Understanding the thermal safety evolution of lithium-ion batteries during high-temperature usage conditions bears significant implications for enhancing the safety management of aging batteries.This work investigates...Understanding the thermal safety evolution of lithium-ion batteries during high-temperature usage conditions bears significant implications for enhancing the safety management of aging batteries.This work investigates the thermal safety evolution mechanism of lithium-ion batteries during high-temperature aging.Similarities arise in the thermal safety evolution and degradation mechanisms for lithium-ion batteries undergoing cyclic aging and calendar aging.Employing multi-angle characterization analysis,the intricate mechanism governing the thermal safety evolution of lithium-ion batteries during high-temperature aging is clarified.Specifically,lithium plating serves as the pivotal factor contributing to the reduction in the self-heating initial temperature.Additionally,the crystal structure of the cathode induced by the dissolution of transition metals and the reductive gas generated during aging attacking the crystal structure of the cathode lead to a decrease in thermal runaway triggering temperature.Furthermore,the loss of active materials and active lithium during aging contributes to a decline in both the maximum temperature and the maximum temperature rise rate,ultimately indicating a decrease in the thermal hazards of aging batteries.展开更多
This study investigated the physicochemical properties,enzyme activities,volatile flavor components,microbial communities,and sensory evaluation of high-temperature Daqu(HTD)during the maturation process,and a standar...This study investigated the physicochemical properties,enzyme activities,volatile flavor components,microbial communities,and sensory evaluation of high-temperature Daqu(HTD)during the maturation process,and a standard system was established for comprehensive quality evaluation of HTD.There were obvious changes in the physicochemical properties,enzyme activities,and volatile flavor components at different storage periods,which affected the sensory evaluation of HTD to a certain extent.The results of high-throughput sequencing revealed significant microbial diversity,and showed that the bacterial community changed significantly more than did the fungal community.During the storage process,the dominant bacterial genera were Kroppenstedtia and Thermoascus.The correlation between dominant microorganisms and quality indicators highlighted their role in HTD quality.Lactococcus,Candida,Pichia,Paecilomyces,and protease activity played a crucial role in the formation of isovaleraldehyde.Acidic protease activity had the greatest impact on the microbial community.Moisture promoted isobutyric acid generation.Furthermore,the comprehensive quality evaluation standard system was established by the entropy weight method combined with multi-factor fuzzy mathematics.Consequently,this study provides innovative insights for comprehensive quality evaluation of HTD during storage and establishes a groundwork for scientific and rational storage of HTD and quality control of sauce-flavor Baijiu.展开更多
High-temperature and short-time(HTST)solution heat treatment combined with non-isothermal aging(NIA)was employed to regulate the microstructure and properties of Al−4.5Mg−2.0Zn−0.3Ag alloy.Results indicate that HTST s...High-temperature and short-time(HTST)solution heat treatment combined with non-isothermal aging(NIA)was employed to regulate the microstructure and properties of Al−4.5Mg−2.0Zn−0.3Ag alloy.Results indicate that HTST solution heat treatment can not only retain partial deformation dislocations,but inhibit the recrystallization behavior and increase the proportion of low-angle grain boundaries(LAGBs).In the subsequent NIA process,HTST solution heat treatment combined with NIA is instrumental in restraining the degradation of dislocations and promoting precipitation of nano-scale T'-Mg_(32)(Al,Zn,Ag)49 phase,which improves the strength of the alloy greatly.In addition,a higher fraction of LAGBs and the discontinuous distribution of grain boundary precipitates caused by this novel technology meliorate the corrosion resistance of Al−4.5Mg−2.0Zn−0.3Ag alloy.展开更多
Integrating different active substances through carriers and fully exerting their synergistic corrosion inhibition ability is an efficient anticor-rosion strategy.Biotemplate(diatomite)was used to integrate polyanilin...Integrating different active substances through carriers and fully exerting their synergistic corrosion inhibition ability is an efficient anticor-rosion strategy.Biotemplate(diatomite)was used to integrate polyaniline and sodium phosphate,an active antisepticfiller(PANI/DM/SP)was prepared in this work.Moreover,activefillers were combined with epoxy resins to prepare high-efficiency anti-corrosion coatings for mag-nesium alloy protection.The stability of the corrosion inhibitor(sodium phosphate)released by the activefiller was analyzed by establishing a mathematical model.Simultaneously,electrochemical impedance spectroscopy tests demonstrate excellent corrosion inhibition properties of activefillers and the impedance modulus of composite coatings was three orders of magnitude higher than that of the EP coating,due to the synergistic effect of each component of the activefiller.In addition,the mechanical properties of the composite coating were significantly improved,with tests showing a 51.31%increase in rub resistance and two grades of adhesion improvement(ASTM standard).The key of this work was to give full play to the slow-release characteristics of diatomite through scientific methods and promote the synergistic anticorrosion effect of sodium phosphate and polyaniline.展开更多
Currently,the design of high-temperature superconducting(HTS)maglev trains adopts a U-shaped track operation mode,and the height of the side track significantly impacts the train’s aerodynamic characteristics.In this...Currently,the design of high-temperature superconducting(HTS)maglev trains adopts a U-shaped track operation mode,and the height of the side track significantly impacts the train’s aerodynamic characteristics.In this study,we used computational fluid dynamics(CFD)methods,based on the 3D Reynolds-averaged Navier-Stokes(RANS)method and shear stress transport(SST)k-ωturbulence model,to deeply investigate the effects of the presence or absence of a U-shaped track and different side track heights(800,880,and 960 mm)on the pressure distribution,velocity distribution,and flow field structure of HTS maglev trains at a speed of 400 km/h under crosswinds.The numerical methods were verified using a scaled ICE-2 model wind tunnel test.First,the aerodynamic characteristics of the train under different wind direction angles with and without side tracks were studied.We found that the aerodynamic performance of the train is the most adverse when the wind direction angle is 90°.The presence of a U-shaped track can effectively reduce the lateral force,lift,and yawing moment of the train.The aerodynamic performance of the first suspension bogie at the bottom,which is the worst,will also be effectively improved.Next,the aerodynamic effects of different side track heights on the HTS maglev train were studied.An increase in side track height will reduce the lift and lateral force of the train,while the increase in drag is relatively small.Under the premise of ensuring passengers can conveniently alight,we found that a U-shaped track with a side track height of 960 mm has the best aerodynamic performance.The research findings offer a valuable reference for the engineering application and design of the track structure of HTS maglev train systems.展开更多
