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Investigation Study of Structure Real Load Spectra Acquisition and Fatigue Life Prediction Based on the Optimized E cient Hinging Hyperplane Neural Network Model 被引量:1
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作者 Lin Zhu Benao Xing +2 位作者 Xingbao Li Min Chen Minping Jia 《Chinese Journal of Mechanical Engineering》 CSCD 2024年第6期628-648,共21页
In the realm of engineering practice,various factors such as limited availability of measurement data and complex working conditions pose significant challenges to obtaining accurate load spectra.Thus,accurately predi... In the realm of engineering practice,various factors such as limited availability of measurement data and complex working conditions pose significant challenges to obtaining accurate load spectra.Thus,accurately predicting the fatigue life of structures becomes notably arduous.This paper proposed an approach to predict the fatigue life of structure based on the optimized load spectra,which is accurately estimated by an efficient hinging hyperplane neural network(EHH-NN)model.The construction of the EHH-NN model includes initial network generation and parameter optimization.Through the combination of working conditions design,multi-body dynamics analysis and structural static mechanics analysis,the simulated load spectra of the structure are obtained.The simulated load spectra are taken as the input variables for the optimized EHH-NN model,while the measurement load spectra are used as the output variables.The prediction results of case structure indicate that the optimized EHH-NN model can achieve the high-accuracy load spectra,in comparison with support vector machine(SVM),random forest(RF)model and back propagation(BP)neural network.The error rate between the prediction values and the measurement values of the optimized EHH-NN model is 4.61%.In the Cauchy-Lorentz distribution,the absolute error data of 92%with EHH-NN model appear in the intermediate range of±1.65%.Also,the fatigue life analysis is performed for the case structure,based on the accurately predicted load spectra.The fatigue life of the case structure is calculated based on the comparison between the measured and predicted load spectra,with an accuracy of 93.56%.This research proposes the optimized EHH-NN model can more accurately reflect the measurement load spectra,enabling precise calculation of fatigue life.Additionally,the optimized EHH-NN model provides reliability assessment for industrial engineering equipment. 展开更多
关键词 Efficient hinging hyperplane neural network model ANOVA decomposition Load spectra optimization Optimal parameter Fatigue life prediction
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Mechanical Study of Marine Drilling Conductor Under Ice Load:Based on Plastic Hinge Theory 被引量:1
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作者 ZHANG Ming-he ZHOU Yi-su +2 位作者 YANG Jin WANG Hai-ge CUI Long-lian 《China Ocean Engineering》 2025年第5期971-983,共13页
