Osmotic energy,existing between the seawater and river water,is a renewable energy source,which can be directly converted into electricity by ion-exchange membranes(IEM).In traditional IEMs,the ion transport channels ...Osmotic energy,existing between the seawater and river water,is a renewable energy source,which can be directly converted into electricity by ion-exchange membranes(IEM).In traditional IEMs,the ion transport channels are formed by nanophase separation of hydrophilic ion carriers and hydrophobic segments.It is difficult to realize high-density ion channels with controlled spatial arrangement and length scale of ion carriers.Herein,we construct high-density 1D ion wires as transmission channels.Through molecular design,hydrophilic imidazole groups and hydrophobic alkyl tails were introduced into the repeat units,which self-assembled into 1D ion transporting core and protecting shell along the main chains.The areal density of the ionic wire arrays is up to~10^(12)cm^(-2),which is the highest value.The ionic wires ensure both high ion flux transport and high selectivity,achieving an ultrahigh-power density of 40.5 W m^(-2)at a 500-fold salinity gradient.Besides,the ionic wire array membrane is well recyclable and antibacterial.The ionic wires provide novel concept for next generation of high-performance membranes.展开更多
Metal-support interactions and hydrogen spillover effects in heterogeneous catalysts play a crucial role in aromatic hydrogenation reactions;however,these effects are limited by the metal dispersion on the catalyst an...Metal-support interactions and hydrogen spillover effects in heterogeneous catalysts play a crucial role in aromatic hydrogenation reactions;however,these effects are limited by the metal dispersion on the catalyst and the number of acceptable H*receptors.This study prepares highly dispersed Ni nanoparticles(NPs)catalysts on a Beta substrate via precursor structure topology transformation.In contrast to traditional support materials,the coordination and electronic structure changes between the Ni NPs and the support were achieved,further optimizing the active interface sites and enhancing hydrogen activation and hydrogenation performance.Additionally,the-OH groups at the strong acid sites in zeolite effectively intensified the hydrogen spillover effect as receptors for H^(*)migration and anchoring,accelerating the hydrogenation rate of aromatic rings.Under solvent-free conditions,this catalyst was used for the hydrogenation reaction of aromatic-rich oils,directly producing a C_(8)-C_(14)branched cycloalkanes mixture with an aromatic conversion rate of>99%.The cycloalkanes mixture produced by this method features high density(0.92 g/mL)and a low freezing point(<-60℃),making it suitable for use as high-density aviation fuel or as an additive to enhance the volumetric heat value of conventional aviation fuels in practical applications.展开更多
In rotationally extruded fittings,high-density polyethylene(HDPE)pipes prepared using conventional processing methods often suffer from poor pressure resistance and low toughness.This study introduces an innovative ro...In rotationally extruded fittings,high-density polyethylene(HDPE)pipes prepared using conventional processing methods often suffer from poor pressure resistance and low toughness.This study introduces an innovative rotary shear system(RSS)to address these deficiencies through controlled mandrel rotation and cooling rates.We successfully prepared self-reinforced HDPE pipes with a three-layer structure combining spherical and shish-kebab crystals.Rotational processing aligned the molecular chains in the ring direction and formed shish-kebab crystals.As a result,the annular tensile strength of the rotationally processed three-layer shish-kebab structure(TSK)pipe increased from 26.7 MPa to 76.3 MPa,an enhancement of 185.8%.Notably,while maintaining excellent tensile strength(73.4 MPa),the elongation at break of the spherulite shishkebab spherulite(SKS)tubes was improved to 50.1%,as compared to 33.8%in the case of shish-kebab spherulite shish-kebab(KSK)tubes.This improvement can be attributed to the changes in the micro-morphology and polymer structure within the SKS tubes,specifically due to the formation of small-sized shish-kebab crystals and the low degrees of interlocking.In addition,2D-SAXS analysis revealed that KSK tubes have higher tensile strength due to smaller crystal sizes and larger shish dimensions,forming dense interlocking structures.In contrast,the SKS and TSK tubes had thicker amorphous regions and smaller shish sizes,resulting in reduced interlocking and mechanical performance.展开更多
Evaluation of backfilling effectiveness plays a crucial role in the geological environment management and restoration of abandoned open-pit quarries,providing a scientific basis for subsequent greening efforts.Backfil...Evaluation of backfilling effectiveness plays a crucial role in the geological environment management and restoration of abandoned open-pit quarries,providing a scientific basis for subsequent greening efforts.Backfill soil,predominantly composed of silty clay,demonstrates high water retention capacity and elevated moisture content,leading to a pronounced resistivity contrast with the bedrock exposed by quarrying activities.To investigate the distribution of backfill soil subsurface and assess backfilling effectiveness in the study area,this study conducted a comprehensive geophysical investigation utilizing the high-density electrical resistivity tomography(ERT).A total of 19 ERT survey lines were deployed across three distinct areas in Liuyao Village,Huaibei City,Anhui Province,China.The inversion results,derived from both two-dimensional(2D)and three-dimensional(3D),reveal distinct electrical properties of the subsurface materials:the backfill soil layer shows low resistivity features,the fill stone layer exhibits medium to high resistivity,and the bedrock shows the highest resistivity.The 2D inversion results,from the data measured using the Wenner array effectively capture the spatial distribution and structural features of the backfill soil layer.The findings indicate a gradual east-west thinning of the clay layer within the quarry.Furthermore,the northern pit area exhibits a uniform distribution of backfill soil layer,indicative of effective backfilling operations.In contrast,the southern pit area lacks a well-defined clay layer,suggesting suboptimal backfilling effectiveness.展开更多
High-density interconnect(HDI)soft electronics that can integrate multiple individual functions into one miniaturized monolithic system is promising for applications related to smart healthcare,soft robotics,and human...High-density interconnect(HDI)soft electronics that can integrate multiple individual functions into one miniaturized monolithic system is promising for applications related to smart healthcare,soft robotics,and human-machine interactions.However,despite the recent advances,the development of three-dimensional(3D)soft electronics with both high resolution and high integration is still challenging because of the lack of efficient manufacturing methods to guarantee interlayer alignment of the high-density vias and reliable interlayer electrical conductivity.Here,an advanced 3D laser printing pathway,based on femtosecond laser direct writing(FLDW),is demonstrated for preparing liquid metal(LM)-based any layer HDI soft electronics.FLDW technology,with the characteristics of high spatial resolution and high precision,allows the maskless fabrication of high-resolution embedded LM microchannels and high-density vertical interconnect accesses for 3D integrated circuits.High-aspect-ratio blind/through LM microstructures are formed inside the elastomer due to the supermetalphobicity induced during laser ablation.The LM-based HDI circuit featuring high resolution(~1.5μm)and high integration(10-layer electrical interconnection)is achieved for customized soft electronics,including various customized multilayer passive electric components,soft multilayer circuit,and cross-scale multimode sensors.The 3D laser printing method provides a versatile approach for developing chip-level soft electronics.展开更多