Geothermal energy is a clean and ecologically friendly energy source with significant potential. The temperature variations between the Polycrystalline Diamond Compact (PDC) cutter and the rock of the reservoir are th...Geothermal energy is a clean and ecologically friendly energy source with significant potential. The temperature variations between the Polycrystalline Diamond Compact (PDC) cutter and the rock of the reservoir are the key factors affecting the cutting performance when drilling through formations with thermally damaged rock. To better investigate the temperature rise, a series of rock samples treated at high temperatures (9–300℃) were broken with a PDC cutter. The performance of the PDC cutter on these samples was studied using cutting force sensors, high-speed photography, and the thermal infrared imager. Based on the experimental data, a new cutting force evaluation parameter, η, is suggested. The link between the cutting force and rock properties is discussed in detail. The present results indicate that the average cutting force of high-temperature-treated granite is 3–5 times that of the thermally damaged sandstone. Furthermore, a critical temperature for thermal damage has been identified in granite cutting at 100–200℃ and in sandstone at 100℃. This corresponds to the temperature at which interlayer water loss and thermal crack closure occur. The results also indicate that when the treatment temperature exceeds the critical threshold, both the cutting force and temperature rise exhibit more significant changes with increasing temperature. Additionally, the maximum temperature of the PDC cutter during granite cutting can reach 47.6 ℃, which is almost 34℃ higher than that of sandstone. Regarding debris size, granite is much less sensitive to the treatment temperature, showing only slight changes in debris size compared to sandstone as the treatment temperature increases. The increasing cutter-rock interface area can significantly reduce frictional heat generation while increasing the cutting force and enhancing the temperature rise. The parameter valuation of the newly defined parameter η, which is related to frictional heating, shows that the capacity of the thermal generation and the heat transfer change as the temperature rises at the cutter-rock interface. At last, the correlation analysis indicates that the cutting force of sandstone and granite is highly correlated with , E/σc and σt. This study serves as a theoretical support and technical guidance for cutting hot dry rock (HDR), which is of great significance to HDR drilling.展开更多
Aviation turbine engine oils require excellent thermal-oxidative stability because of their high-temperature environments.High-temperature bearing deposit testing is a mandatory method for measuring the thermal-oxidat...Aviation turbine engine oils require excellent thermal-oxidative stability because of their high-temperature environments.High-temperature bearing deposit testing is a mandatory method for measuring the thermal-oxidative performance of aviation lubricant oils,and the relevant apparatus was improved in the present study.Two different commercial aviation turbine engine oils were tested,one with standard performance(known as the SL oil)and the other with high thermal stability,and their thermal-oxidative stability characteristics were evaluated.After 100 h of high-temperature bearing testing,the SL oil was analyzed by using various analytical techniques to investigate its thermal-oxidative process in the bearing test,with its thermal-oxidative degradation mechanism also being discussed.The results indicate that the developed high-temperature bearing apparatus easily meets the test requirements of method 3410.1 in standard FED-STD-791D.The viscosity and total acid number(TAN)of the SL oil increased with the bearing test time,and various deposits were produced in the bearing test,with the micro-particles of the carbon deposits being sphere-like,rod-like,and sheet-like in appearance.The antioxidant additives in the oil were consumed very rapidly in the first 30 h of the bearing test,with N-phenyl-1-naphthylamine being consumed faster than dioctyldiphenylamine.Overall,the oil thermal-oxidative process involves very complex physical and chemical mechanisms.展开更多
Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulat...Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and death.However,excessive activation of regulated cell death may lead to the progression of aging-related diseases.This review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related diseases.Notably,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative diseases.These forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein aggregation.The review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and disulfidptosis.For instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis sensitivity.Additionally,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to disulfidptosis.These insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death mechanisms.In conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.展开更多
Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a w...Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).展开更多
The oral cavity is a complex physiological community encompassing a wide range of microorganisms.Dysbiosis of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even...The oral cavity is a complex physiological community encompassing a wide range of microorganisms.Dysbiosis of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative diseases.Recent studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention strategies.In this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and neurodegeneration.We also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.展开更多
High-temperature industries,as the primary consumers of energy,are greatly concerned with energy savings.Designing refractory linings with low thermal conductivity to reduce heat dissipation through high-temperature f...High-temperature industries,as the primary consumers of energy,are greatly concerned with energy savings.Designing refractory linings with low thermal conductivity to reduce heat dissipation through high-temperature furnace linings is a critical concern.In this study,a series of novel entropy-stabilized spinel materials are reported,and their potential applications in high-temperature industries are investigated.XRD and TEM results indicate that all materials possess a cubic spinel crystal structure with the■space group.Furthermore,these materials exhibit good phase stability at high temperatures.All entropy-stabilized spinel aggregates demonstrated high refractoriness(>1800℃)and a high load softening temperature(>1700℃).The impact of configurational entropy on the properties of entropy-stabilized spinel materials was also studied.As configurational entropy increased,the thermal conductivity of the entropy-stabilized spinel decreased,while slag corrosion resistance deteriorated.For the entropy-stabilized spinel with a configurational entropy value of 1.126R,it showed good high-temperature stability,reliable resistance to slag attack,and a low thermal conductivity of 2.776 W·m^(-1)·K^(-1)at 1000℃.展开更多