With increasing water depth,marine drilling conductors exhibit higher slenderness ratios,significantly reducing their resistance to environmental loads in Arctic waters.These conductors,when subjected to combined wind... With increasing water depth,marine drilling conductors exhibit higher slenderness ratios,significantly reducing their resistance to environmental loads in Arctic waters.These conductors,when subjected to combined wind,current,and ice loads,may experience substantial horizontal displacements and bending moments,potentially compromising off-shore operational safety and wellhead stability.Additionally,soil disturbance near the mudline diminishes the conductor’s bearing capacity,potentially rendering it inadequate for wellhead support and increasing operational risks.This study introduces a static analysis model based on plastic hinge theory to evaluate conductor survivability.The conductor analysis divides the structure into three segments:above waterline,submerged,and embedded below mudline.An idealized elastic-plastic p-y curve model characterizes soil behavior beneath the mudline,while the finite difference method(FDM)analyzes the conductor’s mechanical response under complex pile-head boundary conditions.Numerical simulations using ABAQUS validate the plastic hinge approach against conventional methods,confirming its accuracy in predicting structural performance.These results provide valuable insights for optimizing installation depths and bearing capacity designs of marine drilling conductors in ice-prone regions. 展开更多
关键词 marine drilling conductor ice load mechanical property apparent plastic hinge depth-to-fixity
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Theoretical Investigation on an Oscillating Wave Energy Converter in Different Degrees of Freedom in Front of a Seawall
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作者 WANG Yuhan DONG Sheng 《Journal of Ocean University of China》 2025年第2期289-302,共14页
The interaction between regular waves and an oscillating wave energy converter(WEC)in front of a vertical seawall is investigated using a 2D analytical model.A three-degree of freedom(DOF)WEC and a WEC hinged to the s... The interaction between regular waves and an oscillating wave energy converter(WEC)in front of a vertical seawall is investigated using a 2D analytical model.A three-degree of freedom(DOF)WEC and a WEC hinged to the seawall(constrained to pitch mode)are considered to examine the influence of the DOF of the WEC on the wave energy extraction performance.Results show that the piston-mode water resonance in the gap and the coupled WEC and water column resonant motion significantly influence the wave energy extraction efficiency.At low frequency,the case with a 3-DOF WEC has a broader high-efficiency bandwidth than that with a heaving WEC.However,3-DOF WEC exhibits worse performance at high frequencies.The frequency response of the wave energy capture width ratio(CWR)for the pitching WEC case shows a trimodal trend under the specified conditions.It showcases the best overall wave energy extraction performance in terms of the high-efficiency bandwidth.Furthermore,a parametric study indicates that the gap distance between the WEC and the seawall has tremendous effects on the CWR of both cases.As the position of the hinge point of the pitching WEC changes,the CWR at the low and high frequencies shows opposite trends. 展开更多
