BACKGROUND SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma is a highly aggressive tumor,and spontaneous splenic rupture(SSR)as its presenting manifestation is rarely reported among pancreatic mal...BACKGROUND SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma is a highly aggressive tumor,and spontaneous splenic rupture(SSR)as its presenting manifestation is rarely reported among pancreatic malignancies.CASE SUMMARY We herein report a rare case of a 59-year-old female who presented with acute left upper quadrant abdominal pain without any history of trauma.Abdominal imaging demonstrated a heterogeneous splenic lesion with hemoperitoneum,raising clinical suspicion of SSR.Emergency laparotomy revealed a pancreatic tumor invading the spleen and left kidney,with associated splenic rupture and dense adhesions,necessitating en bloc resection of the distal pancreas,spleen,and left kidney.Histopathology revealed a biphasic malignancy composed of moderately differentiated pancreatic ductal adenocarcinoma and an undifferentiated carcinoma with rhabdoid morphology and loss of SMARCB1 expression.Immunohistochemical analysis confirmed complete loss of SMARCB1/INI1 in the undifferentiated component,along with a high Ki-67 index(approximately 80%)and CD10 positivity.The ductal adenocarcinoma component retained SMARCB1/INI1 expression and was positive for CK7 and CK-pan.Transitional zones between the two tumor components suggested progressive dedifferentiation and underlying genomic instability.The patient received adjuvant chemotherapy with gemcitabine and nab-paclitaxel and maintained a satisfactory quality of life at the 6-month follow-up.CONCLUSION This study reports a rare case of SMARCB1/INI1-deficient undifferentiated rhabdoid carcinoma of the pancreas combined with ductal adenocarcinoma,presenting as SSR-an exceptionally uncommon initial manifestation of pancreatic malignancy.展开更多
In the field of intelligent air combat,real-time and accurate recognition of within-visual-range(WVR)maneuver actions serves as the foundational cornerstone for constructing autonomous decision-making systems.However,...In the field of intelligent air combat,real-time and accurate recognition of within-visual-range(WVR)maneuver actions serves as the foundational cornerstone for constructing autonomous decision-making systems.However,existing methods face two major challenges:traditional feature engineering suffers from insufficient effective dimensionality in the feature space due to kinematic coupling,making it difficult to distinguish essential differences between maneuvers,while end-to-end deep learning models lack controllability in implicit feature learning and fail to model high-order long-range temporal dependencies.This paper proposes a trajectory feature pre-extraction method based on a Long-range Masked Autoencoder(LMAE),incorporating three key innovations:(1)Random Fragment High-ratio Masking(RFH-Mask),which enforces the model to learn long-range temporal correlations by masking 80%of trajectory data while retaining continuous fragments;(2)Kalman Filter-Guided Objective Function(KFG-OF),integrating trajectory continuity constraints to align the feature space with kinematic principles;and(3)Two-stage Decoupled Architecture,enabling efficient and controllable feature learning through unsupervised pre-training and frozen-feature transfer.Experimental results demonstrate that LMAE significantly improves the average recognition accuracy for 20-class maneuvers compared to traditional end-to-end models,while significantly accelerating convergence speed.The contributions of this work lie in:introducing high-masking-rate autoencoders into low-informationdensity trajectory analysis,proposing a feature engineering framework with enhanced controllability and efficiency,and providing a novel technical pathway for intelligent air combat decision-making systems.展开更多
In the article“A Lightweight Approach for Skin Lesion Detection through Optimal Features Fusion”by Khadija Manzoor,Fiaz Majeed,Ansar Siddique,Talha Meraj,Hafiz Tayyab Rauf,Mohammed A.El-Meligy,Mohamed Sharaf,Abd Ela...In the article“A Lightweight Approach for Skin Lesion Detection through Optimal Features Fusion”by Khadija Manzoor,Fiaz Majeed,Ansar Siddique,Talha Meraj,Hafiz Tayyab Rauf,Mohammed A.El-Meligy,Mohamed Sharaf,Abd Elatty E.Abd Elgawad Computers,Materials&Continua,2022,Vol.70,No.1,pp.1617–1630.DOI:10.32604/cmc.2022.018621,URL:https://www.techscience.com/cmc/v70n1/44361,there was an error regarding the affiliation for the author Hafiz Tayyab Rauf.Instead of“Centre for Smart Systems,AI and Cybersecurity,Staffordshire University,Stoke-on-Trent,UK”,the affiliation should be“Independent Researcher,Bradford,BD80HS,UK”.展开更多
BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features ...BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment planning.AIM To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging features.METHODS We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our institution.Pathological types were determined by histopathological examination of the surgical spe-cimens or biopsy samples.The imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic ultrasound.Statistical analyses were performed to identify significant associations between pathological types and specific imaging characteristics.RESULTS There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare types.Distinct imaging features were identified in each pathological type.Pancreatic ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural nodules.Neuroendocrine tumors often appear as hypervascular lesions in contrast-enhanced imaging.Statistical analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging features.These findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.展开更多
During Donald Trump’s first term,the“Trump Shock”brought world politics into an era of uncertainties and pulled the transatlantic alliance down to its lowest point in history.The Trump 2.0 tsunami brewed by the 202...During Donald Trump’s first term,the“Trump Shock”brought world politics into an era of uncertainties and pulled the transatlantic alliance down to its lowest point in history.The Trump 2.0 tsunami brewed by the 2024 presidential election of the United States has plunged the U.S.-Europe relations into more gloomy waters,ushering in a more complex and turbulent period of adjustment.展开更多
The fusion of infrared and visible images should emphasize the salient targets in the infrared image while preserving the textural details of the visible images.To meet these requirements,an autoencoder-based method f...The fusion of infrared and visible images should emphasize the salient targets in the infrared image while preserving the textural details of the visible images.To meet these requirements,an autoencoder-based method for infrared and visible image fusion is proposed.The encoder designed according to the optimization objective consists of a base encoder and a detail encoder,which is used to extract low-frequency and high-frequency information from the image.This extraction may lead to some information not being captured,so a compensation encoder is proposed to supplement the missing information.Multi-scale decomposition is also employed to extract image features more comprehensively.The decoder combines low-frequency,high-frequency and supplementary information to obtain multi-scale features.Subsequently,the attention strategy and fusion module are introduced to perform multi-scale fusion for image reconstruction.Experimental results on three datasets show that the fused images generated by this network effectively retain salient targets while being more consistent with human visual perception.展开更多
