Traditional Chinese medicine(TCM)demonstrates distinctive advantages in disease prevention and treatment.However,analyzing its biological mechanisms through the modern medical research paradigm of“single drug,single ...Traditional Chinese medicine(TCM)demonstrates distinctive advantages in disease prevention and treatment.However,analyzing its biological mechanisms through the modern medical research paradigm of“single drug,single target”presents significant challenges due to its holistic approach.Network pharmacology and its core theory of network targets connect drugs and diseases from a holistic and systematic perspective based on biological networks,overcoming the limitations of reductionist research models and showing considerable value in TCM research.Recent integration of network target computational and experimental methods with artificial intelligence(AI)and multi-modal multi-omics technologies has substantially enhanced network pharmacology methodology.The advancement in computational and experimental techniques provides complementary support for network target theory in decoding TCM principles.This review,centered on network targets,examines the progress of network target methods combined with AI in predicting disease molecular mechanisms and drug-target relationships,alongside the application of multi-modal multi-omics technologies in analyzing TCM formulae,syndromes,and toxicity.Looking forward,network target theory is expected to incorporate emerging technologies while developing novel approaches aligned with its unique characteristics,potentially leading to significant breakthroughs in TCM research and advancing scientific understanding and innovation in TCM.展开更多
It is difficult to improve both energy consumption and detection accuracy simultaneously,and even to obtain the trade-off between them,when detecting and tracking moving targets,especially for Underwater Wireless Sens...It is difficult to improve both energy consumption and detection accuracy simultaneously,and even to obtain the trade-off between them,when detecting and tracking moving targets,especially for Underwater Wireless Sensor Networks(UWSNs).To this end,this paper investigates the relationship between the Degree of Target Change(DoTC)and the detection period,as well as the impact of individual nodes.A Hierarchical Detection and Tracking Approach(HDTA)is proposed.Firstly,the network detection period is determined according to DoTC,which reflects the variation of target motion.Secondly,during the network detection period,each detection node calculates its own node detection period based on the detection mutual information.Taking DoTC as pheromone,an ant colony algorithm is proposed to adaptively adjust the network detection period.The simulation results show that the proposed HDTA with the optimizations of network level and node level significantly improves the detection accuracy by 25%and the network energy consumption by 10%simultaneously,compared to the traditional adaptive period detection schemes.展开更多
Satellite and terrestrial cellular networks can be integrated together to achieve extended broad-band coverage for,e.g.,maritime communication sce-narios,in the upcoming sixth-generation(6G)era.To counter spectrum sca...Satellite and terrestrial cellular networks can be integrated together to achieve extended broad-band coverage for,e.g.,maritime communication sce-narios,in the upcoming sixth-generation(6G)era.To counter spectrum scarcity,collaborative spectrum sharing is considered for hybrid satellite-terrestrial networks(HSTNs)in this paper.With only slowly-varying large-scale channel state information(CSI),joint power and channel allocation is implemented for terrestrial mobile terminals(MTs)which share the same frequency band with the satellite MTs oppor-tunistically.Specially,strict quality service assurance is adopted for terrestrial MTs under the constraint of leakage interference to satellite MTs.With the tar-get of maximizing both the number of served terres-trial MTs and the average sum transmission rate,a double-target spectrum sharing problem is formulated.To solve the complicated mixed integer programming(MIP)problem efficiently,user-centric channel pools are introduced.Simulations demonstrate that the proposed spectrum sharing scheme could achieve a significant performance gain for the HSTN.展开更多
Traditional Chinese medicine(TCM),especially the plant-based,represents complex chemical system containing various primary and secondary metabolites.These botanical metabolites are structurally diversified and exhibit...Traditional Chinese medicine(TCM),especially the plant-based,represents complex chemical system containing various primary and secondary metabolites.These botanical metabolites are structurally diversified and exhibit significant difference in the acidity,alkalinity,molecular weight,polarity,and content,etc,which thus poses great challenges in assessing the quality of TCM[1].展开更多
Addressing the critical detection range limitation in active electrosensing(AES)for underwater sensing,this study proposes an enhanced AES system via novel array optimization.While AES offers advantages like interfere...Addressing the critical detection range limitation in active electrosensing(AES)for underwater sensing,this study proposes an enhanced AES system via novel array optimization.While AES offers advantages like interference immunity,acoustic stealth detection,and low cost,its short range restricts applicability.A target perturbation model under differential signal acquisition reveals that signal strength increases with local electric field intensity,target size,differential channel spacing,and conductivity contrast,but decreases with target-electrode distance.To extend detection,novel array configurations were explored.Simulations demonstrate that both rectangular and offset arrays significantly outperform the traditional collinear layout.Specifically,an offset array(with 8 m transmitting–receiving spacing)achieved an effective detection range enhancement exceeding 83%under the same distortion threshold while maintaining simplified electrode structure.Experimental validation confirmed a 100%increase in maximum detection distance to 5 m under identical noise thresholds compared to the collinear array.Furthermore,a fully connected neural network-based localization model achieved a mean positioning error of 14.12 cm at 3.15 m in static scenarios.In dynamic scenarios within 1–3 m,mean errors were controlled between 13.19 cm and 27.56 cm.Mechanistic analysis indicates that increasing the array baseline enhances the signal-to-noise ratio by simultaneously suppressing near-field environmental noise and amplifying far-field signal reception.Structural innovations in array design enabled this study to significantly expand the detection range of AES systems without compromising cost efficiency.These advancements directly promote the engineering application of AES technology,offering critical technical support for underwater defense security monitoring,long-range early warning systems,and maritime rights protection.展开更多