关键词 analytical model wave energy converter hinge connection multiple degrees of freedom gap resonance
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Higher-Order Topological States in Chiral Split Magnons of Honeycomb Altermagnets
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作者 Xuan Guo Meng-Han Zhang Dao-Xin Yao 《Chinese Physics Letters》 2025年第12期220-225,共6页
We theoretically explore higher-order topological magnons in collinear altermagnets,encompassing a dimensional hierarchy ranging from localized corner modes to propagating hinge excitations.By employing antiferromagne... We theoretically explore higher-order topological magnons in collinear altermagnets,encompassing a dimensional hierarchy ranging from localized corner modes to propagating hinge excitations.By employing antiferromagnetic interlayer coupling in bosonic Bogoliubov–de Gennes Hamiltonian,our work reveals anisotropic surface states and spatially distributed hinge modes propagating along facet intersections.We track the adiabatic evolution of Wannier centers to identify the bulk polarization with second-order topological magnon insulator,where various magnon spectra demonstrate symmetry-protected band structure beyond conventional topology.Leveraging the stability and propagative properties of hinge modes,these unconventional magnons demonstrate manipulability in atomic-scale modifications of termination.Our study integrates altermagnetism with higher-order topology,which advances magnon-based quantum computing processing energy-efficient integrated architectures and information transfer. 展开更多
关键词 propagating hinge excitationsby bosonic bogoliubov de gennes hamiltonianour corner modes adiabatic evolution wannier centers antiferromagnetic interlayer coupling bulk polarization anisotropic surface states collinear altermagnetsencompassing
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Micro-displacement amplifying mechanism driven by piezoelectric actuator 被引量:10
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作者 马浩全 胡德金 张凯 《Journal of Southeast University(English Edition)》 EI CAS 2004年第1期75-79,共5页
Piezoelectric actuator has high stiffness, high frequency and infinite control precision, but a short output displacement which is often 1/1 000 of its length. In order to meet the requirements that tools feeding shou... Piezoelectric actuator has high stiffness, high frequency and infinite control precision, but a short output displacement which is often 1/1 000 of its length. In order to meet the requirements that tools feeding should be long-travel, high-frequency and high-precision in non-circular precision turning, a new one-freedom flexure hinge structure is put forward to amplify the output displacement of piezoelectric actuator. Theoretical analysis is done on the static and dynamic characteristics of the structure, differential equations are presented, and it is also verified by the finite element method. It's proved by experiments that the output displacement of the structure is 293 μm and its resonant frequency is 312 Hz. 展开更多
关键词 piezoelectric actuator flexure hinge micro displacement amplifying structure