The characteristics of typical AE signals initiated by mechanical component damages are analyzed. Based on the extracting principle of acoustic emission(AE) signals from damaged components,the paper introduces Wigner ...The characteristics of typical AE signals initiated by mechanical component damages are analyzed. Based on the extracting principle of acoustic emission(AE) signals from damaged components,the paper introduces Wigner high-order spectra to the field of feature extraction and fault diagnosis of AE signals. Some main performances of Wigner binary spectra,Wigner triple spectra and Wigner-Ville distribution (WVD) are discussed,including of time-frequency resolution,energy accumulation,reduction of crossing items and noise elimination. Wigner triple spectra is employed to the fault diagnosis of rolling bearings with AE techniques. The fault features reading from experimental data analysis are clear,accurate and intuitionistic. The validity and accuracy of Wigner high-order spectra methods proposed agree quite well with simulation results. Simulation and research results indicate that wigner high-order spectra is quite useful for condition monitoring and fault diagnosis in conjunction with AE technique,and has very important research and application values in feature extraction and faults diagnosis based on AE signals due to mechanical component damages.展开更多
Smart contracts are widely used on the blockchain to implement complex transactions,such as decentralized applications on Ethereum.Effective vulnerability detection of large-scale smart contracts is critical,as attack...Smart contracts are widely used on the blockchain to implement complex transactions,such as decentralized applications on Ethereum.Effective vulnerability detection of large-scale smart contracts is critical,as attacks on smart contracts often cause huge economic losses.Since it is difficult to repair and update smart contracts,it is necessary to find the vulnerabilities before they are deployed.However,code analysis,which requires traversal paths,and learning methods,which require many features to be trained,are too time-consuming to detect large-scale on-chain contracts.Learning-based methods will obtain detection models from a feature space compared to code analysis methods such as symbol execution.But the existing features lack the interpretability of the detection results and training model,even worse,the large-scale feature space also affects the efficiency of detection.This paper focuses on improving the detection efficiency by reducing the dimension of the features,combined with expert knowledge.In this paper,a feature extraction model Block-gram is proposed to form low-dimensional knowledge-based features from bytecode.First,the metadata is separated and the runtime code is converted into a sequence of opcodes,which are divided into segments based on some instructions(jumps,etc.).Then,scalable Block-gram features,including 4-dimensional block features and 8-dimensional attribute features,are mined for the learning-based model training.Finally,feature contributions are calculated from SHAP values to measure the relationship between our features and the results of the detection model.In addition,six types of vulnerability labels are made on a dataset containing 33,885 contracts,and these knowledge-based features are evaluated using seven state-of-the-art learning algorithms,which show that the average detection latency speeds up 25×to 650×,compared with the features extracted by N-gram,and also can enhance the interpretability of the detection model.展开更多
Biometric characteristics are playing a vital role in security for the last few years.Human gait classification in video sequences is an important biometrics attribute and is used for security purposes.A new framework...Biometric characteristics are playing a vital role in security for the last few years.Human gait classification in video sequences is an important biometrics attribute and is used for security purposes.A new framework for human gait classification in video sequences using deep learning(DL)fusion assisted and posterior probability-based moth flames optimization(MFO)is proposed.In the first step,the video frames are resized and finetuned by two pre-trained lightweight DL models,EfficientNetB0 and MobileNetV2.Both models are selected based on the top-5 accuracy and less number of parameters.Later,both models are trained through deep transfer learning and extracted deep features fused using a voting scheme.In the last step,the authors develop a posterior probabilitybased MFO feature selection algorithm to select the best features.The selected features are classified using several supervised learning methods.The CASIA-B publicly available dataset has been employed for the experimental process.On this dataset,the authors selected six angles such as 0°,18°,90°,108°,162°,and 180°and obtained an average accuracy of 96.9%,95.7%,86.8%,90.0%,95.1%,and 99.7%.Results demonstrate comparable improvement in accuracy and significantly minimize the computational time with recent state-of-the-art techniques.展开更多
Due to the limitations of existing imaging hardware, obtaining high-resolution hyperspectral images is challenging. Hyperspectral image super-resolution(HSI SR) has been a very attractive research topic in computer vi...Due to the limitations of existing imaging hardware, obtaining high-resolution hyperspectral images is challenging. Hyperspectral image super-resolution(HSI SR) has been a very attractive research topic in computer vision, attracting the attention of many researchers. However, most HSI SR methods focus on the tradeoff between spatial resolution and spectral information, and cannot guarantee the efficient extraction of image information. In this paper, a multidimensional features network(MFNet) for HSI SR is proposed, which simultaneously learns and fuses the spatial,spectral, and frequency multidimensional features of HSI. Spatial features contain rich local details,spectral features contain the information and correlation between spectral bands, and frequency feature can reflect the global information of the image and can be used to obtain the global context of HSI. The fusion of the three features can better guide image super-resolution, to obtain higher-quality high-resolution hyperspectral images. In MFNet, we use the frequency feature extraction module(FFEM) to extract the frequency feature. On this basis, a multidimensional features extraction module(MFEM) is designed to learn and fuse multidimensional features. In addition, experimental results on two public datasets demonstrate that MFNet achieves state-of-the-art performance.展开更多
