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HIGHER-ORDER ANALYSIS OF NEAR-TIP FIELDS AROUND AN INTERFACIAL CRACK BETWEEN TWO DISSIMILAR POWER LAW HARDENING MATERIALS
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作者 夏霖 王自强 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 1994年第1期27-39,共13页
By means of an asymptotic expansion method of a regular series, an exact higher-order analysis has been carried out for the near-tip fields of an in- terfacial crack between two different elastic-plastic materials. Th... By means of an asymptotic expansion method of a regular series, an exact higher-order analysis has been carried out for the near-tip fields of an in- terfacial crack between two different elastic-plastic materials. The condition of plane strain is invoked. Two group of solutions have been obtained for the crack surface conditions: (1) traction free and (2) frictionless contact, respectively. It is found that along the interface ahead of crack tip the stress fields are co-order continuous while the displacement fields are cross-order continuous. The zone of dominance of the asymptotic solutions has been estimated. 展开更多
关键词 interfacial crack ELASTIC-PLASTIC near-tip fields higher-order asymptotic analysis
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Magneto-Electro-Elastic Analysis of Doubly-Curved Shells: Higher-Order Equivalent Layer-Wise Formulation
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作者 Francesco Tornabene Matteo Viscoti Rossana Dimitri 《Computer Modeling in Engineering & Sciences》 2025年第2期1767-1838,共72页
Recent engineering applications increasingly adopt smart materials,whose mechanical responses are sensitive to magnetic and electric fields.In this context,new and computationally efficient modeling strategies are ess... Recent engineering applications increasingly adopt smart materials,whose mechanical responses are sensitive to magnetic and electric fields.In this context,new and computationally efficient modeling strategies are essential to predict the multiphysic behavior of advanced structures accurately.Therefore,the manuscript presents a higher-order formulation for the static analysis of laminated anisotropic magneto-electro-elastic doubly-curved shell structures.The fundamental relations account for the full coupling between the electric field,magnetic field,and mechanical elasticity.The configuration variables are expanded along the thickness direction using a generalized formulation based on the Equivalent Layer-Wise approach.Higher-order polynomials are selected,allowing for the assessment of prescribed values of the configuration variables at the top and bottom sides of solids.In addition,an effective strategy is provided for modeling general surface distributions of mechanical pressures and electromagnetic external fluxes.The model is based on a continuum-based formulation which employs an analytical homogenization of the multifield material properties,based on Mori&Tanaka approach,of a magneto-electro-elastic composite material obtained from a piezoelectric and a piezomagnetic phase,with coupled magneto-electro-elastic effects.A semi-analytical Navier solution is applied to the fundamental equations,and an efficient post-processing equilibrium-based procedure is here used,based on the numerical assessment with the Generalized Differential Quadrature(GDQ)method,to recover the response of three-dimensional shells.The formulation is validated through various examples,investigating the multifield response of panels of different curvatures and lamination schemes.An efficient homogenization procedure,based on the Mori&Tanaka approach,is employed to obtain the three-dimensional constitutive relation of magneto-electro-elastic materials.Each model is validated against three-dimensional finite-element simulations,as developed in commercial codes.Furthermore,the full coupling effect between the electric and magnetic response is evaluated via a parametric investigation,with useful insights for design purposes of many engineering applications.The paper,thus,provides a formulation for the magneto-electro-elastic analysis of laminated structures,with a high computational efficiency,since it provides results with three-dimensional capabilities with a two-dimensional formulation.The adoption of higher-order theories,indeed,allows us to efficiently predict not only the mechanical response of the structure as happens in existing literature,but also the through-the-thickness distribution of electric and magnetic variables.A novel higher-order theory has been proposed in this work for the magneto-electro-elastic analysis of laminated shell structures with varying curvatures.This theory employs a generalized method to model the distribution of the displacement field components,electrostatic,and magneto-static potential,accounting for higher-order polynomials.The thickness functions have been