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基于次梯度的L1正则化Hinge损失问题求解研究 被引量:4
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作者 孔康 陶卿 +1 位作者 汪群山 储德军 《计算机研究与发展》 EI CSCD 北大核心 2012年第7期1494-1499,共6页
Hinge损失函数是支持向量机(support vector machines,SVM)成功的关键,L1正则化在稀疏学习的研究中起关键作用.鉴于两者均是不可导函数,高阶梯度信息无法使用.利用随机次梯度方法系统研究L1正则化项的Hinge损失大规模数据问题求解.首先... Hinge损失函数是支持向量机(support vector machines,SVM)成功的关键,L1正则化在稀疏学习的研究中起关键作用.鉴于两者均是不可导函数,高阶梯度信息无法使用.利用随机次梯度方法系统研究L1正则化项的Hinge损失大规模数据问题求解.首先描述了直接次梯度方法和投影次梯度方法的随机算法形式,并对算法的收敛性和收敛速度进行了理论分析.大规模真实数据集上的实验表明,投影次梯度方法对于处理大规模稀疏数据具有更快的收敛速度和更好的稀疏性.实验进一步阐明了投影阈值对算法稀疏度的影响. 展开更多
关键词 L1正则化 Hinge损失 稀疏性 大规模数据 机器学习
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平滑削边绝对偏离惩罚截断Hinge损失支持向量机的财务危机预报 被引量:2
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作者 刘遵雄 黄志强 +1 位作者 刘江伟 陈英 《计算机应用》 CSCD 北大核心 2014年第3期873-878,共6页
针对传统支持向量机(SVM)分类存在对离群点敏感、支持向量(SV)个数多和分类面参数非稀疏的问题,提出了平滑削边绝对偏离(SCAD)惩罚截断Hinge损失SVM(SCAD-TSVM)算法,并将其用于构建财务预警模型,同时就该模型的求解设计了一个迭代更新... 针对传统支持向量机(SVM)分类存在对离群点敏感、支持向量(SV)个数多和分类面参数非稀疏的问题,提出了平滑削边绝对偏离(SCAD)惩罚截断Hinge损失SVM(SCAD-TSVM)算法,并将其用于构建财务预警模型,同时就该模型的求解设计了一个迭代更新算法。结合沪深股市A股制造业上市公司的财务数据进行实证分析,同时对比L1范数惩罚SVM、SCAD惩罚SVM和截断Hinge损失SVM(TSVM)构建的T-2和T-3模型,结果发现SCAD-TSVM构建的T-2和T-3模型都具有最好的稀疏性和最高的预报精度,而且其在不同训练样本数上的平均预测准确率都要比L1范数SVM(L1-SVM)、SCAD-SVM和TSVM算法的高。 展开更多
关键词 支持向量机 平滑削边绝对偏离惩罚 截断Hinge损失支持向量机 财务预警 L1范数惩罚
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直接优化AUC进行网络链接预测 被引量:1
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作者 戴彩艳 陈崚 《小型微型计算机系统》 CSCD 北大核心 2017年第7期1430-1435,共6页
快速扩展的互联网形成了具有高维、稀疏和冗余特性的复杂网络.因此需要有效的技术从这些复杂网络数据中提取出最为重要的信息进行链接预测,以便为用户服务.本文提出一种基于AUC(Area under Curve)优化的链接预测算法.在该算法中,将AUC... 快速扩展的互联网形成了具有高维、稀疏和冗余特性的复杂网络.因此需要有效的技术从这些复杂网络数据中提取出最为重要的信息进行链接预测,以便为用户服务.本文提出一种基于AUC(Area under Curve)优化的链接预测算法.在该算法中,将AUC作为优化的目标函数,将链接预测问题转化为二分分类问题.将顶点之间是否存在链接作为它所在的类的标号.通过优化AUC来进行二分分类,使用铰链函数按随机次梯度下降算法迭代更新权重矩阵.最后在一些来自不同领域的真实网络上对本算法进行了测试.实验结果表明,本算法与其他算法的结果相比可以实现更高质量的预测. 展开更多
关键词 链接预测 hinge函数 权重矩阵 随机次梯度
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基于Hinge损失函数的垂向全变差约束全波形反演 被引量:3
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作者 王志强 韩立国 《地球物理学报》 SCIE EI CAS CSCD 北大核心 2018年第4期1460-1470,共11页
全波形反演可以为叠前深度偏移成像提供更高精度的速度模型,但该方法具有较强的非线性,对初始速度模型的依赖性较强,尤其是在实际应用中,地质条件复杂多变,速度变化不连续,增加了反演非线性程度,常常使反演陷入局部极小值,影响反演的精... 全波形反演可以为叠前深度偏移成像提供更高精度的速度模型,但该方法具有较强的非线性,对初始速度模型的依赖性较强,尤其是在实际应用中,地质条件复杂多变,速度变化不连续,增加了反演非线性程度,常常使反演陷入局部极小值,影响反演的精度.全变差约束在图像去噪领域应用广泛,属于非光滑约束,在去噪过程中能有效的保留图像的不连续界面和边缘信息.本文提出基于Hinge损失函数的垂向全变差约束全波形反演方法,在全变差约束的基础上,利用Hinge损失函数控制模型的更新方向,并使用原-对偶混合梯度算法进行求解,给出这一优化问题的迭代格式,有效提高了对地下不连续界面的重构精度,同时也降低反演对初始速度模型的依赖程度.数值算例证明:与常规全波形反演方法相比,基于全变差约束的全波形反演方法可以有效的重构速度模型中的不连续界面,尤其对高速体边缘的重构效果更明显,但该方法对初始速度模型的依赖性仍然较强;基于Hinge损失函数的垂向全变差约束全波形反演方法降低了对初始速度模型的依赖程度,可以从一个较差的初始模型通过循环迭代的方式最终得到同样精确的速度模型,较好的重构了高速体边缘和不连续界面. 展开更多
关键词 全波形反演 全变差 Hinge损失函数 速度建模 地震成像
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Theoretical Analysis of a New Artificial Plastic Hinge at the Frame Beam End
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作者 傅传国 蒋永生 +2 位作者 刘美景 梁书亭 许清风 《Journal of Southeast University(English Edition)》 EI CAS 2000年第1期89-94,共6页