Recognizing road scene context from a single image remains a critical challenge for intelligent autonomous driving systems,particularly in dynamic and unstructured environments.While recent advancements in deep learni...Recognizing road scene context from a single image remains a critical challenge for intelligent autonomous driving systems,particularly in dynamic and unstructured environments.While recent advancements in deep learning have significantly enhanced road scene classification,simultaneously achieving high accuracy,computational efficiency,and adaptability across diverse conditions continues to be difficult.To address these challenges,this study proposes HybridLSTM,a novel and efficient framework that integrates deep learning-based,object-based,and handcrafted feature extraction methods within a unified architecture.HybridLSTM is designed to classify four distinct road scene categories—crosswalk(CW),highway(HW),overpass/tunnel(OP/T),and parking(P)—by leveraging multiple publicly available datasets,including Places-365,BDD100K,LabelMe,and KITTI,thereby promoting domain generalization.The framework fuses object-level features extracted using YOLOv5 and VGG19,scene-level global representations obtained from a modified VGG19,and fine-grained texture features captured through eight handcrafted descriptors.This hybrid feature fusion enables the model to capture both semantic context and low-level visual cues,which are critical for robust scene understanding.To model spatial arrangements and latent sequential dependencies present even in static imagery,the combined features are processed through a Long Short-Term Memory(LSTM)network,allowing the extraction of discriminative patterns across heterogeneous feature spaces.Extensive experiments conducted on 2725 annotated road scene images,with an 80:20 training-to-testing split,validate the effectiveness of the proposed model.HybridLSTM achieves a classification accuracy of 96.3%,a precision of 95.8%,a recall of 96.1%,and an F1-score of 96.0%,outperforming several existing state-of-the-art methods.These results demonstrate the robustness,scalability,and generalization capability of HybridLSTM across varying environments and scene complexities.Moreover,the framework is optimized to balance classification performance with computational efficiency,making it highly suitable for real-time deployment in embedded autonomous driving systems.Future work will focus on extending the model to multi-class detection within a single frame and optimizing it further for edge-device deployments to reduce computational overhead in practical applications.展开更多
Drug resistance remains a major challenge in breast cancer chemotherapy,yet the metabolic alterations underlying this phenomenon are not fully understood.There is much evidence indicating the cellular heterogeneity am...Drug resistance remains a major challenge in breast cancer chemotherapy,yet the metabolic alterations underlying this phenomenon are not fully understood.There is much evidence indicating the cellular heterogeneity among cancer cells,which exhibit varying degrees of metabolic reprogramming and thus may result in differential contributions to drug resistance.A home-built single-cell quantitative mass spectrometry(MS)platform,which integrates micromanipulation and electro-osmotic sampling,was developed to quantitatively profile the tricarboxylic acid(TCA)cycle metabolites at the single-cell level.Using this platform,the metabolic profiles of drug-sensitive MCF-7 breast cancer cells and their drug-resistant derivative MCF-7/ADR cells were compared.This results revealed a selective upregulation of downstream TCA cycle metabolites includingα-ketoglutarate,succinate,fumarate,and malate in drug-resistant cancer cells,while early TCA metabolites remained largely unchanged.Furthermore,notable variations in the abundance of the metabolites were observed in individual cells.The comparative analysis also revealed that not all MCF-7/ADR cells exhibit the same degree of metabolic deviation from the parental line in the metabolites during resistance acquisition.The observed metabolic profiles indicate enhanced glutaminolysis,altered mitochondrial electron transport chain activity,and increased metabolic flexibility in drug-resistant cancer cells that support their survival under chemotherapeutic stress.The findings further suggest the potential for incorporating cellular metabolic heterogeneity into future drug resistance studies.展开更多
We investigate theoretically the effects of chirped laser pulses on high-order harmonic generation(HHG)from solids.We find that the harmonic spectra display redshifts for the driving laser pulses with negative chirp a...We investigate theoretically the effects of chirped laser pulses on high-order harmonic generation(HHG)from solids.We find that the harmonic spectra display redshifts for the driving laser pulses with negative chirp and blueshifts for those with positive chirp,which is due to the change in the instantaneous frequency of the driving laser for different chirped pulses.The analysis of crystal-momentum-resolved(k-resolved)HHG reveals that the frequency shifts are equal for the harmonics generated by different crystal momentum channels.The frequency shifts in the cutoff region are larger than those in the plateau region.With the increase of the absolute value of the chirp parameters,the frequency shifts of HHG become more significant,leading to the shifts from odd-to even-order harmonics.We also demonstrate that the frequency shifts of harmonic spectra are related to the duration of the chirped laser field,but are insensitive to the laser intensity and dephasing time.展开更多
A new oxidative N-heterocyclic carbene(NHC)-catalyzed high-order[7+3]annulation reaction ofγ-indolyl phenols as 1,7-dinucleophiles andα,β-alkynals with the aid of Sc(OTf)_(3)is reported,enabling the highly regiosel...A new oxidative N-heterocyclic carbene(NHC)-catalyzed high-order[7+3]annulation reaction ofγ-indolyl phenols as 1,7-dinucleophiles andα,β-alkynals with the aid of Sc(OTf)_(3)is reported,enabling the highly regioselective access to unprecedented polyarene-fused ten-membered lactams bearing a bridged aryl-aryl-indole scaffold in moderate to good yields.This protocol demonstrates a broad substrate scope,good compatibility with substituents and complete regioselectivity,providing an organocatalytic modular synthetic strategy for creating medium-sized lactams.展开更多
Thermal expansion is crucial for various industrial processes and is increasingly the focus of research endeavors aimed at improving material performance.However,it is the continuous advancements in first-principles c...Thermal expansion is crucial for various industrial processes and is increasingly the focus of research endeavors aimed at improving material performance.However,it is the continuous advancements in first-principles calculations that have enabled researchers to understand the microscopic origins of thermal expansion.In this study,we propose a coefficient of thermal expansion(CTE)calculation scheme based on self-consistent phonon theory,incorporating the fourth-order anharmonicity.We selected four structures(Si,CaZrF_(6),SrTiO_(3),NaBr)to investigate high-order anharmonicity’s impact on their CTEs,based on bonding types.The results indicate that our method goes beyond the second-order quasi-harmonic approximation and the third-order perturbation theory,aligning closely with experimental data.Furthermore,we observed that an increase in the ionicity of the structures leads to a more pronounced influence of high-order anharmonicity on CTE,with this effect primarily manifesting in variations of the Grüneisen parameter.Our research provides a theoretical foundation for accurately predicting and regulating the thermal expansion behavior of materials.展开更多