Dislocation strengthening,as one of the methods to simultaneously enhance the room temperature strength and ductility of alloys,does not achieve the desired strengthening and plasticity effect during elevated-temperat...Dislocation strengthening,as one of the methods to simultaneously enhance the room temperature strength and ductility of alloys,does not achieve the desired strengthening and plasticity effect during elevated-temperature deformation.Here,we report a novel strategy to boost the dislocation multiplication and accumulation during deformation at elevated temperatures through dynamic strain aging(DSA).With the introduction of the rare-earth element Ho in Mg-Y-Zn alloy,Ho atoms diffuse toward dislocations during deformation at elevated temperatures,provoking the DSA effect,which increases the dislocation density significantly via the interactions of mobile dislocations and Ho atoms.The resulting alloy achieves a great enhancement of dislocation hardening and obtains the dual benefits of high strength and good ductility simultaneously at high homologous temperatures.The present work provides an effective strategy to enhancing the strength and ductility for elevated-temperature materials.展开更多
In the context of rapid urbanization,high-density construction areas face significant challenges,including the reduction of ecological spaces and the deterioration of their functions.Planning and managing ecological s...In the context of rapid urbanization,high-density construction areas face significant challenges,including the reduction of ecological spaces and the deterioration of their functions.Planning and managing ecological spaces have emerged as essential strategies to address the conflict between urban development and ecological conservation.Using Jinjiang City,Fujian Province as the case study,this paper systematically examines the significance and primary challenges of ecological space planning in highdensity construction areas.It also identifies prevailing issues within the current research domain,including“an overemphasis on top-level design at the expense of implementation,a focus on isolated aspects rather than systemic integration,and prioritization of control over coordination”.This study proposes the key aspects of ecological space planning and management in high-density construction areas,focusing on three fundamental dimensions:human-centered demand orientation,the integration of top-down and bottomup linkage mechanisms,and a differentiated control system.Drawing on the full-element assessment of the ecosystem,ecological network construction,and full-process control system implemented in Jinjiang City,an integrated approach to ecological space governance,encompassing assessment,planning,and control,has been developed.This approach offers both theoretical insights and practical guidance for optimizing ecological spaces in comparable urban contexts.展开更多
BACKGROUND The association between the uric acid-to-high-density lipoprotein cholesterol ratio(UHR)and mental health among individuals with type 2 diabetes mellitus(T2DM)has not been thoroughly investigated.AIM To exa...BACKGROUND The association between the uric acid-to-high-density lipoprotein cholesterol ratio(UHR)and mental health among individuals with type 2 diabetes mellitus(T2DM)has not been thoroughly investigated.AIM To examine the link between UHR and symptoms of depression and anxiety in patients with T2DM.METHODS A cross-sectional analysis was carried out from March 2023 to April 2024,involving participants diagnosed with T2DM.Data on sociodemographic characteristics,clinical parameters,and UHR values were systematically gathered.The Self-Rating Depression Scale(SDS)and Self-Rating Anxiety Scale(SAS)were utilized to evaluate depressive and anxiety symptoms,respectively.To assess the relationships between UHR and SDS/SAS scores,linear regression models were employed,incorporating adjustments for potential confounding variables.Additionally,smooth curve fitting and threshold effect analyses were conducted to explore potential nonlinear relationships.RESULTS A total of 285 patients with T2DM were included.Initial univariate analysis demonstrated a significant positive correlation between elevated UHR levels and higher SDS and SAS scores.Multivariate regression analysis revealed that a one-unit rise in UHR was associated with a 1.13-point increase in SDS scores(95%CI:0.69-1.58)and a 0.57-point increase in SAS scores(95%CI:0.20-0.93).After controlling for confounders,UHR remained positively correlated with SDS(β=1.55,95%CI:0.57-2.53)and SAS(β=0.72,95%CI:0.35-1.09).Nonlinear analysis identified critical thresholds at UHR values of 5.02 for SDS and 4.00 for SAS,beyond which the relationships between UHR and psychological symptom scores became markedly stronger(P<0.05).CONCLUSION Higher UHR levels are significantly linked to exacerbated depressive and anxiety symptoms in patients with T2DM.These results indicate that UHR may function as a promising biomarker to identify individuals at greater risk of mental health complications within this population.展开更多
Rapeseed mustard(Brassica juncea L.) is the third most important oilseed crop in the world, but the geneticmechanism underlying its massive phenotypic variation remains largely unexplored. In this study, specific leng...Rapeseed mustard(Brassica juncea L.) is the third most important oilseed crop in the world, but the geneticmechanism underlying its massive phenotypic variation remains largely unexplored. In this study, specific length amplified fragment sequencing(SLAF-Seq) was used to resequence a population comprising 197 F8recombinantinbred lines(RILs) derived from a cross between vegetable-type Qichi881 and oilseed-type YufengZC of B. juncea. In total, 438,895 high-quality SLAFs were discovered, 47,644 of which were polymorphic, and 3,887 of the polymorphic markers met the requirements for genetic map construction. The final map included 3,887 markers on 18 linkage groups and was 1,830.23 centiMorgan(cM) in length, with an average distance of 0.47 cM between adjacent markers. Using the newly constructed high-density genetic map, a total of 53 QTLs for erucicacid(EA), oleic acid(OA), and linolenic acid(LNA) were detected and integrated into eight consensus QTLswith two for each of these traits. For each of these three traits, two candidate genes were cloned and sequence analysis indicated colocalization with their respective consensus QTLs. The co-dominant allele-specific markers for Bju.FAD3.A03 and Bju.FAD3.B07 were developed and showed co-localization with their consensus QTLs andco-segregation with LNA content, further supporting the results of QTL mapping and bioinformatic analysis. Theexpression levels of the cloned homologous genes were also determined, and the genes were tightly correlatedwith the EA, OA and LNA contents of different lines. The results of this study will facilitate the improvement offatty acid traits and molecular breeding of B. juncea. Further uses of the high-density genetic map created in this study are also discussed.展开更多
Stroke survivors often face significant challenges when performing daily self-care activities due to upper limb motor impairments.Traditional surface electromyography(sEMG)analysis typically focuses on isolated hand p...Stroke survivors often face significant challenges when performing daily self-care activities due to upper limb motor impairments.Traditional surface electromyography(sEMG)analysis typically focuses on isolated hand postures,overlooking the complexity of object-interactive behaviors that are crucial for promoting patient independence.This study introduces a novel framework that combines high-density sEMG(HD-sEMG)signals with an improved Whale Optimization Algorithm(IWOA)-optimized Long Short-Term Memory(LSTM)network to address this limitation.The key contributions of this work include:(1)the creation of a specialized HD-sEMG dataset that captures nine continuous self-care behaviors,along with time and posture markers,to better reflect real-world patient interactions;(2)the development of a multi-channel feature fusion module based on Pascal’s theorem,which enables efficient signal segmentation and spatial–temporal feature extraction;and(3)the enhancement of the IWOA algorithm,which integrates optimal point set initialization,a diversity-driven pooling mechanism,and cosine-based differential evolution to optimize LSTM hyperparameters,thereby improving convergence and global search capabilities.Experimental results demonstrate superior performance,achieving 99.58%accuracy in self-care behavior recognition and 86.19%accuracy for 17 continuous gestures on the Ninapro db2 benchmark.The framework operates with low latency,meeting the real-time requirements for assistive devices.By enabling precise,context-aware recognition of daily activities,this work advances personalized rehabilitation technologies,empowering stroke patients to regain autonomy in self-care tasks.The proposed methodology offers a robust,scalable solution for clinical applications,bridging the gap between laboratory-based gesture recognition and practical,patient-centered care.展开更多