Opening horizontal slit in the middle web of the beam end formed a new type of artificial plastic hinge. The calculation formulas about the hinge’s interior force and bearing capacity are set up. Based on these, the ... Opening horizontal slit in the middle web of the beam end formed a new type of artificial plastic hinge. The calculation formulas about the hinge’s interior force and bearing capacity are set up. Based on these, the condition of transfer, the location of crack and the cracking length of the artificial plastic hinge were studied further. The calculation method for the ductility factor was also presented. The calculation results and the test ones were compatible. 展开更多
关键词 artificial plastic hinge ductility factor transfer condition cracking length
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封面图片说明
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作者 刘立武 赵伟 +2 位作者 兰鑫 刘彦菊 冷劲松 《哈尔滨工业大学学报》 EI CAS CSCD 北大核心 2016年第5期22-22,共1页
形状记忆聚合物SMP(shape memory polymer)是指具有某一特定的初始形状,在一定条件下变形固定后,通过热、电、磁等外部条件的刺激,能够恢复至其初始形状的聚合物,其密度低、可大尺寸成形、形变大.它具有形状记忆特性、自锁紧特性和大... 形状记忆聚合物SMP(shape memory polymer)是指具有某一特定的初始形状,在一定条件下变形固定后,通过热、电、磁等外部条件的刺激,能够恢复至其初始形状的聚合物,其密度低、可大尺寸成形、形变大.它具有形状记忆特性、自锁紧特性和大刚度变化特性,在航天航空、生物医学等领域的应用备受关注.基于形状记忆聚合物复合材料的铰链和桁架等空间展开结构和锁紧释放机构,通过材料和结构自身的变形实现结构的展开、驱动和释放,无需机械、电机和火工品等驱动装置,具有冲击小、重量轻、结构简单、展开稳定和可靠性高等优点. 展开更多
关键词 形状记忆聚合物 初始形状 图片说明 刚度变化 空间展开 火工品 记忆特性 可大 驱动装置 HINGE
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一种求解截断Hinge损失的软阈值坐标下降算法
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作者 朱烨雷 王玉军 +1 位作者 罗强 陶卿 《计算机研究与发展》 EI CSCD 北大核心 2013年第11期2295-2303,共9页
有效地减少支持向量数目能够提高分类器的鲁棒性和精确性,缩短支持向量机(support vector machine,SVM)的训练和测试时间.在众多稀疏算法中,截断Hinge损失方法可以显著降低支持向量的数目,但却导致了非凸优化问题.一些研究者使用CCCP(co... 有效地减少支持向量数目能够提高分类器的鲁棒性和精确性,缩短支持向量机(support vector machine,SVM)的训练和测试时间.在众多稀疏算法中,截断Hinge损失方法可以显著降低支持向量的数目,但却导致了非凸优化问题.一些研究者使用CCCP(concave-convex procedure)方法将非凸问题转化为多阶段凸问题求解,不仅增加了额外计算量,而且只能得到局部最优解.为了弥补上述不足,提出了一种基于CCCP的软阈值坐标下降算法.用坐标下降方法求解CCCP子阶段凸问题,提高计算效率;对偶SVM中引入软阈值投影技巧,能够减少更多的支持向量数目,同时选择合适的正则化参数可消除局部最优解的不良影响,提高分类器的分类精度.仿真数据库、UCI数据库和大规模真实数据库的实验证实了所提算法正确性和有效性. 展开更多
关键词 机器学习 支持向量 截断Hinge损失 CCCP 坐标下降 软阈值
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一种非光滑损失坐标下降算法 被引量:2
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作者 吴卫邦 朱烨雷 陶卿 《计算机应用研究》 CSCD 北大核心 2012年第10期3688-3692,3700,共6页
针对非光滑损失问题提出一种新的坐标下降算法,采用排序搜索的方式求解子问题解析解。分析了算法的时间复杂度,并给出了三种提高收敛速度的实用技巧。实验表明算法对正则化Hinge损失问题具有良好的性能,达到了预期的效果。
关键词 机器学习 优化 坐标下降 非光滑损失 HINGE
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基于改进支持向量机的药品包装纸盒快速鉴别研究 被引量:4
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作者 孙家政 刘津彤 +4 位作者 张岚泽 姜红 曾文远 段斌 刘峰 《包装工程》 CAS 北大核心 2022年第9期131-137,共7页
目的为实现在司法鉴定中对药品包装纸盒类检材的简单快速无损检验。方法利用X射线荧光光谱法,以Rh做阳极靶,在电压为50 kV、电流为30μA、功率为1.5 kW的条件下,对40组不同产地、不同厂家的药品包装纸盒样本进行检验。依据药品包装纸盒... 目的为实现在司法鉴定中对药品包装纸盒类检材的简单快速无损检验。方法利用X射线荧光光谱法,以Rh做阳极靶,在电压为50 kV、电流为30μA、功率为1.5 kW的条件下,对40组不同产地、不同厂家的药品包装纸盒样本进行检验。依据药品包装纸盒的化学元素组成对样本设置标签,建立蒙特卡洛算法(Monte Carlo Algorithm,MC)优化下的支持向量机(Support Vector Machine,SVM)分类模型,对惩罚因子进行仿真寻优,同时结合分治算法实现折半查找,使迭代过程具有自我学习能力,最终基于K-fold交叉验证,得到兼具拟合性和衍生性的惩罚因子组。结果计算机模拟结果表明,当3组支持向量机惩罚因子设置为933、280、732时,MC-SVM模型可实现对100%的训练集的拟合以及90%的预测集的分类,Hinge Loss函数最低损失值为0.0938。结论此方法可为药品包装纸盒类物证的检验以及支持向量机的参数优化提供新思路。 展开更多
关键词 药品包装纸盒 X射线荧光光谱法 支持向量机 蒙特卡洛算法 折半查找 Hinge Loss函数