An efficient and accurate scalar auxiliary variable(SAV)scheme for numerically solving nonlinear parabolic integro-differential equation(PIDE)is developed in this paper.The original equation is first transformed into ...An efficient and accurate scalar auxiliary variable(SAV)scheme for numerically solving nonlinear parabolic integro-differential equation(PIDE)is developed in this paper.The original equation is first transformed into an equivalent system,and the k-order backward differentiation formula(BDF k)and central difference formula are used to discretize the temporal and spatial derivatives,respectively.Different from the traditional discrete method that adopts full implicit or full explicit for the nonlinear integral terms,the proposed scheme is based on the SAV idea and can be treated semi-implicitly,taking into account both accuracy and effectiveness.Numerical results are presented to demonstrate the high-order convergence(up to fourth-order)of the developed schemes and it is computationally efficient in long-time computations.展开更多
We present a comprehensive study on the role of various excited states in high-order harmonic generation of hydrogen atoms driven by a long-wavelength(1500 nm)laser field.By numerically solving the time-dependent Schr...We present a comprehensive study on the role of various excited states in high-order harmonic generation of hydrogen atoms driven by a long-wavelength(1500 nm)laser field.By numerically solving the time-dependent Schrodinger equation(TDSE)and performing a time-frequency analysis,we investigate the influence of individual excited states on the harmonic spectrum.Our results reveal that the 2s excited state primarily contributes to the enhancement of high-energy harmonic yields by facilitating long electron trajectories,while the 2p excited state predominantly suppresses harmonic yields in the lower-energy region(20th-50th orders)by altering the contributions of electron trajectories.Our results highlight the critical role of the excited states in the HHG process,even at longer laser wavelengths.展开更多
Remote sensing cross-modal image-text retrieval(RSCIR)can flexibly and subjectively retrieve remote sensing images utilizing query text,which has received more researchers’attention recently.However,with the increasi...Remote sensing cross-modal image-text retrieval(RSCIR)can flexibly and subjectively retrieve remote sensing images utilizing query text,which has received more researchers’attention recently.However,with the increasing volume of visual-language pre-training model parameters,direct transfer learning consumes a substantial amount of computational and storage resources.Moreover,recently proposed parameter-efficient transfer learning methods mainly focus on the reconstruction of channel features,ignoring the spatial features which are vital for modeling key entity relationships.To address these issues,we design an efficient transfer learning framework for RSCIR,which is based on spatial feature efficient reconstruction(SPER).A concise and efficient spatial adapter is introduced to enhance the extraction of spatial relationships.The spatial adapter is able to spatially reconstruct the features in the backbone with few parameters while incorporating the prior information from the channel dimension.We conduct quantitative and qualitative experiments on two different commonly used RSCIR datasets.Compared with traditional methods,our approach achieves an improvement of 3%-11% in sumR metric.Compared with methods finetuning all parameters,our proposed method only trains less than 1% of the parameters,while maintaining an overall performance of about 96%.展开更多
We performed real-time and real-space numerical simulations of high-order harmonic generation in the threedimensional structured molecule methane(CH_(4)) using time-dependent density functional theory. By irradiating ...We performed real-time and real-space numerical simulations of high-order harmonic generation in the threedimensional structured molecule methane(CH_(4)) using time-dependent density functional theory. By irradiating the methane molecule with an elliptically polarized laser pulse polarized in the x–y plane, we observed significant even-order harmonic emission in the z-direction. By analyzing the electron dynamics in the electric field and the multi-orbital effects of the molecule, we revealed that electron recombination near specific atoms in methane is the primary source of highorder harmonic generation in the z-direction. Furthermore, we identified the dominant molecular orbitals responsible for the enhancement of harmonics in this direction and demonstrated the critical role played by multi-orbital effects in this process.展开更多
The high-speed development of space defense technology demands a high state estimation capacity for spacecraft tracking methods.However,reentry flight is accompanied by complex flight environments,which brings to the ...The high-speed development of space defense technology demands a high state estimation capacity for spacecraft tracking methods.However,reentry flight is accompanied by complex flight environments,which brings to the uncertain,complex,and strongly coupled non-Gaussian detection noise.As a result,there are several intractable considerations on the problem of state estimation tasks corrupted by complex non-Gaussian outliers for non-linear dynamics systems in practical application.To address these issues,a new iterated rational quadratic(RQ)kernel high-order unscented Kalman filtering(IRQHUKF)algorithm via capturing the statistics to break through the limitations of the Gaussian assumption is proposed.Firstly,the characteristic analysis of the RQ kernel is investigated in detail,which is the first attempt to carry out an exploration of the heavy-tailed characteristic and the ability on capturing highorder moments of the RQ kernel.Subsequently,the RQ kernel method is first introduced into the UKF algorithm as an error optimization criterion,termed the iterated RQ kernel-UKF(RQ-UKF)algorithm by derived analytically,which not only retains the high-order moments propagation process but also enhances the approximation capacity in the non-Gaussian noise problem for its ability in capturing highorder moments and heavy-tailed characteristics.Meanwhile,to tackle the limitations of the Gaussian distribution assumption in the linearization process of the non-linear systems,the high-order Sigma Points(SP)as a subsidiary role in propagating the state high-order statistics is devised by the moments matching method to improve the RQ-UKF.Finally,to further improve the flexibility of the IRQ-HUKF algorithm in practical application,an adaptive kernel parameter is derived analytically grounded in the Kullback-Leibler divergence(KLD)method and parametric sensitivity analysis of the RQ kernel.The simulation results demonstrate that the novel IRQ-HUKF algorithm is more robust and outperforms the existing advanced UKF with respect to the kernel method in reentry vehicle tracking scenarios under various noise environments.展开更多