defined to prescribe the arbitrary values of configuration variables at the top and bottom surfaces,even though the model is ESL-based.The fundamental governing equations have been derived in curvilinear principal coordinates,considering all coupling effects among different physical phenomena,including piezoelectric,piezomagnetic,and magneto-electric effects.A homogenization algorithm based on a Mori&Tanaka approach has been adopted to obtain the equivalent magneto-electro-mechanical properties of a two-phase transversely isotropic composite.In addition,an effective method has been adopted involving the external loads in terms of surface tractions,as well as the electric and magnetic fluxes.In the post-processing stage,a GDQ-based procedure provides the actual 3D response of a doubly-curved solid.The model has been validated through significant numerical examples,showing that the results of this semi-analytical theory align well with those obtained from 3D numerical models from commercial codes.In particular,the accuracy of the model has been verified for lamination schemes with soft layers and various curvatures under different loading conditions.Moreover,this formulation has been used to predict the effect of combined electric and magnetic loads on the mechanical response of panels with different curvatures and lamination schemes.As a consequence,this theory can be applied in engineering applications where the combined effect of electric and magnetic loads is crucial,thus facilitating their study and design.An existing limitation of this study is that the solution is that it is derived only for structures with uniform curvature,cross-ply lamination scheme,and simply supported boundary conditions.Furthermore,it requires that each lamina within the stacking sequence exhibits magneto-electro-elastic behavior.Therefore,at the present stage,it cannot be used for multifield analysis of classical composite structures with magneto-electric patches.A further enhancement of the research work could be the derivation of a solution employing a numerical technique,to overcome the limitations of the Navier method.In this way,the same theory may be adopted to predict the multifield response of structures with variable curvatures and thickness,as well as anisotropic materials and more complicated boundary conditions.Acknowledgement:The authors are grateful to the Department of Innovation Engineering of Univer-sity of Salento for the support. 展开更多
关键词 Magneto-electro-elastic materials equivalent layer-wise generalized differential quadrature higher-order theories navier solution recovery procedure smart structures
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Dynamical analysis and localized waves of the n-component nonlinear Schrödinger equation with higher-order effects
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作者 Yu Lou Guoan Xu 《Chinese Physics B》 2025年第3期204-213,共10页
Under investigation is the n-component nonlinear Schrödinger equation with higher-order effects,which describes the ultrashort pulses in the birefringent fiber.Based on the Lax pair,the eigenfunction and generali... Under investigation is the n-component nonlinear Schrödinger equation with higher-order effects,which describes the ultrashort pulses in the birefringent fiber.Based on the Lax pair,the eigenfunction and generalized Darboux transformation are derived.Next,we construct several novel higher-order localized waves and classified them into three categories:(i)higher-order rogue waves interacting with bright/antidark breathers,(ii)higher-order breather fission/fusion,(iii)higherorder breather interacting with soliton.Moreover,we explore the effects of parameters on the structure,collision process and energy distribution of localized waves and these characteristics are significantly different from previous ones.Finally,the dynamical properties of these solutions are discussed in detail. 展开更多
关键词 n-component nonlinear Schrödinger equation with higher-order effects generalized Darboux transformation localized waves soliton BREATHER rogue wave
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Crystal structure,thermal analysis,and luminescence properties of six heterocyclic lanthanide complexes
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作者 SONG Zihe ZHAO Jinjin +1 位作者 REN Ning ZHANG Jianjun 《无机化学学报》 北大核心 2026年第1期181-192,共12页
Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'... Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6. 展开更多
关键词 lanthanide complexes fluorescence property crystal structure thermal analysis
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Changes in border-associated macrophages after stroke: Single-cell sequencing analysis 被引量:1
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作者 Ning Yu Yang Zhao +3 位作者 Peng Wang Fuqiang Zhang Cuili Wen Shilei Wang 《Neural Regeneration Research》 2026年第1期346-356,共11页
