The addition of cold flow improvers(CFIs)is considered as the optimum strategy to improve the cold flow properties(CFPs)of diesel fuels,but this strategy is always limited by the required large dosage.To obtain low-do...The addition of cold flow improvers(CFIs)is considered as the optimum strategy to improve the cold flow properties(CFPs)of diesel fuels,but this strategy is always limited by the required large dosage.To obtain low-dosage and high-efficiency CFIs for diesel,1,2,3,6-tetrahydrophthalic anhydride(THPA)was introduced as a third and polar monomer to enhance the depressive effects of alkyl methacrylatetrans anethole copolymers(C_(14)MC-TA).The terpolymers of alkyl methacrylate-trans anethole-1,2,3,6-tetrahydrophthalic anhydride(C_(14)MC-TA-THPA)were synthesized and compared with the binary copolymers of C_(14)MC-TA and alkyl methacrylate-1,2,3,6-tetrahydrophthalic anhydride(C_(14)MC-THPA).Results showed that C_(14)MC-THPA achieved the best depressive effects on the cold filter plugging point(CFPP)and solid point(SP)by 11℃and 16℃at a dosage of 1250 mg/L and monomer ratio of 6:1,while 1500mg/L C_(14)MC-TA(1:1)reached the optimal depressive effects on the CFPP and SP by 12℃and 18℃.THPA introduction significantly improved the depressive effects of C_(14)MC-TA.Lower dosages of C_(14)MCTA-THPA in diesel exerted better improvement effects on the CFPP and SP than that of C_(14)MC-TA and C_(14)MC-THPA.When the monomer ratio and dosage were 6:0.6:0.4 and 1000 mg/L,the improvement effect of C_(14)MC-TA-THPA on diesel reached the optimum level,and the CFPP and SP were reduced by 13℃and 19℃,respectively.A 3D nonlinear surface diagram fitted by a mathematical model was also used for the first time to better understand the relationships of monomer ratios,dosages,and depressive effects of CFIs in diesel.Surface analysis results showed that C_(14)MC-TA-THPA achieved the optimum depressive effects at a monomer ratio of 6:0.66:0.34 and dosage of 1000 mg/L,and the CFPP and SP decreased by 14℃ and 19℃,respectively.The predicted results were consistent with the actual ones.Additionally,the improvement mechanism of these copolymers in diesel was also explored.展开更多
Graphene,owing to its exceptional electronic,optical,thermal,and mechanical properties,has emerged as a highly promising material.Currently,the synthesis of large-area graphene films on metal substrates via chemical v...Graphene,owing to its exceptional electronic,optical,thermal,and mechanical properties,has emerged as a highly promising material.Currently,the synthesis of large-area graphene films on metal substrates via chemical vapor deposition remains the predominant approach for producing high-quality graphene.To realize the potential applications of graphene,it is essential to transfer graphene films to target substrates in a manner that is non-destructive,clean,and efficient,as this significantly affects the performance of graphene devices.This review examines the current methods for graphene transfer from three perspectives:non-destructive transfer,clean transfer,and high-efficiency transfer.It analyzes and compares the advancements and limitations of various transfer techniques.Finally,the review identifies the key challenges faced by current graphene transfer methods and anticipates future developmental prospects.展开更多
Through literature analysis and case study, the introduction history, variety selection (high bush, half high bush, low bush) and regional cultivation techniques of blueberry in China were summarized, and the practica...Through literature analysis and case study, the introduction history, variety selection (high bush, half high bush, low bush) and regional cultivation techniques of blueberry in China were summarized, and the practical effects of precision cultivation (water and fertilizer integration, wild planting) and under-forest economic model (forest-blueberry-fungus system, ecological tourism) were evaluated. It provided a technical reference for expanding the planting scale of blueberry and improving the fruit quality.展开更多
Gamma titanium-aluminum intermetallic compounds(γ-TiAl)have gained considerable attentions in the aerospace industry due to their exceptional thermal resilience and comprehensive attributes,making them a prime exampl...Gamma titanium-aluminum intermetallic compounds(γ-TiAl)have gained considerable attentions in the aerospace industry due to their exceptional thermal resilience and comprehensive attributes,making them a prime example of lightweight and advanced materials.To address the frequent occurrence of burns and severe tool deterioration during the process of high-efficiency deep grinding(HEDG)onγ-TiAl alloys,ultrasonic vibration-assisted high-efficiency deep grinding(UVHEDG)has been emerged.Results indicate that in UVHEDG,the grinding temperature is on average 15.4%lower than HEDG due to the employment of ultrasonic vibrations,enhancing coolant penetration into the grinding area and thus reducing heat generation.Besides,UVHEDG possesses superior performance in terms of grinding forces compared to HEDG.As the material removal volume(MRV)increases,the tangential grinding force(F_(t))and normal grinding force(F_(n))of UVHEDG increase but to a lesser extent than in HEDG,with an average reduction of16.25%and 14.7%,respectively.UVHEDG primarily experiences microfracture of grains,whereas HEDG undergoes large-scale wear later in the process due to increased grinding forces.The surface roughness(R_(a))characteristics of UVHEDG are superior,with the average value of R_(a)decreasing by 46.5%compared to HEDG as MRV increases.The surface morphology in UVHEDG exhibits enhanced smoothness and a shallower layer of plastic deformation.Grinding chips generated by UVHEDG show a more shear-like shape,with the applied influence of ultrasonic vibration on chip morphology,thereby impacting material removal behaviors.These aforementioned findings contribute to enhanced machining efficiency and product quality ofγ-TiAl alloys after employing ultrasonic vibrations into HEDG.展开更多
To solve the problem of only surface carbonation and realize high-efficiency carbonation of recycled coarse aggregate,the method of carbonated recycled coarse aggregate with nano materials pre-soaking was first put fo...To solve the problem of only surface carbonation and realize high-efficiency carbonation of recycled coarse aggregate,the method of carbonated recycled coarse aggregate with nano materials pre-soaking was first put forward.The carbonation effect of modified recycled coarse aggregate with three different carbonation methods was evaluated,and water absorption,apparent density and crush index of modified recycled coarse aggregate were measured.Combined with XRD,SEM,and MIP microscopic analysis,the high-efficiency carbonation strengthening mechanism of modified recycled coarse aggregate was revealed.The experimental results show that,compared with the non-carbonated recycled coarse aggregate,the physical and microscopic properties of carbonated recycled coarse aggregate are improved.The method of carbonation with nano-SiO_(2) pre-soaking can realize the high-efficiency carbonation of recycled coarse aggregate,for modified recycled coarse aggregate with the method,water absorption is reduced by 23.03%,porosity is reduced by 44.06%,and the average pore diameter is 21.82 nm.The high-efficiency carbonation strengthening mechanism show that the pre-socked nano-SiO_(2) is bound to the hydration product Ca(OH)_(2) of the old mortar with nano-scale C-S-H,which can improve the CO_(2) absorption rate,accelerate the carbonation reaction,generate more stable CaCO_(3) and nano-scale silica gel,and bond to the dense three-dimensional network structure to realize the bidirectional enhancement of nano-materials and pressurized carbonation.It is concluded that the method of carbonation with nano-SiO_(2) pre-soaking is a novel high-efficiency carbonation modification of recycled coarse aggregate.展开更多