For the high altitude cruising flight phase of a hypersonic cruise missile （HCM）, a relative motion mod- el between the missile and the target is established by defining virtual target and combining the theory of th...For the high altitude cruising flight phase of a hypersonic cruise missile （HCM）, a relative motion mod- el between the missile and the target is established by defining virtual target and combining the theory of the dif- ferential geometry with missile motion equations. Based on the model, the motion between the missile and the tar- get is considered as a single target differential game problem, and a new open-loop differential game midcourse guidance law （DGMGL） is deduced by solving the corresponding Hamiltonian Function. Meanwhile, a new struc- ture of a closed-loop DGMGL is presented and the training data for back propagation neural network （BPNN） are designed. By combining the theory of BPNN with the open-loop DGMGL obtained above, the law intelligence is realized. Finally, simulation is carried out and the validity of the law is testified.展开更多
AIM： To illuminate the molecular targets for schisandrin against cerebrovascular disease based on the combined methods of network pharmacology prediction and experimental verification. METHOD： A protein database was...AIM： To illuminate the molecular targets for schisandrin against cerebrovascular disease based on the combined methods of network pharmacology prediction and experimental verification. METHOD： A protein database was established through constructing the drug-protein network from literature mining data. The protein-protein network was built through an in-depth exploration of the relationships between the proteins. The computational platform was implemented to predict and extract the sensitive sub-network with significant P-values from the protein-protein network. Then the key targets and pathways were identified from the sensitive sub-network. The most related targets and pathways were also confirmed in hydrogen peroxide （H202）-induced PC 12 cells by Western blotting. RESULTS： Twelve differentially expressed proteins （gene names： NFKB1, RELA, TNFSF10, MAPK1, CHUK, CASP8, PIGS2, MAPK 14, CREBI, IFNG, APR and BCL2） were confirmed as the central nodes of the interaction network （45 nodes, 93 edges）. The NF-KB signaling pathway was suggested as the most related pathway of schisandrin for cerebrovascular disease. Furthermore, schisandrin was found to suppress the expression and phosphorylation of 1KKct, as well as p50 and p65 induced by H2O2 in PC12 cells by Western blotting. CONCLUSION： The computational platform that integrates literature mining data, protein-protein interactions, sensitive sub-network, and pathway results in identification of the NF-arB signaling pathway as the key targets and pathways for schisandrin.展开更多
Wireless sensor network (WSN) of active sensors suffers from serious inter-sensor interference (ISI) and imposes new design and implementation challenges. In this paper, based on the ultrasonic sensor network, two tim...Wireless sensor network (WSN) of active sensors suffers from serious inter-sensor interference (ISI) and imposes new design and implementation challenges. In this paper, based on the ultrasonic sensor network, two time-division based distributed sensor scheduling schemes are proposed to deal with ISI by scheduling sensors periodically and adaptively respectively. Extended Kalman filter (EKF) is used as the tracking algorithm in distributed manner. Simulation results show that the adaptive sensor scheduling scheme can achieve superior tracking accuracy with faster tracking convergence speed.展开更多
Sensor scheduling is essential to collaborative target tracking in wireless sensor networks （WSNs）. In the existing works for target tracking in WSNs, such as the information-driven sensor query （IDSQ）, the taskin...Sensor scheduling is essential to collaborative target tracking in wireless sensor networks （WSNs）. In the existing works for target tracking in WSNs, such as the information-driven sensor query （IDSQ）, the tasking sensors are scheduled to maximize the information gain while minimizing the resource cost based on the uniform sampling intervals, ignoring the changing of the target dynamics and the specific desirable tracking goals. This paper proposes a novel energy-efficient adaptive sensor scheduling approach that jointly selects tasking sensors and determines their associated sampling intervals according to the predicted tracking accuracy and tracking energy cost. At each time step, the sensors are scheduled in alternative tracking mode, namely, the fast tracking mode with smallest sampling interval or the tracking maintenance mode with larger sampling interval, according to a specified tracking error threshold. The approach employs an extended Kalman filter （EKF）-based estimation technique to predict the tracking accuracy and adopts an energy consumption model to predict the energy cost. Simulation results demonstrate that, compared to a non-adaptive sensor scheduling approach, the proposed approach can save energy cost significantly without degrading the tracking accuracy.展开更多
How to recognize targets with similar appearances from remote sensing images(RSIs) effectively and efficiently has become a big challenge. Recently, convolutional neural network(CNN) is preferred in the target classif...How to recognize targets with similar appearances from remote sensing images(RSIs) effectively and efficiently has become a big challenge. Recently, convolutional neural network(CNN) is preferred in the target classification due to the powerful feature representation ability and better performance. However,the training and testing of CNN mainly rely on single machine.Single machine has its natural limitation and bottleneck in processing RSIs due to limited hardware resources and huge time consuming. Besides, overfitting is a challenge for the CNN model due to the unbalance between RSIs data and the model structure.When a model is complex or the training data is relatively small,overfitting occurs and leads to a poor predictive performance. To address these problems, a distributed CNN architecture for RSIs target classification is proposed, which dramatically increases the training speed of CNN and system scalability. It improves the storage ability and processing efficiency of RSIs. Furthermore,Bayesian regularization approach is utilized in order to initialize the weights of the CNN extractor, which increases the robustness and flexibility of the CNN model. It helps prevent the overfitting and avoid the local optima caused by limited RSI training images or the inappropriate CNN structure. In addition, considering the efficiency of the Na¨?ve Bayes classifier, a distributed Na¨?ve Bayes classifier is designed to reduce the training cost. Compared with other algorithms, the proposed system and method perform the best and increase the recognition accuracy. The results show that the distributed system framework and the proposed algorithms are suitable for RSIs target classification tasks.展开更多