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro... Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment. 展开更多
关键词 border-associated macrophages CLODRONATE hypoxia ISCHEMIA-REPERFUSION ischemic stroke liposomes neuroinflammation single-cell sequencing analysis STAT3 tumor necrosis factor
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Comprehensive pan-cancer analysis of the receptor-interacting protein kinase family expression,genomic alterations,and functional implications
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作者 Wan-Rong Li Xin Li Jian Wang 《Life Research》 2026年第1期35-44,共10页
Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations... Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications. 展开更多
关键词 RIPK family pan-cancer analysis tumor mutation burden microsatellite instability gene set enrichment analysis
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Advanced isoconversional kinetic analysis of lepidolite sulfation product decomposition reactions for selectively extracting lithium
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作者 Yubo Liu Baozhong Ma +4 位作者 Jiahui Cheng Xiang Li Hui Yang Chengyan Wang Yongqiang Chen 《International Journal of Minerals,Metallurgy and Materials》 2026年第1期217-227,共11页
The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.A... The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.Accordingly,comprehensive kinetic study by employing thermalgravimetric analysis at various heating rates was presented in this paper.Two main weight loss regions were observed during heating.The initial region corresponded to the dehydration of crystal water,whereas the subsequent region with overlapping peaks involved complex decomposition reactions.The overlapping peaks were separated into two individual reaction peaks and the activation energy of each peak was calculated using isoconversional kinetics methods.The activation energy of peak 1 exhibited a continual increase as the reaction conversion progressed,while that of peak 2 steadily decreased.The optimal kinetic models,identified as belonging to the random nucleation and subsequent growth category,provided valuable insights into the mechanism of the decomposition reactions.Furthermore,the adjustment factor was introduced to reconstruct the kinetic mechanism models,and the reconstructed models described the kinetic mechanism model more accurately for the decomposition reactions.This study enhanced the understanding of the thermochemical behavior and kinetic parameters of the lepidolite sulfation product decomposition reactions,further providing theoretical basis for promoting the selective extraction of lithium. 展开更多
关键词 LITHIUM LEPIDOLITE decomposition reactions KINETICS isoconversional analysis
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Global research status in the treatment of glaucoma:a systematic bibliometric analysis
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作者 Wen-Hui Liu Chang Shu +1 位作者 Bei-Di Jia Xiao-Rong Li 《International Journal of Ophthalmology(English edition)》 2026年第2期379-392,共14页
AIM:To present an overview of the research on global glaucoma treatment in the last decade in terms of publication year,journals,countries/regions,organizations,references,and keywords,to investigate the current resea... AIM:To present an overview of the research on global glaucoma treatment in the last decade in terms of publication year,journals,countries/regions,organizations,references,and keywords,to investigate the current research international trends and hot topics in this area.METHODS:Bibliometric analysis was conducted on 9128 articles in the Web of Science Core Collection(WoSCC;Clarivate)database.Quantitative and qualitative analysis was employed using VOSviewer(v1.6.18),Pajek(v1.0.0.0),and CiteSpace(v6.1.R2)software.RESULTS:The 9128 papers relating to glaucoma treatment were published from April 2013 to April 2023,of which 7482 articles(82%)were original research articles and 1464(18%)were review articles.The United States(2867)and Johns Hopkins University(166)were the most productive country and institution,respectively,but the University College London had the highest h-index(54).The Journal of Glaucoma was the most productive and Ophthalmology had the highest h-index compared with other journals.The Keywords of interest included treatment surgery,cyclophotocoagulation,minimally invasive glaucoma surgery(MIGS),trabeculectomy,baerveldt,epidemiology,medication adherence,nanoparticle,optical coherence tomography(OCT),gene therapy,and artificial intelligence(AI).Glaucoma surgery appeared as a current research hotspot through the analysis of keywords.CONCLUSION:This study provides insights into the research trends and potential research hotspots in the treatment of glaucoma.This will help researchers to evaluate research policies and to promote international cooperation. 展开更多