Metal halide perovskite solar cells(PSCs)are one of the most promising photovoltaic devices.Over time,many strategies have been adopted to improve PSC efficiency,and the certified efficiency has reached 26.1%.However,...Metal halide perovskite solar cells(PSCs)are one of the most promising photovoltaic devices.Over time,many strategies have been adopted to improve PSC efficiency,and the certified efficiency has reached 26.1%.However,only a few research groups have fabricated PSCs with an efficiency of>25%,indicating that achieving this efficiency remains uncommon.To develop the PSC industry,outstanding talent must be reserved with the latest technologies.Herein,we summarize the recent developments in high-efficiency PSCs(>25%)and highlight their effective strategies in crystal regulation,interface passivation,and component layer structural design.Finally,we propose perspectives based on current research to further enhance the efficiency and promote the commercialization process of PSCs.展开更多
The isolation of circulating tumor cells(CTCs)from complex biological samples is of paramount signifi-cance for advancing cancer diagnosis,prognosis,and treatment.However,the low concentration of CTCs and nonspecific ...The isolation of circulating tumor cells(CTCs)from complex biological samples is of paramount signifi-cance for advancing cancer diagnosis,prognosis,and treatment.However,the low concentration of CTCs and nonspecific adhesion of white blood cells(WBCs)present challenges that hinder the efficiency and purity of captured CTCs.Microfluidic-based strategies utilize precise fluid control at the micron level to incorporate specific micro/nanostructures or recognition molecules,enabling effective CTCs separation.Moreover,by employing surface modification designs that exhibit exceptional anti-adhesion properties against WBCs,the purity of isolated CTCs can be further enhanced.This review offers an in-depth explo-ration of recent advancements,challenges,and opportunities associated with microfluidic-based CTCs iso-lation from biological samples.Firstly,we will comprehensively introduce the microfluidic-based strate-gies for achieving high-efficiency CTCs isolation,which includes the morphological design of microchan-nels for physical force-based CTCs isolation and the specific modification of microchannel surfaces for affinity-based CTCs isolation.Subsequently,a review of recent research advances in microfluidic-based high-purity CTCs isolation is presented,focusing on strategies that decrease the nonspecific adhesion of WBCs through surface micro-/nanostructure construction or chemical and biological modification.Finally,we will summarize the article by providing the prospective opportunities and challenges for the future development of microfluidic-based CTCs isolation.展开更多
The preparation of Pd-based catalysts with rich electrons and a high atom dispersion rate is of great significance for improving the reactivity of cross-coupling reactions,which is a powerful tool for pharmaceutical a...The preparation of Pd-based catalysts with rich electrons and a high atom dispersion rate is of great significance for improving the reactivity of cross-coupling reactions,which is a powerful tool for pharmaceutical and fine chemical synthesis.Here,we report a PdNi single-atom alloy(SAA)catalyst in which isolated Pd single atoms are anchored onto the surface of Ni nanoparticles(NPs)applied for Suzuki coupling reactions and Heck coupling reactions.The 0.1%PdNi SAA exhibits extraordinary catalytic activity(reaction rate:17,032.25 mmol h^(-1)gPd^(-1))toward the Suzuki cross-coupling reaction between 4-bromoanisole and phenylboronic acid at 80℃for 1 h.The excellent activity is supposed to attribute to the 100 percent utilization rate of Pd atoms and the highly stable surface zero-valance Pd atoms,which provides abundant sites and electrons for the adsorption and fracture of the C-X(X=Cl,Br,I)bond.Moreover,our work demonstrates the excellent application prospect of SAAs for cross-coupling reactions.展开更多
The high-efficiency planting mode for five crops a year of fresh edible ＂faba bean/spring maize＋soybean-autumn maize/autumn soybean＂ was introduced, and its yield and economic benefits were compared with the planti...The high-efficiency planting mode for five crops a year of fresh edible ＂faba bean/spring maize＋soybean-autumn maize/autumn soybean＂ was introduced, and its yield and economic benefits were compared with the planting mode of three crops a year of ＂faba bean-spring maize/red bean＂. The results showed that the planting method for fresh edible ＂faba bean/spring maize＋soybean-autumn maize/autumn soybean＂ was much easier to operate with the input-output ratio of about185.6%, and its yield and economic benefits were 2.09 and 1.83 times of that of the planting mode for three crops a year, significantly improving the agricultural yield and income of farmers. In addition, the cropping index of the planting mode for fresh edible fresh edible ＂faba bean/spring maize ＋soybean-autumn maize/autumn soybean＂ reached up to 350%, and planting faba bean once a year and soybean twice a year could make the biological fixation amount of nitrogen increase 350-450kg/m^2, which equaled to up to 700 kg/m^2 of urea, showing significant ecological and social benefits. Based on the comparison results, the high-yield culture techniques of the planting mode of fresh edible ＂faba bean/spring maize＋soybean-autumn maize/autumn soybean＂ were summarized.展开更多
The high-efficiency video coder(HEVC)is one of the most advanced techniques used in growing real-time multimedia applications today.However,they require large bandwidth for transmission through bandwidth,and bandwidth...The high-efficiency video coder(HEVC)is one of the most advanced techniques used in growing real-time multimedia applications today.However,they require large bandwidth for transmission through bandwidth,and bandwidth varies with different video sequences/formats.This paper proposes an adaptive information-based variable quantization matrix(AIVQM)developed for different video formats having variable energy levels.The quantization method is adapted based on video sequence using statistical analysis,improving bit budget,quality and complexity reduction.Further,to have precise control over bit rate and quality,a multi-constraint prune algorithm is proposed in the second stage of the AI-VQM technique for pre-calculating K numbers of paths.The same should be handy to selfadapt and choose one of the K-path automatically in dynamically changing bandwidth availability as per requirement after extensive testing of the proposed algorithm in the multi-constraint environment for multiple paths and evaluating the performance based on peak signal to noise ratio(PSNR),bit-budget and time complexity for different videos a noticeable improvement in rate-distortion(RD)performance is achieved.Using the proposed AIVQM technique,more feasible and efficient video sequences are achieved with less loss in PSNR than the variable quantization method(VQM)algorithm with approximately a rise of 10%–20%based on different video sequences/formats.展开更多