Burial dissolution is a critical diagenetic process influencing ultra-deep carbonate reservoir development and preservation.Artificial carbonate samples with different internal structures were prepared,and high-temper...Burial dissolution is a critical diagenetic process influencing ultra-deep carbonate reservoir development and preservation.Artificial carbonate samples with different internal structures were prepared,and high-temperature and highpressure dissolution kinetic simulations were conducted.The results demonstrate that the intensity of burial dissolution is controlled by temperature and pressure,while tectonic-fluid activity influences the development pattern of burial dissolution,ultimately determining the direction of its differential modification.Extensive burial dissolution is likely to occur primarily at relatively shallow depths,significantly influencing reservoir formation,preservation,modification,and adjustment.The development of faults facilitates the maintenance of the intensity of burial dissolution.The maximum intensity of burial dissolution occurs at the tips and overlap zones of faults and intersections of multiple faults.The larger the scale of the faults,the more conducive it is to the development of burial dissolution.Burial dissolution fosters the formation of fault networks characterized by enhanced reservoir capacity and permeability.Burial dissolution controlled by episodic tectonic-fluid activity is a plausible explanation for forming the Tarim Basin's ultra-deep fault-controlled“stringbead-like”reservoirs.展开更多
Although the plastic loading can enhance creep deformation and yield strength,the anisotropic Stress Relaxation Aging(SRA)behavior and mechanism under plastic loading remain unclear,which presents a significant challe...Although the plastic loading can enhance creep deformation and yield strength,the anisotropic Stress Relaxation Aging(SRA)behavior and mechanism under plastic loading remain unclear,which presents a significant challenge in accurately shaping aluminum alloy panels.In this study,the SRA behavior of 2195-T4 Al-Cu-Li alloys were thoroughly studied under initial loading stresses within the elastic(210/250 MPa)and plastic(380/420 MPa)ranges at 180℃by stress relaxation and tensile tests as well as microstructure characterization.The findings reveal that compared with those under elastic loadings,in-plane anisotropy(IPA)values of the stress relaxation amount,yield strength and fracture elongation under plastic loadings are reduced by 60%–80%,70%–90% and 72%–89%,respectively.Similarly,IPA values of precipitate size in grains and PrecipitationFree Zones(PFZ)width at grain boundaries under plastic loading decrease by 31.4%and 94.4%respectively.These results indicate plastic loading significantly weakens the anisotropic SRA behavior,owing to numerous uniformly distributed fine T1phases and small IPA values of both T1precipitates size and PFZ width in various loading directions.Compared with those of elastic loadingaged alloys,yield strength of plastic loading-aged alloys shows high strength-ductility because of the combined effect of closely dispersed fine T1precipitates,narrowed PFZ and numerous sheared and rotated T1phases at different locations during tensile process.The uniformly distributed larger Kernel Average Misorientation(KAM)and Schmidt factor values of the plastic loading-aged alloy,as well as the cross-slip generated,also help to enhance the strength and ductility of the alloy.展开更多
Optimizing the high-temperature energy storage characteristics of energy storage dielectrics is of great significance for the development of pulsed power devices and power control systems.Selecting a polymer with a hi...Optimizing the high-temperature energy storage characteristics of energy storage dielectrics is of great significance for the development of pulsed power devices and power control systems.Selecting a polymer with a higher glass transition temperature(T_(g))as the matrix is one of the effective ways to increase the upper limit of the polymer operating temperature.However,current high-T_(g)polymers have limitations,and it is difficult to meet the demand for high-temperature energy storage dielectrics with only one polymer.For example,polyetherimide has high-energy storage efficiency,but low breakdown strength at high temperatures.Polyimide has high corona resistance,but low high-temperature energy storage efficiency.In this work,combining the advantages of two polymer,a novel high-T_(g)polymer fiber-reinforced microstructure is designed.Polyimide is designed as extremely fine fibers distributed in the composite dielectric,which will facilitate the reduction of high-temperature conductivity loss for polyimide.At the same time,due to the high-temperature resistance and corona resistance of polyimide,the high-temperature breakdown strength of the composite dielectric is enhanced.After the polyimide content with the best high-temperature energy storage characteristics is determined,molecular semiconductors(ITIC)are blended into the polyimide fibers to further improve the high-temperature efficiency.Ultimately,excellent high-temperature energy storage properties are obtained.The 0.25 vol%ITIC-polyimide/polyetherimide composite exhibits high-energy density and high discharge efficiency at 150℃(2.9 J cm^(-3),90%)and 180℃(2.16 J cm^(-3),90%).This work provides a scalable design idea for high-performance all-organic high-temperature energy storage dielectrics.展开更多
The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ ...The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout adulthood.Degenerated NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).展开更多
“Last scene of all that ends this strange,eventful history,is second childishness and mere oblivion.I am sans teeth,sans eyes,sans taste,sans everything.”William Shakespeare‘As You Like It'Act 2,Sc.7,l.139Aging...“Last scene of all that ends this strange,eventful history,is second childishness and mere oblivion.I am sans teeth,sans eyes,sans taste,sans everything.”William Shakespeare‘As You Like It'Act 2,Sc.7,l.139Aging of the human brain is characterized by a progressive decline of its functional capacity;this decline however varies widely,and cognitive longevity differs substantially between individuals.展开更多