关键词 glaucoma treatment bibliometric analysis SURGERY minimally invasive glaucoma surgery NANOPARTICLE
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Combined Fault Tree Analysis and Bayesian Network for Reliability Assessment of Marine Internal Combustion Engine
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作者 Ivana Jovanović Çağlar Karatuğ +1 位作者 Maja Perčić Nikola Vladimir 《哈尔滨工程大学学报(英文版)》 2026年第1期239-258,共20页
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ... This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels. 展开更多
关键词 Fault tree analysis Bayesian network RELIABILITY REDUNDANCY Internal combustion engine
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Sensitivity analysis of rod rearrangement in criticality safety for PWR fuel assemblies under transportation accidents
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作者 Xin‑Ling Dai De‑Chang Cai +1 位作者 Yan‑Min Zhang Jin Cai 《Nuclear Science and Techniques》 2026年第1期263-282,共20页
To ensure the safe transportation of radioactive materials,numerous countries have established specific standards.For the transfer of fissile materials,it is imperative that the material within the packaging remains i... To ensure the safe transportation of radioactive materials,numerous countries have established specific standards.For the transfer of fissile materials,it is imperative that the material within the packaging remains in a subcritical state during routine,normal,and accidental transport conditions.In the event of an accident,the rods within the storage tank may become rearranged,introducing uncertainty that must be accounted for to ensure that criticality analysis results are conservative.Historically,this uncertainty was addressed overly conservatively due to limited research on non-uniform arrangement scenarios,which proved unsuitable for criticality safety analysis of spent fuel packages.This paper introduced three distinct methods to non-uniformly rearrange fuel rods—Uniform Arrangement by Blocks,Layer-by-Layer Determination,and Birdcage Deformation—and meticulously evaluates the influences of rod rearrangement on the effective multiplication factor of neutrons,k eff,utilizing the Monte Carlo method.Ultimately,this study presents a holistic method capable of encompassing the entire spectrum of potential effects stemming from the rearrangement of fuel rods during rods mispositioning accident.By augmenting the safety margin,this approach proves to be adeptly suited for the criticality safety analysis of nuclear fuel transport containers. 展开更多
关键词 Criticality safety analysis Fuel transports Rods mispositioning accident Non-uniform arrangement
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Heavy metal risks and policy analysis on using industrial waste salts for making value-added snow-melting agents
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作者 Yubiao Ma Jiaxin Yin +2 位作者 Yunfei Wang Lei Wang Jianxin Zhu 《Journal of Environmental Sciences》 2026年第1期756-766,共11页
Industrial waste salts are commonly used to make value-added snow-melting agents to ensure traffic safety in northern China during winter and spring after snowfall.However,heavy metals in industrial waste salts may po... Industrial waste salts are commonly used to make value-added snow-melting agents to ensure traffic safety in northern China during winter and spring after snowfall.However,heavy metals in industrial waste salts may pose certain environmental risks.Snow-melting agents and snow samples were collected and analyzed from highways,arterial roads,footbridges,and other locations in Beijing after the snowstorm in December 2023.It was found that the main component of snow-melting agents was sodium chloride with high concentrations of Cu,Mn,and Zn,which are not regulated in the current policies,despite the recent promotion of environmentally friendly snow-melting agents.The Pb,Zn and Cr contents of some snow samples exceeded the limitation value of surface water quality standards,potentially affecting the soil and water environment near roadsides,although the snow-melting agents comply with relevant standards,which indicates the policy gap in the management of recycled industrial salts.We reviewed and analyzed the relevant standards for snow-melting agents and industrial waste salts proposed nationally and internationally over the past 30 years.Through comparative analysis,we proposed relevant policy recommendations to the existing quality standards of snow-melting agents and the management regulations of industrial waste salts,and the formulation of corresponding usage strategies,aimed at reducing the potential environmental release of heavy metals from the use of snow-melting agents,thereby promoting more sustainable green urban development and environmentally sound waste management. 展开更多
关键词 Snow-melting agent Heavy metals Industrial waste salts recycled Comparative analysis
