To the Editor:Common respiratory diseases such as chronic obstructive pulmonary disease(COPD)and asthma induce significant health burdens worldwide.[1,2]Airway/lung microbiome and microbial metabolites have been prove...To the Editor:Common respiratory diseases such as chronic obstructive pulmonary disease(COPD)and asthma induce significant health burdens worldwide.[1,2]Airway/lung microbiome and microbial metabolites have been proven to be closely related to multiple respiratory diseases.[3]However,few relevant studies show characteristics and horizontal comparisons of metabolites of dominant bacteria in respiratory diseases.Additionally,most results are based on association analyses of microbiome sequences,especially those of the gut microbiome,and untargeted metabolomics,without evidence that the metabolites are directly produced and secreted by certain bacteria.[4]In this context,our study aimed to analyze and compare the key metabolites and metabolic pathways of common bacteria involved in respiratory diseases.展开更多
基金supported by grants from the National Natural Science Foundation of China(Nos.82090013,82071805,and 82241011)Beijing Natural Science Foundation(Nos.7212001,7242010,and 7242002).
文摘To the Editor:Common respiratory diseases such as chronic obstructive pulmonary disease(COPD)and asthma induce significant health burdens worldwide.[1,2]Airway/lung microbiome and microbial metabolites have been proven to be closely related to multiple respiratory diseases.[3]However,few relevant studies show characteristics and horizontal comparisons of metabolites of dominant bacteria in respiratory diseases.Additionally,most results are based on association analyses of microbiome sequences,especially those of the gut microbiome,and untargeted metabolomics,without evidence that the metabolites are directly produced and secreted by certain bacteria.[4]In this context,our study aimed to analyze and compare the key metabolites and metabolic pathways of common bacteria involved in respiratory diseases.
