Research highlight related to:DeLeon O.,Mocanu M.,Tan A.,Sidebottom A.M.,Koval J.et al.Cell(2025);188,3927-3941,https://doi.org/10.1016/j.cell.2025.05.014.In a recent paper published in Cell,1 DeLeon and colleagues co...Research highlight related to:DeLeon O.,Mocanu M.,Tan A.,Sidebottom A.M.,Koval J.et al.Cell(2025);188,3927-3941,https://doi.org/10.1016/j.cell.2025.05.014.In a recent paper published in Cell,1 DeLeon and colleagues compared the impact of faecal microbiota transplantation(FMT)with the outcomes of transplanting jejunal or caecal microbiota material,to explore the concept of‘microbiome matching/mismatching’.They observed differential impacts upon hostmicrobe interactions based on the source of the microbiota,and expressed concern about‘unintended consequences’of microbial therapeutics in clinical practice.展开更多
基金The Division of Digestive Diseases at Imperial College London receives financial support from the National Institute of Health Research(NIHR)Imperial Biomedical Research Centre(BRC)based at Imperial College London and Imperial College Healthcare NHS Trust,BHM is the recipient of a Medical Research Council(MRC)Clinician Scientist award(MR/Z504002/1).
文摘Research highlight related to:DeLeon O.,Mocanu M.,Tan A.,Sidebottom A.M.,Koval J.et al.Cell(2025);188,3927-3941,https://doi.org/10.1016/j.cell.2025.05.014.In a recent paper published in Cell,1 DeLeon and colleagues compared the impact of faecal microbiota transplantation(FMT)with the outcomes of transplanting jejunal or caecal microbiota material,to explore the concept of‘microbiome matching/mismatching’.They observed differential impacts upon hostmicrobe interactions based on the source of the microbiota,and expressed concern about‘unintended consequences’of microbial therapeutics in clinical practice.