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基于Rescaled Hinge损失函数的多子支持向量机 被引量:6
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作者 李卉 杨志霞 《计算机应用》 CSCD 北大核心 2020年第11期3139-3145,共7页
针对多分类学习模型性能会受异常值影响的问题,提出基于Rescaled Hinge损失函数的多子支持向量机(RHMBSVM)。首先,该方法通过引入有界、非凸的Rescaled Hinge损失函数来构建相应的优化问题;然后,利用共轭函数理论将优化问题作等价变换;... 针对多分类学习模型性能会受异常值影响的问题,提出基于Rescaled Hinge损失函数的多子支持向量机(RHMBSVM)。首先,该方法通过引入有界、非凸的Rescaled Hinge损失函数来构建相应的优化问题;然后,利用共轭函数理论将优化问题作等价变换;最后,使用变量交替策略形成一个迭代算法来求解非凸优化问题,该方法在求解的过程中可自动调节每个样本点的惩罚权重,从而削弱了异常值对K个超平面的影响,增强了鲁棒性。使用5折交叉验证的方法进行数值实验,实验结果表明,在数据集无异常值的情况下,该方法的正确率比多子支持向量机(MBSVM)提升了1.11个百分点,比基于Rescaled Hinge损失函数的鲁棒支持向量机(RSVM-RHHQ)提升了0.74个百分点;在数据集有异常值的情况下,该方法的正确率比MBSVM提升了2.10个百分点,比RSVM-RHHQ提升了1.47个百分点。实验结果证明了所提方法在解决有异常值的多分类问题上的鲁棒性。 展开更多
关键词 机器学习 最优化方法 支持向量机 Rescaled Hinge损失函数 多子支持向量机
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Effect of temperature and moisture on soil organic carbon mineralization of predominantly permafrost peatland in the Great Hing'an Mountains,Northeastern China 被引量:27
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作者 Xianwei Wang Xiuzhen Li +4 位作者 Yuanman Hu Jiujun Lv Ju Sun Zongmei Li Zhifeng Wu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2010年第7期1057-1066,共10页
Boreal peatlands represent a large global carbon pool. The relationships between carbon mineralization, soil temperature and moisture in the permafrost peatlands of the Great Hing'an Mountains, China, were examined. ... Boreal peatlands represent a large global carbon pool. The relationships between carbon mineralization, soil temperature and moisture in the permafrost peatlands of the Great Hing'an Mountains, China, were examined. The CO2 emissions were measured during laboratory incubations of samples from four sites under different temperatures (5, 10, 15, and 20℃) and moisture contents (0%, 30%, 60%, 100% water holding capacity (WHC) and completely water saturated). Total carbon mineralization ranged from 15.51 to 112.92 mg C under the treatments for all sites. Carbon mineralization rates decreased with soil depth, increased with temperature, and reached the highest at 60% WHC at the same temperature. The calculated temperature coefficient (Q10) values ranged from 1.84 to 2.51 with the soil depths and moisture. However, the values were not significantly affected by soil moisture and depth for all sites due to the different peat properties (P 〉 0.05). We found that the carbon mineralization could be successfully predicted as a two-compartment function with temperature and moisture (R^2 〉 0.96) and total carbon mineralization was significantly affected by temperature and moisture (P 〈 0.05). Thus, temperature and moisture would play important roles in carbon mineralization of permafrost peatlands in the Great Hing'an Mountains, indicating that the permafrost peatlands would be sensitive to the environment change, and the permafrost peatlands would be potentially mineralized under future climate change. 展开更多
关键词 Great Hing'an Mountains permafrost peatland MINERALIZATION climate change
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Ad-hING4联合^(125)Ⅰ粒子对裸鼠胰腺癌移植瘤的抑癌增效作用
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作者 翟红彦 杨吉成 +3 位作者 盛伟华 谢宇锋 法逸华 苏成海 《核技术》 CAS CSCD 北大核心 2009年第12期940-946,共7页