文摘BACKGROUND SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma is a highly aggressive tumor,and spontaneous splenic rupture(SSR)as its presenting manifestation is rarely reported among pancreatic malignancies.CASE SUMMARY We herein report a rare case of a 59-year-old female who presented with acute left upper quadrant abdominal pain without any history of trauma.Abdominal imaging demonstrated a heterogeneous splenic lesion with hemoperitoneum,raising clinical suspicion of SSR.Emergency laparotomy revealed a pancreatic tumor invading the spleen and left kidney,with associated splenic rupture and dense adhesions,necessitating en bloc resection of the distal pancreas,spleen,and left kidney.Histopathology revealed a biphasic malignancy composed of moderately differentiated pancreatic ductal adenocarcinoma and an undifferentiated carcinoma with rhabdoid morphology and loss of SMARCB1 expression.Immunohistochemical analysis confirmed complete loss of SMARCB1/INI1 in the undifferentiated component,along with a high Ki-67 index(approximately 80%)and CD10 positivity.The ductal adenocarcinoma component retained SMARCB1/INI1 expression and was positive for CK7 and CK-pan.Transitional zones between the two tumor components suggested progressive dedifferentiation and underlying genomic instability.The patient received adjuvant chemotherapy with gemcitabine and nab-paclitaxel and maintained a satisfactory quality of life at the 6-month follow-up.CONCLUSION This study reports a rare case of SMARCB1/INI1-deficient undifferentiated rhabdoid carcinoma of the pancreas combined with ductal adenocarcinoma,presenting as SSR-an exceptionally uncommon initial manifestation of pancreatic malignancy.
文摘In the field of intelligent air combat,real-time and accurate recognition of within-visual-range(WVR)maneuver actions serves as the foundational cornerstone for constructing autonomous decision-making systems.However,existing methods face two major challenges:traditional feature engineering suffers from insufficient effective dimensionality in the feature space due to kinematic coupling,making it difficult to distinguish essential differences between maneuvers,while end-to-end deep learning models lack controllability in implicit feature learning and fail to model high-order long-range temporal dependencies.This paper proposes a trajectory feature pre-extraction method based on a Long-range Masked Autoencoder(LMAE),incorporating three key innovations:(1)Random Fragment High-ratio Masking(RFH-Mask),which enforces the model to learn long-range temporal correlations by masking 80%of trajectory data while retaining continuous fragments;(2)Kalman Filter-Guided Objective Function(KFG-OF),integrating trajectory continuity constraints to align the feature space with kinematic principles;and(3)Two-stage Decoupled Architecture,enabling efficient and controllable feature learning through unsupervised pre-training and frozen-feature transfer.Experimental results demonstrate that LMAE significantly improves the average recognition accuracy for 20-class maneuvers compared to traditional end-to-end models,while significantly accelerating convergence speed.The contributions of this work lie in:introducing high-masking-rate autoencoders into low-informationdensity trajectory analysis,proposing a feature engineering framework with enhanced controllability and efficiency,and providing a novel technical pathway for intelligent air combat decision-making systems.
文摘In the article“A Lightweight Approach for Skin Lesion Detection through Optimal Features Fusion”by Khadija Manzoor,Fiaz Majeed,Ansar Siddique,Talha Meraj,Hafiz Tayyab Rauf,Mohammed A.El-Meligy,Mohamed Sharaf,Abd Elatty E.Abd Elgawad Computers,Materials&Continua,2022,Vol.70,No.1,pp.1617–1630.DOI:10.32604/cmc.2022.018621,URL:https://www.techscience.com/cmc/v70n1/44361,there was an error regarding the affiliation for the author Hafiz Tayyab Rauf.Instead of“Centre for Smart Systems,AI and Cybersecurity,Staffordshire University,Stoke-on-Trent,UK”,the affiliation should be“Independent Researcher,Bradford,BD80HS,UK”.
文摘BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment planning.AIM To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging features.METHODS We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our institution.Pathological types were determined by histopathological examination of the surgical spe-cimens or biopsy samples.The imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic ultrasound.Statistical analyses were performed to identify significant associations between pathological types and specific imaging characteristics.RESULTS There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare types.Distinct imaging features were identified in each pathological type.Pancreatic ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural nodules.Neuroendocrine tumors often appear as hypervascular lesions in contrast-enhanced imaging.Statistical analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging features.These findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.
文摘During Donald Trump’s first term,the“Trump Shock”brought world politics into an era of uncertainties and pulled the transatlantic alliance down to its lowest point in history.The Trump 2.0 tsunami brewed by the 2024 presidential election of the United States has plunged the U.S.-Europe relations into more gloomy waters,ushering in a more complex and turbulent period of adjustment.
基金Supported by the Henan Province Key Research and Development Project(231111211300)the Central Government of Henan Province Guides Local Science and Technology Development Funds(Z20231811005)+2 种基金Henan Province Key Research and Development Project(231111110100)Henan Provincial Outstanding Foreign Scientist Studio(GZS2024006)Henan Provincial Joint Fund for Scientific and Technological Research and Development Plan(Application and Overcoming Technical Barriers)(242103810028)。
文摘The fusion of infrared and visible images should emphasize the salient targets in the infrared image while preserving the textural details of the visible images.To meet these requirements,an autoencoder-based method for infrared and visible image fusion is proposed.The encoder designed according to the optimization objective consists of a base encoder and a detail encoder,which is used to extract low-frequency and high-frequency information from the image.This extraction may lead to some information not being captured,so a compensation encoder is proposed to supplement the missing information.Multi-scale decomposition is also employed to extract image features more comprehensively.The decoder combines low-frequency,high-frequency and supplementary information to obtain multi-scale features.Subsequently,the attention strategy and fusion module are introduced to perform multi-scale fusion for image reconstruction.Experimental results on three datasets show that the fused images generated by this network effectively retain salient targets while being more consistent with human visual perception.