Lightweight nodes are crucial for blockchain scalability,but verifying the availability of complete block data puts significant strain on bandwidth and latency.Existing data availability sampling(DAS)schemes either re...Lightweight nodes are crucial for blockchain scalability,but verifying the availability of complete block data puts significant strain on bandwidth and latency.Existing data availability sampling(DAS)schemes either require trusted setups or suffer from high communication overhead and low verification efficiency.This paper presents ISTIRDA,a DAS scheme that lets light clients certify availability by sampling small random codeword symbols.Built on ISTIR,an improved Reed–Solomon interactive oracle proof of proximity,ISTIRDA combines adaptive folding with dynamic code rate adjustment to preserve soundness while lowering communication.This paper formalizes opening consistency and prove security with bounded error in the random oracle model,giving polylogarithmic verifier queries and no trusted setup.In a prototype compared with FRIDA under equal soundness,ISTIRDA reduces communication by 40.65%to 80%.For data larger than 16 MB,ISTIRDA verifies faster and the advantage widens;at 128 MB,proofs are about 60%smaller and verification time is roughly 25%shorter,while prover overhead remains modest.In peer-to-peer emulation under injected latency and loss,ISTIRDA reaches confidence more quickly and is less sensitive to packet loss and load.These results indicate that ISTIRDA is a scalable and provably secure DAS scheme suitable for high-throughput,large-block public blockchains,substantially easing bandwidth and latency pressure on lightweight nodes.展开更多
BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning ofte...BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning often fail to capture the sparse and diagnostically critical features of metastatic potential.AIM To develop and validate a case-level multiple-instance learning(MIL)framework mimicking a pathologist's comprehensive review and improve T3/T4 CRC LNM prediction.METHODS The whole-slide images of 130 patients with T3/T4 CRC were retrospectively collected.A case-level MIL framework utilising the CONCH v1.5 and UNI2-h deep learning models was trained on features from all haematoxylin and eosinstained primary tumour slides for each patient.These pathological features were subsequently integrated with clinical data,and model performance was evaluated using the area under the curve(AUC).RESULTS The case-level framework demonstrated superior LNM prediction over slide-level training,with the CONCH v1.5 model achieving a mean AUC(±SD)of 0.899±0.033 vs 0.814±0.083,respectively.Integrating pathology features with clinical data further enhanced performance,yielding a top model with a mean AUC of 0.904±0.047,in sharp contrast to a clinical-only model(mean AUC 0.584±0.084).Crucially,a pathologist’s review confirmed that the model-identified high-attention regions correspond to known high-risk histopathological features.CONCLUSION A case-level MIL framework provides a superior approach for predicting LNM in advanced CRC.This method shows promise for risk stratification and therapy decisions,requiring further validation.展开更多
Graph neural networks(GNN)have shown strong performance in node classification tasks,yet most existing models rely on uniform or shared weight aggregation,lacking flexibility in modeling the varying strength of relati...Graph neural networks(GNN)have shown strong performance in node classification tasks,yet most existing models rely on uniform or shared weight aggregation,lacking flexibility in modeling the varying strength of relationships among nodes.This paper proposes a novel graph coupling convolutional model that introduces an adaptive weighting mechanism to assign distinct importance to neighboring nodes based on their similarity to the central node.Unlike traditional methods,the proposed coupling strategy enhances the interpretability of node interactions while maintaining competitive classification performance.The model operates in the spatial domain,utilizing adjacency list structures for efficient convolution and addressing the limitations of weight sharing through a coupling-based similarity computation.Extensive experiments are conducted on five graph-structured datasets,including Cora,Citeseer,PubMed,Reddit,and BlogCatalog,as well as a custom topology dataset constructed from the Open University Learning Analytics Dataset(OULAD)educational platform.Results demonstrate that the proposed model achieves good classification accuracy,while significantly reducing training time through direct second-order neighbor fusion and data preprocessing.Moreover,analysis of neighborhood order reveals that considering third-order neighbors offers limited accuracy gains but introduces considerable computational overhead,confirming the efficiency of first-and second-order convolution in practical applications.Overall,the proposed graph coupling model offers a lightweight,interpretable,and effective framework for multi-label node classification in complex networks.展开更多
BACKGROUND Early screening,preoperative staging,and diagnosis of lymph node metastasis are crucial for improving the prognosis of gastric cancer(GC).AIM To evaluate the diagnostic value of combined multidetector compu...BACKGROUND Early screening,preoperative staging,and diagnosis of lymph node metastasis are crucial for improving the prognosis of gastric cancer(GC).AIM To evaluate the diagnostic value of combined multidetector computed tomography(MDCT)and gastrointestinal endoscopy for GC screening,preoperative staging,and lymph node metastasis detection,thereby providing a reference for clinical diagnosis and treatment.METHODS In this retrospective study clinical and imaging data of 134 patients with suspected GC who were admitted between January 2023 and October 2024 were initially reviewed.According to the inclusion and exclusion criteria,102 patients were finally enrolled in the analysis.All enrolled patients had undergone both MDCT and gastrointestinal endoscopy examinations prior to surgical intervention.Preoperative clinical staging and lymph node metastasis findings were compared with pathological results.RESULTS The combined use of MDCT and gastrointestinal endoscopy demonstrated a sensitivity of 98.53%,specificity of 97.06%,accuracy of 98.04%,positive predictive value of 98.53%,and negative predictive value of 97.06%for diagnosing GC.These factors were all significantly higher than those of MDCT or endoscopy alone(P<0.05).The accuracy rates of the combined approach for detecting clinical T and N stages were 97.06%and 92.65%,respectively,outperforming MDCT alone(86.76% and 79.41%)and endoscopy alone(85.29% and 70.59%)(P<0.05).Among 68 patients with confirmed GC,50(73.53%)were pathologically diagnosed with lymph node metastasis.The accuracy for detecting lymph node metastasis was 66.00%with endoscopy,76.00%with MDCT,and 92.00% with the combined approach,all with statistically significant differences(P<0.05).CONCLUSION The combined application of MDCT and gastrointestinal endoscopy enhanced diagnostic accuracy for GC,provided greater consistency in preoperative staging,and improved the detection of lymph node metastasis,thereby demonstrating significant clinical utility.展开更多
Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a referen...Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a reference for the selection of clinical treatment plans.Methods:A retrospective analysis was conducted on the clinical data of 68 patients with early-stage breast cancer admitted from January 2022 to December 2025.Based on the surgical approach,patients were divided into an observation group(breast-conserving surgery+sentinel lymph node biopsy)and a control group(other surgical methods such as modified radical mastectomy/total mastectomy).Clinical and pathological characteristics,incidence of postoperative complications,follow-up prognosis,and satisfaction with cosmetic outcomes were compared between the two groups.Results:Among the 68 patients,41 were in the observation group and 27 in the control group.The average age of patients in the observation group was(54.32±8.15)years,while that in the control group was(62.45±9.76)years.The average tumor size in the observation group was(1.86±0.72)cm,compared to(3.21±1.45)cm in the control group.The incidence of postoperative complications in the observation group was 9.76%,significantly lower than that in the control group at 33.33%(P<0.05).The 6-month disease-free survival rate was 95.12%in the observation group and 88.89%in the control group,with no statistically significant difference between the two groups(P>0.05).The excellent and good rate of cosmetic outcomes in the observation group was 87.80%,significantly higher than that in the control group at 29.63%(P<0.05).Conclusion:Breast-conserving surgery combined with sentinel lymph node biopsy for early-stage breast cancer can achieve long-term prognostic outcomes comparable to those of traditional radical surgery,with the advantages of fewer postoperative complications and superior cosmetic results.This approach is worthy of clinical promotion and application,particularly for early-stage breast cancer patients who have a demand for preserving breast morphology.展开更多
