Unraveling the precise mineralization age is vital to understand the geodynamic setting and ore-forming mechanism of the sediment-hosted Pb-Zn deposit;this has long been a challenge.The Sichuan-Yunnan-Guizhou(SYG)tria...Unraveling the precise mineralization age is vital to understand the geodynamic setting and ore-forming mechanism of the sediment-hosted Pb-Zn deposit;this has long been a challenge.The Sichuan-Yunnan-Guizhou(SYG)triangle in the southwestern margin of the Yangtze Block is a globally recognized carbonate-hosted Pb-Zn metallogenic province and also an essential part of the South China low-temperature metallogenic domain.This region has>30 million tons(Mt)Zn and Pb resources and shows the enrichment of dispersed metals,such as Ga,Ge,Cd,Se,and Tl.During the past 2 decades,abundant data on mineralization ages of Pb-Zn deposits within the SYG triangle have been documented based on various radioisotopic dating methods,resulting in significant progress in understanding the geodynamic background and ore formation of Pb-Zn deposits hosted in sedimentary rocks at SYG triangle.This paper provides a comprehensive summary of the geochronological results and Pb-Sr isotopic data regarding Pb-Zn deposits in the SYG triangle,which identified two distinct Pb-Zn mineralization periods influencing the dynamic processes associated with the expansion and closure of the Paleo-Tethys Ocean in the western margin of the Yangtze Block.The predominant phase of Pb-Zn mineralization at SYG triangle spanned from the Middle Triassic to Early Jurassic(226-191 Ma),which was intensely correlated with the large-scale basin fluid transport triggered by the closure of the Paleo-Tethys Ocean and Indosinian orogeny.The secondary Pb-Zn mineralization phase occurred during the Late Devonian to Late Carboniferous and was controlled by extensional structures associated with the expansion of the Paleo-Tethys Ocean.Further investigation is necessary to clarify the occurrence and potential factors involved in the Pb-Zn mineralization events during the Late Devonian to Late Carboniferous.展开更多
ZTE announced that it successfully hosted IEEE802.16’s Session 31 on 17-20 May,2004 in Shenzhen,China.It isthe first time that IEEE802 session was hostedby a Chinese enterprise,and it is also anotherachievement Z’FE...ZTE announced that it successfully hosted IEEE802.16’s Session 31 on 17-20 May,2004 in Shenzhen,China.It isthe first time that IEEE802 session was hostedby a Chinese enterprise,and it is also anotherachievement Z’FE hasmade in the international展开更多
This October, besides the usual China International Trade Fair for Apparel Fabrics and Accessories held in the city of Shanghai, another important event was set to take place in Shanghai—the 2009 Annual Conference of...This October, besides the usual China International Trade Fair for Apparel Fabrics and Accessories held in the city of Shanghai, another important event was set to take place in Shanghai—the 2009 Annual Conference of the International Textile Manufacturers Federation (ITMF), making Shanghai the place focusing all the attention of the global textile industries markedly.展开更多
Despite their high theoretical capacity and energy density,lithiumsulfur(Li–S)batteries still face challenges such as soluble lithium polysulfides(LiPSs)shuttling and sluggish redox kinetics.In this work,we used a no...Despite their high theoretical capacity and energy density,lithiumsulfur(Li–S)batteries still face challenges such as soluble lithium polysulfides(LiPSs)shuttling and sluggish redox kinetics.In this work,we used a novel MoS_(2)-Mo_(2)C heterostructure anchored on a carbon sponge(CS)as a Li_(2)S host to solve these problems.A simple hydrothermal process following carbothermal reduction was used to construct the MoS_(2)-Mo_(2)C heterostructure,enabling control of the phases and integration of MoS_(2) and Mo_(2)C.Structural characterization confirmed the coherent interface of the heterostructure with a precise orientation relationship between the two phases and their uniform distribution.An evaluation of the adsorption and catalytic performance of the material showed that it has an exceptional LiPSs adsorption capacity with faster conversion from Li_(2)S_(4) to Li_(2)S_(2).Density functional theory calculations further confirmed these results.As a result,the cathode had a high initial discharge capacity of 693 mAh g^(−1) at 0.2 C and achieved stable cycling at 2 C for 500 cycles with a low decay rate of 0.107%per cycle.The heterostructure design,coupled with the macroporous CS framework,effectively prevented the shuttling and increased sulfur utilization,offering a promising way to produce practical high-energydensity Li–S batteries.展开更多
Disruption of host physiological processes,leading to symptom expression,is a common hallmark during plant virus infections.The concept of“symptoms as strategy”is rapidly reshaping our understanding of plant virolog...Disruption of host physiological processes,leading to symptom expression,is a common hallmark during plant virus infections.The concept of“symptoms as strategy”is rapidly reshaping our understanding of plant virology.An emerging theme is that symptom expressions—such as stunting,curling,and yellowing,which devastate yield—may themselves be evolved viral adaptation strategies rather than collateral damage.展开更多