基金Supported by the Project of Hunan Provincial Science and Technology Research (2007FJ3025)
文摘The characteristics of typical AE signals initiated by mechanical component damages are analyzed. Based on the extracting principle of acoustic emission(AE) signals from damaged components,the paper introduces Wigner high-order spectra to the field of feature extraction and fault diagnosis of AE signals. Some main performances of Wigner binary spectra,Wigner triple spectra and Wigner-Ville distribution (WVD) are discussed,including of time-frequency resolution,energy accumulation,reduction of crossing items and noise elimination. Wigner triple spectra is employed to the fault diagnosis of rolling bearings with AE techniques. The fault features reading from experimental data analysis are clear,accurate and intuitionistic. The validity and accuracy of Wigner high-order spectra methods proposed agree quite well with simulation results. Simulation and research results indicate that wigner high-order spectra is quite useful for condition monitoring and fault diagnosis in conjunction with AE technique,and has very important research and application values in feature extraction and faults diagnosis based on AE signals due to mechanical component damages.
基金partially supported by the National Natural Science Foundation (62272248)the Open Project Fund of State Key Laboratory of Computer Architecture,Institute of Computing Technology,Chinese Academy of Sciences (CARCHA202108,CARCH201905)+1 种基金the Natural Science Foundation of Tianjin (20JCZDJC00610)Sponsored by Zhejiang Lab (2021KF0AB04)。
文摘Smart contracts are widely used on the blockchain to implement complex transactions,such as decentralized applications on Ethereum.Effective vulnerability detection of large-scale smart contracts is critical,as attacks on smart contracts often cause huge economic losses.Since it is difficult to repair and update smart contracts,it is necessary to find the vulnerabilities before they are deployed.However,code analysis,which requires traversal paths,and learning methods,which require many features to be trained,are too time-consuming to detect large-scale on-chain contracts.Learning-based methods will obtain detection models from a feature space compared to code analysis methods such as symbol execution.But the existing features lack the interpretability of the detection results and training model,even worse,the large-scale feature space also affects the efficiency of detection.This paper focuses on improving the detection efficiency by reducing the dimension of the features,combined with expert knowledge.In this paper,a feature extraction model Block-gram is proposed to form low-dimensional knowledge-based features from bytecode.First,the metadata is separated and the runtime code is converted into a sequence of opcodes,which are divided into segments based on some instructions(jumps,etc.).Then,scalable Block-gram features,including 4-dimensional block features and 8-dimensional attribute features,are mined for the learning-based model training.Finally,feature contributions are calculated from SHAP values to measure the relationship between our features and the results of the detection model.In addition,six types of vulnerability labels are made on a dataset containing 33,885 contracts,and these knowledge-based features are evaluated using seven state-of-the-art learning algorithms,which show that the average detection latency speeds up 25×to 650×,compared with the features extracted by N-gram,and also can enhance the interpretability of the detection model.
基金King Saud University,Grant/Award Number:RSP2024R157。
文摘Biometric characteristics are playing a vital role in security for the last few years.Human gait classification in video sequences is an important biometrics attribute and is used for security purposes.A new framework for human gait classification in video sequences using deep learning(DL)fusion assisted and posterior probability-based moth flames optimization(MFO)is proposed.In the first step,the video frames are resized and finetuned by two pre-trained lightweight DL models,EfficientNetB0 and MobileNetV2.Both models are selected based on the top-5 accuracy and less number of parameters.Later,both models are trained through deep transfer learning and extracted deep features fused using a voting scheme.In the last step,the authors develop a posterior probabilitybased MFO feature selection algorithm to select the best features.The selected features are classified using several supervised learning methods.The CASIA-B publicly available dataset has been employed for the experimental process.On this dataset,the authors selected six angles such as 0°,18°,90°,108°,162°,and 180°and obtained an average accuracy of 96.9%,95.7%,86.8%,90.0%,95.1%,and 99.7%.Results demonstrate comparable improvement in accuracy and significantly minimize the computational time with recent state-of-the-art techniques.
基金supported by the Fundamental Research Funds for the Provincial Universities of Zhejiang (No.GK249909299001-036)National Key Research and Development Program of China (No. 2023YFB4502803)Zhejiang Provincial Natural Science Foundation of China (No.LDT23F01014F01)。
文摘Due to the limitations of existing imaging hardware, obtaining high-resolution hyperspectral images is challenging. Hyperspectral image super-resolution(HSI SR) has been a very attractive research topic in computer vision, attracting the attention of many researchers. However, most HSI SR methods focus on the tradeoff between spatial resolution and spectral information, and cannot guarantee the efficient extraction of image information. In this paper, a multidimensional features network(MFNet) for HSI SR is proposed, which simultaneously learns and fuses the spatial,spectral, and frequency multidimensional features of HSI. Spatial features contain rich local details,spectral features contain the information and correlation between spectral bands, and frequency feature can reflect the global information of the image and can be used to obtain the global context of HSI. The fusion of the three features can better guide image super-resolution, to obtain higher-quality high-resolution hyperspectral images. In MFNet, we use the frequency feature extraction module(FFEM) to extract the frequency feature. On this basis, a multidimensional features extraction module(MFEM) is designed to learn and fuse multidimensional features. In addition, experimental results on two public datasets demonstrate that MFNet achieves state-of-the-art performance.