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Evaluation of the protective effects of Crocus sativus L.against cypermethrin induced reproductive toxicity in male rats through the Nrf2 pathway and in silico ADMET analysis
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作者 Fareena Tariq Farah Ijaz +9 位作者 Yasameen Hameed Jasim Farah Naz Channa Sohail Ahmed Ahmed Shandookh Hameed Sobia Alyas Ahmed Raheem Rayshan Tahira Bibi Nazima Yousaf Khan Sadia Bibi Jameel Ahmed Buzdar 《Traditional Medicine Research》 2026年第3期12-25,共14页
Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to i... Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to its therapeutic properties,but its exact role and molecular mechanisms in treatment of reproductive dysfunction remain unclear.Methods:During this study,36 rats were randomly divided into six groups(n=6):control,CYP-induced(60 mg/kg),standard(leuprolide 3 mg/kg)and three treatment groups receiving aqueous,ethanolic,and oil extracts(50 mg/kg or 20 mL/kg)for post-toxicity induction.Results:The finding represented that exposure of CYP significantly increased oxidative stress,disrupted testicular architecture,and markedly reduced testosterone levels(P<0.05).Importantly,Crocus sativus L.treatment alleviated these changes by increasing the expression of Nrf2(nuclear factor erythroid 2-related factor 2),restoring the activity of antioxidant enzymes,and enhancing testicular histomorphology.Surprisingly,molecular docking established a high binding affinity of Crocus sativus L.phytoconstituents such as gallic acid,cinnamic acid and quercetin to the Nrf2-Keap1 complex.It is worth noting that,Crocus sativus L.exhibited a high level of protection against reproductive toxicity caused by CYP in male rats,which was mediated by the activation of Nrf2 pathway,reduction of oxidative damage,and favorable ADMET characteristics.Conclusion:Notably,this research provides a more valid,safe,and effective method of developing new drugs for reproductive disorders,however,further investigation is needed to support the research findings and implement it in clinical practice. 展开更多
关键词 Crocus sativus L. CYPERMETHRIN male reproductive toxicity Nrf2 pathway in silico ADMET analysis
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Analysis of ocular structural parameters and higher-order aberrations in Chinese children with myopia 被引量:5
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作者 Xue Li Qi Hu +3 位作者 Qian-Ru Wang Zi-Qing Feng Fan Yang Chun-Yu Du 《World Journal of Clinical Cases》 SCIE 2021年第27期8035-8043,共9页
BACKGROUND Myopia and high myopia are global public health concerns.Patients with high myopia account for 0.5%-5.0%of the global population.AIM To examine diopters,axial length(AL),higher-order aberrations,and other o... BACKGROUND Myopia and high myopia are global public health concerns.Patients with high myopia account for 0.5%-5.0%of the global population.AIM To examine diopters,axial length(AL),higher-order aberrations,and other ocular parameters in Chinese children with myopia,to analyze the influence of structural parameters associated with myopia on visual quality,and to provide a theoretical basis for the prevention and treatment of childhood myopia and high myopia.METHODS This study included 195 children aged 6–17 years with myopia.The AL was measured with an ultrasonic ophthalmic diagnostic instrument,and the aberrations,corneal curvature(minimum K1,maximum K2,and average Km),central corneal thickness,anterior chamber depth,and anterior chamber angle were measured using a Sirius three-dimensional anterior segment analyzer.Using a standard formula,the corneal radius of curvature R(337.3/Km)and AL/R values were obtained.RESULTS The diopter of high myopia compared with low-middle myopia was correlated with age and AL(r=-0.336,-0.405,P<0.001),and AL of high myopia was negatively correlated with K1,K2,and Km(r=-0.673,-0.661,and-0.680,respectively;P<0.001),and positively correlated with age and the anterior chamber depth(r=0.214 and 0.275,respectively;P<0.05).AL/R was more closely related to diopter than AL in children with myopia,and 94.4%of children with myopia had an AL/R of>3.00.CONCLUSION The ocular structural parameters of children change because of different diopters.AL/R is more specific and sensitive than AL in evaluating the refractive status of myopia in children.An AL/R of>3.00 may be used as a specific index of myopia in children.There are differences in AL/R between high myopia and low-middle myopia,which can be used for the classification of ametropia.The degree of myopia has a certain influence on higher-order aberrations. 展开更多
关键词 MYOPIA higher-order aberrations DIOPTER Axial length Cornea radius of curvature
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SAR tomography imaging via higher-order spectrum analysis 被引量:2
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作者 Wang Jinfeng Pi Yiming 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2009年第4期748-754,共7页