Converting body heat into electricity presents an appealing route for sustainably powering wearable electronics;however,conventional thermoelectric materials face significant drawbacks,including high ionic concentrati...Converting body heat into electricity presents an appealing route for sustainably powering wearable electronics;however,conventional thermoelectric materials face significant drawbacks,including high ionic concentrations,toxicity,and limited thermoelectric efficiency.Here,we report an ionic thermoelectric hydrogel designed through precise supramolecular chemistry,utilizing dual molecular interactions,host-vip complexation ofα-cyclodextrin(α-CD)with I_(3)^(-)ions and hydrogen bonding between polyvinyl alcohol(PVA)polymer chains and I_(3)^(-).This molecularly tailored approach markedly amplifies thermoelectric performance,achieving a high thermopower of 2.21 mV/K and a tenfold enhancement in peak power output at an exceptionally low iodine concentration(10 mmol/L I^(-)+2.5 mmol/L I_(3)^(-)).The hydrogel maintains excellent biocompatibility and mechanical robustness,suitable for direct skin contact.Demonstrated applications include flexible thermoelectric devices generating nearly 100 mV from body heat and sensor arrays capable of motion and spatial temperature sensing.These results underscore the substantial potential of supramolecularly designed ionic thermoelectric hydrogels for wearable energy harvesting,personalized healthcare monitoring,and advanced human-computer interfaces.展开更多
Fungi play crucial roles in nutrient acquisition,plant growth promotion,and the enhancement of resistance to both abiotic and biotic stresses.However,studies on the fungal communities associated with peas (Pisum sativ...Fungi play crucial roles in nutrient acquisition,plant growth promotion,and the enhancement of resistance to both abiotic and biotic stresses.However,studies on the fungal communities associated with peas (Pisum sativum L.) remain limited.In this study,we systematically investigated the ecological effects of host niches (soil,root,stem,leaf,and pod) and genotypes on the diversity and composition of fungal communities in peas using a multi-level approach that encompassed pattern recognition (β-diversity decomposition),mechanism validation (neutral community model testing),and dynamic tracking methods (migration pathway source-tracking).The results revealed that the dominant fungal phyla across niches and genotypes were Ascomycota,Basidiomycota,and Mortierellomycota,and the community structures of the soil–plant continuum were primarily determined by the pea niches rather than genotypes.β-diversity decomposition was largely attributed to species replacement rather than richness differences,indicating strong niche specificity and microbial replacement across microhabitats.Neutral model analysis revealed that stochastic processes influenced genotypeassociated communities,while deterministic processes played a dominant role in niche-based community assembly.Source-tracking analysis identified niche-to-niche fungal migration,with Erysiphe,Fusarium,Cephaliophora,Ascobolus,Alternaria,and Aspergillus as the key genera.Migration rates from exogenous to endogenous niches were low (1.3–61.5%),whereas those within exogenous (64.4–83.7%) or endogenous (73.9–96.4%) compartments were much higher,suggesting that the pea epidermis acts as a selective barrier that filters and enriches microbial communities prior to internal colonization.This study provides comprehensive insights into the mechanisms of host filtering,enrichment and microbial sourcing,which increases our understanding of the assembly rules of the pea-associated fungal microbiome.展开更多
The antioxidant activity of selenium-containing soybean peptides(SePPs)has been previously demonstrated,despite their limited absorption in the small intestine.This study investigates the antioxidant mechanism of a se...The antioxidant activity of selenium-containing soybean peptides(SePPs)has been previously demonstrated,despite their limited absorption in the small intestine.This study investigates the antioxidant mechanism of a selenium-containing tetrapeptide,Ser-Phe-Gln-SeM(SFQSeM),identified from SePPs,with particular emphasis on its interaction with the intestinal microbiota and its role in modulating host antioxidant defenses.The effects of SFQSeM were evaluated in a D-galactose-induced oxidative stress model and an antibiotictreated mouse model.SFQSeM supplementation significantly reduced the oxidative stress in D-galactosetreated mice.It also promoted the growth of beneficial bacteria and increased the levels of acetate,butyrate and lactate in the intestine(P<0.05).In the antibiotic-treated mouse model,depletion of the intestinal microbiota significantly reduced hepatic glutathione peroxidase(GSH-Px)activity(26.6%)and glutathione peroxidase 1(GPx-1)expression(48.77%)compared to normal mice supplemented with SFQSeM(P<0.05).In contrast to Na_(2)SeO_(3)and selenomethionine,SFQSeM effectively restored the diversity of the intestinal microbiota disrupted by antibiotics.Lactobacillus,Lachnospiraceae_NK4A136_group,and Muribaculaceae were identified as predominant bacteria in the SFQSeM group,and were strongly associated with increased hepatic GSH-Px activity and GPx-1 mRNA expression(P<0.05).In conclusion,intestinal microbiota enhances the antioxidant efficacy of SFQSeM by modulating microbial composition,producing active metabolites,and converting SFQSeM into a bioactive form of selenium.展开更多