文摘Recognizing road scene context from a single image remains a critical challenge for intelligent autonomous driving systems,particularly in dynamic and unstructured environments.While recent advancements in deep learning have significantly enhanced road scene classification,simultaneously achieving high accuracy,computational efficiency,and adaptability across diverse conditions continues to be difficult.To address these challenges,this study proposes HybridLSTM,a novel and efficient framework that integrates deep learning-based,object-based,and handcrafted feature extraction methods within a unified architecture.HybridLSTM is designed to classify four distinct road scene categories—crosswalk(CW),highway(HW),overpass/tunnel(OP/T),and parking(P)—by leveraging multiple publicly available datasets,including Places-365,BDD100K,LabelMe,and KITTI,thereby promoting domain generalization.The framework fuses object-level features extracted using YOLOv5 and VGG19,scene-level global representations obtained from a modified VGG19,and fine-grained texture features captured through eight handcrafted descriptors.This hybrid feature fusion enables the model to capture both semantic context and low-level visual cues,which are critical for robust scene understanding.To model spatial arrangements and latent sequential dependencies present even in static imagery,the combined features are processed through a Long Short-Term Memory(LSTM)network,allowing the extraction of discriminative patterns across heterogeneous feature spaces.Extensive experiments conducted on 2725 annotated road scene images,with an 80:20 training-to-testing split,validate the effectiveness of the proposed model.HybridLSTM achieves a classification accuracy of 96.3%,a precision of 95.8%,a recall of 96.1%,and an F1-score of 96.0%,outperforming several existing state-of-the-art methods.These results demonstrate the robustness,scalability,and generalization capability of HybridLSTM across varying environments and scene complexities.Moreover,the framework is optimized to balance classification performance with computational efficiency,making it highly suitable for real-time deployment in embedded autonomous driving systems.Future work will focus on extending the model to multi-class detection within a single frame and optimizing it further for edge-device deployments to reduce computational overhead in practical applications.
基金supported by National Natural Science Foundation of China(22374080,22174068,21722504)Primary Research&Development Plan of Jiangsu Province(BK20221303,BE2022796)+1 种基金Open Foundation of State Key Laboratory of Reproductive Medicine(SKLRM-2022BP1,JX116GSP20240507)Science and Technology Development Fund of NJMU(NJMUQY2022003)。
文摘Drug resistance remains a major challenge in breast cancer chemotherapy,yet the metabolic alterations underlying this phenomenon are not fully understood.There is much evidence indicating the cellular heterogeneity among cancer cells,which exhibit varying degrees of metabolic reprogramming and thus may result in differential contributions to drug resistance.A home-built single-cell quantitative mass spectrometry(MS)platform,which integrates micromanipulation and electro-osmotic sampling,was developed to quantitatively profile the tricarboxylic acid(TCA)cycle metabolites at the single-cell level.Using this platform,the metabolic profiles of drug-sensitive MCF-7 breast cancer cells and their drug-resistant derivative MCF-7/ADR cells were compared.This results revealed a selective upregulation of downstream TCA cycle metabolites includingα-ketoglutarate,succinate,fumarate,and malate in drug-resistant cancer cells,while early TCA metabolites remained largely unchanged.Furthermore,notable variations in the abundance of the metabolites were observed in individual cells.The comparative analysis also revealed that not all MCF-7/ADR cells exhibit the same degree of metabolic deviation from the parental line in the metabolites during resistance acquisition.The observed metabolic profiles indicate enhanced glutaminolysis,altered mitochondrial electron transport chain activity,and increased metabolic flexibility in drug-resistant cancer cells that support their survival under chemotherapeutic stress.The findings further suggest the potential for incorporating cellular metabolic heterogeneity into future drug resistance studies.
基金Project supported by the Natural Science Foundation of Jilin Province of China(Grant No.20230101014JC)the National Natural Science Foundation of China(Grant No.12374265)。
文摘We investigate theoretically the effects of chirped laser pulses on high-order harmonic generation(HHG)from solids.We find that the harmonic spectra display redshifts for the driving laser pulses with negative chirp and blueshifts for those with positive chirp,which is due to the change in the instantaneous frequency of the driving laser for different chirped pulses.The analysis of crystal-momentum-resolved(k-resolved)HHG reveals that the frequency shifts are equal for the harmonics generated by different crystal momentum channels.The frequency shifts in the cutoff region are larger than those in the plateau region.With the increase of the absolute value of the chirp parameters,the frequency shifts of HHG become more significant,leading to the shifts from odd-to even-order harmonics.We also demonstrate that the frequency shifts of harmonic spectra are related to the duration of the chirped laser field,but are insensitive to the laser intensity and dephasing time.
基金National Natural Science Foundation of China(Nos.21971090 and 22271123)the NSF of Jiangsu Province(No.BK20230201)+1 种基金the Natural Science Foundation of Jiangsu Education Committee(No.22KJB150024)the Natural Science Foundation of Jiangsu Normal University(No.21XSRX010)。
文摘A new oxidative N-heterocyclic carbene(NHC)-catalyzed high-order[7+3]annulation reaction ofγ-indolyl phenols as 1,7-dinucleophiles andα,β-alkynals with the aid of Sc(OTf)_(3)is reported,enabling the highly regioselective access to unprecedented polyarene-fused ten-membered lactams bearing a bridged aryl-aryl-indole scaffold in moderate to good yields.This protocol demonstrates a broad substrate scope,good compatibility with substituents and complete regioselectivity,providing an organocatalytic modular synthetic strategy for creating medium-sized lactams.
基金Project supported by the National Natural Science Foundation of China(Grant No.62125402).
文摘Thermal expansion is crucial for various industrial processes and is increasingly the focus of research endeavors aimed at improving material performance.However,it is the continuous advancements in first-principles calculations that have enabled researchers to understand the microscopic origins of thermal expansion.In this study,we propose a coefficient of thermal expansion(CTE)calculation scheme based on self-consistent phonon theory,incorporating the fourth-order anharmonicity.We selected four structures(Si,CaZrF_(6),SrTiO_(3),NaBr)to investigate high-order anharmonicity’s impact on their CTEs,based on bonding types.The results indicate that our method goes beyond the second-order quasi-harmonic approximation and the third-order perturbation theory,aligning closely with experimental data.Furthermore,we observed that an increase in the ionicity of the structures leads to a more pronounced influence of high-order anharmonicity on CTE,with this effect primarily manifesting in variations of the Grüneisen parameter.Our research provides a theoretical foundation for accurately predicting and regulating the thermal expansion behavior of materials.