New and perhaps unexpected progress in rate-independent elastoplastic modeling is reported with a unified approach toward simulating widely ranging non-elastic effects of various advanced engineering materials such as...New and perhaps unexpected progress in rate-independent elastoplastic modeling is reported with a unified approach toward simulating widely ranging non-elastic effects of various advanced engineering materials such as metals,shape memory alloys,granular materials,fiber-reinforced composites,as well as crystalline solids,etc.This progress originates from a simple idea of bypassing inherent limitations of usual elastoplastic formulations centered on the notion of yielding.With no reference to any yield criteria,the plastic strain-rate should be induced at all stress levels in a more realistic sense that it is small for stresses within a classical yield surface and becomes appreciable for stresses close to and on this surface.A new and unified flow rule for the plastic strain-rate is then proposed of the same smooth form for all cases of both the stress level and the stress rate.Without imposing the ad hoc simplified conditions introduced in usual Prandtl-Reuss equations,new elastoplastic equations are then established by incorporating such small deviations from realistic behaviors as neglected just by postulating these conditions.It turns out that the new equations are not only essentially simpler in both conceptual and structural formulations,but can automatically as inherent response features incorporate significant effects excluded from usual Prandtl-Reuss equations,such as the yielding and unloading behaviors with smooth transitions,the pseudo-elastic effect with hysteresis loops,the non-elastic recovery during unloading as well as failure effects under either monotone or cyclic loading conditions,etc.Since such effects not only go beyond the scope of usual elastoplastic equations but can be only partially simulated even if augmented constitutive equations are postulated toward further characterizing damaging and fracturing effects resulting from evolving micro-defects and macro-cracks,it may be probably surprising that now the new equations of essentially simpler structure not only can in a unified manner simulate all these effects but also can bypass numerical complexities in integrating various rate constitutive equations of complex structures.New results in treating long-standing issues in a few respects are presented,including(i)the yielding and the unloading behaviors with smooth transitions,(ii)the non-elastic recovery during unloading,(iii)the pseudo-elastic effect as extraordinary Bauschinger effect,(iv)failure effects under monotone and cyclic loading,(v)anisotropic multi-mode failure effects of unidirectional composites,(vi)new formulation of crystal elastoplasticity without involving non-uniqueness and singularity issues,(vii)non-normality effects for non-proportional multi-axial loading cases,and(viii)high efficiency algorithms for simulating multi-axial fatigue effects.展开更多
On-chip devices for generating pre-designed vectorial optical fields(VOFs)under surface wave(SW)excitations are highly desired in integrated photonics.However,conventional devices are usually of large footprints,low e...On-chip devices for generating pre-designed vectorial optical fields(VOFs)under surface wave(SW)excitations are highly desired in integrated photonics.However,conventional devices are usually of large footprints,low efficiencies,and limited wave-control capabilities.Here,we present a generic approach to design ultra-compact on-chip devices that can efficiently generate pre-designed VOFs under SW excitations,and experimentally verify the concept in terahertz(THz)regime.We first describe how to design SW-excitation metasurfaces for generating circularly polarized complex beams,and experimentally demonstrate two meta-devices to realize directional emission and focusing of THz waves with oppo-site circular polarizations,respectively.We then establish a systematic approach to construct an integrated device via merging two carefully designed metasurfaces,which,under SW excitations,can separately produce pre-designed far-field patterns with different circular polarizations and generate target VOF based on their interference.As a proof of con-cept,we demonstrate experimentally a meta-device that can generate a radially polarized Bessel beam under SW excita-tion at~0.4 THz.Experimental results agree well with full-wave simulations,collectively verifying the performance of our device.Our study paves the road to realizing highly integrated on-chip functional THz devices,which may find many ap-plications in biological sensing,communications,displays,image multiplexing,and beyond.展开更多
Perovskite solar cells (PSCs) exhibit significant development potential in the last decade due to their high efficiency and low manufacturing cost, with power conversion efficiencies (PCE) as high as 26.1 %. However, ...Perovskite solar cells (PSCs) exhibit significant development potential in the last decade due to their high efficiency and low manufacturing cost, with power conversion efficiencies (PCE) as high as 26.1 %. However, several problems still limit PSCs' performance and industrialization, including layer defects, energy level mismatch, and chemical instability. MXenes are a promising class of two-dimensional (2D) transition metal carbides and nitrides with excellent hydrophilicity, the tunable figure of merit, desirable electrical conductivity, abundant surface chemical end groups, and low-temperature solution processability. These properties make MXenes easy to combine with other materials and enrich their composites' physical and chemical properties, making them more useful in PSCs. This review systematically summarizes the relationship and development of PSCs and MXenes. Several strategies for combining MXenes with various layer components in PSCs were introduced. Further, we discussed the advantages of MXenes as the hole-transporting layer, electron-transporting layer, perovskite active layer, and electrodes. Finally, we look forward to future research on MXene-based materials in the field of PSC and the next step of commercialization.展开更多
Notum,a negative feedback regulator of the Wnt signaling,has emerged as a promising target for treating glucocorticoid-induced osteoporosis(GIOP).This study showcases an efficient strategy for discovering the anti-Not...Notum,a negative feedback regulator of the Wnt signaling,has emerged as a promising target for treating glucocorticoid-induced osteoporosis(GIOP).This study showcases an efficient strategy for discovering the anti-Notum constituents from herbal medicines(HMs)as novel anti-GIOP agents.Firstly,a rapid-responding near-infrared fluorogenic substrate for Notum was rationally engineered for high-throughput identifying the anti-Notum HMs.The results showed that Bu-Gu-Zhi(BGZ),a known anti-osteoporosis herb,potently inhibited Notum in a competitive-inhibition manner.To uncover the key anti-Notum constituents in BGZ,an efficient strategy was adapted via integrating biochemical,phytochemical,computational,and pharmacological assays.Among all identified BGZ constituents,three furanocoumarins were validated as strong Notum inhibitors,while 5-methoxypsoralen(5-MP)showed the most potent anti-Notum activity and favorable safety profiles.Mechanistically,5-MP acted as a competitive inhibitor of Notum via creating strong hydrophobic interactions with Trp128 and Phe268 in the catalytic cavity of Notum.Cellular assays showed that 5-MP remarkably promoted osteoblast differentiation and activated Wnt signaling in dexamethasone(DXMS)-challenged MC3T3-E1 osteoblasts.In dexamethasone-induced osteoporotic mice,5-MP strongly elevated bone mineral density(BMD)and improved cancellous and cortical bone thickness.Collectively,this study constructs a high-efficient platform for discovering key anti-Notum constituents from HMs,while 5-MP emerges as a promising antiGIOP agent.展开更多