The intrinsic insulation and drastic volume change of the red phosphorus during the 3-electron alloying process greatly limits its widespread applications in sodium-ion batteries.Here,we report a monomicelle-directed ...The intrinsic insulation and drastic volume change of the red phosphorus during the 3-electron alloying process greatly limits its widespread applications in sodium-ion batteries.Here,we report a monomicelle-directed assembly approach for controllable synthesis of monodispersed mesoporous polypyrrole(PPy)nanospheres,which allows for the shape-preserving conversion into N-doped carbon with regular mesoscopic pore and high surface area,thus affording a high dispersion of red phosphorus during melt impregnation process due to the available diffusion apertures and strong molecular chemical anchoring.Moreover,the theoretical calculations further revealed that positively polarized pyridine N atoms in N-doped mesoporous carbon nanospheres can empower comprehensive regulation of red phosphorus adsorption by strong chemical binding.Benefitting from the above advantages,the resultant red phosphorus host for sodium-ion batteries delivered an outstanding reversible capacity of 856 mAh/g with a capacity fading rate of only 0.025%per cycle during 1000 cycles at 1.0 A/g.This work provides an effective approach based on monomicelle-directed assembly engineering of carbon-based phosphorus hosts for advanced energy conversion and storage systems.展开更多
Background:The Colorectal Cancer(CRC)pathogenesis and therapeutic efficacy are influenced by the gut microbiome,making it a promising biomarker for predicting treatment responses and adverse effects.This systematic re...Background:The Colorectal Cancer(CRC)pathogenesis and therapeutic efficacy are influenced by the gut microbiome,making it a promising biomarker for predicting treatment responses and adverse effects.This systematic review aims to outline the gut microbiome composition in individuals with CRC undergoing the same therapeutic regimen and evaluate interindividual microbiome profile variations to better understand how these differences may influence therapeutic outcomes.Methods:Key studies investigating the microbiome’s role in therapeutic approaches for CRC were searched in both PubMed and Cochrane databases on 12 and 22 March 2025,respectively.Eligible studies included free full-text English-language randomized clinical trials and human observational studies reporting on gut microbiome composition and treatment outcomes.RoB 2 and ROBINS-I were employed in the evaluation of bias for randomized trials and observational studies,respectively.Data extracted was narratively analyzed.Results:Six studies involving a total of 361 individuals were included.Therapeutic interventions,either standard treatments and/or those targeting the gut microbiome,generally increased probiotic taxa and reduced pro-carcinogenic bacteria.However,no consistent pattern of improved clinical outcomes was observed,suggesting that treatment mechanisms,the tumor’s nature,and individual characteristics play critical roles in microbiome modulation.Conclusion:The gut microbiome holds significant potential in clinical settings.Nonetheless,further research is needed to better understand its functional aspects and to consider the influence of treatment mechanisms,the tumor’s nature,and individual characteristics as modulators,in order to optimize clinical outcomes.展开更多
Thermally activated delayed fluorescence(TADF)exciplexes,constituted of donor-acceptor moieties,have garnered mounting interest because of their promising potential to obtain high-performance electroluminescent device...Thermally activated delayed fluorescence(TADF)exciplexes,constituted of donor-acceptor moieties,have garnered mounting interest because of their promising potential to obtain high-performance electroluminescent devices.However,the moderate reverse intersystem crossing(RISC)of current reported exciplex systems and the lack of clear molecular design concepts to improve this situation have distinctly hindered the further use of exciplexes in organic light-emitting diodes(OLEDs).Herein,we conduct an exploration of exciplex systems founded upon[2,2]paracyclophane(PCP)-containing donor molecules and a triazine acceptor,which exhibit very fast RISC processes with a rate constant(k_(RISC))up to 8.3×10^(6) s^(-1)benefiting from the efficient interactions between the donor and acceptor fragments induced by the peripheral spatial-blocking of PCP group.Utilizing these deep-blue exciplexes as hosts and a multiple resonance(MR)molecule as emitter,pure-blue narrowband OLEDs with CIE coordinates of(0.124,0.137),a full-width at half-maximum(FWHM)of 23 nm,and a high external quantum efficiency(EQE)of around 30%are accessed.This study paves the way for developing blue OLEDs using PCP-based exciplex materials with an enhanced RISC process.展开更多