High-nickel ternary cathodes hold a great application prospect in solid-state lithium metal batteries to achieve high-energy density,but they still suffer from structural instability and detrimental side reactions wit...High-nickel ternary cathodes hold a great application prospect in solid-state lithium metal batteries to achieve high-energy density,but they still suffer from structural instability and detrimental side reactions with the solid-state electrolytes.To circumvent these issues,a continuous uniform layer polyacrylonitrile(PAN)was introduced on the surface of LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2) via in situ polymerization of acrylonitrile(AN).Furthermore,the partial-cyclized treatment of PAN(cPAN)coating layer presents high ionic and electron conductivity,which can accelerate interfacial Li+and electron diffusion simultaneously.And the thermodynamically stabilized cPAN coating layer cannot only effectively inhibit detrimental side reactions between cathode and solid-state electrolytes but also provide a homogeneous stress to simultaneously address the problems of bulk structural degradation,which contributes to the exceptional mechanical and electrochemical stabilities of the modified electrode.Besides,the coordination bond interaction between the cPAN and NCM811 can suppress the migration of Ni to elevate the stability of the crystal structure.Benefited from these,the In-cPAN-260@NCM811 shows excellent cycling performance with a retention of 86.8%after 300 cycles and superior rate capability.And endow the solid-state battery with thermal safety stability even at hightemperature extreme environment.This facile and scalable surface engineering represents significant progress in developing high-performance solid-state lithium metal batteries.展开更多
In this work,the aging response and mechanism of dual-phase Mg-Li-Al-Zn alloy at various temperatures are investigated.The results show that the strengthening after quenching is primarily attributed to the immediate p...In this work,the aging response and mechanism of dual-phase Mg-Li-Al-Zn alloy at various temperatures are investigated.The results show that the strengthening after quenching is primarily attributed to the immediate precipitation of the semi-coherent~Mg_(3)Zn phase.The aging softening of the studied alloy is mainly caused by the rapid transformation of the strengthening~Mg_(3)Zn phase to the softening MgLi(Al,Zn)phase,along with the coarsening of theα-Mg matrix and precipitates withinβ-Li matrix.Further analysis indicates that the quick precipitation and transformation of~Mg_(3)Zn is a consequence of the high diffusion rate of solute atoms,resulting from dense vacancy concentration in theβ-Li matrix.This research bridges a critical gap in the study of aging mechanism in the dual-phase Mg-Li-Al-Zn alloy,providing a theoretical basis for the development and application of high-performance and thermal-stable Mg-Li alloys.展开更多
The research on high-performance electromagnetic wave absorption materials with high-temperature and oxidative stability in extreme environments is gaining popularity.Herein,the lightweight silicon carbide nanowires(S...The research on high-performance electromagnetic wave absorption materials with high-temperature and oxidative stability in extreme environments is gaining popularity.Herein,the lightweight silicon carbide nanowires(SiC_(nws))/SiC composites are fabricated with in-situ SiC interface on one-dimensional oriented SiC_(nws)skeleton,which collaborative configuration by 3D printing and freeze casting assembly.The con-structed porous structure optimizes the impedance matching degree and scattering intensity,the maximum effective absorption bandwidth(EAB_(max))of 5.9 GHz and the minimum reflection loss(RL_(min))of−41.4 dB can be realized.Considering the inherent oxidation resistance of SiC,the composites present well-maintained absorption performance at 600℃.Even at 1100℃,the EAB_(max)of 4.9 GHz and RLmin of−30.4 dB also demonstrate the high-temperature absorption stability of the composites,indicating exceptional wave absorption properties and thermal stability.The slight attenuation can be attributed to the decrease in impedance matching capability accompanying the elevated dielectric constant.This work clarifies the impact of structure and component synergy on wave absorption behavior,and offers a novel approach to producing high-performance and high-temperature resistance ceramic-based electromagnetic wave absorption materials suitable for extreme environments.展开更多
This article is based on a recent bibliometric analysis of research progress on liver aging.The liver is notable for its extraordinary ability to rejuvenate,thereby safeguarding and maintaining the organism’s integri...This article is based on a recent bibliometric analysis of research progress on liver aging.The liver is notable for its extraordinary ability to rejuvenate,thereby safeguarding and maintaining the organism’s integrity.With advancing age,there is a noteworthy reduction in both the liver’s size and blood circulation.Furthermore,the wide range of physiological alterations driven on by aging may foster the development of illnesses.Previous studies indicate that liver aging is linked to impaired lipid metabolism and abnormal gene expression associated with chronic inflammation.Factors such as mitochondrial dysfunction and telomere shortening accumulate,which may result in increased hepatic steatosis,which impacts liver regeneration,metabolism,and other functions.Knowing the structural and functional changes could help elderly adults delay liver aging.Increasing public awareness of anti-aging interventions is essential.Besides the use of dietary supplements,alterations in lifestyle,including changes in dietary habits and physical exercise routines,are the most efficacious means to decelerate the aging process of the liver.This article highlights recent advances in the mechanism research of liver aging and summarizes the promising intervention options to delay liver aging for preventing related diseases.展开更多
基金supported by the National Natural Science Foundation of China(NSFC,Nos.52176199,and U20A20310)supported by the Program of Shanghai Academic/Technology Research Leader(22XD1423800)。
文摘Understanding the thermal safety evolution of lithium-ion batteries during high-temperature usage conditions bears significant implications for enhancing the safety management of aging batteries.This work investigates the thermal safety evolution mechanism of lithium-ion batteries during high-temperature aging.Similarities arise in the thermal safety evolution and degradation mechanisms for lithium-ion batteries undergoing cyclic aging and calendar aging.Employing multi-angle characterization analysis,the intricate mechanism governing the thermal safety evolution of lithium-ion batteries during high-temperature aging is clarified.Specifically,lithium plating serves as the pivotal factor contributing to the reduction in the self-heating initial temperature.Additionally,the crystal structure of the cathode induced by the dissolution of transition metals and the reductive gas generated during aging attacking the crystal structure of the cathode lead to a decrease in thermal runaway triggering temperature.Furthermore,the loss of active materials and active lithium during aging contributes to a decline in both the maximum temperature and the maximum temperature rise rate,ultimately indicating a decrease in the thermal hazards of aging batteries.
