFB2c increased theanine content,while its overexpression significantly decreased theanine levels.Consistent with these changes,silencing CsHSFB2c upregulated the expression of CsTS1 and CsGS1,while overexpression of CsHSFB2c downregulated their expression.Yeast one-hybrid(Y1H)and dual-luciferase reporter gene(Dual-LUC)assays showed that CsHSFB2c directly binds to the promoters of CsTS1 and CsGS1 and inhibits their expression.These results demonstrate that CsHSFB2c mediates heat-induced suppression of theanine biosynthesis by directly inhibiting the expression of CsTS1 and CsGS1.This study provides a theoretical basis for improving the heat resistance and quality of tea plants via molecular breeding.展开更多
Chromatin remodeling and transcriptional reprogramming play critical roles during mammalian meiotic prophase I;however,the precise mechanisms regulating these processes remain poorly understood.Our previous work demon...Chromatin remodeling and transcriptional reprogramming play critical roles during mammalian meiotic prophase I;however,the precise mechanisms regulating these processes remain poorly understood.Our previous work demonstrated that deletion of heat shock factor 5(HSF5),a member of the heat shock factor family,induces meiotic arrest and male infertility.However,the molecular pathways through which HSF5 governs meiotic progression have not yet been fully elucidated.In this study,a comprehensive multi-omics approach was applied to investigate the role of HSF5 in modulating chromatin dynamics and transcriptional reprogramming during pachynema progression.Analysis of ATAC-seq and single-cell RNA sequencing data revealed significant alterations in chromatin accessibility and disruption of the transcriptional regulatory network(TRN)in Hsf5−/−spermatocytes.Additionally,HSF5 deficiency resulted in defective XY body formation and altered histone modifications.Notably,Hsf5−/−spermatocytes also exhibited abnormal spermatoproteasome activity specifically on sex chromosomes,with evidence indicating that HSF5 may form a complex with USP7 in vivo to suppress H2AK119ub on meiotic sex chromosomes.These findings provide new insights into the complex,multifunctional role of HSF5 in regulating key meiotic events and advancing our understanding of its function during pachynema progression.展开更多
文摘Oncology Research Editorial Office Published:19 January 2026 The published article titled“miR-202 Promotes Cell Apoptosis in Esophageal Squamous Cell Carcinoma by Targeting HSF2”has been retracted from Oncology Research,Vol.25,No.2,2017,pp.215-223.DOI:10.3727/096504016X14732772150541 URL:https://www.techscience.com/or/v25n2/56800.
基金supported by the Major Project of Guizhou Provincial Science and Technology Program,China([2024]027)the High-Level Innovative Talents Project of Guizhou Province,China(GCC[2023]014)+1 种基金the Guizhou Provincial Tea Industry Technology System,China(GZCYCYJSTX-03)the Science and Technology Project of China Huaneng Group(HNKJ2022-H135)。
文摘Heat stress reduces theanine content in tea plants,but the underlying molecular mechanism remains unclear.In this study,a temperature gradient treatment(20℃,25℃,30℃,and 35℃)was performed to unveil the effect of heat stress on biosynthesis and accumulation of theanine.We found that heat stress induced metabolic changes,characterized by decreased theanine content and increased catechin levels.In addition,heat stress up-regulated the expression of the class B heat shock transcription factor gene CsHSFB2c,while significantly suppressing the transcription of key theanine biosynthetic genes CsTS1 and CsGS1.Functional studies showed that silencing CsHSFB2c increased theanine content,while its overexpression significantly decreased theanine levels.Consistent with these changes,silencing CsHSFB2c upregulated the expression of CsTS1 and CsGS1,while overexpression of CsHSFB2c downregulated their expression.Yeast one-hybrid(Y1H)and dual-luciferase reporter gene(Dual-LUC)assays showed that CsHSFB2c directly binds to the promoters of CsTS1 and CsGS1 and inhibits their expression.These results demonstrate that CsHSFB2c mediates heat-induced suppression of theanine biosynthesis by directly inhibiting the expression of CsTS1 and CsGS1.This study provides a theoretical basis for improving the heat resistance and quality of tea plants via molecular breeding.
基金supported by the National Natural Science Foundation of China(U24A20657,82371613 to F.S.82301798)+2 种基金Key Research and Development Program of Zhejiang Province(2023C03035 to F.S.)China Post-doctoral Science Foundation(2022M722767)Fellowship of China National Postdoctoral Program for Innovative Talents(BX20230314)。
文摘Chromatin remodeling and transcriptional reprogramming play critical roles during mammalian meiotic prophase I;however,the precise mechanisms regulating these processes remain poorly understood.Our previous work demonstrated that deletion of heat shock factor 5(HSF5),a member of the heat shock factor family,induces meiotic arrest and male infertility.However,the molecular pathways through which HSF5 governs meiotic progression have not yet been fully elucidated.In this study,a comprehensive multi-omics approach was applied to investigate the role of HSF5 in modulating chromatin dynamics and transcriptional reprogramming during pachynema progression.Analysis of ATAC-seq and single-cell RNA sequencing data revealed significant alterations in chromatin accessibility and disruption of the transcriptional regulatory network(TRN)in Hsf5−/−spermatocytes.Additionally,HSF5 deficiency resulted in defective XY body formation and altered histone modifications.Notably,Hsf5−/−spermatocytes also exhibited abnormal spermatoproteasome activity specifically on sex chromosomes,with evidence indicating that HSF5 may form a complex with USP7 in vivo to suppress H2AK119ub on meiotic sex chromosomes.These findings provide new insights into the complex,multifunctional role of HSF5 in regulating key meiotic events and advancing our understanding of its function during pachynema progression.