Axon regeneration is crucial for recovery from neurological diseases. Numerous studies have identified several genes, microRNAs （miRNAs）, and transcription factors （TFs） that influence axon regeneration. However, ...Axon regeneration is crucial for recovery from neurological diseases. Numerous studies have identified several genes, microRNAs （miRNAs）, and transcription factors （TFs） that influence axon regeneration. However, the regulatory networks involved have not been fully elucidated. In the present study, we analyzed a regulatory network of 51 miRNAs, 27 TFs, and 59 target genes, which is involved in axon regeneration. We identified 359 pairs of feed- forward loops （FFLs）, seven important genes （Naplll, Arhgef12, Sema6d, Akt3, Trim2, Rabllfip2, and Rps6ka3）, six important miRNAs （hsa-miR-204-5p, hsa-miR-124-3p, hsa-miR-26a-5p, hsa-miR-16-5p, hsa-miR-17-5p, and hsa- miR-15b-5p）, and eight important TFs （Smada2, Flil, Wtl, Sp6, Sp3, Smad4, Smad5, and Crebl）, which appear to play an important role in axon regeneration. Functional enrichment analysis revealed that axon-associated genes are involved mainly in the regulation of cellular component organization, axonogenesis, and cell morphogenesis during neuronal differentiation. However, these findings need to be validated by further studies.展开更多
Remote tracking for mobile targets is one of the most important applications in wireless sensor networks （WSNs）. A target tracking protoco–exponential distributed predictive tracking （EDPT） is proposed. To reduce...Remote tracking for mobile targets is one of the most important applications in wireless sensor networks （WSNs）. A target tracking protoco–exponential distributed predictive tracking （EDPT） is proposed. To reduce energy waste and response time, an improved predictive algorithm–exponential smoothing predictive algorithm （ESPA） is presented. With the aid of an additive proportion and differential （PD） controller, ESPA decreases the system predictive delay effectively. As a recovery mechanism, an optimal searching radius （OSR） algorithm is applied to calculate the optimal radius of the recovery zone. The simulation results validate that the proposed EDPT protocol performes better in terms of track failed ratio, energy waste ratio and enlarged sensing nodes ratio, respectively.展开更多
Underwater target recognition is a key technology for underwater acoustic countermeasure.How to classify and recognize underwater targets according to the noise information of underwater targets has been a hot topic i...Underwater target recognition is a key technology for underwater acoustic countermeasure.How to classify and recognize underwater targets according to the noise information of underwater targets has been a hot topic in the field of underwater acoustic signals.In this paper,the deep learning model is applied to underwater target recognition.Improved anti-noise Power-Normalized Cepstral Coefficients(ia-PNCC)is proposed,based on PNCC applied to underwater noises.Multitaper and normalized Gammatone filter banks are applied to improve the anti-noise capacity.The method is combined with a convolutional neural network in order to recognize the underwater target.Experiment results show that the acoustic feature presented by ia-PNCC has lower noise and are wellsuited to underwater target recognition using a convolutional neural network.Compared with the combination of convolutional neural network with single acoustic feature,such as MFCC(Mel-scale Frequency Cepstral Coefficients)or LPCC(Linear Prediction Cepstral Coefficients),the combination of the ia-PNCC with a convolutional neural network offers better accuracy for underwater target recognition.展开更多
In this paper, the problems of target tracking and obstacle avoidance for multi-agent networks with input constraints are investigated. When there is a moving obstacle, the control objectives are to make the agents tr...In this paper, the problems of target tracking and obstacle avoidance for multi-agent networks with input constraints are investigated. When there is a moving obstacle, the control objectives are to make the agents track a moving target and to avoid collisions among agents. First, without considering the input constraints, a novel distributed controller can be obtained based on the potential function. Second, at each sampling time, the control algorithm is optimized. Furthermore, to solve the problem that agents cannot effectively avoid the obstacles in dynamic environment where the obstacles are moving, a new velocity repulsive potential is designed. One advantage of the designed control algorithm is that each agent only requires local knowledge of its neighboring agents. Finally, simulation results are provided to verify the effectiveness of the proposed approach.展开更多
Since the issues of low communication bandwidth supply and limited battery capacity are very crucial for wireless sensor networks,this paper focuses on the problem of event-triggered cooperative target tracking based ...Since the issues of low communication bandwidth supply and limited battery capacity are very crucial for wireless sensor networks,this paper focuses on the problem of event-triggered cooperative target tracking based on set-membership information filtering.We study some fundamental properties of the set-membership information filter with multiple sensor measurements.First,a sufficient condition is derived for the set-membership information filter,under which the boundedness of the outer ellipsoidal approximation set of the estimation means is guaranteed.Second,the equivalence property between the parallel and sequential versions of the setmembership information filter is presented.Finally,the results are applied to a 1D eventtriggered target tracking scenario in which the negative information is exploited in the sense that the measurements that do not satisfy the triggering conditions are modelled as set-membership measurements.The tracking performance of the proposed method is validated with extensive Monte Carlo simulations.展开更多
Target tracking is considered as one of the cardinal applications of a wireless sensor network. Tracking multiple targets is more challenging than tracking a single target in a wireless sensor network due to targets’...Target tracking is considered as one of the cardinal applications of a wireless sensor network. Tracking multiple targets is more challenging than tracking a single target in a wireless sensor network due to targets’ movement in different directions, targets’ speed variations and frequent connectivity failures of low powered sensor nodes. If all the low-powered sensor nodes are kept active in tracking multiple targets coming from different directions of the network, there is high probability of network failure due to wastage of power. It would be more realistic if the tracking area can be reduced so that less number of sensor nodes will be active and therefore, the network will consume less energy. Tracking area can be reduced by using the target’s kinematics. There is almost no method to track multiple targets based on targets’ kinematics. In our paper, we propose a distributed tracking method for tracking multiple targets considering targets’ kinematics. We simulate our method by a sensor network simulator OMNeT++ and empirical results state that our proposed methodology outperforms traditional tracking algorithms.展开更多
