Effect of various pesticides (insecticides, fungicides and herbicides) has been studied on growth and efficiency of symbiotic properties of 3 fast growing Rhizobium sp. under green house conditions. The results reveal...Effect of various pesticides (insecticides, fungicides and herbicides) has been studied on growth and efficiency of symbiotic properties of 3 fast growing Rhizobium sp. under green house conditions. The results revealed adverse effects on plant growth and nitrogen fixing capacity as measured by dry weight and total nitrogen content of plants infected with pesticide treated Rhizobium. Of the pesticides tested, herbicides were found to be more effective on the above parameters than the insecticides and fungicides.展开更多
BACKGROUND Graft-vs-host disease (GVHD) is a major cause of mortality after allogeneic hematopoietic stem cell transplantation.Some patients have steroid-refractory(SR) GVHD.AIM To evaluate the effect and safety of ru...BACKGROUND Graft-vs-host disease (GVHD) is a major cause of mortality after allogeneic hematopoietic stem cell transplantation.Some patients have steroid-refractory(SR) GVHD.AIM To evaluate the effect and safety of ruxolitinib add-on in the treatment of patients with SR acute (a) and chronic (c) GVHD.METHODS We retrospectively analyzed 38 patients administered ruxolitinib add-on to standard immunosuppressive therapy for SR-aGVHD or SR-cGVHD following allogeneic hematopoietic stem cell transplantation.Ruxolitinib was administered5-10 mg/d depending on disease severity,patient status,and the use of antifungal drugs.Overall response rate,time to best response,malignancy relapse rate,infection rate,and treatment-related adverse events were assessed.RESULTS The analysis included 10 patients with SR-aGVHD (gradeⅢ/Ⅳ,n=9) and 28patients with SR-cGVHD (moderate/severe,n=24).For the SR-aGVHD and SRcGVHD groups,respectively:Median number of previous GVHD therapies was 2(range:1-3) and 2 (1-4);median follow-up was 2.5 (1.5-4) and 5 (1.5-10) mo;median time to best response was 1 (0.5-2.5) and 3 (1-9.5) mo;and overall response rate was 100%(complete response:80%) and 82.1%(complete response:10.7%) with a response observed in all GVHD-affected organs.The malignancy relapse rates for the SR-aGVHD and SR-cGVHD groups were 10.0%and 10.7%,respectively.Reactivation rates for cytomegalovirus,Epstein-Barr virus,and varicella-zoster virus,respectively,were 30.0%,10.0%,and 0%for the SR-aGVHD group and 0%,14.3%,and 7.1%for the SR-cGVHD group.CONCLUSION Ruxolitinib add-on was effective and safe as salvage therapy for SR-GVHD.展开更多
Laboratory interspecific competition and grain-hosts selection experiments involving maize weevil (MW), Sitophilus zeamais (Motsch.) and larger grain borer (LGB), Prostephanus truncatus (Horn) were performed under amb...Laboratory interspecific competition and grain-hosts selection experiments involving maize weevil (MW), Sitophilus zeamais (Motsch.) and larger grain borer (LGB), Prostephanus truncatus (Horn) were performed under ambient temperature and relative humidity (25°C - 35°C and 70% - 80% relative humidity) in their major host cereal, maize grains. The species reproductive rate and grain-hosts preference were evaluated by a number of emerged adults. In combined infestation, both species competed intensively by simultaneously increasing their individuals’ emergence, 9-fold or greater than when reared alone. Even though both species simultaneously increased their progeny, S. zeamais was the dominant competitor and had a significant suppressant effect on P. truncatus. The selection result of grain-hosts showed that P. truncatus placed in the environment containing both uninfested maize grains and grains previously infested by S. zeamais, the insect prefers uninfested grains. Indeed, P. truncatus individuals’ emergences were significantly more important to uninfested grains than to infested grains. The weevil-infested grains seemed to have deterrent and detrimental effects on P. truncatus. Conversely, S. zeamais selection of grain-hosts was significantly (P = 0.0001) more attracted by P. truncatus infested grains than to uninfested grains. Sitophilus zeamais individuals’ emergences were significantly (P = 0.0008) more important to infested grains than to uninfested grains. The S. zeamais preference on grains previously infested would be stimulated by P. truncatus larval vibrations in grain.展开更多
文摘Effect of various pesticides (insecticides, fungicides and herbicides) has been studied on growth and efficiency of symbiotic properties of 3 fast growing Rhizobium sp. under green house conditions. The results revealed adverse effects on plant growth and nitrogen fixing capacity as measured by dry weight and total nitrogen content of plants infected with pesticide treated Rhizobium. Of the pesticides tested, herbicides were found to be more effective on the above parameters than the insecticides and fungicides.