文摘This study investigated the physicochemical properties,enzyme activities,volatile flavor components,microbial communities,and sensory evaluation of high-temperature Daqu(HTD)during the maturation process,and a standard system was established for comprehensive quality evaluation of HTD.There were obvious changes in the physicochemical properties,enzyme activities,and volatile flavor components at different storage periods,which affected the sensory evaluation of HTD to a certain extent.The results of high-throughput sequencing revealed significant microbial diversity,and showed that the bacterial community changed significantly more than did the fungal community.During the storage process,the dominant bacterial genera were Kroppenstedtia and Thermoascus.The correlation between dominant microorganisms and quality indicators highlighted their role in HTD quality.Lactococcus,Candida,Pichia,Paecilomyces,and protease activity played a crucial role in the formation of isovaleraldehyde.Acidic protease activity had the greatest impact on the microbial community.Moisture promoted isobutyric acid generation.Furthermore,the comprehensive quality evaluation standard system was established by the entropy weight method combined with multi-factor fuzzy mathematics.Consequently,this study provides innovative insights for comprehensive quality evaluation of HTD during storage and establishes a groundwork for scientific and rational storage of HTD and quality control of sauce-flavor Baijiu.
基金National Natural Science Foundation of China(Nos.52204400,52204401)Natural Science Foundation of Hebei Province,China(No.E2022203033)。
文摘High-temperature and short-time(HTST)solution heat treatment combined with non-isothermal aging(NIA)was employed to regulate the microstructure and properties of Al−4.5Mg−2.0Zn−0.3Ag alloy.Results indicate that HTST solution heat treatment can not only retain partial deformation dislocations,but inhibit the recrystallization behavior and increase the proportion of low-angle grain boundaries(LAGBs).In the subsequent NIA process,HTST solution heat treatment combined with NIA is instrumental in restraining the degradation of dislocations and promoting precipitation of nano-scale T'-Mg_(32)(Al,Zn,Ag)49 phase,which improves the strength of the alloy greatly.In addition,a higher fraction of LAGBs and the discontinuous distribution of grain boundary precipitates caused by this novel technology meliorate the corrosion resistance of Al−4.5Mg−2.0Zn−0.3Ag alloy.
基金support provided by the National Natural Science Foundation of China(Grant No.51908092)Projects(No.2020CDJXZ001,2021CDJJMRH-005 and SKLMT-ZZKT-2021M04)supported by the Fundamental Research Funds for the Central Universities+6 种基金the Joint Funds of the National Natural Science Foundation of China-Guangdong(Grant No.U1801254)the project funded by Chongqing Special Postdoctoral Science Foundation(XmT2018043)the Chongqing Research Program of Basic Research and Frontier Technology(cstc2017jcyjBX0080)Natural Science Foundation Project of Chongqing for Post-doctor(cstc2019jcyjbsh0079,cstc2019jcyjbshX0085)Technological projects of Chongqing Municipal Education Commission(KJZDK201800801)the Innovative Research Team of Chongqing(CXTDG201602014)the Innovative technology of New materials and metallurgy(2019CDXYCL0031)。
文摘Integrating different active substances through carriers and fully exerting their synergistic corrosion inhibition ability is an efficient anticor-rosion strategy.Biotemplate(diatomite)was used to integrate polyaniline and sodium phosphate,an active antisepticfiller(PANI/DM/SP)was prepared in this work.Moreover,activefillers were combined with epoxy resins to prepare high-efficiency anti-corrosion coatings for mag-nesium alloy protection.The stability of the corrosion inhibitor(sodium phosphate)released by the activefiller was analyzed by establishing a mathematical model.Simultaneously,electrochemical impedance spectroscopy tests demonstrate excellent corrosion inhibition properties of activefillers and the impedance modulus of composite coatings was three orders of magnitude higher than that of the EP coating,due to the synergistic effect of each component of the activefiller.In addition,the mechanical properties of the composite coating were significantly improved,with tests showing a 51.31%increase in rub resistance and two grades of adhesion improvement(ASTM standard).The key of this work was to give full play to the slow-release characteristics of diatomite through scientific methods and promote the synergistic anticorrosion effect of sodium phosphate and polyaniline.
基金supported by the National Natural Science Foundation of China(No.U23A20681)the S&T Program of Hebei Province,China(No.23567602H).
文摘Currently,the design of high-temperature superconducting(HTS)maglev trains adopts a U-shaped track operation mode,and the height of the side track significantly impacts the train’s aerodynamic characteristics.In this study,we used computational fluid dynamics(CFD)methods,based on the 3D Reynolds-averaged Navier-Stokes(RANS)method and shear stress transport(SST)k-ωturbulence model,to deeply investigate the effects of the presence or absence of a U-shaped track and different side track heights(800,880,and 960 mm)on the pressure distribution,velocity distribution,and flow field structure of HTS maglev trains at a speed of 400 km/h under crosswinds.The numerical methods were verified using a scaled ICE-2 model wind tunnel test.First,the aerodynamic characteristics of the train under different wind direction angles with and without side tracks were studied.We found that the aerodynamic performance of the train is the most adverse when the wind direction angle is 90°.The presence of a U-shaped track can effectively reduce the lateral force,lift,and yawing moment of the train.The aerodynamic performance of the first suspension bogie at the bottom,which is the worst,will also be effectively improved.Next,the aerodynamic effects of different side track heights on the HTS maglev train were studied.An increase in side track height will reduce the lift and lateral force of the train,while the increase in drag is relatively small.Under the premise of ensuring passengers can conveniently alight,we found that a U-shaped track with a side track height of 960 mm has the best aerodynamic performance.The research findings offer a valuable reference for the engineering application and design of the track structure of HTS maglev train systems.