A prediction based energy-efficient target tracking protocol in wireless sensor networks(PET) was proposed for tracking a mobile target in terms of sensing and communication energy consumption.In order to maximize the...A prediction based energy-efficient target tracking protocol in wireless sensor networks(PET) was proposed for tracking a mobile target in terms of sensing and communication energy consumption.In order to maximize the lifetime of a wireless sensor network(WSN),the volume of messages and the time for neighbor discovery operations were minimized.The target was followed in a special region known as a face obtained by planarization technique in face-aware routing.An election process was conducted to choose a minimal number of appropriate sensors that are the nearest to the target and a wakeup strategy was proposed to wakeup the appropriate sensors in advance to track the target.In addition,a tracking algorithm to track a target step by step was introduced.Performance analysis and simulation results show that the proposed protocol efficiently tracks a target in WSNs and outperforms some existing protocols of target tracking with energy saving under certain ideal situations.展开更多
Passive detection of moving target is an important part of intelligent surveillance. Satellite has the potential to play a key role in many applications of space-air-ground integrated networks(SAGIN). In this paper, w...Passive detection of moving target is an important part of intelligent surveillance. Satellite has the potential to play a key role in many applications of space-air-ground integrated networks(SAGIN). In this paper, we propose a novel intelligent passive detection method for aerial target based on reservoir computing networks. Specifically, delayed feedback networks are utilized to refine the direct signals from the satellite in the reference channels. In addition, the satellite direct wave interference in the monitoring channels adopts adaptive interference suppression using the minimum mean square error filter. Furthermore, we employ decoupling echo state networks to predict the clutter interference in the monitoring channels and construct the detection statistics accordingly. Finally, a multilayer perceptron is adopted to detect the echo signal after interference suppression. Extensive simulations is conducted to evaluate the performance of our proposed method. Results show that the detection probability is almost 100% when the signal-to-interference ratio of echo signal is-36 dB, which demonstrates that our proposed method achieves efficient passive detection for aerial targets in typical SAGIN scenarios.展开更多
Multi-target tracking is facing the difficulties of modeling uncertain motion and observation noise.Traditional tracking algorithms are limited by specific models and priors that may mismatch a real-world scenario.In ...Multi-target tracking is facing the difficulties of modeling uncertain motion and observation noise.Traditional tracking algorithms are limited by specific models and priors that may mismatch a real-world scenario.In this paper,considering the model-free purpose,we present an online Multi-Target Intelligent Tracking(MTIT)algorithm based on a Deep Long-Short Term Memory(DLSTM)network for complex tracking requirements,named the MTIT-DLSTM algorithm.Firstly,to distinguish trajectories and concatenate the tracking task in a time sequence,we define a target tuple set that is the labeled Random Finite Set(RFS).Then,prediction and update blocks based on the DLSTM network are constructed to predict and estimate the state of targets,respectively.Further,the prediction block can learn the movement trend from the historical state sequence,while the update block can capture the noise characteristic from the historical measurement sequence.Finally,a data association scheme based on Hungarian algorithm and the heuristic track management strategy are employed to assign measurements to targets and adapt births and deaths.Experimental results manifest that,compared with the existing tracking algorithms,our proposed MTIT-DLSTM algorithm can improve effectively the accuracy and robustness in estimating the state of targets appearing at random positions,and be applied to linear and nonlinear multi-target tracking scenarios.展开更多
Considering the problem that the scattering echo images of airborne Doppler weather radar are often reduced by ground clutters,the accuracy and confidence of meteorology target detection are reduced.In this paper,a de...Considering the problem that the scattering echo images of airborne Doppler weather radar are often reduced by ground clutters,the accuracy and confidence of meteorology target detection are reduced.In this paper,a deep convolutional neural network(DCNN)is proposed for meteorology target detection and ground clutter suppression with a large collection of airborne weather radar images as network input.For each weather radar image,the corresponding digital elevation model(DEM)image is extracted on basis of the radar antenna scan-ning parameters and plane position,and is further fed to the net-work as a supplement for ground clutter suppression.The fea-tures of actual meteorology targets are learned in each bottle-neck module of the proposed network and convolved into deeper iterations in the forward propagation process.Then the network parameters are updated by the back propagation itera-tion of the training error.Experimental results on the real mea-sured images show that our proposed DCNN outperforms the counterparts in terms of six evaluation factors.Meanwhile,the network outputs are in good agreement with the expected mete-orology detection results(labels).It is demonstrated that the pro-posed network would have a promising meteorology observa-tion application with minimal effort on network variables or parameter changes.展开更多
文摘Traditional Chinese medicine(TCM)demonstrates distinctive advantages in disease prevention and treatment.However,analyzing its biological mechanisms through the modern medical research paradigm of“single drug,single target”presents significant challenges due to its holistic approach.Network pharmacology and its core theory of network targets connect drugs and diseases from a holistic and systematic perspective based on biological networks,overcoming the limitations of reductionist research models and showing considerable value in TCM research.Recent integration of network target computational and experimental methods with artificial intelligence(AI)and multi-modal multi-omics technologies has substantially enhanced network pharmacology methodology.The advancement in computational and experimental techniques provides complementary support for network target theory in decoding TCM principles.This review,centered on network targets,examines the progress of network target methods combined with AI in predicting disease molecular mechanisms and drug-target relationships,alongside the application of multi-modal multi-omics technologies in analyzing TCM formulae,syndromes,and toxicity.Looking forward,network target theory is expected to incorporate emerging technologies while developing novel approaches aligned with its unique characteristics,potentially leading to significant breakthroughs in TCM research and advancing scientific understanding and innovation in TCM.