The gut microbiota:The human body is colonized by a diverse and complex microbial community–including bacteria,viruses,archaea,and unicellular eukaryotes–that plays a central role in human wellbeing.Indeed,microbiot...The gut microbiota:The human body is colonized by a diverse and complex microbial community–including bacteria,viruses,archaea,and unicellular eukaryotes–that plays a central role in human wellbeing.Indeed,microbiota is crucial for several functions,including host metabolism,physiology,maintenance of the intestinal epithelial integrity,nutrition,and immune function,earning it the designation of a“vital organ”(Guinane and Cotter,2013).展开更多
Luminescent metal-organic frameworks(MOFs)have garnered significant attention due to their structural tunability and potential applications in solid-state lighting,bioimaging,sensing,anticounterfeiting,and other field...Luminescent metal-organic frameworks(MOFs)have garnered significant attention due to their structural tunability and potential applications in solid-state lighting,bioimaging,sensing,anticounterfeiting,and other fields.Nevertheless,due to the tendency of1,4-benzenedicarboxylic acid(BDC)to rotate within the framework,MOFs composed of it exhibit significant non-radiative energy dissipation and thus impair the emissive properties.In this study,efficient luminescence of MIL-140A nanocrystals(NCs)with BDC rotors as ligands is achieved by pressure treatment strategy.Pressure treatment effectively modulates the pore structure of the framework,enhancing the interactions between the N,N-dimethylformamide vip molecules and the BDC ligands.The enhanced host-vip interaction contributes to the structural rigidity of the MOF,thereby suppressing the rotation-induced excited-state energy loss.As a result,the pressure-treated MIL-140A NCs displayed bright blue-light emission,with the photoluminescence quantum yield increasing from an initial 6.8%to 69.2%.This study developed an effective strategy to improve the luminescence performance of rotor ligand MOFs,offers a new avenue for the rational design and synthesis of MOFs with superior luminescent properties.展开更多
It has been well recognized that sand particles significantly affect the mechanical properties of reconstituted sandy clays,including the hosted clay and sand particles.However,interrelation between the permeability a...It has been well recognized that sand particles significantly affect the mechanical properties of reconstituted sandy clays,including the hosted clay and sand particles.However,interrelation between the permeability and compressibility of reconstituted sandy clays by considering the structural effects of sand particles is still rarely reported.For this,a series of consolidation-permeability coefficient tests were conducted on reconstituted sandy clays with different sand fractions(ψ_(ss)),initial void ratio of hosted clays(e_(c0))and void ratio at liquid limit of hosted clays(e_(cL)).The roles of ψ_(ss) in both the relationships of permeability coefficient of hosted clay(k_(v-hosted clay))versus effective vertical stress(σ'_(v))and void ratio of hosted clay(e_(c-hosted clay))versus σ'_(v) were analyzed.The results show that the permeability coefficient of reconstituted sandy clays(k_(v))is dominated by hosted clay(k_(v)=k_(v-hosted clay)).Both ψ_(ss) and σ'_(v) affect the k_(v) of sandy clays by changing the e_(c-hosted clay) at any given σ'_(v).Due to the partial contacts and densified clay bridges between the sand particles(i.e.structure effects),the e_(c-hosted clay) in sandy clays is higher than that in clays at the same σ'_(v)v.The k_(v)-e_(c-hosted clay) relationship of sandy clays is independent of σ'_(v) and ψ_(ss)but is a function of e_(cL).The types of hosted clays affect the k_(v) of sandy clays by changing the e_(cL).Based on the relationship between permeability coefficient and void ratio for the reconstituted clays,an empirical method for determining the k_(v) is proposed and validated for sandy clays.The predicted values are almost consistent with the measured values with k_(v-predicted)=k_(v-measured)=0.6-2.5.展开更多
Recently,a roundtable on carrying forward the Bandung Spirit,co-hosted by the Chinese People’s Institute of Foreign Affairs(CPIFA)and the Embassy of the Republic of Indonesia in China,took place in Beijing.Wang Yi,me...Recently,a roundtable on carrying forward the Bandung Spirit,co-hosted by the Chinese People’s Institute of Foreign Affairs(CPIFA)and the Embassy of the Republic of Indonesia in China,took place in Beijing.Wang Yi,member of the Political Bureau of the Communist Party of China Central Committee and Minister of Foreign Affairs,delivered a written speech.Indonesian Deputy Foreign Minister Siti Nugraha Mauludiah delivered a keynote speech.CPIFA President Wang Chao,Indonesian Ambassador to Bandung Spirit Driving Modernization of the Global South China Djauhari Oratmangun,former Pakistani Foreign Minister Khurshid Mahmud Kasuri,former Deputy Foreign Minister of Myanmar U Thant Kyaw,and former Under-Secretary-General of the UN Wu Hongbo attended the roundtable and delivered speeches.Also attending were more than 60 Chinese and Indonesian experts and scholars,representatives from countries that participated in the Bandung Conference,and heads of UN agencies in China.Chinese and foreign vips carried out in-depth exchange and discussion on the theme“The Global South:Carrying Forward the Bandung Spirit and Marching Together toward Modernization.”展开更多