Rice is a staple food for more than half of the human population.It has been estimated that by 2030,40%more rice needs to be produced in order to meet the growing demand（Khush,2005）.One of the strategies to improve ...Rice is a staple food for more than half of the human population.It has been estimated that by 2030,40%more rice needs to be produced in order to meet the growing demand（Khush,2005）.One of the strategies to improve rice productivity is to enlarge rice growth areas, such as the northward expansion of the growth region in Heilongjiang Province, the northernmost region of China （Li et al., 2015）. However, the northward cultivation is accompanied with daylength extension and temperature decrease, which are unfavor- able for rice, a tropical short-day plant, to complete flowering and seed setting. Thus, the need for early-maturing rice cultivars with extremely low photoperiod sensitivity is urgent.展开更多
We propose a controllable high-efficiency electrostatic surface trap for cold polar molecules on a chip by using two insulator-embedded charged rings and a grounded conductor plate. We calculate Stark energy structure...We propose a controllable high-efficiency electrostatic surface trap for cold polar molecules on a chip by using two insulator-embedded charged rings and a grounded conductor plate. We calculate Stark energy structure pattern of ND3 molecules in an external electric field using the method of matrix diagonalization. We analyze how the voltages that are applied to the ring electrodes affect the depth of the efficient well and the controllability of the distance between the trap center and the surface of the chip. To obtain a better understanding, we simulate the dynamical loading and trapping processes of ND3 molecules in a ｜J, KM = ｜1,-1 state by using classical Monte–Carlo method. Our study shows that the loading efficiency of our trap can reach ～ 88%. Finally, we study the adiabatic cooling of cold molecules in our surface trap by linearly lowering the potential-well depth（i.e., lowering the trapping voltage）, and find that the temperature of the trapped ND3 molecules can be adiabatically cooled from 34.5 m K to ～ 5.8 m K when the trapping voltage is reduced from-35 k V to-3 k V.展开更多
We demonstrate a high-emciency mid-infrared picosecond optical parametric oscillator （OPO） based on MgO doped periodically poled lithium niobate （MgO：PPLN） with a laser diode array （LDA） pumped Innoslab amplifi...We demonstrate a high-emciency mid-infrared picosecond optical parametric oscillator （OPO） based on MgO doped periodically poled lithium niobate （MgO：PPLN） with a laser diode array （LDA） pumped Innoslab amplifier as the pumping source. Under a 16 W synchronously pumping power, 4.5 W of idler light at 2896nm is obtained. A tuning range of idler light from 2688nm to 3016nm is achieved, within which the highest optical-optical conversion ettlciency from pump power to OPO output is 35.1%. Moreover, a signal light of -500mW from 1644 to 1700nm with a repetition rate of 233.8 MHz is generated.展开更多
The clustered regularly interspaced short palindromic repeats(CRISPR)–CRISPR-associated protein(Cas) system has been widely used for genome editing. In this system, the cytosine base editor(CBE) and adenine base edit...The clustered regularly interspaced short palindromic repeats(CRISPR)–CRISPR-associated protein(Cas) system has been widely used for genome editing. In this system, the cytosine base editor(CBE) and adenine base editor(ABE) allow generating precise and irreversible base mutations in a programmable manner and have been used in many different types of cells and organisms. However, their applications are limited by low editing efficiency at certain genomic target sites or at specific target cytosine(C) or adenine(A) residues. Using a strategy of combining optimized synergistic core components, we developed a new multiplex super-assembled ABE(sABE) in rice that showed higher base-editing efficiency than previously developed ABEs. We also designed a new type of nuclear localization signal(NLS) comprising a FLAG epitope tag with four copies of a codon-optimized NLS(F4NLS^(r2)) to generate another ABE named F4NLS-sABE. This new NLS increased editing efficiency or edited additional A at several target sites. A new multiplex super-assembled CBE(sCBE) and F4NLS^(r2) involved F4NLS-sCBE were also created using the same strategy. F4NLS-sCBE was proven to be much more efficient than sCBE in rice. These optimized base editors will serve as powerful genome-editing tools for basic research or molecular breeding in rice and will provide a reference for the development of superior editing tools for other plants or animals.展开更多
In this paper,the structure and characteristics of the NS high-efficiency composite trays based on the doublelayer aperture jet sieve plate and compositely structured packing were investigated.The effect of aperture a...In this paper,the structure and characteristics of the NS high-efficiency composite trays based on the doublelayer aperture jet sieve plate and compositely structured packing were investigated.The effect of aperture and opening ratio of plate on the fluid dynamics of the NS high-efficiency composite trays,such as the dry tray pressure drop,the wet tray pressure drop,the entrainment,the froth height,the leakage and mass transfer characteristics,were investigated.As a result, the low pressure drop,the high efficiency and the high capacity are the main advantages of the NS high-efficiency composite trays compared to other types of trays.According to this study,small aperture is useful for reducing the pressure drop and entrainment with a high mass transfer efficiency;while large aperture can achieve high capacity and efficiency in a broader operating range at the same pressure drop and entrainment.展开更多
A new thermal model with triangular heat flux distribution is given in high-efficiency deep grinding. The mathematical expressions are driven to calculate the surface temperature. The transient behavior of the maximum...A new thermal model with triangular heat flux distribution is given in high-efficiency deep grinding. The mathematical expressions are driven to calculate the surface temperature. The transient behavior of the maximum temperature on contact area is investigated in different grinding conditions with a J-type thermocouple. The maximum contact temperatures measured in different conditions are found to be between 1 000 ℃ and 1 500 ℃ in burn-out conditions. The experiment results show good agreement with the new thermal model.展开更多
基金supported from the Natural Science Foundation Project of Shanghai(Nos.23ZR1425300 and 22ZR1426100)Experimental Technical Team Construction Project of Shanghai Education Commission(No.10110N230080)+1 种基金National Natural Science Foundation of China(No.22075183)Research and Innovation Project of Shanghai Municipal Education Commission(No.2023ZKZD54).