文摘It is difficult to improve both energy consumption and detection accuracy simultaneously,and even to obtain the trade-off between them,when detecting and tracking moving targets,especially for Underwater Wireless Sensor Networks(UWSNs).To this end,this paper investigates the relationship between the Degree of Target Change(DoTC)and the detection period,as well as the impact of individual nodes.A Hierarchical Detection and Tracking Approach(HDTA)is proposed.Firstly,the network detection period is determined according to DoTC,which reflects the variation of target motion.Secondly,during the network detection period,each detection node calculates its own node detection period based on the detection mutual information.Taking DoTC as pheromone,an ant colony algorithm is proposed to adaptively adjust the network detection period.The simulation results show that the proposed HDTA with the optimizations of network level and node level significantly improves the detection accuracy by 25%and the network energy consumption by 10%simultaneously,compared to the traditional adaptive period detection schemes.
基金supported in part by the National Natural Science Foundation of China under Grant 62425110 and Grant U22A2002in part by the National Key Research and Development Program of China under Grant 2020YFA0711301+2 种基金in part by the Leading Project of Minzu University of China under Grant 2023QNYL23in part by the Key Research and Development Project of Nantong(Special Project for Prospective Technology Innovation)under Grant GZ2024002in part by the Suzhou Science and Technology Project,and in part by the FAW Jiefang Automotive Co.,Ltd.
文摘Satellite and terrestrial cellular networks can be integrated together to achieve extended broad-band coverage for,e.g.,maritime communication sce-narios,in the upcoming sixth-generation(6G)era.To counter spectrum scarcity,collaborative spectrum sharing is considered for hybrid satellite-terrestrial networks(HSTNs)in this paper.With only slowly-varying large-scale channel state information(CSI),joint power and channel allocation is implemented for terrestrial mobile terminals(MTs)which share the same frequency band with the satellite MTs oppor-tunistically.Specially,strict quality service assurance is adopted for terrestrial MTs under the constraint of leakage interference to satellite MTs.With the tar-get of maximizing both the number of served terres-trial MTs and the average sum transmission rate,a double-target spectrum sharing problem is formulated.To solve the complicated mixed integer programming(MIP)problem efficiently,user-centric channel pools are introduced.Simulations demonstrate that the proposed spectrum sharing scheme could achieve a significant performance gain for the HSTN.
文摘Traditional Chinese medicine(TCM),especially the plant-based,represents complex chemical system containing various primary and secondary metabolites.These botanical metabolites are structurally diversified and exhibit significant difference in the acidity,alkalinity,molecular weight,polarity,and content,etc,which thus poses great challenges in assessing the quality of TCM[1].
基金supported in part by National Natural Science Foundation of China(Grant No.62273075).
文摘Addressing the critical detection range limitation in active electrosensing(AES)for underwater sensing,this study proposes an enhanced AES system via novel array optimization.While AES offers advantages like interference immunity,acoustic stealth detection,and low cost,its short range restricts applicability.A target perturbation model under differential signal acquisition reveals that signal strength increases with local electric field intensity,target size,differential channel spacing,and conductivity contrast,but decreases with target-electrode distance.To extend detection,novel array configurations were explored.Simulations demonstrate that both rectangular and offset arrays significantly outperform the traditional collinear layout.Specifically,an offset array(with 8 m transmitting–receiving spacing)achieved an effective detection range enhancement exceeding 83%under the same distortion threshold while maintaining simplified electrode structure.Experimental validation confirmed a 100%increase in maximum detection distance to 5 m under identical noise thresholds compared to the collinear array.Furthermore,a fully connected neural network-based localization model achieved a mean positioning error of 14.12 cm at 3.15 m in static scenarios.In dynamic scenarios within 1–3 m,mean errors were controlled between 13.19 cm and 27.56 cm.Mechanistic analysis indicates that increasing the array baseline enhances the signal-to-noise ratio by simultaneously suppressing near-field environmental noise and amplifying far-field signal reception.Structural innovations in array design enabled this study to significantly expand the detection range of AES systems without compromising cost efficiency.These advancements directly promote the engineering application of AES technology,offering critical technical support for underwater defense security monitoring,long-range early warning systems,and maritime rights protection.