基金supported by the National Natural Science Foundation of China(Grant No.52004236)the Key Program of National Natural Science Foundation of China(Grant No.52234003)+2 种基金Sichuan Provincial Returned Scholars'Scientific and Technological Activities Merit-based Funding Programs(Grant No.2023016)Open project of the International Joint Research Center for Deep Earth Drilling and Deep Earth Resources Development of the Ministry of Science and Technology(Grant No.DEDRD-2023-06)the National Natural Science Foundation of China Outstanding Youth Science Fund Program(Grant No.52222402).
文摘Geothermal energy is a clean and ecologically friendly energy source with significant potential. The temperature variations between the Polycrystalline Diamond Compact (PDC) cutter and the rock of the reservoir are the key factors affecting the cutting performance when drilling through formations with thermally damaged rock. To better investigate the temperature rise, a series of rock samples treated at high temperatures (9–300℃) were broken with a PDC cutter. The performance of the PDC cutter on these samples was studied using cutting force sensors, high-speed photography, and the thermal infrared imager. Based on the experimental data, a new cutting force evaluation parameter, η, is suggested. The link between the cutting force and rock properties is discussed in detail. The present results indicate that the average cutting force of high-temperature-treated granite is 3–5 times that of the thermally damaged sandstone. Furthermore, a critical temperature for thermal damage has been identified in granite cutting at 100–200℃ and in sandstone at 100℃. This corresponds to the temperature at which interlayer water loss and thermal crack closure occur. The results also indicate that when the treatment temperature exceeds the critical threshold, both the cutting force and temperature rise exhibit more significant changes with increasing temperature. Additionally, the maximum temperature of the PDC cutter during granite cutting can reach 47.6 ℃, which is almost 34℃ higher than that of sandstone. Regarding debris size, granite is much less sensitive to the treatment temperature, showing only slight changes in debris size compared to sandstone as the treatment temperature increases. The increasing cutter-rock interface area can significantly reduce frictional heat generation while increasing the cutting force and enhancing the temperature rise. The parameter valuation of the newly defined parameter η, which is related to frictional heating, shows that the capacity of the thermal generation and the heat transfer change as the temperature rises at the cutter-rock interface. At last, the correlation analysis indicates that the cutting force of sandstone and granite is highly correlated with , E/σc and σt. This study serves as a theoretical support and technical guidance for cutting hot dry rock (HDR), which is of great significance to HDR drilling.
基金supported by the National Key Research and Development Program of China(2022YFB3809005)by SINOPEC(120060-6,121027,and 122042).
文摘Aviation turbine engine oils require excellent thermal-oxidative stability because of their high-temperature environments.High-temperature bearing deposit testing is a mandatory method for measuring the thermal-oxidative performance of aviation lubricant oils,and the relevant apparatus was improved in the present study.Two different commercial aviation turbine engine oils were tested,one with standard performance(known as the SL oil)and the other with high thermal stability,and their thermal-oxidative stability characteristics were evaluated.After 100 h of high-temperature bearing testing,the SL oil was analyzed by using various analytical techniques to investigate its thermal-oxidative process in the bearing test,with its thermal-oxidative degradation mechanism also being discussed.The results indicate that the developed high-temperature bearing apparatus easily meets the test requirements of method 3410.1 in standard FED-STD-791D.The viscosity and total acid number(TAN)of the SL oil increased with the bearing test time,and various deposits were produced in the bearing test,with the micro-particles of the carbon deposits being sphere-like,rod-like,and sheet-like in appearance.The antioxidant additives in the oil were consumed very rapidly in the first 30 h of the bearing test,with N-phenyl-1-naphthylamine being consumed faster than dioctyldiphenylamine.Overall,the oil thermal-oxidative process involves very complex physical and chemical mechanisms.
基金supported by the Key Projects of Medical Science and Technology of Henan Province,No.SBGJ202002099(to JY)。
文摘Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and death.However,excessive activation of regulated cell death may lead to the progression of aging-related diseases.This review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related diseases.Notably,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative diseases.These forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein aggregation.The review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and disulfidptosis.For instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis sensitivity.Additionally,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to disulfidptosis.These insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death mechanisms.In conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.
基金funded by CONAHCYT grant(252808)to GFCONAHCYT’s“Estancias Posdoctorales por México”program(662350)to HTB。
文摘Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).
基金supported by the National Natural Science Foundation of China,No.81921006(to GHL)。
文摘The oral cavity is a complex physiological community encompassing a wide range of microorganisms.Dysbiosis of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative diseases.Recent studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention strategies.In this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and neurodegeneration.We also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.