基金supported by the National Natural Science Foundation of China(92162218,42302101,42202099)the Guizhou Provincial Natural Science Foundation(ZK[2023]477)。
文摘Unraveling the precise mineralization age is vital to understand the geodynamic setting and ore-forming mechanism of the sediment-hosted Pb-Zn deposit;this has long been a challenge.The Sichuan-Yunnan-Guizhou(SYG)triangle in the southwestern margin of the Yangtze Block is a globally recognized carbonate-hosted Pb-Zn metallogenic province and also an essential part of the South China low-temperature metallogenic domain.This region has>30 million tons(Mt)Zn and Pb resources and shows the enrichment of dispersed metals,such as Ga,Ge,Cd,Se,and Tl.During the past 2 decades,abundant data on mineralization ages of Pb-Zn deposits within the SYG triangle have been documented based on various radioisotopic dating methods,resulting in significant progress in understanding the geodynamic background and ore formation of Pb-Zn deposits hosted in sedimentary rocks at SYG triangle.This paper provides a comprehensive summary of the geochronological results and Pb-Sr isotopic data regarding Pb-Zn deposits in the SYG triangle,which identified two distinct Pb-Zn mineralization periods influencing the dynamic processes associated with the expansion and closure of the Paleo-Tethys Ocean in the western margin of the Yangtze Block.The predominant phase of Pb-Zn mineralization at SYG triangle spanned from the Middle Triassic to Early Jurassic(226-191 Ma),which was intensely correlated with the large-scale basin fluid transport triggered by the closure of the Paleo-Tethys Ocean and Indosinian orogeny.The secondary Pb-Zn mineralization phase occurred during the Late Devonian to Late Carboniferous and was controlled by extensional structures associated with the expansion of the Paleo-Tethys Ocean.Further investigation is necessary to clarify the occurrence and potential factors involved in the Pb-Zn mineralization events during the Late Devonian to Late Carboniferous.
文摘ZTE announced that it successfully hosted IEEE802.16’s Session 31 on 17-20 May,2004 in Shenzhen,China.It isthe first time that IEEE802 session was hostedby a Chinese enterprise,and it is also anotherachievement Z’FE hasmade in the international
文摘This October, besides the usual China International Trade Fair for Apparel Fabrics and Accessories held in the city of Shanghai, another important event was set to take place in Shanghai—the 2009 Annual Conference of the International Textile Manufacturers Federation (ITMF), making Shanghai the place focusing all the attention of the global textile industries markedly.
文摘Despite their high theoretical capacity and energy density,lithiumsulfur(Li–S)batteries still face challenges such as soluble lithium polysulfides(LiPSs)shuttling and sluggish redox kinetics.In this work,we used a novel MoS_(2)-Mo_(2)C heterostructure anchored on a carbon sponge(CS)as a Li_(2)S host to solve these problems.A simple hydrothermal process following carbothermal reduction was used to construct the MoS_(2)-Mo_(2)C heterostructure,enabling control of the phases and integration of MoS_(2) and Mo_(2)C.Structural characterization confirmed the coherent interface of the heterostructure with a precise orientation relationship between the two phases and their uniform distribution.An evaluation of the adsorption and catalytic performance of the material showed that it has an exceptional LiPSs adsorption capacity with faster conversion from Li_(2)S_(4) to Li_(2)S_(2).Density functional theory calculations further confirmed these results.As a result,the cathode had a high initial discharge capacity of 693 mAh g^(−1) at 0.2 C and achieved stable cycling at 2 C for 500 cycles with a low decay rate of 0.107%per cycle.The heterostructure design,coupled with the macroporous CS framework,effectively prevented the shuttling and increased sulfur utilization,offering a promising way to produce practical high-energydensity Li–S batteries.
基金supported by the National Natural Science Foundation of China(32272482)the Innovation Research 2035 Pilot Plan of Southwest University(SWU-XDZD22002).
文摘Disruption of host physiological processes,leading to symptom expression,is a common hallmark during plant virus infections.The concept of“symptoms as strategy”is rapidly reshaping our understanding of plant virology.An emerging theme is that symptom expressions—such as stunting,curling,and yellowing,which devastate yield—may themselves be evolved viral adaptation strategies rather than collateral damage.