文摘For the high altitude cruising flight phase of a hypersonic cruise missile （HCM）, a relative motion mod- el between the missile and the target is established by defining virtual target and combining the theory of the dif- ferential geometry with missile motion equations. Based on the model, the motion between the missile and the tar- get is considered as a single target differential game problem, and a new open-loop differential game midcourse guidance law （DGMGL） is deduced by solving the corresponding Hamiltonian Function. Meanwhile, a new struc- ture of a closed-loop DGMGL is presented and the training data for back propagation neural network （BPNN） are designed. By combining the theory of BPNN with the open-loop DGMGL obtained above, the law intelligence is realized. Finally, simulation is carried out and the validity of the law is testified.
基金supported by the National Natural Science Foundation of China(No.81274004)National Key Technologies R&D Program of China(No.2008BAI51B03)+1 种基金2011’Program for Excellent Scientific and Technological Innovation Team of Jiangsu Higher Education,a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions,the Project Program of the State Key Laboratory of Natural Medicines,China Pharmaceutical University(No.JKGZ201107)the Graduate Student Scientific Research Innovation Plan of Jiangsu Higher Education Institutions(No.CXZZ11_0795)
文摘AIM： To illuminate the molecular targets for schisandrin against cerebrovascular disease based on the combined methods of network pharmacology prediction and experimental verification. METHOD： A protein database was established through constructing the drug-protein network from literature mining data. The protein-protein network was built through an in-depth exploration of the relationships between the proteins. The computational platform was implemented to predict and extract the sensitive sub-network with significant P-values from the protein-protein network. Then the key targets and pathways were identified from the sensitive sub-network. The most related targets and pathways were also confirmed in hydrogen peroxide （H202）-induced PC 12 cells by Western blotting. RESULTS： Twelve differentially expressed proteins （gene names： NFKB1, RELA, TNFSF10, MAPK1, CHUK, CASP8, PIGS2, MAPK 14, CREBI, IFNG, APR and BCL2） were confirmed as the central nodes of the interaction network （45 nodes, 93 edges）. The NF-KB signaling pathway was suggested as the most related pathway of schisandrin for cerebrovascular disease. Furthermore, schisandrin was found to suppress the expression and phosphorylation of 1KKct, as well as p50 and p65 induced by H2O2 in PC12 cells by Western blotting. CONCLUSION： The computational platform that integrates literature mining data, protein-protein interactions, sensitive sub-network, and pathway results in identification of the NF-arB signaling pathway as the key targets and pathways for schisandrin.
基金Supported by Science & Engineering Research Council of Singnpore (0521010037)
文摘Wireless sensor network (WSN) of active sensors suffers from serious inter-sensor interference (ISI) and imposes new design and implementation challenges. In this paper, based on the ultrasonic sensor network, two time-division based distributed sensor scheduling schemes are proposed to deal with ISI by scheduling sensors periodically and adaptively respectively. Extended Kalman filter (EKF) is used as the tracking algorithm in distributed manner. Simulation results show that the adaptive sensor scheduling scheme can achieve superior tracking accuracy with faster tracking convergence speed.
基金partly supported by the Agency for Science,Technology and Research(A*Star)SERC(No.0521010037,0521210082)
文摘Sensor scheduling is essential to collaborative target tracking in wireless sensor networks （WSNs）. In the existing works for target tracking in WSNs, such as the information-driven sensor query （IDSQ）, the tasking sensors are scheduled to maximize the information gain while minimizing the resource cost based on the uniform sampling intervals, ignoring the changing of the target dynamics and the specific desirable tracking goals. This paper proposes a novel energy-efficient adaptive sensor scheduling approach that jointly selects tasking sensors and determines their associated sampling intervals according to the predicted tracking accuracy and tracking energy cost. At each time step, the sensors are scheduled in alternative tracking mode, namely, the fast tracking mode with smallest sampling interval or the tracking maintenance mode with larger sampling interval, according to a specified tracking error threshold. The approach employs an extended Kalman filter （EKF）-based estimation technique to predict the tracking accuracy and adopts an energy consumption model to predict the energy cost. Simulation results demonstrate that, compared to a non-adaptive sensor scheduling approach, the proposed approach can save energy cost significantly without degrading the tracking accuracy.
基金supported by the National Natural Science Foundation of China(U1435220)
文摘How to recognize targets with similar appearances from remote sensing images(RSIs) effectively and efficiently has become a big challenge. Recently, convolutional neural network(CNN) is preferred in the target classification due to the powerful feature representation ability and better performance. However,the training and testing of CNN mainly rely on single machine.Single machine has its natural limitation and bottleneck in processing RSIs due to limited hardware resources and huge time consuming. Besides, overfitting is a challenge for the CNN model due to the unbalance between RSIs data and the model structure.When a model is complex or the training data is relatively small,overfitting occurs and leads to a poor predictive performance. To address these problems, a distributed CNN architecture for RSIs target classification is proposed, which dramatically increases the training speed of CNN and system scalability. It improves the storage ability and processing efficiency of RSIs. Furthermore,Bayesian regularization approach is utilized in order to initialize the weights of the CNN extractor, which increases the robustness and flexibility of the CNN model. It helps prevent the overfitting and avoid the local optima caused by limited RSI training images or the inappropriate CNN structure. In addition, considering the efficiency of the Na¨?ve Bayes classifier, a distributed Na¨?ve Bayes classifier is designed to reduce the training cost. Compared with other algorithms, the proposed system and method perform the best and increase the recognition accuracy. The results show that the distributed system framework and the proposed algorithms are suitable for RSIs target classification tasks.
