To the Editor:Basal cell carcinoma(BCC)is the most prevalent skin malignancy,with an increasing incidence and economic burden worldwide.[1]Various histopathological subtypes of BCC have been well described,and subtype...To the Editor:Basal cell carcinoma(BCC)is the most prevalent skin malignancy,with an increasing incidence and economic burden worldwide.[1]Various histopathological subtypes of BCC have been well described,and subtype confirmation is essential for BCC classification according to the risk of recurrence.[2]Early diagnosis and intervention are important,especially considering that the incidence of aggressive subtypes of BCC is increasing faster than that of indolent subtypes.展开更多
The present study aimed to investigate the relationship between histopathological subtype and the probability of inguinal lymph node metastasis （ILNM） in patients with penile squamous cell carcinoma （PSCC）. The cl...The present study aimed to investigate the relationship between histopathological subtype and the probability of inguinal lymph node metastasis （ILNM） in patients with penile squamous cell carcinoma （PSCC）. The clinical records of 198 consecutive patients with PSCC were analyzed retrospectively. Primary lesions were reevaluated according to the 2016 World Health Organization （WHO） histopathological classification. We retrieved the clinicopathological factors from the medical records including age, clinical lymph node stage, pathological tumor stage, lymphatic invasion, and nerve invasion. Uni- and multivariate logistic regression analyses were used to explore the risk factors of ILNM. Multivariate analyses identified clinical lymph node stage （P = 0.000）, pathological tumor stage （P = 0.016）, histologic grade （P = 0.000）, and risk group of histological subtypes （P = 0.029） as independent predictors for ILNM. Compared with the low-risk group of PSCC subtypes, the intermediate- （HR： 3.66, 95% CI. 1.30-10.37, P = 0.021） and high-risk groups （HR： 28.74, 95% Ch 2.37-348.54, P = 0.008） were significantly associated with ILNM. In conclusion, the histopathological subtype of the primary lesion is a significant predictor for ILNM in patients with PSCC.展开更多
Background The clinical and histopathological characteristics of basal cell carcinoma （BCC） have been relatively well studied in Caucasian population. To characterize BCC in Chinese population, we analyzed the assoc...Background The clinical and histopathological characteristics of basal cell carcinoma （BCC） have been relatively well studied in Caucasian population. To characterize BCC in Chinese population, we analyzed the association of the histopathological subtypes with gender, age and anatomical location in this study. Methods The clinical and histopathological data of 243 BCC cases diagnosed at three hospitals in Beijing from January 2000 to April 2009 were reviewed retrospectively. Gender, age, location and histopathological subtype were analyzed. Results Among 243 patients enrolled, 118 were males and 125 were females. The male/female ratio was 0.94：1. The mean age was （65.16±12.62） years old. The head and neck were the most common sites of BCC （77.4%）. Of the BCCs, 53.9% were nodular, 18.9% superficial and 18.5% infiltrative-morphoeic. The nodular, infiltrative-morphoeic and micronodular subtypes were predominant located on the head and neck, whereas the trunk was the most common location for the superficial subtype （P 〈0.05）. The age at first presentation for females was lower than that for males （P 〈0.05）. The age at first presentation for the superficial BCCs was younger than the non-superficial subtypes （P 〈0.05）. Women with superficial BCC subtype visited hospital earlier than men （P 〈0.05）. Conclusions Consistent with previous reports in Caucasian patient, our study find that different histopathological subtypes of BCC has distinct clinical features. It is speculated that the mechanisms underlining the pathogenesis of the superficial BCC may be different than those of non-superficiai subtypes of BCC.展开更多
基金This work was supported by grants from CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2022-I2M-C&T-A-007)the National Natural Science Foundation of China(No.92354307)the Fundamental Research Funds for the Central Universities(No.2023RC09).
文摘To the Editor:Basal cell carcinoma(BCC)is the most prevalent skin malignancy,with an increasing incidence and economic burden worldwide.[1]Various histopathological subtypes of BCC have been well described,and subtype confirmation is essential for BCC classification according to the risk of recurrence.[2]Early diagnosis and intervention are important,especially considering that the incidence of aggressive subtypes of BCC is increasing faster than that of indolent subtypes.
基金This study was supported by the Natural Science Foundation of Anhui Province （No. 1608085QH173） and the Research Foundation of Anhui Medical University （No. 2015xkj025）.
文摘The present study aimed to investigate the relationship between histopathological subtype and the probability of inguinal lymph node metastasis （ILNM） in patients with penile squamous cell carcinoma （PSCC）. The clinical records of 198 consecutive patients with PSCC were analyzed retrospectively. Primary lesions were reevaluated according to the 2016 World Health Organization （WHO） histopathological classification. We retrieved the clinicopathological factors from the medical records including age, clinical lymph node stage, pathological tumor stage, lymphatic invasion, and nerve invasion. Uni- and multivariate logistic regression analyses were used to explore the risk factors of ILNM. Multivariate analyses identified clinical lymph node stage （P = 0.000）, pathological tumor stage （P = 0.016）, histologic grade （P = 0.000）, and risk group of histological subtypes （P = 0.029） as independent predictors for ILNM. Compared with the low-risk group of PSCC subtypes, the intermediate- （HR： 3.66, 95% CI. 1.30-10.37, P = 0.021） and high-risk groups （HR： 28.74, 95% Ch 2.37-348.54, P = 0.008） were significantly associated with ILNM. In conclusion, the histopathological subtype of the primary lesion is a significant predictor for ILNM in patients with PSCC.
文摘Background The clinical and histopathological characteristics of basal cell carcinoma （BCC） have been relatively well studied in Caucasian population. To characterize BCC in Chinese population, we analyzed the association of the histopathological subtypes with gender, age and anatomical location in this study. Methods The clinical and histopathological data of 243 BCC cases diagnosed at three hospitals in Beijing from January 2000 to April 2009 were reviewed retrospectively. Gender, age, location and histopathological subtype were analyzed. Results Among 243 patients enrolled, 118 were males and 125 were females. The male/female ratio was 0.94：1. The mean age was （65.16±12.62） years old. The head and neck were the most common sites of BCC （77.4%）. Of the BCCs, 53.9% were nodular, 18.9% superficial and 18.5% infiltrative-morphoeic. The nodular, infiltrative-morphoeic and micronodular subtypes were predominant located on the head and neck, whereas the trunk was the most common location for the superficial subtype （P 〈0.05）. The age at first presentation for females was lower than that for males （P 〈0.05）. The age at first presentation for the superficial BCCs was younger than the non-superficial subtypes （P 〈0.05）. Women with superficial BCC subtype visited hospital earlier than men （P 〈0.05）. Conclusions Consistent with previous reports in Caucasian patient, our study find that different histopathological subtypes of BCC has distinct clinical features. It is speculated that the mechanisms underlining the pathogenesis of the superficial BCC may be different than those of non-superficiai subtypes of BCC.
