Introduction:Pre-exposure prophylaxis(PrEP)and post-exposure prophylaxis(PEP)are promising interventions to curb HIV transmission among men who have sex with men(MSM).However,incorrect use may elevate HIV risk.This st...Introduction:Pre-exposure prophylaxis(PrEP)and post-exposure prophylaxis(PEP)are promising interventions to curb HIV transmission among men who have sex with men(MSM).However,incorrect use may elevate HIV risk.This study investigated the impact of improper PrEP/PEP use on HIV infection among MSM.Methods:A cross-sectional survey was conducted in Shenzhen(2021-2023)using time-location sampling and respondent-driven sampling.χ^(2)tests and Poisson regression with robust error variance were employed for univariate and multivariate analyses.Results:Compared to PrEP/PEP non-users,MSM who incorrectly used PrEP[adjusted odds ratio(aOR)=2.17,95%confidence interval(CI):1.05,4.49]and PEP(aOR=3.76,95%CI:1.40,10.15)were more likely to be HIV-positive.No HIV-positive cases were reported among MSM who correctly used PrEP.Correct PEP users showed no significant difference in HIV prevalence compared to non-users.Conclusions:Correct PrEP/PEP use is an effective HIV prevention strategy for MSM,but incorrect use may increase infection risk.Public health efforts must prioritize interventions promoting adherence to PrEP/PEP guidelines,emphasizing that PrEP/PEP should complement—not replace—consistent condom use.展开更多
基金Supported by grants from the National Natural Science Foundation of China(82373651)the Shenzhen San-Ming Project of Medicine in Shenzhen(SZSM202311015)the Shenzhen Key Medical Discipline Construction Fund(SZXK064).
文摘Introduction:Pre-exposure prophylaxis(PrEP)and post-exposure prophylaxis(PEP)are promising interventions to curb HIV transmission among men who have sex with men(MSM).However,incorrect use may elevate HIV risk.This study investigated the impact of improper PrEP/PEP use on HIV infection among MSM.Methods:A cross-sectional survey was conducted in Shenzhen(2021-2023)using time-location sampling and respondent-driven sampling.χ^(2)tests and Poisson regression with robust error variance were employed for univariate and multivariate analyses.Results:Compared to PrEP/PEP non-users,MSM who incorrectly used PrEP[adjusted odds ratio(aOR)=2.17,95%confidence interval(CI):1.05,4.49]and PEP(aOR=3.76,95%CI:1.40,10.15)were more likely to be HIV-positive.No HIV-positive cases were reported among MSM who correctly used PrEP.Correct PEP users showed no significant difference in HIV prevalence compared to non-users.Conclusions:Correct PrEP/PEP use is an effective HIV prevention strategy for MSM,but incorrect use may increase infection risk.Public health efforts must prioritize interventions promoting adherence to PrEP/PEP guidelines,emphasizing that PrEP/PEP should complement—not replace—consistent condom use.