基金Project supported by the Key Project of Hebei North University(No.120177)the Science and Technology Bureau Research Development Plan of Zhangjiakou City in Hebei(No.0911021D-4)China
文摘Axon regeneration is crucial for recovery from neurological diseases. Numerous studies have identified several genes, microRNAs （miRNAs）, and transcription factors （TFs） that influence axon regeneration. However, the regulatory networks involved have not been fully elucidated. In the present study, we analyzed a regulatory network of 51 miRNAs, 27 TFs, and 59 target genes, which is involved in axon regeneration. We identified 359 pairs of feed- forward loops （FFLs）, seven important genes （Naplll, Arhgef12, Sema6d, Akt3, Trim2, Rabllfip2, and Rps6ka3）, six important miRNAs （hsa-miR-204-5p, hsa-miR-124-3p, hsa-miR-26a-5p, hsa-miR-16-5p, hsa-miR-17-5p, and hsa- miR-15b-5p）, and eight important TFs （Smada2, Flil, Wtl, Sp6, Sp3, Smad4, Smad5, and Crebl）, which appear to play an important role in axon regeneration. Functional enrichment analysis revealed that axon-associated genes are involved mainly in the regulation of cellular component organization, axonogenesis, and cell morphogenesis during neuronal differentiation. However, these findings need to be validated by further studies.
基金supported by the National Basic Research Program of China (973 Program) (2010CB731800)the National Natural Science Foundation of China (60934003+2 种基金 60974123 60804010)the Hebei Provincial Educational Foundation of China (2008147)
文摘Remote tracking for mobile targets is one of the most important applications in wireless sensor networks （WSNs）. A target tracking protoco–exponential distributed predictive tracking （EDPT） is proposed. To reduce energy waste and response time, an improved predictive algorithm–exponential smoothing predictive algorithm （ESPA） is presented. With the aid of an additive proportion and differential （PD） controller, ESPA decreases the system predictive delay effectively. As a recovery mechanism, an optimal searching radius （OSR） algorithm is applied to calculate the optimal radius of the recovery zone. The simulation results validate that the proposed EDPT protocol performes better in terms of track failed ratio, energy waste ratio and enlarged sensing nodes ratio, respectively.
基金This work was funded by the National Natural Science Foundation of China under Grant(Nos.61772152,61502037)the Basic Research Project(Nos.JCKY2016206B001,JCKY2014206C002,JCKY2017604C010)and the Technical Foundation Project(No.JSQB2017206C002).
文摘Underwater target recognition is a key technology for underwater acoustic countermeasure.How to classify and recognize underwater targets according to the noise information of underwater targets has been a hot topic in the field of underwater acoustic signals.In this paper,the deep learning model is applied to underwater target recognition.Improved anti-noise Power-Normalized Cepstral Coefficients(ia-PNCC)is proposed,based on PNCC applied to underwater noises.Multitaper and normalized Gammatone filter banks are applied to improve the anti-noise capacity.The method is combined with a convolutional neural network in order to recognize the underwater target.Experiment results show that the acoustic feature presented by ia-PNCC has lower noise and are wellsuited to underwater target recognition using a convolutional neural network.Compared with the combination of convolutional neural network with single acoustic feature,such as MFCC(Mel-scale Frequency Cepstral Coefficients)or LPCC(Linear Prediction Cepstral Coefficients),the combination of the ia-PNCC with a convolutional neural network offers better accuracy for underwater target recognition.
基金supported by National Basic Research Program of China (973 Program) (No. 2010CB731800)Key Project of National Science Foundation of China (No. 60934003)+2 种基金National Nature Science Foundation of China (No. 61074065)Key Project for Natural Science Research of Hebei Education Department, PRC(No. ZD200908)Key Project for Shanghai Committee of Science and Technology (No. 08511501600)
文摘In this paper, the problems of target tracking and obstacle avoidance for multi-agent networks with input constraints are investigated. When there is a moving obstacle, the control objectives are to make the agents track a moving target and to avoid collisions among agents. First, without considering the input constraints, a novel distributed controller can be obtained based on the potential function. Second, at each sampling time, the control algorithm is optimized. Furthermore, to solve the problem that agents cannot effectively avoid the obstacles in dynamic environment where the obstacles are moving, a new velocity repulsive potential is designed. One advantage of the designed control algorithm is that each agent only requires local knowledge of its neighboring agents. Finally, simulation results are provided to verify the effectiveness of the proposed approach.
基金supported by the National Natural Science Foundation of China(No.61273349)
文摘Since the issues of low communication bandwidth supply and limited battery capacity are very crucial for wireless sensor networks,this paper focuses on the problem of event-triggered cooperative target tracking based on set-membership information filtering.We study some fundamental properties of the set-membership information filter with multiple sensor measurements.First,a sufficient condition is derived for the set-membership information filter,under which the boundedness of the outer ellipsoidal approximation set of the estimation means is guaranteed.Second,the equivalence property between the parallel and sequential versions of the setmembership information filter is presented.Finally,the results are applied to a 1D eventtriggered target tracking scenario in which the negative information is exploited in the sense that the measurements that do not satisfy the triggering conditions are modelled as set-membership measurements.The tracking performance of the proposed method is validated with extensive Monte Carlo simulations.
文摘Target tracking is considered as one of the cardinal applications of a wireless sensor network. Tracking multiple targets is more challenging than tracking a single target in a wireless sensor network due to targets’ movement in different directions, targets’ speed variations and frequent connectivity failures of low powered sensor nodes. If all the low-powered sensor nodes are kept active in tracking multiple targets coming from different directions of the network, there is high probability of network failure due to wastage of power. It would be more realistic if the tracking area can be reduced so that less number of sensor nodes will be active and therefore, the network will consume less energy. Tracking area can be reduced by using the target’s kinematics. There is almost no method to track multiple targets based on targets’ kinematics. In our paper, we propose a distributed tracking method for tracking multiple targets considering targets’ kinematics. We simulate our method by a sensor network simulator OMNeT++ and empirical results state that our proposed methodology outperforms traditional tracking algorithms.