本工作探讨腺病毒介导的人ING4基因(Ad-hING4)联合125I粒子对裸鼠胰腺癌移植瘤的抑癌增效作用及其可能的机制。将本室构建的Ad-hING4腺病毒感染QBI-293A细胞,扩增后获得高滴度的病毒。建立25只裸鼠胰腺癌PANC-1皮下移植瘤模型,分成PBS... 本工作探讨腺病毒介导的人ING4基因(Ad-hING4)联合125I粒子对裸鼠胰腺癌移植瘤的抑癌增效作用及其可能的机制。将本室构建的Ad-hING4腺病毒感染QBI-293A细胞,扩增后获得高滴度的病毒。建立25只裸鼠胰腺癌PANC-1皮下移植瘤模型,分成PBS对照组、空病毒Ad组、125I粒子近距离放疗组、Ad-hING4基因治疗组、125I粒子和Ad-hING4联合治疗组,进行抑瘤治疗实验;此后每5天测量1次肿瘤体积,20天后处死,计算抑瘤率和金氏q值。常规病理切片观察细胞生长形态、组织损伤程度和范围,并进行凋亡细胞计数(AI);免疫组化SP法检测肿瘤标本中微血管密度(MVD)、生存素Survivin和活化的Caspase-3凋亡相关蛋白的表达。结果发现,125I粒子组、Ad-hING4组、联合治疗组抑瘤率分别达到34.19%(P<0.01)、31.50%(P<0.01)、67.15%(P<0.01),联合治疗组抑瘤率明显高于125I粒子和Ad-hING4治疗组(P<0.01);病理切片检查显示近粒子处肿瘤细胞变性坏死,远离粒子处可见存活肿瘤细胞;三个治疗组凋亡指数(AI)、Caspase-3阳性细胞数明显高于PBS组(P<0.05),且联合治疗组明显高于125I粒子和Ad-hING4治疗组(P<0.01);三个治疗组MVD值、Survivin阳性细胞明显低于PBS组(P<0.05),且联合治疗组明显低于125I粒子和Ad-hING4治疗组(P<0.01);Ad组与PBS组的各指标无显著性差异(P>0.05)。可见125I粒子、Ad-hING4可显著抑制裸鼠PANC-1胰腺癌移植瘤的生长,两者联用具有抑癌增效的协同作用,Ad-hING4有望作为一种新的放疗增敏剂;其抑瘤机制可能是通过下调Survivin和上调Caspase3的表达,以诱导肿瘤细胞凋亡、抑制肿瘤血管形成。 展开更多
关键词 125I粒子 近距离治疗 hING4 胰腺肿瘤 裸鼠 基因治疗 放疗增敏剂 机制
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Large-scale Vacuum Vessel Design and Finite Element Analysis 被引量:10
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作者 WANG Wenlong CAI Guobiao ZHOU Jianping 《Chinese Journal of Aeronautics》 SCIE EI CSCD 2012年第2期189-197,共9页
The vacuum plume effects experimental system (PES) is the first experimental system designed to study the effects of vacuum plume in China. The main equipment, a vacuum chamber of 5.5 m in diameter and 12.8 m in len... The vacuum plume effects experimental system (PES) is the first experimental system designed to study the effects of vacuum plume in China. The main equipment, a vacuum chamber of 5.5 m in diameter and 12.8 m in length, and structure design of hinged door are described. The finite element method (FEM) is adopted to analyze the static strength and stability of the PES vacuum chamber. It is demonstrated that the static strength and stability are qualified. For the 5.5 m diameter vacuum chamber door, three design schemes are put forward. After comparisons are made, the single-axis-double-pin hinged door is selected. The FEM is applied to checking its static strength as well as distortions. The results show that the door’s distortion and displacement change mainly due to the gravity of the door which leads to its sinking. The calculated displacement is less than 7.8 mm, while the actual measurement is 5 mm. The single-axis-double-pin hinged door mechanism completely satisfies the design requirements. This innovative structure can be introduced as a reference for the design of large-scale hinged doors. 展开更多
关键词 VACUUM DESIGN finite element method BUCKLING CHAMBER HINGES
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Design and experiment of concentrated flexibility-based variable camber morphing wing 被引量:13
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作者 Yuzhu LI Wenjie GE +4 位作者 Jin ZHOU Yonghong ZHANG Donglai ZHAO Zhuo WANG Dianbiao DONG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2022年第5期455-469,共15页