基金financially supported by the National Natural Science Foundation of China(Nos.52472032 and 52172023)the Key Program of Natural Science Foundation of Hubei Province(No.2024AFA083)
文摘High-temperature industries,as the primary consumers of energy,are greatly concerned with energy savings.Designing refractory linings with low thermal conductivity to reduce heat dissipation through high-temperature furnace linings is a critical concern.In this study,a series of novel entropy-stabilized spinel materials are reported,and their potential applications in high-temperature industries are investigated.XRD and TEM results indicate that all materials possess a cubic spinel crystal structure with the■space group.Furthermore,these materials exhibit good phase stability at high temperatures.All entropy-stabilized spinel aggregates demonstrated high refractoriness(>1800℃)and a high load softening temperature(>1700℃).The impact of configurational entropy on the properties of entropy-stabilized spinel materials was also studied.As configurational entropy increased,the thermal conductivity of the entropy-stabilized spinel decreased,while slag corrosion resistance deteriorated.For the entropy-stabilized spinel with a configurational entropy value of 1.126R,it showed good high-temperature stability,reliable resistance to slag attack,and a low thermal conductivity of 2.776 W·m^(-1)·K^(-1)at 1000℃.
基金supported by the National Natural Science Foundation of China(Grant No.U21B2062)supported by the Key Laboratory for Carbonate Reservoirs of China National Petroleum Corporation。
文摘Burial dissolution is a critical diagenetic process influencing ultra-deep carbonate reservoir development and preservation.Artificial carbonate samples with different internal structures were prepared,and high-temperature and highpressure dissolution kinetic simulations were conducted.The results demonstrate that the intensity of burial dissolution is controlled by temperature and pressure,while tectonic-fluid activity influences the development pattern of burial dissolution,ultimately determining the direction of its differential modification.Extensive burial dissolution is likely to occur primarily at relatively shallow depths,significantly influencing reservoir formation,preservation,modification,and adjustment.The development of faults facilitates the maintenance of the intensity of burial dissolution.The maximum intensity of burial dissolution occurs at the tips and overlap zones of faults and intersections of multiple faults.The larger the scale of the faults,the more conducive it is to the development of burial dissolution.Burial dissolution fosters the formation of fault networks characterized by enhanced reservoir capacity and permeability.Burial dissolution controlled by episodic tectonic-fluid activity is a plausible explanation for forming the Tarim Basin's ultra-deep fault-controlled“stringbead-like”reservoirs.
基金support from the Key Program of the National Natural Science Foundation of China(No.51235010)。
文摘Although the plastic loading can enhance creep deformation and yield strength,the anisotropic Stress Relaxation Aging(SRA)behavior and mechanism under plastic loading remain unclear,which presents a significant challenge in accurately shaping aluminum alloy panels.In this study,the SRA behavior of 2195-T4 Al-Cu-Li alloys were thoroughly studied under initial loading stresses within the elastic(210/250 MPa)and plastic(380/420 MPa)ranges at 180℃by stress relaxation and tensile tests as well as microstructure characterization.The findings reveal that compared with those under elastic loadings,in-plane anisotropy(IPA)values of the stress relaxation amount,yield strength and fracture elongation under plastic loadings are reduced by 60%–80%,70%–90% and 72%–89%,respectively.Similarly,IPA values of precipitate size in grains and PrecipitationFree Zones(PFZ)width at grain boundaries under plastic loading decrease by 31.4%and 94.4%respectively.These results indicate plastic loading significantly weakens the anisotropic SRA behavior,owing to numerous uniformly distributed fine T1phases and small IPA values of both T1precipitates size and PFZ width in various loading directions.Compared with those of elastic loadingaged alloys,yield strength of plastic loading-aged alloys shows high strength-ductility because of the combined effect of closely dispersed fine T1precipitates,narrowed PFZ and numerous sheared and rotated T1phases at different locations during tensile process.The uniformly distributed larger Kernel Average Misorientation(KAM)and Schmidt factor values of the plastic loading-aged alloy,as well as the cross-slip generated,also help to enhance the strength and ductility of the alloy.
基金funded by National Natural Science Foundation of China(No.U20A20308,52177017 and 51977050)Heilongjiang Province Natural Science Foundation of China(No.ZD2020E009)+3 种基金China Postdoctoral Science Foundation(No.2020T130156)Heilongjiang Postdoctoral Financial Assistance(No.LBHZ18098)Fundamental Research Foundation for Universities of Heilongjiang Province(No.2019-KYYWF-0207 and 2018-KYYWF-1624)University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province(No.UNPYSCT-2020177)
文摘Optimizing the high-temperature energy storage characteristics of energy storage dielectrics is of great significance for the development of pulsed power devices and power control systems.Selecting a polymer with a higher glass transition temperature(T_(g))as the matrix is one of the effective ways to increase the upper limit of the polymer operating temperature.However,current high-T_(g)polymers have limitations,and it is difficult to meet the demand for high-temperature energy storage dielectrics with only one polymer.For example,polyetherimide has high-energy storage efficiency,but low breakdown strength at high temperatures.Polyimide has high corona resistance,but low high-temperature energy storage efficiency.In this work,combining the advantages of two polymer,a novel high-T_(g)polymer fiber-reinforced microstructure is designed.Polyimide is designed as extremely fine fibers distributed in the composite dielectric,which will facilitate the reduction of high-temperature conductivity loss for polyimide.At the same time,due to the high-temperature resistance and corona resistance of polyimide,the high-temperature breakdown strength of the composite dielectric is enhanced.After the polyimide content with the best high-temperature energy storage characteristics is determined,molecular semiconductors(ITIC)are blended into the polyimide fibers to further improve the high-temperature efficiency.Ultimately,excellent high-temperature energy storage properties are obtained.The 0.25 vol%ITIC-polyimide/polyetherimide composite exhibits high-energy density and high discharge efficiency at 150℃(2.9 J cm^(-3),90%)and 180℃(2.16 J cm^(-3),90%).This work provides a scalable design idea for high-performance all-organic high-temperature energy storage dielectrics.
基金funded by the Japan Society for the Promotion of Science,JSPS,23K07290(to MF).
文摘The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout adulthood.Degenerated NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).