基金supported by the National Natural Science Foundation of China(22271110)the Natural Science Founda-tion of Hubei Province(2022CFA031)。
文摘Converting body heat into electricity presents an appealing route for sustainably powering wearable electronics;however,conventional thermoelectric materials face significant drawbacks,including high ionic concentrations,toxicity,and limited thermoelectric efficiency.Here,we report an ionic thermoelectric hydrogel designed through precise supramolecular chemistry,utilizing dual molecular interactions,host-vip complexation ofα-cyclodextrin(α-CD)with I_(3)^(-)ions and hydrogen bonding between polyvinyl alcohol(PVA)polymer chains and I_(3)^(-).This molecularly tailored approach markedly amplifies thermoelectric performance,achieving a high thermopower of 2.21 mV/K and a tenfold enhancement in peak power output at an exceptionally low iodine concentration(10 mmol/L I^(-)+2.5 mmol/L I_(3)^(-)).The hydrogel maintains excellent biocompatibility and mechanical robustness,suitable for direct skin contact.Demonstrated applications include flexible thermoelectric devices generating nearly 100 mV from body heat and sensor arrays capable of motion and spatial temperature sensing.These results underscore the substantial potential of supramolecularly designed ionic thermoelectric hydrogels for wearable energy harvesting,personalized healthcare monitoring,and advanced human-computer interfaces.
基金financial y supported by the National Key Research and Development Program of China (2023YFD1900902)the Joint Funds of the Zhejiang Provincial Natural Science Foundation of China (LLSSZ24C030001)+1 种基金the Earmarked Fund for China Agriculture Research System (CARS-08-G-09)sponsored by the K.C.Wong Magna Fund of Ningbo University,China。
文摘Fungi play crucial roles in nutrient acquisition,plant growth promotion,and the enhancement of resistance to both abiotic and biotic stresses.However,studies on the fungal communities associated with peas (Pisum sativum L.) remain limited.In this study,we systematically investigated the ecological effects of host niches (soil,root,stem,leaf,and pod) and genotypes on the diversity and composition of fungal communities in peas using a multi-level approach that encompassed pattern recognition (β-diversity decomposition),mechanism validation (neutral community model testing),and dynamic tracking methods (migration pathway source-tracking).The results revealed that the dominant fungal phyla across niches and genotypes were Ascomycota,Basidiomycota,and Mortierellomycota,and the community structures of the soil–plant continuum were primarily determined by the pea niches rather than genotypes.β-diversity decomposition was largely attributed to species replacement rather than richness differences,indicating strong niche specificity and microbial replacement across microhabitats.Neutral model analysis revealed that stochastic processes influenced genotypeassociated communities,while deterministic processes played a dominant role in niche-based community assembly.Source-tracking analysis identified niche-to-niche fungal migration,with Erysiphe,Fusarium,Cephaliophora,Ascobolus,Alternaria,and Aspergillus as the key genera.Migration rates from exogenous to endogenous niches were low (1.3–61.5%),whereas those within exogenous (64.4–83.7%) or endogenous (73.9–96.4%) compartments were much higher,suggesting that the pea epidermis acts as a selective barrier that filters and enriches microbial communities prior to internal colonization.This study provides comprehensive insights into the mechanisms of host filtering,enrichment and microbial sourcing,which increases our understanding of the assembly rules of the pea-associated fungal microbiome.
基金Financial support from the National Natural Science Foundation of China(32502106)One health Interdisciplinary Research Project,Institute of One Health Science,Ningbo University(NBUOH202502)the Ningbo Top Talent Project(215-432094250).
文摘The antioxidant activity of selenium-containing soybean peptides(SePPs)has been previously demonstrated,despite their limited absorption in the small intestine.This study investigates the antioxidant mechanism of a selenium-containing tetrapeptide,Ser-Phe-Gln-SeM(SFQSeM),identified from SePPs,with particular emphasis on its interaction with the intestinal microbiota and its role in modulating host antioxidant defenses.The effects of SFQSeM were evaluated in a D-galactose-induced oxidative stress model and an antibiotictreated mouse model.SFQSeM supplementation significantly reduced the oxidative stress in D-galactosetreated mice.It also promoted the growth of beneficial bacteria and increased the levels of acetate,butyrate and lactate in the intestine(P<0.05).In the antibiotic-treated mouse model,depletion of the intestinal microbiota significantly reduced hepatic glutathione peroxidase(GSH-Px)activity(26.6%)and glutathione peroxidase 1(GPx-1)expression(48.77%)compared to normal mice supplemented with SFQSeM(P<0.05).In contrast to Na_(2)SeO_(3)and selenomethionine,SFQSeM effectively restored the diversity of the intestinal microbiota disrupted by antibiotics.Lactobacillus,Lachnospiraceae_NK4A136_group,and Muribaculaceae were identified as predominant bacteria in the SFQSeM group,and were strongly associated with increased hepatic GSH-Px activity and GPx-1 mRNA expression(P<0.05).In conclusion,intestinal microbiota enhances the antioxidant efficacy of SFQSeM by modulating microbial composition,producing active metabolites,and converting SFQSeM into a bioactive form of selenium.