基金Project(07JJ1010) supported by the Hunan Provincial Natural Science Foundation, ChinaProject(NCET-06-0686) supported by Program for New Century Excellent Talents in UniversityProject(IRT0661) supported by Program for Changjiang Scholars and Innovative Research Team in University
文摘A prediction based energy-efficient target tracking protocol in wireless sensor networks(PET) was proposed for tracking a mobile target in terms of sensing and communication energy consumption.In order to maximize the lifetime of a wireless sensor network(WSN),the volume of messages and the time for neighbor discovery operations were minimized.The target was followed in a special region known as a face obtained by planarization technique in face-aware routing.An election process was conducted to choose a minimal number of appropriate sensors that are the nearest to the target and a wakeup strategy was proposed to wakeup the appropriate sensors in advance to track the target.In addition,a tracking algorithm to track a target step by step was introduced.Performance analysis and simulation results show that the proposed protocol efficiently tracks a target in WSNs and outperforms some existing protocols of target tracking with energy saving under certain ideal situations.
基金supported by the National Natural Science Foundation of China under Grant 62071364in part by the Aeronautical Science Foundation of China under Grant 2020Z073081001+2 种基金in part by the Fundamental Research Funds for the Central Universities under Grant JB210104in part by the Shaanxi Provincial Key Research and Development Program under Grant 2019GY-043in part by the 111 Project under Grant B08038。
文摘Passive detection of moving target is an important part of intelligent surveillance. Satellite has the potential to play a key role in many applications of space-air-ground integrated networks(SAGIN). In this paper, we propose a novel intelligent passive detection method for aerial target based on reservoir computing networks. Specifically, delayed feedback networks are utilized to refine the direct signals from the satellite in the reference channels. In addition, the satellite direct wave interference in the monitoring channels adopts adaptive interference suppression using the minimum mean square error filter. Furthermore, we employ decoupling echo state networks to predict the clutter interference in the monitoring channels and construct the detection statistics accordingly. Finally, a multilayer perceptron is adopted to detect the echo signal after interference suppression. Extensive simulations is conducted to evaluate the performance of our proposed method. Results show that the detection probability is almost 100% when the signal-to-interference ratio of echo signal is-36 dB, which demonstrates that our proposed method achieves efficient passive detection for aerial targets in typical SAGIN scenarios.
基金supported by the National Natural Science Foundation of China(No.62276204)Open Foundation of Science and Technology on Electronic Information Control Laboratory,Natural Science Basic Research Program of Shanxi,China(Nos.2022JM-340 and 2023-JC-QN-0710)China Postdoctoral Science Foundation(Nos.2020T130494 and 2018M633470).
文摘Multi-target tracking is facing the difficulties of modeling uncertain motion and observation noise.Traditional tracking algorithms are limited by specific models and priors that may mismatch a real-world scenario.In this paper,considering the model-free purpose,we present an online Multi-Target Intelligent Tracking(MTIT)algorithm based on a Deep Long-Short Term Memory(DLSTM)network for complex tracking requirements,named the MTIT-DLSTM algorithm.Firstly,to distinguish trajectories and concatenate the tracking task in a time sequence,we define a target tuple set that is the labeled Random Finite Set(RFS).Then,prediction and update blocks based on the DLSTM network are constructed to predict and estimate the state of targets,respectively.Further,the prediction block can learn the movement trend from the historical state sequence,while the update block can capture the noise characteristic from the historical measurement sequence.Finally,a data association scheme based on Hungarian algorithm and the heuristic track management strategy are employed to assign measurements to targets and adapt births and deaths.Experimental results manifest that,compared with the existing tracking algorithms,our proposed MTIT-DLSTM algorithm can improve effectively the accuracy and robustness in estimating the state of targets appearing at random positions,and be applied to linear and nonlinear multi-target tracking scenarios.
基金supported by the China Ministry of Industry and Information Technology Foundation and Aeronautical Science Foundation of China(ASFC-201920007002)the National Key Research and Development Plan(2021YFB1600603)the Open Fund of Key Laboratory of Civil Aircraft Airworthiness Technology,Civil Aviation University of China.
文摘Considering the problem that the scattering echo images of airborne Doppler weather radar are often reduced by ground clutters,the accuracy and confidence of meteorology target detection are reduced.In this paper,a deep convolutional neural network(DCNN)is proposed for meteorology target detection and ground clutter suppression with a large collection of airborne weather radar images as network input.For each weather radar image,the corresponding digital elevation model(DEM)image is extracted on basis of the radar antenna scan-ning parameters and plane position,and is further fed to the net-work as a supplement for ground clutter suppression.The fea-tures of actual meteorology targets are learned in each bottle-neck module of the proposed network and convolved into deeper iterations in the forward propagation process.Then the network parameters are updated by the back propagation itera-tion of the training error.Experimental results on the real mea-sured images show that our proposed DCNN outperforms the counterparts in terms of six evaluation factors.Meanwhile,the network outputs are in good agreement with the expected mete-orology detection results(labels).It is demonstrated that the pro-posed network would have a promising meteorology observa-tion application with minimal effort on network variables or parameter changes.