The morphing wing has a significant positive effect on the aerodynamic performance of the aircraft.This paper describes a leading-edge of variable camber wing with concentrated flexibility based on the geared five-bar... The morphing wing has a significant positive effect on the aerodynamic performance of the aircraft.This paper describes a leading-edge of variable camber wing with concentrated flexibility based on the geared five-bar mechanism.The driving points of morphing skin formed by the glass fibre composite sheet were optimized to make the skin deformation smooth.A geared fivebar kinematic mechanism rigidly connected to the skin was proposed to drive the leading-edge deformation.Besides,a new kind of concentrated flexure hinge was designed using the pseudorigid-body method and applied to the joint between the rigid mechanism and the skin.Finally,the leading-edge prototypes with traditional hinges and flexure hinges were produced,respectively.The feasibility of the concentrated flexibility leading-edge was verified through the comparative experiments of ground deformation.Simultaneously,aerodynamic analysis was carried out to compare the concentrated flexure leading-edge wing with the original airfoil. 展开更多
关键词 AIRCRAFT Concentrated flexure hinge LEADING-EDGE Morphing wing Pseudo-rigid-body model
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Topological and Shape Optimization of Flexure Hinges for Designing Compliant Mechanisms Using the Level Set Method 被引量:8
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作者 Benliang Zhu Xianmin Zhang +2 位作者 Min Liu Qi Chen Hai Li 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2019年第1期42-53,共12页
A flexure hinge is a major component in designing compliant mechanisms that o ers unique possibilities in a wide range of application fields in which high positioning accuracy is required. Although various flexure hin... A flexure hinge is a major component in designing compliant mechanisms that o ers unique possibilities in a wide range of application fields in which high positioning accuracy is required. Although various flexure hinges with di erent configurations have been successively proposed, they are often designed based on designers' experiences and inspirations. This study presents a systematic method for topological optimization of flexure hinges by using the level set method. Optimization formulations are developed by considering the functional requirements and geometrical constraints of flexure hinges. The functional requirements are first constructed by maximizing the compliance in the desired direction while minimizing the compliances in the other directions. The weighting sum method is used to construct an objective function in which a self-adjust method is used to set the weighting factors. A constraint on the symmetry of the obtained configuration is developed. Several numerical examples are presented to demonstrate the validity of the proposed method. The obtained results reveal that the design of a flexure hinge starting from the topology level can yield more choices for compliant mechanism design and obtain better designs that achieve higher performance. 展开更多
关键词 TOPOLOGY optimization Compliant mechanisms Flexure HINGES Level SET METHOD
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