文摘The addition of cold flow improvers(CFIs)is considered as the optimum strategy to improve the cold flow properties(CFPs)of diesel fuels,but this strategy is always limited by the required large dosage.To obtain low-dosage and high-efficiency CFIs for diesel,1,2,3,6-tetrahydrophthalic anhydride(THPA)was introduced as a third and polar monomer to enhance the depressive effects of alkyl methacrylatetrans anethole copolymers(C_(14)MC-TA).The terpolymers of alkyl methacrylate-trans anethole-1,2,3,6-tetrahydrophthalic anhydride(C_(14)MC-TA-THPA)were synthesized and compared with the binary copolymers of C_(14)MC-TA and alkyl methacrylate-1,2,3,6-tetrahydrophthalic anhydride(C_(14)MC-THPA).Results showed that C_(14)MC-THPA achieved the best depressive effects on the cold filter plugging point(CFPP)and solid point(SP)by 11℃and 16℃at a dosage of 1250 mg/L and monomer ratio of 6:1,while 1500mg/L C_(14)MC-TA(1:1)reached the optimal depressive effects on the CFPP and SP by 12℃and 18℃.THPA introduction significantly improved the depressive effects of C_(14)MC-TA.Lower dosages of C_(14)MCTA-THPA in diesel exerted better improvement effects on the CFPP and SP than that of C_(14)MC-TA and C_(14)MC-THPA.When the monomer ratio and dosage were 6:0.6:0.4 and 1000 mg/L,the improvement effect of C_(14)MC-TA-THPA on diesel reached the optimum level,and the CFPP and SP were reduced by 13℃and 19℃,respectively.A 3D nonlinear surface diagram fitted by a mathematical model was also used for the first time to better understand the relationships of monomer ratios,dosages,and depressive effects of CFIs in diesel.Surface analysis results showed that C_(14)MC-TA-THPA achieved the optimum depressive effects at a monomer ratio of 6:0.66:0.34 and dosage of 1000 mg/L,and the CFPP and SP decreased by 14℃ and 19℃,respectively.The predicted results were consistent with the actual ones.Additionally,the improvement mechanism of these copolymers in diesel was also explored.
基金supported by the National Key R&D Program of China(2020YFB2009002).
文摘Graphene,owing to its exceptional electronic,optical,thermal,and mechanical properties,has emerged as a highly promising material.Currently,the synthesis of large-area graphene films on metal substrates via chemical vapor deposition remains the predominant approach for producing high-quality graphene.To realize the potential applications of graphene,it is essential to transfer graphene films to target substrates in a manner that is non-destructive,clean,and efficient,as this significantly affects the performance of graphene devices.This review examines the current methods for graphene transfer from three perspectives:non-destructive transfer,clean transfer,and high-efficiency transfer.It analyzes and compares the advancements and limitations of various transfer techniques.Finally,the review identifies the key challenges faced by current graphene transfer methods and anticipates future developmental prospects.
文摘Through literature analysis and case study, the introduction history, variety selection (high bush, half high bush, low bush) and regional cultivation techniques of blueberry in China were summarized, and the practical effects of precision cultivation (water and fertilizer integration, wild planting) and under-forest economic model (forest-blueberry-fungus system, ecological tourism) were evaluated. It provided a technical reference for expanding the planting scale of blueberry and improving the fruit quality.
基金financially supported by the National Natural Science Foundation of China(Nos.92160301,92060203,52175415 and 52205475)the Science Center for Gas Turbine Project(Nos.P2022-AB-Ⅳ-002-001 and P2023-B-Ⅳ-003-001)+4 种基金the Natural Science Foundation of Jiangsu Province(No.BK20210295)the Superior Postdoctoral Project of Jiangsu Province(No.2022ZB215)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_0355)the Interdisciplinary Innovation Fund for Doctoral Students of Nanjing University of Aeronautics and Astronautics(KXKCXJJ202305)the Fundamental Research Funds for the Central Universities(Nos.NS2023028 and NG2024015)。
文摘Gamma titanium-aluminum intermetallic compounds(γ-TiAl)have gained considerable attentions in the aerospace industry due to their exceptional thermal resilience and comprehensive attributes,making them a prime example of lightweight and advanced materials.To address the frequent occurrence of burns and severe tool deterioration during the process of high-efficiency deep grinding(HEDG)onγ-TiAl alloys,ultrasonic vibration-assisted high-efficiency deep grinding(UVHEDG)has been emerged.Results indicate that in UVHEDG,the grinding temperature is on average 15.4%lower than HEDG due to the employment of ultrasonic vibrations,enhancing coolant penetration into the grinding area and thus reducing heat generation.Besides,UVHEDG possesses superior performance in terms of grinding forces compared to HEDG.As the material removal volume(MRV)increases,the tangential grinding force(F_(t))and normal grinding force(F_(n))of UVHEDG increase but to a lesser extent than in HEDG,with an average reduction of16.25%and 14.7%,respectively.UVHEDG primarily experiences microfracture of grains,whereas HEDG undergoes large-scale wear later in the process due to increased grinding forces.The surface roughness(R_(a))characteristics of UVHEDG are superior,with the average value of R_(a)decreasing by 46.5%compared to HEDG as MRV increases.The surface morphology in UVHEDG exhibits enhanced smoothness and a shallower layer of plastic deformation.Grinding chips generated by UVHEDG show a more shear-like shape,with the applied influence of ultrasonic vibration on chip morphology,thereby impacting material removal behaviors.These aforementioned findings contribute to enhanced machining efficiency and product quality ofγ-TiAl alloys after employing ultrasonic vibrations into HEDG.
基金Funded by Joint Funds of the National Natural Science Foundation of China(No.U1904188)the Jiangxi Provincial Department of Education Science and Technology Project(Nos.GJJ171079,GJJ181023,and GJJ181022)。
文摘To solve the problem of only surface carbonation and realize high-efficiency carbonation of recycled coarse aggregate,the method of carbonated recycled coarse aggregate with nano materials pre-soaking was first put forward.The carbonation effect of modified recycled coarse aggregate with three different carbonation methods was evaluated,and water absorption,apparent density and crush index of modified recycled coarse aggregate were measured.Combined with XRD,SEM,and MIP microscopic analysis,the high-efficiency carbonation strengthening mechanism of modified recycled coarse aggregate was revealed.The experimental results show that,compared with the non-carbonated recycled coarse aggregate,the physical and microscopic properties of carbonated recycled coarse aggregate are improved.The method of carbonation with nano-SiO_(2) pre-soaking can realize the high-efficiency carbonation of recycled coarse aggregate,for modified recycled coarse aggregate with the method,water absorption is reduced by 23.03%,porosity is reduced by 44.06%,and the average pore diameter is 21.82 nm.The high-efficiency carbonation strengthening mechanism show that the pre-socked nano-SiO_(2) is bound to the hydration product Ca(OH)_(2) of the old mortar with nano-scale C-S-H,which can improve the CO_(2) absorption rate,accelerate the carbonation reaction,generate more stable CaCO_(3) and nano-scale silica gel,and bond to the dense three-dimensional network structure to realize the bidirectional enhancement of nano-materials and pressurized carbonation.It is concluded that the method of carbonation with nano-SiO_(2) pre-soaking is a novel high-efficiency carbonation modification of recycled coarse aggregate.