Early-stage gastric cancer;Extent of lymph node dissection;D1 dissection;D2 dissection;Recurrence rate;Survival rateObjective:To investigate the impact of different lymph node dissection scopes on postoperative recurr...Early-stage gastric cancer;Extent of lymph node dissection;D1 dissection;D2 dissection;Recurrence rate;Survival rateObjective:To investigate the impact of different lymph node dissection scopes on postoperative recurrence and survival rates in patients with early gastric cancer,providing evidence-based support for optimizing clinical surgical plans.Methods:A retrospective analysis was conducted on the clinical data of 100 patients with early gastric cancer who underwent surgical treatment at our hospital from October 2021 to October 2023.Patients were divided into Group D1(n=50)and Group D2(n=50)based on the extent of lymph node dissection.Group D1 underwent limited lymph node dissection(dissection of the first station of lymph nodes around the stomach),while Group D2 underwent standard lymph node dissection(dissection of the first and second stations of lymph nodes around the stomach).Surgical-related indicators,the incidence of postoperative complications,the 2-year recurrence rate,and the 2-year survival rate were compared between the two groups of patients.Results:The operative time,intraoperative blood loss,postoperative hospital stay,and the number of lymph nodes dissected were significantly higher in the D2 group than in the D1 group(all P<0.001).The overall incidence of postoperative complications was higher in the D1 group than in the D2 group,but the difference was not statistically significant(χ^(2)=0.884,P=0.766).After a 2-year follow-up,the recurrence rate was significantly higher in the D1 group than in the D2 group(χ^(2)=4.000,P=0.046).The 2-year survival rate was significantly lower in the D1 group than in the D2 group(χ^(2)=5.005,P=0.025).A total of 100 patients with early-stage gastric cancer were grouped according to the depth of invasion,degree of differentiation,and lymph node metastasis status,and the recurrence rates of different subgroups were compared.The results showed that the recurrence rate was higher in patients with T1b stage than in those with T1a stage(χ^(2)=5.005,P=0.025),higher in poorly differentiated patients than in moderately and well-differentiated patients(χ^(2)=4.155,P=0.042),and higher in patients with lymph node metastasis than in those without lymph node metastasis(χ^(2)=4.512,P=0.034).Conclusion:Compared with D1 limited lymph node dissection,D2 standard lymph node dissection can significantly reduce the postoperative recurrence rate and improve the 2-year survival rate in patients with early-stage gastric cancer without significantly increasing the risk of postoperative complications.Although the surgical trauma is slightly greater,the overall prognosis is better,making it a preferred surgical treatment option for patients with early-stage gastric cancer.展开更多
The 2D data processing adopted by the high-density resistivity method regards the geological structures as two degrees, which makes the results of the 2D data inversion only an approximate interpretation;the accuracy ...The 2D data processing adopted by the high-density resistivity method regards the geological structures as two degrees, which makes the results of the 2D data inversion only an approximate interpretation;the accuracy and effect can not meet the precise requirement of the inversion. Two typical models of the geological bodies were designed, and forward calculation was carried out using finite element method. The forward-modeled profiles were obtained. 1% Gaussian random error was added in the forward models and then 2D and 3D inversions using a high-density resistivity method were undertaken to realistically simulate field data and analyze the sensitivity of the 2D and 3D inversion algorithms to noise. Contrast between the 2D and 3D inversion results of least squares inversion shows that two inversion results of high-density resistivity method all can basically reflect the spatial position of an anomalous body. However, the 3D inversion can more effectively eliminate the influence of interference from Gaussian random error and better reflect the distribution of resistivity in the anomalous bodies. Overall, the 3D inversion was better than 2D inversion in terms of embodying anomalous body positions, morphology and resistivity properties.展开更多
Various previous studies have found a negative cor-relation between the risk of cardiovascular events and serum high-density lipoprotein(HDL) cholesterol levels. The reverse cholesterol transport, a pathway of choles-...Various previous studies have found a negative cor-relation between the risk of cardiovascular events and serum high-density lipoprotein(HDL) cholesterol levels. The reverse cholesterol transport, a pathway of choles-terol from peripheral tissue to liver which has several potent antiatherogenic properties. For instance, the particles of HDL mediate to transport cholesterol from cells in arterial tissues, particularly from atherosclerotic plaques, to the liver. Both ATP-binding cassette trans-porters(ABC) A1 and ABCG1 are membrane cholesterol transporters and have been implicated in mediating cholesterol effluxes from cells in the presence of HDL and apolipoprotein A-I, a major protein constituent of HDL. Previous studies demonstrated that ABCA1 and ABCG1 or the interaction between ABCA1 and ABCG1 exerted antiatherosclerotic effects. As a therapeutic approach for increasing HDL cholesterol levels, much focus has been placed on increasing HDL cholesterol levels as well as enhancing HDL biochemical functions. HDL therapies that use injections of reconstituted HDL, apoA-I mimetics, or full-length apoA-I have shown dramatic effectiveness. In particular, a novel apoA-I mi-metic peptide, Fukuoka University ApoA-I Mimetic Pep-tide, effectively removes cholesterol via specific ABCA1 and other transporters, such as ABCG1, and has an an-tiatherosclerotic effect by enhancing the biological func-tions of HDL without changing circulating HDL choles-terol levels. Thus, HDL-targeting therapy has significant atheroprotective potential, as it uses lipid transporter-targeting agents, and may prove to be a therapeutic tool for atherosclerotic cardiovascular diseases.展开更多
基金financially supported by the Key R&D Program of Shandong Province(2022SFGC0801)the National Natural Science Foundation of China(No.22005162 and 22175009)the Natural Science Foundation of Shandong Province(No.ZR2020QE093)。
文摘Osmotic energy,existing between the seawater and river water,is a renewable energy source,which can be directly converted into electricity by ion-exchange membranes(IEM).In traditional IEMs,the ion transport channels are formed by nanophase separation of hydrophilic ion carriers and hydrophobic segments.It is difficult to realize high-density ion channels with controlled spatial arrangement and length scale of ion carriers.Herein,we construct high-density 1D ion wires as transmission channels.Through molecular design,hydrophilic imidazole groups and hydrophobic alkyl tails were introduced into the repeat units,which self-assembled into 1D ion transporting core and protecting shell along the main chains.The areal density of the ionic wire arrays is up to~10^(12)cm^(-2),which is the highest value.The ionic wires ensure both high ion flux transport and high selectivity,achieving an ultrahigh-power density of 40.5 W m^(-2)at a 500-fold salinity gradient.Besides,the ionic wire array membrane is well recyclable and antibacterial.The ionic wires provide novel concept for next generation of high-performance membranes.