基金supported by the National Natural Science Foundation of China(Nos.52373208 and 61831021)the Shanghai Undergraduate Training Program on Innovation and Entrepreneurship(No.202310269131S).
文摘The intrinsic insulation and drastic volume change of the red phosphorus during the 3-electron alloying process greatly limits its widespread applications in sodium-ion batteries.Here,we report a monomicelle-directed assembly approach for controllable synthesis of monodispersed mesoporous polypyrrole(PPy)nanospheres,which allows for the shape-preserving conversion into N-doped carbon with regular mesoscopic pore and high surface area,thus affording a high dispersion of red phosphorus during melt impregnation process due to the available diffusion apertures and strong molecular chemical anchoring.Moreover,the theoretical calculations further revealed that positively polarized pyridine N atoms in N-doped mesoporous carbon nanospheres can empower comprehensive regulation of red phosphorus adsorption by strong chemical binding.Benefitting from the above advantages,the resultant red phosphorus host for sodium-ion batteries delivered an outstanding reversible capacity of 856 mAh/g with a capacity fading rate of only 0.025%per cycle during 1000 cycles at 1.0 A/g.This work provides an effective approach based on monomicelle-directed assembly engineering of carbon-based phosphorus hosts for advanced energy conversion and storage systems.
基金supported by FCT/MCTES UIDP/05608/2020(https://doi.org/10.54499/UIDP/05608/2020)UIDB/05608/2020(https://doi.org/10.54499/UIDB/05608/2020).
文摘Background:The Colorectal Cancer(CRC)pathogenesis and therapeutic efficacy are influenced by the gut microbiome,making it a promising biomarker for predicting treatment responses and adverse effects.This systematic review aims to outline the gut microbiome composition in individuals with CRC undergoing the same therapeutic regimen and evaluate interindividual microbiome profile variations to better understand how these differences may influence therapeutic outcomes.Methods:Key studies investigating the microbiome’s role in therapeutic approaches for CRC were searched in both PubMed and Cochrane databases on 12 and 22 March 2025,respectively.Eligible studies included free full-text English-language randomized clinical trials and human observational studies reporting on gut microbiome composition and treatment outcomes.RoB 2 and ROBINS-I were employed in the evaluation of bias for randomized trials and observational studies,respectively.Data extracted was narratively analyzed.Results:Six studies involving a total of 361 individuals were included.Therapeutic interventions,either standard treatments and/or those targeting the gut microbiome,generally increased probiotic taxa and reduced pro-carcinogenic bacteria.However,no consistent pattern of improved clinical outcomes was observed,suggesting that treatment mechanisms,the tumor’s nature,and individual characteristics play critical roles in microbiome modulation.Conclusion:The gut microbiome holds significant potential in clinical settings.Nonetheless,further research is needed to better understand its functional aspects and to consider the influence of treatment mechanisms,the tumor’s nature,and individual characteristics as modulators,in order to optimize clinical outcomes.
基金supported by the National Key R&D Program of China(2022YFE0109000)the National Natural Science Foundation of China(21975152,92256304,U23A20593)+1 种基金the China Postdoctoral Science Foundation(2022M722028)the Deutsche Forschungsgemeinschaft(DFG)under Germany’s Excellence Strategy(3DMM2O-EXC-2082/1-390761711)。
文摘Thermally activated delayed fluorescence(TADF)exciplexes,constituted of donor-acceptor moieties,have garnered mounting interest because of their promising potential to obtain high-performance electroluminescent devices.However,the moderate reverse intersystem crossing(RISC)of current reported exciplex systems and the lack of clear molecular design concepts to improve this situation have distinctly hindered the further use of exciplexes in organic light-emitting diodes(OLEDs).Herein,we conduct an exploration of exciplex systems founded upon[2,2]paracyclophane(PCP)-containing donor molecules and a triazine acceptor,which exhibit very fast RISC processes with a rate constant(k_(RISC))up to 8.3×10^(6) s^(-1)benefiting from the efficient interactions between the donor and acceptor fragments induced by the peripheral spatial-blocking of PCP group.Utilizing these deep-blue exciplexes as hosts and a multiple resonance(MR)molecule as emitter,pure-blue narrowband OLEDs with CIE coordinates of(0.124,0.137),a full-width at half-maximum(FWHM)of 23 nm,and a high external quantum efficiency(EQE)of around 30%are accessed.This study paves the way for developing blue OLEDs using PCP-based exciplex materials with an enhanced RISC process.