基金support from the National Natural Science Foundation of China(Grant Nos.52025028,52332008,52372214,and U22A20137)the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.
文摘Metal halide perovskite solar cells(PSCs)are one of the most promising photovoltaic devices.Over time,many strategies have been adopted to improve PSC efficiency,and the certified efficiency has reached 26.1%.However,only a few research groups have fabricated PSCs with an efficiency of>25%,indicating that achieving this efficiency remains uncommon.To develop the PSC industry,outstanding talent must be reserved with the latest technologies.Herein,we summarize the recent developments in high-efficiency PSCs(>25%)and highlight their effective strategies in crystal regulation,interface passivation,and component layer structural design.Finally,we propose perspectives based on current research to further enhance the efficiency and promote the commercialization process of PSCs.
基金supported by the National Natural Science Foundation of China(Nos.52025132,22005255,21975209,21621091,22021001,T2241022)the National Science Foundation of Fujian Province of China(No.2022J02059)+2 种基金the Fundamental Research Funds for the Central Universities of China(No.20720220085)the 111 Project(Nos.B17027,B16029)the Science and Technology Projects of Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(No.RD2022070601),the New Cornerstone Science Foundation through the XPLORER PRIZE.
文摘The isolation of circulating tumor cells(CTCs)from complex biological samples is of paramount signifi-cance for advancing cancer diagnosis,prognosis,and treatment.However,the low concentration of CTCs and nonspecific adhesion of white blood cells(WBCs)present challenges that hinder the efficiency and purity of captured CTCs.Microfluidic-based strategies utilize precise fluid control at the micron level to incorporate specific micro/nanostructures or recognition molecules,enabling effective CTCs separation.Moreover,by employing surface modification designs that exhibit exceptional anti-adhesion properties against WBCs,the purity of isolated CTCs can be further enhanced.This review offers an in-depth explo-ration of recent advancements,challenges,and opportunities associated with microfluidic-based CTCs iso-lation from biological samples.Firstly,we will comprehensively introduce the microfluidic-based strate-gies for achieving high-efficiency CTCs isolation,which includes the morphological design of microchan-nels for physical force-based CTCs isolation and the specific modification of microchannel surfaces for affinity-based CTCs isolation.Subsequently,a review of recent research advances in microfluidic-based high-purity CTCs isolation is presented,focusing on strategies that decrease the nonspecific adhesion of WBCs through surface micro-/nanostructure construction or chemical and biological modification.Finally,we will summarize the article by providing the prospective opportunities and challenges for the future development of microfluidic-based CTCs isolation.
基金supported by the financial aid from National Science and Technology Major Project of China(No.2021YFB3500700)National Natural Science Foundation of China(Nos.22020102003,22025506 and 22271274)Program of Science and Technology Development Plan of Jilin Province of China(Nos.20230101035JC and 20230101022JC)。
文摘The preparation of Pd-based catalysts with rich electrons and a high atom dispersion rate is of great significance for improving the reactivity of cross-coupling reactions,which is a powerful tool for pharmaceutical and fine chemical synthesis.Here,we report a PdNi single-atom alloy(SAA)catalyst in which isolated Pd single atoms are anchored onto the surface of Ni nanoparticles(NPs)applied for Suzuki coupling reactions and Heck coupling reactions.The 0.1%PdNi SAA exhibits extraordinary catalytic activity(reaction rate:17,032.25 mmol h^(-1)gPd^(-1))toward the Suzuki cross-coupling reaction between 4-bromoanisole and phenylboronic acid at 80℃for 1 h.The excellent activity is supposed to attribute to the 100 percent utilization rate of Pd atoms and the highly stable surface zero-valance Pd atoms,which provides abundant sites and electrons for the adsorption and fracture of the C-X(X=Cl,Br,I)bond.Moreover,our work demonstrates the excellent application prospect of SAAs for cross-coupling reactions.
基金Supported by the China Agriculture Research System(CARS-09)the Technological Innovation and Industrialization Project for the Rural Area of Nantong City,Jiangsu Province(H12014012)~~
文摘The high-efficiency planting mode for five crops a year of fresh edible ＂faba bean/spring maize＋soybean-autumn maize/autumn soybean＂ was introduced, and its yield and economic benefits were compared with the planting mode of three crops a year of ＂faba bean-spring maize/red bean＂. The results showed that the planting method for fresh edible ＂faba bean/spring maize＋soybean-autumn maize/autumn soybean＂ was much easier to operate with the input-output ratio of about185.6%, and its yield and economic benefits were 2.09 and 1.83 times of that of the planting mode for three crops a year, significantly improving the agricultural yield and income of farmers. In addition, the cropping index of the planting mode for fresh edible fresh edible ＂faba bean/spring maize ＋soybean-autumn maize/autumn soybean＂ reached up to 350%, and planting faba bean once a year and soybean twice a year could make the biological fixation amount of nitrogen increase 350-450kg/m^2, which equaled to up to 700 kg/m^2 of urea, showing significant ecological and social benefits. Based on the comparison results, the high-yield culture techniques of the planting mode of fresh edible ＂faba bean/spring maize＋soybean-autumn maize/autumn soybean＂ were summarized.
文摘The high-efficiency video coder(HEVC)is one of the most advanced techniques used in growing real-time multimedia applications today.However,they require large bandwidth for transmission through bandwidth,and bandwidth varies with different video sequences/formats.This paper proposes an adaptive information-based variable quantization matrix(AIVQM)developed for different video formats having variable energy levels.The quantization method is adapted based on video sequence using statistical analysis,improving bit budget,quality and complexity reduction.Further,to have precise control over bit rate and quality,a multi-constraint prune algorithm is proposed in the second stage of the AI-VQM technique for pre-calculating K numbers of paths.The same should be handy to selfadapt and choose one of the K-path automatically in dynamically changing bandwidth availability as per requirement after extensive testing of the proposed algorithm in the multi-constraint environment for multiple paths and evaluating the performance based on peak signal to noise ratio(PSNR),bit-budget and time complexity for different videos a noticeable improvement in rate-distortion(RD)performance is achieved.Using the proposed AIVQM technique,more feasible and efficient video sequences are achieved with less loss in PSNR than the variable quantization method(VQM)algorithm with approximately a rise of 10%–20%based on different video sequences/formats.