To deal with the non-Caussian noise in standard 2-D SAR images, the deramped signal in imaging plane, and the possible symmetric distribution of complex noise, the fourth-order cumulant of complex process is introduce... To deal with the non-Caussian noise in standard 2-D SAR images, the deramped signal in imaging plane, and the possible symmetric distribution of complex noise, the fourth-order cumulant of complex process is introduced into SAR tomography. With the estimated AR parameters of ARMA model of noise through Yule-Walker equation, the signal series of height is pre-filtered. Then, through ESPRIT, the spectrum is obtained and the aperture in height direction is synthesized. Finally, the SAR tomography imaging of scene is achieved. The results of processing on signal with non-Gaussian noise demonstrate the robustness of the proposed method. The tomography imaging of the scenes shows that the higher-order spectrum analysis is feasible in the application. 展开更多
关键词 synthetic aperture radar 3-D imaging TOMOGRAPHY high-order spectrum analysis nongaussian
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Higher-Order Analysis of Crack-Tip Fields in Power Law Hardening Materials
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作者 夏霖 王自强 《Science China Mathematics》 SCIE 1994年第6期704-717,共14页
In this paper,we present an exact higher-order asymptotic analysis on the near-crack-tip fields in elastic-plastic materials under plane strain,Mode 1.A four- or five-term asymptotic series of the solutions is derived... In this paper,we present an exact higher-order asymptotic analysis on the near-crack-tip fields in elastic-plastic materials under plane strain,Mode 1.A four- or five-term asymptotic series of the solutions is derived.It is found that when 1.6 < n≤2.8 (here,n is the hardening exponent),the elastic effect enters the third-order stress field; but when 2.8< n≤3.7 this effect turns to enter the fourth-order field,with the fifth-order field independent.Moreover,if n>3.7,the elasticity only affects the fields whose order is higher than 4.In this case,the fourth-order field remains independent.Our investigation also shows that as long as n is larger than 1.6,the third-order field is always not independent,whose amplitude coefficient K3 depends either on K1 or on both K1 and K2 (K1 and K2 arc the amplitude coefficients of the first- and second-order fields,respectively).Finally,good agreement is found between our results and O'Dowd and Shih's numerical ones by comparison. 展开更多
关键词 higher-order ASYMPTOTIC analysis the near-crack-tip FIELDS
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APPROXIMATE VIBRATION ANALYSIS OF LAMINATED CURVED PANEL USING HIGHER-ORDER SHEAR DEFORMATION THEORY
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作者 侍建伟 中谷彰宏 北川浩 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2004年第3期238-246,共9页
An approximate analysis for free vibration of a laminated curved panel(shell)with four edges simply supported(SS2),is presented in this paper.The transverse shear deformation is considered by using a higher-order shea... An approximate analysis for free vibration of a laminated curved panel(shell)with four edges simply supported(SS2),is presented in this paper.The transverse shear deformation is considered by using a higher-order shear deformation theory.For solving the highly coupled partial differential governing equations and associated boundary conditions,a set of solution functions in the form of double trigonometric Fourier series,which are required to satisfy the geometry part of the considered boundary conditions,is assumed in advance.By applying the Galerkin procedure both to the governing equations and to the natural boundary conditions not satisfied by the assumed solution functions,an approximate solution,capable of providing a reliable prediction for the global response of the panel,is obtained.Numerical results of antisymmetric angle-ply as well as symmetric cross-ply and angle-ply laminated curved panels are presented and discussed. 展开更多
关键词 curved panel modified Galerkin method higher-order shear deformation transverse shear deformation vibration analysis
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Free Vibration Analysis of Moderately-Thick Laminated Doubly-Curved Shells with the Modified Higher-Order Theory
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作者 Yuan Tao Jie Xu +1 位作者 Xuegang Yuan Hang Yin 《Acta Mechanica Solida Sinica》 SCIE EI CSCD 2023年第1期132-142,共11页