基金financially supported by the National Natural Science Foundation of China(Grant 22278439,21776313)the Shandong Province Higher Education Youth Innovation Technology Support Program(Grant 2022KJ074)。
文摘Metal-support interactions and hydrogen spillover effects in heterogeneous catalysts play a crucial role in aromatic hydrogenation reactions;however,these effects are limited by the metal dispersion on the catalyst and the number of acceptable H*receptors.This study prepares highly dispersed Ni nanoparticles(NPs)catalysts on a Beta substrate via precursor structure topology transformation.In contrast to traditional support materials,the coordination and electronic structure changes between the Ni NPs and the support were achieved,further optimizing the active interface sites and enhancing hydrogen activation and hydrogenation performance.Additionally,the-OH groups at the strong acid sites in zeolite effectively intensified the hydrogen spillover effect as receptors for H^(*)migration and anchoring,accelerating the hydrogenation rate of aromatic rings.Under solvent-free conditions,this catalyst was used for the hydrogenation reaction of aromatic-rich oils,directly producing a C_(8)-C_(14)branched cycloalkanes mixture with an aromatic conversion rate of>99%.The cycloalkanes mixture produced by this method features high density(0.92 g/mL)and a low freezing point(<-60℃),making it suitable for use as high-density aviation fuel or as an additive to enhance the volumetric heat value of conventional aviation fuels in practical applications.
基金supported by the National Natural Science Foundation of China(Nos.52373045 and 52033005).
文摘In rotationally extruded fittings,high-density polyethylene(HDPE)pipes prepared using conventional processing methods often suffer from poor pressure resistance and low toughness.This study introduces an innovative rotary shear system(RSS)to address these deficiencies through controlled mandrel rotation and cooling rates.We successfully prepared self-reinforced HDPE pipes with a three-layer structure combining spherical and shish-kebab crystals.Rotational processing aligned the molecular chains in the ring direction and formed shish-kebab crystals.As a result,the annular tensile strength of the rotationally processed three-layer shish-kebab structure(TSK)pipe increased from 26.7 MPa to 76.3 MPa,an enhancement of 185.8%.Notably,while maintaining excellent tensile strength(73.4 MPa),the elongation at break of the spherulite shishkebab spherulite(SKS)tubes was improved to 50.1%,as compared to 33.8%in the case of shish-kebab spherulite shish-kebab(KSK)tubes.This improvement can be attributed to the changes in the micro-morphology and polymer structure within the SKS tubes,specifically due to the formation of small-sized shish-kebab crystals and the low degrees of interlocking.In addition,2D-SAXS analysis revealed that KSK tubes have higher tensile strength due to smaller crystal sizes and larger shish dimensions,forming dense interlocking structures.In contrast,the SKS and TSK tubes had thicker amorphous regions and smaller shish sizes,resulting in reduced interlocking and mechanical performance.
基金Supported by National Key Research and Development Program of China(No.2023YFC3707901)。
文摘Evaluation of backfilling effectiveness plays a crucial role in the geological environment management and restoration of abandoned open-pit quarries,providing a scientific basis for subsequent greening efforts.Backfill soil,predominantly composed of silty clay,demonstrates high water retention capacity and elevated moisture content,leading to a pronounced resistivity contrast with the bedrock exposed by quarrying activities.To investigate the distribution of backfill soil subsurface and assess backfilling effectiveness in the study area,this study conducted a comprehensive geophysical investigation utilizing the high-density electrical resistivity tomography(ERT).A total of 19 ERT survey lines were deployed across three distinct areas in Liuyao Village,Huaibei City,Anhui Province,China.The inversion results,derived from both two-dimensional(2D)and three-dimensional(3D),reveal distinct electrical properties of the subsurface materials:the backfill soil layer shows low resistivity features,the fill stone layer exhibits medium to high resistivity,and the bedrock shows the highest resistivity.The 2D inversion results,from the data measured using the Wenner array effectively capture the spatial distribution and structural features of the backfill soil layer.The findings indicate a gradual east-west thinning of the clay layer within the quarry.Furthermore,the northern pit area exhibits a uniform distribution of backfill soil layer,indicative of effective backfilling operations.In contrast,the southern pit area lacks a well-defined clay layer,suggesting suboptimal backfilling effectiveness.
基金supported by the National Science Foundation of China under the Grant Nos.12127806 and 62175195the International Joint Research Laboratory for Micro/Nano Manufacturing and Measurement Technologies。
文摘High-density interconnect(HDI)soft electronics that can integrate multiple individual functions into one miniaturized monolithic system is promising for applications related to smart healthcare,soft robotics,and human-machine interactions.However,despite the recent advances,the development of three-dimensional(3D)soft electronics with both high resolution and high integration is still challenging because of the lack of efficient manufacturing methods to guarantee interlayer alignment of the high-density vias and reliable interlayer electrical conductivity.Here,an advanced 3D laser printing pathway,based on femtosecond laser direct writing(FLDW),is demonstrated for preparing liquid metal(LM)-based any layer HDI soft electronics.FLDW technology,with the characteristics of high spatial resolution and high precision,allows the maskless fabrication of high-resolution embedded LM microchannels and high-density vertical interconnect accesses for 3D integrated circuits.High-aspect-ratio blind/through LM microstructures are formed inside the elastomer due to the supermetalphobicity induced during laser ablation.The LM-based HDI circuit featuring high resolution(~1.5μm)and high integration(10-layer electrical interconnection)is achieved for customized soft electronics,including various customized multilayer passive electric components,soft multilayer circuit,and cross-scale multimode sensors.The 3D laser printing method provides a versatile approach for developing chip-level soft electronics.