基金the German Science Foundation(DFG)for supportFuyao University of Science and Technology of Fujian,China+1 种基金supported by the National Natural Science Foundation of China(Grant Nos.12172149 and 12172151)the Ministry of Science and Technology of China(Grant No.G20221990122)。
文摘New and perhaps unexpected progress in rate-independent elastoplastic modeling is reported with a unified approach toward simulating widely ranging non-elastic effects of various advanced engineering materials such as metals,shape memory alloys,granular materials,fiber-reinforced composites,as well as crystalline solids,etc.This progress originates from a simple idea of bypassing inherent limitations of usual elastoplastic formulations centered on the notion of yielding.With no reference to any yield criteria,the plastic strain-rate should be induced at all stress levels in a more realistic sense that it is small for stresses within a classical yield surface and becomes appreciable for stresses close to and on this surface.A new and unified flow rule for the plastic strain-rate is then proposed of the same smooth form for all cases of both the stress level and the stress rate.Without imposing the ad hoc simplified conditions introduced in usual Prandtl-Reuss equations,new elastoplastic equations are then established by incorporating such small deviations from realistic behaviors as neglected just by postulating these conditions.It turns out that the new equations are not only essentially simpler in both conceptual and structural formulations,but can automatically as inherent response features incorporate significant effects excluded from usual Prandtl-Reuss equations,such as the yielding and unloading behaviors with smooth transitions,the pseudo-elastic effect with hysteresis loops,the non-elastic recovery during unloading as well as failure effects under either monotone or cyclic loading conditions,etc.Since such effects not only go beyond the scope of usual elastoplastic equations but can be only partially simulated even if augmented constitutive equations are postulated toward further characterizing damaging and fracturing effects resulting from evolving micro-defects and macro-cracks,it may be probably surprising that now the new equations of essentially simpler structure not only can in a unified manner simulate all these effects but also can bypass numerical complexities in integrating various rate constitutive equations of complex structures.New results in treating long-standing issues in a few respects are presented,including(i)the yielding and the unloading behaviors with smooth transitions,(ii)the non-elastic recovery during unloading,(iii)the pseudo-elastic effect as extraordinary Bauschinger effect,(iv)failure effects under monotone and cyclic loading,(v)anisotropic multi-mode failure effects of unidirectional composites,(vi)new formulation of crystal elastoplasticity without involving non-uniqueness and singularity issues,(vii)non-normality effects for non-proportional multi-axial loading cases,and(viii)high efficiency algorithms for simulating multi-axial fatigue effects.
基金the financial support from National Natural Science Foundation of China (Nos. 62192771, 12374344, 12221004)National Key Research and Development Program of China (2022YFA1204700, 2020YFA0710100)+1 种基金Natural Science Foundation of Shanghai (Grant No. 23dz2260100)China Postdoctoral Science Foundation 2021TQ0077
文摘On-chip devices for generating pre-designed vectorial optical fields(VOFs)under surface wave(SW)excitations are highly desired in integrated photonics.However,conventional devices are usually of large footprints,low efficiencies,and limited wave-control capabilities.Here,we present a generic approach to design ultra-compact on-chip devices that can efficiently generate pre-designed VOFs under SW excitations,and experimentally verify the concept in terahertz(THz)regime.We first describe how to design SW-excitation metasurfaces for generating circularly polarized complex beams,and experimentally demonstrate two meta-devices to realize directional emission and focusing of THz waves with oppo-site circular polarizations,respectively.We then establish a systematic approach to construct an integrated device via merging two carefully designed metasurfaces,which,under SW excitations,can separately produce pre-designed far-field patterns with different circular polarizations and generate target VOF based on their interference.As a proof of con-cept,we demonstrate experimentally a meta-device that can generate a radially polarized Bessel beam under SW excita-tion at~0.4 THz.Experimental results agree well with full-wave simulations,collectively verifying the performance of our device.Our study paves the road to realizing highly integrated on-chip functional THz devices,which may find many ap-plications in biological sensing,communications,displays,image multiplexing,and beyond.
基金supported by the National Natural Science Foundation of China(No.11375136).
文摘Perovskite solar cells (PSCs) exhibit significant development potential in the last decade due to their high efficiency and low manufacturing cost, with power conversion efficiencies (PCE) as high as 26.1 %. However, several problems still limit PSCs' performance and industrialization, including layer defects, energy level mismatch, and chemical instability. MXenes are a promising class of two-dimensional (2D) transition metal carbides and nitrides with excellent hydrophilicity, the tunable figure of merit, desirable electrical conductivity, abundant surface chemical end groups, and low-temperature solution processability. These properties make MXenes easy to combine with other materials and enrich their composites' physical and chemical properties, making them more useful in PSCs. This review systematically summarizes the relationship and development of PSCs and MXenes. Several strategies for combining MXenes with various layer components in PSCs were introduced. Further, we discussed the advantages of MXenes as the hole-transporting layer, electron-transporting layer, perovskite active layer, and electrodes. Finally, we look forward to future research on MXene-based materials in the field of PSC and the next step of commercialization.
基金supported by the National Natural Science Foundation of China(82273897,U23A20516,82104281,and 32101202)Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine(2023YZZ02,China)+5 种基金Shanghai Municipal Health Commission’s TCM research project(2022CX005,China)Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTDD-202004,China)Three-year Action Plan for Shanghai TCM Development and Inheritance Program(ZY(2021-2023)-0401,China)the Fundamental Research Funds for the Central Universities(G2024KY05106,China)the State Key Laboratory of Fine Chemicals,Dalian University of Technology(KF2202,China)supported by China Postdoctoral Science Foundation(2024M762108,China).