In this work,the free vibration properties ofmoderately-thick laminated doubly-curved shells are investigated.Themathematical model of the natural frequency of the simply-supported laminated doubly-curved shell is for... In this work,the free vibration properties ofmoderately-thick laminated doubly-curved shells are investigated.Themathematical model of the natural frequency of the simply-supported laminated doubly-curved shell is formulated via the variational principle.Based on the numerical solutions,the influences of the shell type,the aspect ratio,the lamination angle and the layer number on the free vibration are discussed.The obtained results show that,for the symmetrically laminated curved shells with fixed thickness,when the layer number is greater than 4,the increasing number has no impact on the natural frequency;however,the lamination angle plays a key role in the fundamental frequency of the spherical shell,while it has little effect on the hyperbolic paraboloid shell.Particularly,a higher-order shear deformation theory with modified parameters is developed for the moderately-thick laminated doubly-curved shells in this work,i.e.,the geometrically nonlinear strain–displacement relationships are derived with a stricter series expansion form,which are more suitable for the moderately-thick curved shells. 展开更多
关键词 Vibration analysis Laminated doubly-curved shell Modified displacement fields higher-order shear deformation
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KRMN-TYPE EQUATIONS FOR A HIGHER-ORDER SHEARDEFORMATION PLATE THEORY AND ITS USE IN THE THERMAL POSTBUCKLING ANALYSIS
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作者 沈惠申 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1997年第12期0-0,0-0+0-0+0-0+0-0+0-0+0-0+0-0,共16页
arman-type nonlinear large deflection equations are derived occnrding to theReddy's higher-order shear deformation plate theory and used in the thermal postbuckling analysis The effects of initial geometric imperf... arman-type nonlinear large deflection equations are derived occnrding to theReddy's higher-order shear deformation plate theory and used in the thermal postbuckling analysis The effects of initial geometric imperfections of the plate areincluded in the present study which also includes th thermal effects.Simply supported,symmetric cross-ply laminated plates subjected to uniform or nomuniform parabolictemperature distribution are considered. The analysis uses a mixed GalerkinGolerkinperlurbation technique to determine thermal buckling louds and postbucklingequilibrium paths.The effects played by transverse shear deformation plate aspeclraio, total number of plies thermal load ratio and initial geometric imperfections arealso studied. 展开更多
关键词 composite laminated plate higher-order shear deformation plate theory thermal postbuckling Galerkin-perturbation technique
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Phase-plane analysis of conserved higher-order traffic flow model
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作者 吴春秀 宋涛 +1 位作者 张鹏 S.C.WONG 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2012年第12期1505-1512,共8页
The phase-plane analysis is used to study the traveling wave solution of a recently proposed higher-order traffic flow model under the Lagrange coordinate system. The analysis identifies the types and stabilities of t... The phase-plane analysis is used to study the traveling wave solution of a recently proposed higher-order traffic flow model under the Lagrange coordinate system. The analysis identifies the types and stabilities of the equilibrium solutions, and the overall distribution structure of the nearby solutions is drawn in the phase plane for the further analysis and comparison. The analytical and numerical results are in agreement, and may help to explain the simulated phenomena, such as the stop-and-go wave and oscillation near a bottleneck. The findings demonstrate the model ability to describe the complexity of congested traffic. 展开更多
关键词 traffic flow Lagrange coordinates phase-plane analysis traffic congestionpattern
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HIGHER-ORDER NODE-BASED TDFEM FOR TRANSIENT ELECTROMAGNETIC ANALYSIS IN RECTANGULAR WAVEGUIDE
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作者 He Xiaoxiang Tang Wanchu 《Journal of Electronics(China)》 2009年第4期537-542,共6页
Higher-order Time Domain Finite Element Method (TDFEM) based on the nodal inter- polation is proposed for two-dimensional electromagnetic analysis. The detailed algorithms of the method are presented firstly, and then... Higher-order Time Domain Finite Element Method (TDFEM) based on the nodal inter- polation is proposed for two-dimensional electromagnetic analysis. The detailed algorithms of the method are presented firstly, and then the accuracy, CPU time and memory consumption of the higher-order node-based TDFEM are investigated. The high performance of the presented approach is validated by numerical results of the transient responses of Transverse Electric (TE) field and Transverse Magnetic (TM) field in a rectangular waveguide. 展开更多
关键词 Time Domain Finite Element Method (TDFEM) higher-order basis Computational ElectroMagnetism (CEM)
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