Background: Late-onset multiple acyl-CoA dehydrogenase deficiency (MADD) is the most common type of lipid storage myopathies in China. Most patients with late-onset MADD are well responsive to riboflavin. Up to now, t...Background: Late-onset multiple acyl-CoA dehydrogenase deficiency (MADD) is the most common type of lipid storage myopathies in China. Most patients with late-onset MADD are well responsive to riboflavin. Up to now, these patients are often treated with glucocorticoids as the first-line drug because they are misdiagnosed as polymyositis without muscle biopsy or gene analysis. Although glucocorticoids seem to improve the fatty acid metabolism of late-onset MADD, the objective evaluation of their rationalization on this disorder and comparison with riboflavin treatment are unknown. Methods: We performed a historical cohort study on the efficacy of the two drugs among 45 patients with late-onset MADD, who were divided into glucocorticoids group and riboflavin group. Detailed clinical information of baseline and 1-month follow-up were collected. Results: After 1-month treatment, a dramatic improvement of muscle strength was found in riboflavin group (P 〈 0.05). There was no significant difference in muscle enzymes between the two groups. Significantly, the number of patients with full recovery in glucocorticoids group was less than the number in riboflavin group (P 〈 0.05). On the other hand, almost half of the patients in riboflavin group still presented high-level muscle enzymes and weak muscle strength after 1-month riboflavin treatment, meaning that l-month treatment duration maybe insufficient and patients should keep on riboflavin supplement for a longer time. Conclusions: Our results provide credible evidences that the overall efficacy of riboflavin is superior to glucocorticoids, and a longer duration of riboflavin treatment is necessary for patients with late-onset MADD.展开更多
This article focuses on HUANG Mingbiao,a renowned ethnic Zhuang's cultural heritage researcher,and delves into his outstanding contributions to the study of the Zhuang's history and culture.Grounded in grassro...This article focuses on HUANG Mingbiao,a renowned ethnic Zhuang's cultural heritage researcher,and delves into his outstanding contributions to the study of the Zhuang's history and culture.Grounded in grassroots fieldwork,HUANG developed,in his practice,a three dimensional research paradigm encompassing“tangible texts,oral traditions,and cultural ecology”to systematically excavate the Zhuang culural heritage.His groundbreaking achievements span diverse areas,induding Beaurodox(布洛陀)culture studies and research on Madam Washi.Notable milestones include his pioneering field investigations into Madam Washi's historical restance against Japanese pirates and publishing the first academic monograph dedicated to studics on Madam Washi.His work not only enriches the ethnic Zhuang studies with critical data and innovative methodologies but also strengthens cultural identity within the broader framework of Chinese civilization.Theoretically,his research deepens scholarly understanding of the Zhuang culture;methodologically,it drives a logical progression from surface-level investigations to in-depth cultural analyses.As both an explorer of the Zhuang civilization and a guardian of ethnic heritage,HUANG Mingbiao's contributions hold profound significance for the preservation and development of the Zhuang culture.展开更多
A re-thinking of several premise issues in Chinese historiographic theory involves reconsidering and reassessing hitherto unquestioned theoretical and historical premises, re- analyzing and re-observing Chinese histor...A re-thinking of several premise issues in Chinese historiographic theory involves reconsidering and reassessing hitherto unquestioned theoretical and historical premises, re- analyzing and re-observing Chinese history with the theoretical vision of the philosophy of history, and sorting out and correcting ideas of history. It is a process of dialectical comprehension and specific application of the core values of Marxist materialist history, involving adherence to the basic traditions of materialist history in the following areas： the starting point of historical studies, methods of comparative historical research, establishment of the facts and laws of history, explanations of historical concepts and values and integration of reality, history, theory and values, so as to develop a holistic theory and method of historical observation covering a long period and a broad span.展开更多
From November 1 to 3,2024,the 2024 Annual Conference of the Chinese Society of French Historical Studies(CSFHS)was held at the Jinhua campus of Zhejiang Normal University.The conference also marked the 6Oth anniversar...From November 1 to 3,2024,the 2024 Annual Conference of the Chinese Society of French Historical Studies(CSFHS)was held at the Jinhua campus of Zhejiang Normal University.The conference also marked the 6Oth anniversary of Sino-French diplomatic relations.It was hosted by the Chinese Society of French Historical Studies and organized by the School of Humanities at Zhejiang Normal University.Over 60 experts and scholars attended the conference,representing research institutions and universities,including the Chinese Academy of Social Sciences(CASS),Peking University,Zhejiang University,Wuhan University,Sichuan University,Sun Yat-sen University,Capital Normal University,and others.There were also several editors from well-known journals,including Jianghai Academic Journal,World History,and Social Science Front,among others.During the conference,the board meeting of the Chinese Society of French Historical Studies was successfully conducted.展开更多
Since its revival in the mid-1980s,the study of Chinese social history has enjoyed steady growth and prominence as an emerging field.Its development over the past three decades can be roughly divided into three stages...Since its revival in the mid-1980s,the study of Chinese social history has enjoyed steady growth and prominence as an emerging field.Its development over the past three decades can be roughly divided into three stages.The first is the rejuvena-tion stage,when“social history”started to gain ground as a new branch of study and developed into regional and cultural histories.The second stage started around the 1990s when the study of“new social history”arose to break away from the old paradigms and establish new approaches for a self-sustained branch of study.Due to its narrowly targeted narrative framework,obscure jargon,and exclusive rhetoric,it was later reduced to new historical research that focused on investigating concepts without due emphasis on revisiting the origin of the study.The third stage featured the rise of historical anthropology,which sprang up in the late 1990s and brought forth new ideas that spread across the country into the twentieth century with extensive influence.Hence,social history,4<new social history,and historical anthropology mark the three different yet connected stages in the development of Chinese social history studies.Each played a significant part in history with a lasting impact on the development of the field and issues raised for further inquiry.展开更多
基金This work was supported by grants from the National Natural Science Foundation of China (No. 81271254)NationalKey Clinical Specialty Discipline Construction ProgramFujian Key Clinical Specialty Discipline Construction Program.