文摘“Last scene of all that ends this strange,eventful history,is second childishness and mere oblivion.I am sans teeth,sans eyes,sans taste,sans everything.”William Shakespeare‘As You Like It'Act 2,Sc.7,l.139Aging of the human brain is characterized by a progressive decline of its functional capacity;this decline however varies widely,and cognitive longevity differs substantially between individuals.
基金financially supported by the National Natural Science Foundation of China(Nos.22102212 and 22479067).
文摘High-nickel ternary cathodes hold a great application prospect in solid-state lithium metal batteries to achieve high-energy density,but they still suffer from structural instability and detrimental side reactions with the solid-state electrolytes.To circumvent these issues,a continuous uniform layer polyacrylonitrile(PAN)was introduced on the surface of LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2) via in situ polymerization of acrylonitrile(AN).Furthermore,the partial-cyclized treatment of PAN(cPAN)coating layer presents high ionic and electron conductivity,which can accelerate interfacial Li+and electron diffusion simultaneously.And the thermodynamically stabilized cPAN coating layer cannot only effectively inhibit detrimental side reactions between cathode and solid-state electrolytes but also provide a homogeneous stress to simultaneously address the problems of bulk structural degradation,which contributes to the exceptional mechanical and electrochemical stabilities of the modified electrode.Besides,the coordination bond interaction between the cPAN and NCM811 can suppress the migration of Ni to elevate the stability of the crystal structure.Benefited from these,the In-cPAN-260@NCM811 shows excellent cycling performance with a retention of 86.8%after 300 cycles and superior rate capability.And endow the solid-state battery with thermal safety stability even at hightemperature extreme environment.This facile and scalable surface engineering represents significant progress in developing high-performance solid-state lithium metal batteries.
基金supported by the Foundation Strengthening Plan Technical Field Fund(No.2021-JJ-0112)Major Scientific and Technological Innovation Project of Luoyang(No.2201029A)+1 种基金National Science and Technology Innovation Special Zone(No.02-14-01)National Natural Science Foundation of China(No.U2037601).
文摘In this work,the aging response and mechanism of dual-phase Mg-Li-Al-Zn alloy at various temperatures are investigated.The results show that the strengthening after quenching is primarily attributed to the immediate precipitation of the semi-coherent~Mg_(3)Zn phase.The aging softening of the studied alloy is mainly caused by the rapid transformation of the strengthening~Mg_(3)Zn phase to the softening MgLi(Al,Zn)phase,along with the coarsening of theα-Mg matrix and precipitates withinβ-Li matrix.Further analysis indicates that the quick precipitation and transformation of~Mg_(3)Zn is a consequence of the high diffusion rate of solute atoms,resulting from dense vacancy concentration in theβ-Li matrix.This research bridges a critical gap in the study of aging mechanism in the dual-phase Mg-Li-Al-Zn alloy,providing a theoretical basis for the development and application of high-performance and thermal-stable Mg-Li alloys.
基金supported by the National Key R&D Program of China(No.2022YFB3707700)National Natural Science Foundation of China(No.52302121)+3 种基金Shanghai Sailing Program(No.23YF1454700)Shanghai Natural Science Foundation(No.23ZR1472700)Shanghai Post-doctoral Excellent Program(No.2022664)Shanghai Science and Technology Innovation Action Plan(No.21511104800).
文摘The research on high-performance electromagnetic wave absorption materials with high-temperature and oxidative stability in extreme environments is gaining popularity.Herein,the lightweight silicon carbide nanowires(SiC_(nws))/SiC composites are fabricated with in-situ SiC interface on one-dimensional oriented SiC_(nws)skeleton,which collaborative configuration by 3D printing and freeze casting assembly.The con-structed porous structure optimizes the impedance matching degree and scattering intensity,the maximum effective absorption bandwidth(EAB_(max))of 5.9 GHz and the minimum reflection loss(RL_(min))of−41.4 dB can be realized.Considering the inherent oxidation resistance of SiC,the composites present well-maintained absorption performance at 600℃.Even at 1100℃,the EAB_(max)of 4.9 GHz and RLmin of−30.4 dB also demonstrate the high-temperature absorption stability of the composites,indicating exceptional wave absorption properties and thermal stability.The slight attenuation can be attributed to the decrease in impedance matching capability accompanying the elevated dielectric constant.This work clarifies the impact of structure and component synergy on wave absorption behavior,and offers a novel approach to producing high-performance and high-temperature resistance ceramic-based electromagnetic wave absorption materials suitable for extreme environments.
基金Supported by the National Natural Science Foundation of China,No.82104525Open Foundation of Key Laboratory of Tropical Plant Resource Chemistry of Hainan Province,No.rdzw2024s01.
文摘This article is based on a recent bibliometric analysis of research progress on liver aging.The liver is notable for its extraordinary ability to rejuvenate,thereby safeguarding and maintaining the organism’s integrity.With advancing age,there is a noteworthy reduction in both the liver’s size and blood circulation.Furthermore,the wide range of physiological alterations driven on by aging may foster the development of illnesses.Previous studies indicate that liver aging is linked to impaired lipid metabolism and abnormal gene expression associated with chronic inflammation.Factors such as mitochondrial dysfunction and telomere shortening accumulate,which may result in increased hepatic steatosis,which impacts liver regeneration,metabolism,and other functions.Knowing the structural and functional changes could help elderly adults delay liver aging.Increasing public awareness of anti-aging interventions is essential.Besides the use of dietary supplements,alterations in lifestyle,including changes in dietary habits and physical exercise routines,are the most efficacious means to decelerate the aging process of the liver.This article highlights recent advances in the mechanism research of liver aging and summarizes the promising intervention options to delay liver aging for preventing related diseases.