文摘BACKGROUND Graft-vs-host disease (GVHD) is a major cause of mortality after allogeneic hematopoietic stem cell transplantation.Some patients have steroid-refractory(SR) GVHD.AIM To evaluate the effect and safety of ruxolitinib add-on in the treatment of patients with SR acute (a) and chronic (c) GVHD.METHODS We retrospectively analyzed 38 patients administered ruxolitinib add-on to standard immunosuppressive therapy for SR-aGVHD or SR-cGVHD following allogeneic hematopoietic stem cell transplantation.Ruxolitinib was administered5-10 mg/d depending on disease severity,patient status,and the use of antifungal drugs.Overall response rate,time to best response,malignancy relapse rate,infection rate,and treatment-related adverse events were assessed.RESULTS The analysis included 10 patients with SR-aGVHD (gradeⅢ/Ⅳ,n=9) and 28patients with SR-cGVHD (moderate/severe,n=24).For the SR-aGVHD and SRcGVHD groups,respectively:Median number of previous GVHD therapies was 2(range:1-3) and 2 (1-4);median follow-up was 2.5 (1.5-4) and 5 (1.5-10) mo;median time to best response was 1 (0.5-2.5) and 3 (1-9.5) mo;and overall response rate was 100%(complete response:80%) and 82.1%(complete response:10.7%) with a response observed in all GVHD-affected organs.The malignancy relapse rates for the SR-aGVHD and SR-cGVHD groups were 10.0%and 10.7%,respectively.Reactivation rates for cytomegalovirus,Epstein-Barr virus,and varicella-zoster virus,respectively,were 30.0%,10.0%,and 0%for the SR-aGVHD group and 0%,14.3%,and 7.1%for the SR-cGVHD group.CONCLUSION Ruxolitinib add-on was effective and safe as salvage therapy for SR-GVHD.
文摘Laboratory interspecific competition and grain-hosts selection experiments involving maize weevil (MW), Sitophilus zeamais (Motsch.) and larger grain borer (LGB), Prostephanus truncatus (Horn) were performed under ambient temperature and relative humidity (25°C - 35°C and 70% - 80% relative humidity) in their major host cereal, maize grains. The species reproductive rate and grain-hosts preference were evaluated by a number of emerged adults. In combined infestation, both species competed intensively by simultaneously increasing their individuals’ emergence, 9-fold or greater than when reared alone. Even though both species simultaneously increased their progeny, S. zeamais was the dominant competitor and had a significant suppressant effect on P. truncatus. The selection result of grain-hosts showed that P. truncatus placed in the environment containing both uninfested maize grains and grains previously infested by S. zeamais, the insect prefers uninfested grains. Indeed, P. truncatus individuals’ emergences were significantly more important to uninfested grains than to infested grains. The weevil-infested grains seemed to have deterrent and detrimental effects on P. truncatus. Conversely, S. zeamais selection of grain-hosts was significantly (P = 0.0001) more attracted by P. truncatus infested grains than to uninfested grains. Sitophilus zeamais individuals’ emergences were significantly (P = 0.0008) more important to infested grains than to uninfested grains. The S. zeamais preference on grains previously infested would be stimulated by P. truncatus larval vibrations in grain.