文摘Background: Late-onset multiple acyl-CoA dehydrogenase deficiency (MADD) is the most common type of lipid storage myopathies in China. Most patients with late-onset MADD are well responsive to riboflavin. Up to now, these patients are often treated with glucocorticoids as the first-line drug because they are misdiagnosed as polymyositis without muscle biopsy or gene analysis. Although glucocorticoids seem to improve the fatty acid metabolism of late-onset MADD, the objective evaluation of their rationalization on this disorder and comparison with riboflavin treatment are unknown. Methods: We performed a historical cohort study on the efficacy of the two drugs among 45 patients with late-onset MADD, who were divided into glucocorticoids group and riboflavin group. Detailed clinical information of baseline and 1-month follow-up were collected. Results: After 1-month treatment, a dramatic improvement of muscle strength was found in riboflavin group (P 〈 0.05). There was no significant difference in muscle enzymes between the two groups. Significantly, the number of patients with full recovery in glucocorticoids group was less than the number in riboflavin group (P 〈 0.05). On the other hand, almost half of the patients in riboflavin group still presented high-level muscle enzymes and weak muscle strength after 1-month riboflavin treatment, meaning that l-month treatment duration maybe insufficient and patients should keep on riboflavin supplement for a longer time. Conclusions: Our results provide credible evidences that the overall efficacy of riboflavin is superior to glucocorticoids, and a longer duration of riboflavin treatment is necessary for patients with late-onset MADD.
文摘This article focuses on HUANG Mingbiao,a renowned ethnic Zhuang's cultural heritage researcher,and delves into his outstanding contributions to the study of the Zhuang's history and culture.Grounded in grassroots fieldwork,HUANG developed,in his practice,a three dimensional research paradigm encompassing“tangible texts,oral traditions,and cultural ecology”to systematically excavate the Zhuang culural heritage.His groundbreaking achievements span diverse areas,induding Beaurodox(布洛陀)culture studies and research on Madam Washi.Notable milestones include his pioneering field investigations into Madam Washi's historical restance against Japanese pirates and publishing the first academic monograph dedicated to studics on Madam Washi.His work not only enriches the ethnic Zhuang studies with critical data and innovative methodologies but also strengthens cultural identity within the broader framework of Chinese civilization.Theoretically,his research deepens scholarly understanding of the Zhuang culture;methodologically,it drives a logical progression from surface-level investigations to in-depth cultural analyses.As both an explorer of the Zhuang civilization and a guardian of ethnic heritage,HUANG Mingbiao's contributions hold profound significance for the preservation and development of the Zhuang culture.
文摘A re-thinking of several premise issues in Chinese historiographic theory involves reconsidering and reassessing hitherto unquestioned theoretical and historical premises, re- analyzing and re-observing Chinese history with the theoretical vision of the philosophy of history, and sorting out and correcting ideas of history. It is a process of dialectical comprehension and specific application of the core values of Marxist materialist history, involving adherence to the basic traditions of materialist history in the following areas： the starting point of historical studies, methods of comparative historical research, establishment of the facts and laws of history, explanations of historical concepts and values and integration of reality, history, theory and values, so as to develop a holistic theory and method of historical observation covering a long period and a broad span.
文摘From November 1 to 3,2024,the 2024 Annual Conference of the Chinese Society of French Historical Studies(CSFHS)was held at the Jinhua campus of Zhejiang Normal University.The conference also marked the 6Oth anniversary of Sino-French diplomatic relations.It was hosted by the Chinese Society of French Historical Studies and organized by the School of Humanities at Zhejiang Normal University.Over 60 experts and scholars attended the conference,representing research institutions and universities,including the Chinese Academy of Social Sciences(CASS),Peking University,Zhejiang University,Wuhan University,Sichuan University,Sun Yat-sen University,Capital Normal University,and others.There were also several editors from well-known journals,including Jianghai Academic Journal,World History,and Social Science Front,among others.During the conference,the board meeting of the Chinese Society of French Historical Studies was successfully conducted.
文摘Since its revival in the mid-1980s,the study of Chinese social history has enjoyed steady growth and prominence as an emerging field.Its development over the past three decades can be roughly divided into three stages.The first is the rejuvena-tion stage,when“social history”started to gain ground as a new branch of study and developed into regional and cultural histories.The second stage started around the 1990s when the study of“new social history”arose to break away from the old paradigms and establish new approaches for a self-sustained branch of study.Due to its narrowly targeted narrative framework,obscure jargon,and exclusive rhetoric,it was later reduced to new historical research that focused on investigating concepts without due emphasis on revisiting the origin of the study.The third stage featured the rise of historical anthropology,which sprang up in the late 1990s and brought forth new ideas that spread across the country into the twentieth century with extensive influence.Hence,social history,4<new social history,and historical anthropology mark the three different yet connected stages in the development of Chinese social history studies.Each played a significant part in history with a lasting impact on the development of the field and issues raised for further inquiry.