基金Supported by the National Natural Science Foundation of China(Grant Nos.12001210 and 12261103)the Natural Science Foundation of Henan(Grant No.252300420308)the Yunnan Fundamental Research Projects(Grant No.202301AT070117).
文摘An efficient and accurate scalar auxiliary variable(SAV)scheme for numerically solving nonlinear parabolic integro-differential equation(PIDE)is developed in this paper.The original equation is first transformed into an equivalent system,and the k-order backward differentiation formula(BDF k)and central difference formula are used to discretize the temporal and spatial derivatives,respectively.Different from the traditional discrete method that adopts full implicit or full explicit for the nonlinear integral terms,the proposed scheme is based on the SAV idea and can be treated semi-implicitly,taking into account both accuracy and effectiveness.Numerical results are presented to demonstrate the high-order convergence(up to fourth-order)of the developed schemes and it is computationally efficient in long-time computations.
基金supported by the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi。
文摘We present a comprehensive study on the role of various excited states in high-order harmonic generation of hydrogen atoms driven by a long-wavelength(1500 nm)laser field.By numerically solving the time-dependent Schrodinger equation(TDSE)and performing a time-frequency analysis,we investigate the influence of individual excited states on the harmonic spectrum.Our results reveal that the 2s excited state primarily contributes to the enhancement of high-energy harmonic yields by facilitating long electron trajectories,while the 2p excited state predominantly suppresses harmonic yields in the lower-energy region(20th-50th orders)by altering the contributions of electron trajectories.Our results highlight the critical role of the excited states in the HHG process,even at longer laser wavelengths.
基金supported by the National Key R&D Program of China(No.2022ZD0118402)。
文摘Remote sensing cross-modal image-text retrieval(RSCIR)can flexibly and subjectively retrieve remote sensing images utilizing query text,which has received more researchers’attention recently.However,with the increasing volume of visual-language pre-training model parameters,direct transfer learning consumes a substantial amount of computational and storage resources.Moreover,recently proposed parameter-efficient transfer learning methods mainly focus on the reconstruction of channel features,ignoring the spatial features which are vital for modeling key entity relationships.To address these issues,we design an efficient transfer learning framework for RSCIR,which is based on spatial feature efficient reconstruction(SPER).A concise and efficient spatial adapter is introduced to enhance the extraction of spatial relationships.The spatial adapter is able to spatially reconstruct the features in the backbone with few parameters while incorporating the prior information from the channel dimension.We conduct quantitative and qualitative experiments on two different commonly used RSCIR datasets.Compared with traditional methods,our approach achieves an improvement of 3%-11% in sumR metric.Compared with methods finetuning all parameters,our proposed method only trains less than 1% of the parameters,while maintaining an overall performance of about 96%.
基金Project supported by the National Natural Science Foundation of China (Grant No. 12204214)the National Key Research and Development Program of China (Grant No. 2022YFE0134200)+1 种基金the Fundamental Research Funds for the Central Universities (Grant No. GK202207012), QCYRCXM-2022-241the Guangdong Basic and Applied Basic Research Foundation (Grant No. 2025A1515011117)。
文摘We performed real-time and real-space numerical simulations of high-order harmonic generation in the threedimensional structured molecule methane(CH_(4)) using time-dependent density functional theory. By irradiating the methane molecule with an elliptically polarized laser pulse polarized in the x–y plane, we observed significant even-order harmonic emission in the z-direction. By analyzing the electron dynamics in the electric field and the multi-orbital effects of the molecule, we revealed that electron recombination near specific atoms in methane is the primary source of highorder harmonic generation in the z-direction. Furthermore, we identified the dominant molecular orbitals responsible for the enhancement of harmonics in this direction and demonstrated the critical role played by multi-orbital effects in this process.
基金supported by the National Natural Science Foundation of China under Grant No.12072090.
文摘The high-speed development of space defense technology demands a high state estimation capacity for spacecraft tracking methods.However,reentry flight is accompanied by complex flight environments,which brings to the uncertain,complex,and strongly coupled non-Gaussian detection noise.As a result,there are several intractable considerations on the problem of state estimation tasks corrupted by complex non-Gaussian outliers for non-linear dynamics systems in practical application.To address these issues,a new iterated rational quadratic(RQ)kernel high-order unscented Kalman filtering(IRQHUKF)algorithm via capturing the statistics to break through the limitations of the Gaussian assumption is proposed.Firstly,the characteristic analysis of the RQ kernel is investigated in detail,which is the first attempt to carry out an exploration of the heavy-tailed characteristic and the ability on capturing highorder moments of the RQ kernel.Subsequently,the RQ kernel method is first introduced into the UKF algorithm as an error optimization criterion,termed the iterated RQ kernel-UKF(RQ-UKF)algorithm by derived analytically,which not only retains the high-order moments propagation process but also enhances the approximation capacity in the non-Gaussian noise problem for its ability in capturing highorder moments and heavy-tailed characteristics.Meanwhile,to tackle the limitations of the Gaussian distribution assumption in the linearization process of the non-linear systems,the high-order Sigma Points(SP)as a subsidiary role in propagating the state high-order statistics is devised by the moments matching method to improve the RQ-UKF.Finally,to further improve the flexibility of the IRQ-HUKF algorithm in practical application,an adaptive kernel parameter is derived analytically grounded in the Kullback-Leibler divergence(KLD)method and parametric sensitivity analysis of the RQ kernel.The simulation results demonstrate that the novel IRQ-HUKF algorithm is more robust and outperforms the existing advanced UKF with respect to the kernel method in reentry vehicle tracking scenarios under various noise environments.