基金supported by the National Key Research and Development Project(2023YFA1609100)the NSFC Funding(U2141207,52171111,52001083)+6 种基金Natural Science Foundation of Heilongjiang(YQ2023E026)China Postdoctoral Science foundation(2024M754149)Postdoctoral Fellowship Program of CPSF(GZC20242192)support from the National Science Foundation(DMR-1611180 and 1809640)with the program directors,DrsHKU Seed Fund for Collaborative Research(#2207101618)support by Croucher Senior Research Fellowship and City U Project(Project No.9229019)Shenzhen Science and Technology Program(Project No.JCYJ20220818101203007)。
文摘Dislocation strengthening,as one of the methods to simultaneously enhance the room temperature strength and ductility of alloys,does not achieve the desired strengthening and plasticity effect during elevated-temperature deformation.Here,we report a novel strategy to boost the dislocation multiplication and accumulation during deformation at elevated temperatures through dynamic strain aging(DSA).With the introduction of the rare-earth element Ho in Mg-Y-Zn alloy,Ho atoms diffuse toward dislocations during deformation at elevated temperatures,provoking the DSA effect,which increases the dislocation density significantly via the interactions of mobile dislocations and Ho atoms.The resulting alloy achieves a great enhancement of dislocation hardening and obtains the dual benefits of high strength and good ductility simultaneously at high homologous temperatures.The present work provides an effective strategy to enhancing the strength and ductility for elevated-temperature materials.
文摘In the context of rapid urbanization,high-density construction areas face significant challenges,including the reduction of ecological spaces and the deterioration of their functions.Planning and managing ecological spaces have emerged as essential strategies to address the conflict between urban development and ecological conservation.Using Jinjiang City,Fujian Province as the case study,this paper systematically examines the significance and primary challenges of ecological space planning in highdensity construction areas.It also identifies prevailing issues within the current research domain,including“an overemphasis on top-level design at the expense of implementation,a focus on isolated aspects rather than systemic integration,and prioritization of control over coordination”.This study proposes the key aspects of ecological space planning and management in high-density construction areas,focusing on three fundamental dimensions:human-centered demand orientation,the integration of top-down and bottomup linkage mechanisms,and a differentiated control system.Drawing on the full-element assessment of the ecosystem,ecological network construction,and full-process control system implemented in Jinjiang City,an integrated approach to ecological space governance,encompassing assessment,planning,and control,has been developed.This approach offers both theoretical insights and practical guidance for optimizing ecological spaces in comparable urban contexts.
基金Supported by Science and Technology Program of Quzhou,China,No.2022K67Zhejiang Medical Association Clinical Research Fund Project,No.2024ZYC-A526and the Research Project of Quzhou People’s Hospital,No.KYQD2024-006.
文摘BACKGROUND The association between the uric acid-to-high-density lipoprotein cholesterol ratio(UHR)and mental health among individuals with type 2 diabetes mellitus(T2DM)has not been thoroughly investigated.AIM To examine the link between UHR and symptoms of depression and anxiety in patients with T2DM.METHODS A cross-sectional analysis was carried out from March 2023 to April 2024,involving participants diagnosed with T2DM.Data on sociodemographic characteristics,clinical parameters,and UHR values were systematically gathered.The Self-Rating Depression Scale(SDS)and Self-Rating Anxiety Scale(SAS)were utilized to evaluate depressive and anxiety symptoms,respectively.To assess the relationships between UHR and SDS/SAS scores,linear regression models were employed,incorporating adjustments for potential confounding variables.Additionally,smooth curve fitting and threshold effect analyses were conducted to explore potential nonlinear relationships.RESULTS A total of 285 patients with T2DM were included.Initial univariate analysis demonstrated a significant positive correlation between elevated UHR levels and higher SDS and SAS scores.Multivariate regression analysis revealed that a one-unit rise in UHR was associated with a 1.13-point increase in SDS scores(95%CI:0.69-1.58)and a 0.57-point increase in SAS scores(95%CI:0.20-0.93).After controlling for confounders,UHR remained positively correlated with SDS(β=1.55,95%CI:0.57-2.53)and SAS(β=0.72,95%CI:0.35-1.09).Nonlinear analysis identified critical thresholds at UHR values of 5.02 for SDS and 4.00 for SAS,beyond which the relationships between UHR and psychological symptom scores became markedly stronger(P<0.05).CONCLUSION Higher UHR levels are significantly linked to exacerbated depressive and anxiety symptoms in patients with T2DM.These results indicate that UHR may function as a promising biomarker to identify individuals at greater risk of mental health complications within this population.
基金funded by the Scientific and Technological Key Program of Guizhou Province, China (Qiankehezhicheng [2022] Key 031)the National Natural Science Foundation of China (32160483 and 32360497)+2 种基金the Post-Funded Project for the National Natural Science Foundation of China from Guizhou University ([2023]093)the Key Laboratory of Molecular Breeding for Grain and Oil Crops in Guizhou Province, China (Qiankehezhongyindi [2023]008)the Key Laboratory of Functional Agriculture of Guizhou Provincial Higher Education Institutions, China (Qianjiaoji [2023] 007)。
文摘Rapeseed mustard(Brassica juncea L.) is the third most important oilseed crop in the world, but the geneticmechanism underlying its massive phenotypic variation remains largely unexplored. In this study, specific length amplified fragment sequencing(SLAF-Seq) was used to resequence a population comprising 197 F8recombinantinbred lines(RILs) derived from a cross between vegetable-type Qichi881 and oilseed-type YufengZC of B. juncea. In total, 438,895 high-quality SLAFs were discovered, 47,644 of which were polymorphic, and 3,887 of the polymorphic markers met the requirements for genetic map construction. The final map included 3,887 markers on 18 linkage groups and was 1,830.23 centiMorgan(cM) in length, with an average distance of 0.47 cM between adjacent markers. Using the newly constructed high-density genetic map, a total of 53 QTLs for erucicacid(EA), oleic acid(OA), and linolenic acid(LNA) were detected and integrated into eight consensus QTLswith two for each of these traits. For each of these three traits, two candidate genes were cloned and sequence analysis indicated colocalization with their respective consensus QTLs. The co-dominant allele-specific markers for Bju.FAD3.A03 and Bju.FAD3.B07 were developed and showed co-localization with their consensus QTLs andco-segregation with LNA content, further supporting the results of QTL mapping and bioinformatic analysis. Theexpression levels of the cloned homologous genes were also determined, and the genes were tightly correlatedwith the EA, OA and LNA contents of different lines. The results of this study will facilitate the improvement offatty acid traits and molecular breeding of B. juncea. Further uses of the high-density genetic map created in this study are also discussed.
基金supported by the National Natural Science Foundation of China(72061006)the research on the auxiliary diagnosis system of chronic injury of levator scapulae based on the concept of digital twin(Contract No:Qian Kehe Support[2023]General 117)Research on indoor intelligent assisted walking robot for the rehabilitation of walking ability of the elderly(Contract No:Qian kehe Support[2023]General 124).