文摘Notum,a negative feedback regulator of the Wnt signaling,has emerged as a promising target for treating glucocorticoid-induced osteoporosis(GIOP).This study showcases an efficient strategy for discovering the anti-Notum constituents from herbal medicines(HMs)as novel anti-GIOP agents.Firstly,a rapid-responding near-infrared fluorogenic substrate for Notum was rationally engineered for high-throughput identifying the anti-Notum HMs.The results showed that Bu-Gu-Zhi(BGZ),a known anti-osteoporosis herb,potently inhibited Notum in a competitive-inhibition manner.To uncover the key anti-Notum constituents in BGZ,an efficient strategy was adapted via integrating biochemical,phytochemical,computational,and pharmacological assays.Among all identified BGZ constituents,three furanocoumarins were validated as strong Notum inhibitors,while 5-methoxypsoralen(5-MP)showed the most potent anti-Notum activity and favorable safety profiles.Mechanistically,5-MP acted as a competitive inhibitor of Notum via creating strong hydrophobic interactions with Trp128 and Phe268 in the catalytic cavity of Notum.Cellular assays showed that 5-MP remarkably promoted osteoblast differentiation and activated Wnt signaling in dexamethasone(DXMS)-challenged MC3T3-E1 osteoblasts.In dexamethasone-induced osteoporotic mice,5-MP strongly elevated bone mineral density(BMD)and improved cancellous and cortical bone thickness.Collectively,this study constructs a high-efficient platform for discovering key anti-Notum constituents from HMs,while 5-MP emerges as a promising antiGIOP agent.
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences (No.XDA08040101)the Hundred Talents Program of Chinese Academy of Sciences to Q.Y. Bu+1 种基金the Natural Science Foundation of Heilongjiang (No.ZD2015005)Excellent Academic Leaders of Harbin (No.RC2014XK002003)
文摘Rice is a staple food for more than half of the human population.It has been estimated that by 2030,40%more rice needs to be produced in order to meet the growing demand（Khush,2005）.One of the strategies to improve rice productivity is to enlarge rice growth areas, such as the northward expansion of the growth region in Heilongjiang Province, the northernmost region of China （Li et al., 2015）. However, the northward cultivation is accompanied with daylength extension and temperature decrease, which are unfavor- able for rice, a tropical short-day plant, to complete flowering and seed setting. Thus, the need for early-maturing rice cultivars with extremely low photoperiod sensitivity is urgent.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.10674047,10804031,10904037,10904060,10974055,11034002,and61205198)the National Key Basic Research and Development Program of China(Grant Nos.2006CB921604 and 2011CB921602)+2 种基金the Basic Key Program of Shanghai Municipality,China(Grant No.07JC14017)the Fundamental Research Funds for the Central Universitiesthe Shanghai Leading Academic Discipline Project,China(Grant No.B408)
文摘We propose a controllable high-efficiency electrostatic surface trap for cold polar molecules on a chip by using two insulator-embedded charged rings and a grounded conductor plate. We calculate Stark energy structure pattern of ND3 molecules in an external electric field using the method of matrix diagonalization. We analyze how the voltages that are applied to the ring electrodes affect the depth of the efficient well and the controllability of the distance between the trap center and the surface of the chip. To obtain a better understanding, we simulate the dynamical loading and trapping processes of ND3 molecules in a ｜J, KM = ｜1,-1 state by using classical Monte–Carlo method. Our study shows that the loading efficiency of our trap can reach ～ 88%. Finally, we study the adiabatic cooling of cold molecules in our surface trap by linearly lowering the potential-well depth（i.e., lowering the trapping voltage）, and find that the temperature of the trapped ND3 molecules can be adiabatically cooled from 34.5 m K to ～ 5.8 m K when the trapping voltage is reduced from-35 k V to-3 k V.
基金Supported by the National Natural Science Foundation of China under Grant Nos 61275142,61308042,and 51321091the National Key Scientific Instrument and Equipment Development Project under Grant No 2011YQ030127the China Postdoctoral Science Foundation under Grant No 2014T70633
文摘We demonstrate a high-emciency mid-infrared picosecond optical parametric oscillator （OPO） based on MgO doped periodically poled lithium niobate （MgO：PPLN） with a laser diode array （LDA） pumped Innoslab amplifier as the pumping source. Under a 16 W synchronously pumping power, 4.5 W of idler light at 2896nm is obtained. A tuning range of idler light from 2688nm to 3016nm is achieved, within which the highest optical-optical conversion ettlciency from pump power to OPO output is 35.1%. Moreover, a signal light of -500mW from 1644 to 1700nm with a repetition rate of 233.8 MHz is generated.
基金supported by the Beijing Scholars Program[BSP041]。
文摘The clustered regularly interspaced short palindromic repeats(CRISPR)–CRISPR-associated protein(Cas) system has been widely used for genome editing. In this system, the cytosine base editor(CBE) and adenine base editor(ABE) allow generating precise and irreversible base mutations in a programmable manner and have been used in many different types of cells and organisms. However, their applications are limited by low editing efficiency at certain genomic target sites or at specific target cytosine(C) or adenine(A) residues. Using a strategy of combining optimized synergistic core components, we developed a new multiplex super-assembled ABE(sABE) in rice that showed higher base-editing efficiency than previously developed ABEs. We also designed a new type of nuclear localization signal(NLS) comprising a FLAG epitope tag with four copies of a codon-optimized NLS(F4NLS^(r2)) to generate another ABE named F4NLS-sABE. This new NLS increased editing efficiency or edited additional A at several target sites. A new multiplex super-assembled CBE(sCBE) and F4NLS^(r2) involved F4NLS-sCBE were also created using the same strategy. F4NLS-sCBE was proven to be much more efficient than sCBE in rice. These optimized base editors will serve as powerful genome-editing tools for basic research or molecular breeding in rice and will provide a reference for the development of superior editing tools for other plants or animals.
基金supported by the Key Project of Chinese National Programs for Fundamental Research and Development(973 Program) (contract number:2005CB221204-5)
文摘In this paper,the structure and characteristics of the NS high-efficiency composite trays based on the doublelayer aperture jet sieve plate and compositely structured packing were investigated.The effect of aperture and opening ratio of plate on the fluid dynamics of the NS high-efficiency composite trays,such as the dry tray pressure drop,the wet tray pressure drop,the entrainment,the froth height,the leakage and mass transfer characteristics,were investigated.As a result, the low pressure drop,the high efficiency and the high capacity are the main advantages of the NS high-efficiency composite trays compared to other types of trays.According to this study,small aperture is useful for reducing the pressure drop and entrainment with a high mass transfer efficiency;while large aperture can achieve high capacity and efficiency in a broader operating range at the same pressure drop and entrainment.
基金This project is supported by National Natural Science Foundation of China (No.50475052)Provincial Natural Science Foundation of Liaoning (No.20022161)Provincial Scientific Research Plan of Education Office of Uaoning(No.202223206).
文摘A new thermal model with triangular heat flux distribution is given in high-efficiency deep grinding. The mathematical expressions are driven to calculate the surface temperature. The transient behavior of the maximum temperature on contact area is investigated in different grinding conditions with a J-type thermocouple. The maximum contact temperatures measured in different conditions are found to be between 1 000 ℃ and 1 500 ℃ in burn-out conditions. The experiment results show good agreement with the new thermal model.