基金supported by the European Union-Next Generation EU,Mission 4 Component 1,Project Title:“Gut and Neuro Muscular system:investigating the impact of microbiota on nerve regeneration and muscle reinnervation after peripheral nerve injury”,CUP D53D23007770006,MUR:20227YB93W,to GR。
文摘The gut microbiota:The human body is colonized by a diverse and complex microbial community–including bacteria,viruses,archaea,and unicellular eukaryotes–that plays a central role in human wellbeing.Indeed,microbiota is crucial for several functions,including host metabolism,physiology,maintenance of the intestinal epithelial integrity,nutrition,and immune function,earning it the designation of a“vital organ”(Guinane and Cotter,2013).
基金supported by the National Key R&D Program of China(Grant No.2023YFA1406200)the National Natural Science Foundation of China(No.12274177 and 12304261)the China Postdoctoral Science Foundation(No.2024M751076)。
文摘Luminescent metal-organic frameworks(MOFs)have garnered significant attention due to their structural tunability and potential applications in solid-state lighting,bioimaging,sensing,anticounterfeiting,and other fields.Nevertheless,due to the tendency of1,4-benzenedicarboxylic acid(BDC)to rotate within the framework,MOFs composed of it exhibit significant non-radiative energy dissipation and thus impair the emissive properties.In this study,efficient luminescence of MIL-140A nanocrystals(NCs)with BDC rotors as ligands is achieved by pressure treatment strategy.Pressure treatment effectively modulates the pore structure of the framework,enhancing the interactions between the N,N-dimethylformamide vip molecules and the BDC ligands.The enhanced host-vip interaction contributes to the structural rigidity of the MOF,thereby suppressing the rotation-induced excited-state energy loss.As a result,the pressure-treated MIL-140A NCs displayed bright blue-light emission,with the photoluminescence quantum yield increasing from an initial 6.8%to 69.2%.This study developed an effective strategy to improve the luminescence performance of rotor ligand MOFs,offers a new avenue for the rational design and synthesis of MOFs with superior luminescent properties.
基金supported by the National Natural Science Foundation of China (Grant Nos.52278334 and 4197724)Fundamental Research Funds for the Central Universities (Grant No.2242024k30066).
文摘It has been well recognized that sand particles significantly affect the mechanical properties of reconstituted sandy clays,including the hosted clay and sand particles.However,interrelation between the permeability and compressibility of reconstituted sandy clays by considering the structural effects of sand particles is still rarely reported.For this,a series of consolidation-permeability coefficient tests were conducted on reconstituted sandy clays with different sand fractions(ψ_(ss)),initial void ratio of hosted clays(e_(c0))and void ratio at liquid limit of hosted clays(e_(cL)).The roles of ψ_(ss) in both the relationships of permeability coefficient of hosted clay(k_(v-hosted clay))versus effective vertical stress(σ'_(v))and void ratio of hosted clay(e_(c-hosted clay))versus σ'_(v) were analyzed.The results show that the permeability coefficient of reconstituted sandy clays(k_(v))is dominated by hosted clay(k_(v)=k_(v-hosted clay)).Both ψ_(ss) and σ'_(v) affect the k_(v) of sandy clays by changing the e_(c-hosted clay) at any given σ'_(v).Due to the partial contacts and densified clay bridges between the sand particles(i.e.structure effects),the e_(c-hosted clay) in sandy clays is higher than that in clays at the same σ'_(v)v.The k_(v)-e_(c-hosted clay) relationship of sandy clays is independent of σ'_(v) and ψ_(ss)but is a function of e_(cL).The types of hosted clays affect the k_(v) of sandy clays by changing the e_(cL).Based on the relationship between permeability coefficient and void ratio for the reconstituted clays,an empirical method for determining the k_(v) is proposed and validated for sandy clays.The predicted values are almost consistent with the measured values with k_(v-predicted)=k_(v-measured)=0.6-2.5.
文摘Recently,a roundtable on carrying forward the Bandung Spirit,co-hosted by the Chinese People’s Institute of Foreign Affairs(CPIFA)and the Embassy of the Republic of Indonesia in China,took place in Beijing.Wang Yi,member of the Political Bureau of the Communist Party of China Central Committee and Minister of Foreign Affairs,delivered a written speech.Indonesian Deputy Foreign Minister Siti Nugraha Mauludiah delivered a keynote speech.CPIFA President Wang Chao,Indonesian Ambassador to Bandung Spirit Driving Modernization of the Global South China Djauhari Oratmangun,former Pakistani Foreign Minister Khurshid Mahmud Kasuri,former Deputy Foreign Minister of Myanmar U Thant Kyaw,and former Under-Secretary-General of the UN Wu Hongbo attended the roundtable and delivered speeches.Also attending were more than 60 Chinese and Indonesian experts and scholars,representatives from countries that participated in the Bandung Conference,and heads of UN agencies in China.Chinese and foreign vips carried out in-depth exchange and discussion on the theme“The Global South:Carrying Forward the Bandung Spirit and Marching Together toward Modernization.”