文摘Stroke survivors often face significant challenges when performing daily self-care activities due to upper limb motor impairments.Traditional surface electromyography(sEMG)analysis typically focuses on isolated hand postures,overlooking the complexity of object-interactive behaviors that are crucial for promoting patient independence.This study introduces a novel framework that combines high-density sEMG(HD-sEMG)signals with an improved Whale Optimization Algorithm(IWOA)-optimized Long Short-Term Memory(LSTM)network to address this limitation.The key contributions of this work include:(1)the creation of a specialized HD-sEMG dataset that captures nine continuous self-care behaviors,along with time and posture markers,to better reflect real-world patient interactions;(2)the development of a multi-channel feature fusion module based on Pascal’s theorem,which enables efficient signal segmentation and spatial–temporal feature extraction;and(3)the enhancement of the IWOA algorithm,which integrates optimal point set initialization,a diversity-driven pooling mechanism,and cosine-based differential evolution to optimize LSTM hyperparameters,thereby improving convergence and global search capabilities.Experimental results demonstrate superior performance,achieving 99.58%accuracy in self-care behavior recognition and 86.19%accuracy for 17 continuous gestures on the Ninapro db2 benchmark.The framework operates with low latency,meeting the real-time requirements for assistive devices.By enabling precise,context-aware recognition of daily activities,this work advances personalized rehabilitation technologies,empowering stroke patients to regain autonomy in self-care tasks.The proposed methodology offers a robust,scalable solution for clinical applications,bridging the gap between laboratory-based gesture recognition and practical,patient-centered care.
基金supported in part by the Research Fund of Key Lab of Education Blockchain and Intelligent Technology,Ministry of Education(EBME25-F-08).
文摘Lightweight nodes are crucial for blockchain scalability,but verifying the availability of complete block data puts significant strain on bandwidth and latency.Existing data availability sampling(DAS)schemes either require trusted setups or suffer from high communication overhead and low verification efficiency.This paper presents ISTIRDA,a DAS scheme that lets light clients certify availability by sampling small random codeword symbols.Built on ISTIR,an improved Reed–Solomon interactive oracle proof of proximity,ISTIRDA combines adaptive folding with dynamic code rate adjustment to preserve soundness while lowering communication.This paper formalizes opening consistency and prove security with bounded error in the random oracle model,giving polylogarithmic verifier queries and no trusted setup.In a prototype compared with FRIDA under equal soundness,ISTIRDA reduces communication by 40.65%to 80%.For data larger than 16 MB,ISTIRDA verifies faster and the advantage widens;at 128 MB,proofs are about 60%smaller and verification time is roughly 25%shorter,while prover overhead remains modest.In peer-to-peer emulation under injected latency and loss,ISTIRDA reaches confidence more quickly and is less sensitive to packet loss and load.These results indicate that ISTIRDA is a scalable and provably secure DAS scheme suitable for high-throughput,large-block public blockchains,substantially easing bandwidth and latency pressure on lightweight nodes.
基金Supported by Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau),No.2023MSXM060.
文摘BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning often fail to capture the sparse and diagnostically critical features of metastatic potential.AIM To develop and validate a case-level multiple-instance learning(MIL)framework mimicking a pathologist's comprehensive review and improve T3/T4 CRC LNM prediction.METHODS The whole-slide images of 130 patients with T3/T4 CRC were retrospectively collected.A case-level MIL framework utilising the CONCH v1.5 and UNI2-h deep learning models was trained on features from all haematoxylin and eosinstained primary tumour slides for each patient.These pathological features were subsequently integrated with clinical data,and model performance was evaluated using the area under the curve(AUC).RESULTS The case-level framework demonstrated superior LNM prediction over slide-level training,with the CONCH v1.5 model achieving a mean AUC(±SD)of 0.899±0.033 vs 0.814±0.083,respectively.Integrating pathology features with clinical data further enhanced performance,yielding a top model with a mean AUC of 0.904±0.047,in sharp contrast to a clinical-only model(mean AUC 0.584±0.084).Crucially,a pathologist’s review confirmed that the model-identified high-attention regions correspond to known high-risk histopathological features.CONCLUSION A case-level MIL framework provides a superior approach for predicting LNM in advanced CRC.This method shows promise for risk stratification and therapy decisions,requiring further validation.
基金Support by Sichuan Science and Technology Program[2023YFSY0026,2023YFH0004]Guangzhou Huashang University[2024HSZD01,HS2023JYSZH01].
文摘Graph neural networks(GNN)have shown strong performance in node classification tasks,yet most existing models rely on uniform or shared weight aggregation,lacking flexibility in modeling the varying strength of relationships among nodes.This paper proposes a novel graph coupling convolutional model that introduces an adaptive weighting mechanism to assign distinct importance to neighboring nodes based on their similarity to the central node.Unlike traditional methods,the proposed coupling strategy enhances the interpretability of node interactions while maintaining competitive classification performance.The model operates in the spatial domain,utilizing adjacency list structures for efficient convolution and addressing the limitations of weight sharing through a coupling-based similarity computation.Extensive experiments are conducted on five graph-structured datasets,including Cora,Citeseer,PubMed,Reddit,and BlogCatalog,as well as a custom topology dataset constructed from the Open University Learning Analytics Dataset(OULAD)educational platform.Results demonstrate that the proposed model achieves good classification accuracy,while significantly reducing training time through direct second-order neighbor fusion and data preprocessing.Moreover,analysis of neighborhood order reveals that considering third-order neighbors offers limited accuracy gains but introduces considerable computational overhead,confirming the efficiency of first-and second-order convolution in practical applications.Overall,the proposed graph coupling model offers a lightweight,interpretable,and effective framework for multi-label node classification in complex networks.
文摘BACKGROUND Early screening,preoperative staging,and diagnosis of lymph node metastasis are crucial for improving the prognosis of gastric cancer(GC).AIM To evaluate the diagnostic value of combined multidetector computed tomography(MDCT)and gastrointestinal endoscopy for GC screening,preoperative staging,and lymph node metastasis detection,thereby providing a reference for clinical diagnosis and treatment.METHODS In this retrospective study clinical and imaging data of 134 patients with suspected GC who were admitted between January 2023 and October 2024 were initially reviewed.According to the inclusion and exclusion criteria,102 patients were finally enrolled in the analysis.All enrolled patients had undergone both MDCT and gastrointestinal endoscopy examinations prior to surgical intervention.Preoperative clinical staging and lymph node metastasis findings were compared with pathological results.RESULTS The combined use of MDCT and gastrointestinal endoscopy demonstrated a sensitivity of 98.53%,specificity of 97.06%,accuracy of 98.04%,positive predictive value of 98.53%,and negative predictive value of 97.06%for diagnosing GC.These factors were all significantly higher than those of MDCT or endoscopy alone(P<0.05).The accuracy rates of the combined approach for detecting clinical T and N stages were 97.06%and 92.65%,respectively,outperforming MDCT alone(86.76% and 79.41%)and endoscopy alone(85.29% and 70.59%)(P<0.05).Among 68 patients with confirmed GC,50(73.53%)were pathologically diagnosed with lymph node metastasis.The accuracy for detecting lymph node metastasis was 66.00%with endoscopy,76.00%with MDCT,and 92.00% with the combined approach,all with statistically significant differences(P<0.05).CONCLUSION The combined application of MDCT and gastrointestinal endoscopy enhanced diagnostic accuracy for GC,provided greater consistency in preoperative staging,and improved the detection of lymph node metastasis,thereby demonstrating significant clinical utility.
文摘Objective:To investigate the long-term prognosis and postoperative cosmetic outcomes of breast-conserving surgery combined with sentinel lymph node biopsy in patients with early-stage breast cancer,providing a reference for the selection of clinical treatment plans.Methods:A retrospective analysis was conducted on the clinical data of 68 patients with early-stage breast cancer admitted from January 2022 to December 2025.Based on the surgical approach,patients were divided into an observation group(breast-conserving surgery+sentinel lymph node biopsy)and a control group(other surgical methods such as modified radical mastectomy/total mastectomy).Clinical and pathological characteristics,incidence of postoperative complications,follow-up prognosis,and satisfaction with cosmetic outcomes were compared between the two groups.Results:Among the 68 patients,41 were in the observation group and 27 in the control group.The average age of patients in the observation group was(54.32±8.15)years,while that in the control group was(62.45±9.76)years.The average tumor size in the observation group was(1.86±0.72)cm,compared to(3.21±1.45)cm in the control group.The incidence of postoperative complications in the observation group was 9.76%,significantly lower than that in the control group at 33.33%(P<0.05).The 6-month disease-free survival rate was 95.12%in the observation group and 88.89%in the control group,with no statistically significant difference between the two groups(P>0.05).The excellent and good rate of cosmetic outcomes in the observation group was 87.80%,significantly higher than that in the control group at 29.63%(P<0.05).Conclusion:Breast-conserving surgery combined with sentinel lymph node biopsy for early-stage breast cancer can achieve long-term prognostic outcomes comparable to those of traditional radical surgery,with the advantages of fewer postoperative complications and superior cosmetic results.This approach is worthy of clinical promotion and application,particularly for early-stage breast cancer patients who have a demand for preserving breast morphology.
基金Shaanxi Provincial People’s Hospital Science and Technology Development Incubation Fund,“Research on the Role and Mechanism of PIGU in Regulating MUC-1 in Gastric Cancer Immune Escape”(Project No.:2023YJY-29)Shaanxi Provincial Natural Science Basic Research Program,“Research on the Mechanism and Clinical Significance of miR-140-5p Related to Gastric Cancer Recurrence and Metastasis”(Project No.:2023-JC-YB-639)。
文摘Early-stage gastric cancer;Extent of lymph node dissection;D1 dissection;D2 dissection;Recurrence rate;Survival rateObjective:To investigate the impact of different lymph node dissection scopes on postoperative recurrence and survival rates in patients with early gastric cancer,providing evidence-based support for optimizing clinical surgical plans.Methods:A retrospective analysis was conducted on the clinical data of 100 patients with early gastric cancer who underwent surgical treatment at our hospital from October 2021 to October 2023.Patients were divided into Group D1(n=50)and Group D2(n=50)based on the extent of lymph node dissection.Group D1 underwent limited lymph node dissection(dissection of the first station of lymph nodes around the stomach),while Group D2 underwent standard lymph node dissection(dissection of the first and second stations of lymph nodes around the stomach).Surgical-related indicators,the incidence of postoperative complications,the 2-year recurrence rate,and the 2-year survival rate were compared between the two groups of patients.Results:The operative time,intraoperative blood loss,postoperative hospital stay,and the number of lymph nodes dissected were significantly higher in the D2 group than in the D1 group(all P<0.001).The overall incidence of postoperative complications was higher in the D1 group than in the D2 group,but the difference was not statistically significant(χ^(2)=0.884,P=0.766).After a 2-year follow-up,the recurrence rate was significantly higher in the D1 group than in the D2 group(χ^(2)=4.000,P=0.046).The 2-year survival rate was significantly lower in the D1 group than in the D2 group(χ^(2)=5.005,P=0.025).A total of 100 patients with early-stage gastric cancer were grouped according to the depth of invasion,degree of differentiation,and lymph node metastasis status,and the recurrence rates of different subgroups were compared.The results showed that the recurrence rate was higher in patients with T1b stage than in those with T1a stage(χ^(2)=5.005,P=0.025),higher in poorly differentiated patients than in moderately and well-differentiated patients(χ^(2)=4.155,P=0.042),and higher in patients with lymph node metastasis than in those without lymph node metastasis(χ^(2)=4.512,P=0.034).Conclusion:Compared with D1 limited lymph node dissection,D2 standard lymph node dissection can significantly reduce the postoperative recurrence rate and improve the 2-year survival rate in patients with early-stage gastric cancer without significantly increasing the risk of postoperative complications.Although the surgical trauma is slightly greater,the overall prognosis is better,making it a preferred surgical treatment option for patients with early-stage gastric cancer.
基金Projects(41074085,41374118)supported by the National Natural Science Foundation of ChinaProject(20120162110015)supported by Doctoral Fund of Ministry of Education of ChinaProject(NCET-12-0551)supported by Program for New Century Excellent Talents in University,China
文摘The 2D data processing adopted by the high-density resistivity method regards the geological structures as two degrees, which makes the results of the 2D data inversion only an approximate interpretation;the accuracy and effect can not meet the precise requirement of the inversion. Two typical models of the geological bodies were designed, and forward calculation was carried out using finite element method. The forward-modeled profiles were obtained. 1% Gaussian random error was added in the forward models and then 2D and 3D inversions using a high-density resistivity method were undertaken to realistically simulate field data and analyze the sensitivity of the 2D and 3D inversion algorithms to noise. Contrast between the 2D and 3D inversion results of least squares inversion shows that two inversion results of high-density resistivity method all can basically reflect the spatial position of an anomalous body. However, the 3D inversion can more effectively eliminate the influence of interference from Gaussian random error and better reflect the distribution of resistivity in the anomalous bodies. Overall, the 3D inversion was better than 2D inversion in terms of embodying anomalous body positions, morphology and resistivity properties.
文摘Various previous studies have found a negative cor-relation between the risk of cardiovascular events and serum high-density lipoprotein(HDL) cholesterol levels. The reverse cholesterol transport, a pathway of choles-terol from peripheral tissue to liver which has several potent antiatherogenic properties. For instance, the particles of HDL mediate to transport cholesterol from cells in arterial tissues, particularly from atherosclerotic plaques, to the liver. Both ATP-binding cassette trans-porters(ABC) A1 and ABCG1 are membrane cholesterol transporters and have been implicated in mediating cholesterol effluxes from cells in the presence of HDL and apolipoprotein A-I, a major protein constituent of HDL. Previous studies demonstrated that ABCA1 and ABCG1 or the interaction between ABCA1 and ABCG1 exerted antiatherosclerotic effects. As a therapeutic approach for increasing HDL cholesterol levels, much focus has been placed on increasing HDL cholesterol levels as well as enhancing HDL biochemical functions. HDL therapies that use injections of reconstituted HDL, apoA-I mimetics, or full-length apoA-I have shown dramatic effectiveness. In particular, a novel apoA-I mi-metic peptide, Fukuoka University ApoA-I Mimetic Pep-tide, effectively removes cholesterol via specific ABCA1 and other transporters, such as ABCG1, and has an an-tiatherosclerotic effect by enhancing the biological func-tions of HDL without changing circulating HDL choles-terol levels. Thus, HDL-targeting therapy has significant atheroprotective potential, as it uses lipid transporter-targeting agents, and may prove to be a therapeutic tool for atherosclerotic cardiovascular diseases.
