Osmotic energy,existing between the seawater and river water,is a renewable energy source,which can be directly converted into electricity by ion-exchange membranes(IEM).In traditional IEMs,the ion transport channels ...Osmotic energy,existing between the seawater and river water,is a renewable energy source,which can be directly converted into electricity by ion-exchange membranes(IEM).In traditional IEMs,the ion transport channels are formed by nanophase separation of hydrophilic ion carriers and hydrophobic segments.It is difficult to realize high-density ion channels with controlled spatial arrangement and length scale of ion carriers.Herein,we construct high-density 1D ion wires as transmission channels.Through molecular design,hydrophilic imidazole groups and hydrophobic alkyl tails were introduced into the repeat units,which self-assembled into 1D ion transporting core and protecting shell along the main chains.The areal density of the ionic wire arrays is up to~10^(12)cm^(-2),which is the highest value.The ionic wires ensure both high ion flux transport and high selectivity,achieving an ultrahigh-power density of 40.5 W m^(-2)at a 500-fold salinity gradient.Besides,the ionic wire array membrane is well recyclable and antibacterial.The ionic wires provide novel concept for next generation of high-performance membranes.展开更多
The 2D data processing adopted by the high-density resistivity method regards the geological structures as two degrees, which makes the results of the 2D data inversion only an approximate interpretation;the accuracy ...The 2D data processing adopted by the high-density resistivity method regards the geological structures as two degrees, which makes the results of the 2D data inversion only an approximate interpretation;the accuracy and effect can not meet the precise requirement of the inversion. Two typical models of the geological bodies were designed, and forward calculation was carried out using finite element method. The forward-modeled profiles were obtained. 1% Gaussian random error was added in the forward models and then 2D and 3D inversions using a high-density resistivity method were undertaken to realistically simulate field data and analyze the sensitivity of the 2D and 3D inversion algorithms to noise. Contrast between the 2D and 3D inversion results of least squares inversion shows that two inversion results of high-density resistivity method all can basically reflect the spatial position of an anomalous body. However, the 3D inversion can more effectively eliminate the influence of interference from Gaussian random error and better reflect the distribution of resistivity in the anomalous bodies. Overall, the 3D inversion was better than 2D inversion in terms of embodying anomalous body positions, morphology and resistivity properties.展开更多
Metal-support interactions and hydrogen spillover effects in heterogeneous catalysts play a crucial role in aromatic hydrogenation reactions;however,these effects are limited by the metal dispersion on the catalyst an...Metal-support interactions and hydrogen spillover effects in heterogeneous catalysts play a crucial role in aromatic hydrogenation reactions;however,these effects are limited by the metal dispersion on the catalyst and the number of acceptable H*receptors.This study prepares highly dispersed Ni nanoparticles(NPs)catalysts on a Beta substrate via precursor structure topology transformation.In contrast to traditional support materials,the coordination and electronic structure changes between the Ni NPs and the support were achieved,further optimizing the active interface sites and enhancing hydrogen activation and hydrogenation performance.Additionally,the-OH groups at the strong acid sites in zeolite effectively intensified the hydrogen spillover effect as receptors for H^(*)migration and anchoring,accelerating the hydrogenation rate of aromatic rings.Under solvent-free conditions,this catalyst was used for the hydrogenation reaction of aromatic-rich oils,directly producing a C_(8)-C_(14)branched cycloalkanes mixture with an aromatic conversion rate of>99%.The cycloalkanes mixture produced by this method features high density(0.92 g/mL)and a low freezing point(<-60℃),making it suitable for use as high-density aviation fuel or as an additive to enhance the volumetric heat value of conventional aviation fuels in practical applications.展开更多
In rotationally extruded fittings,high-density polyethylene(HDPE)pipes prepared using conventional processing methods often suffer from poor pressure resistance and low toughness.This study introduces an innovative ro...In rotationally extruded fittings,high-density polyethylene(HDPE)pipes prepared using conventional processing methods often suffer from poor pressure resistance and low toughness.This study introduces an innovative rotary shear system(RSS)to address these deficiencies through controlled mandrel rotation and cooling rates.We successfully prepared self-reinforced HDPE pipes with a three-layer structure combining spherical and shish-kebab crystals.Rotational processing aligned the molecular chains in the ring direction and formed shish-kebab crystals.As a result,the annular tensile strength of the rotationally processed three-layer shish-kebab structure(TSK)pipe increased from 26.7 MPa to 76.3 MPa,an enhancement of 185.8%.Notably,while maintaining excellent tensile strength(73.4 MPa),the elongation at break of the spherulite shishkebab spherulite(SKS)tubes was improved to 50.1%,as compared to 33.8%in the case of shish-kebab spherulite shish-kebab(KSK)tubes.This improvement can be attributed to the changes in the micro-morphology and polymer structure within the SKS tubes,specifically due to the formation of small-sized shish-kebab crystals and the low degrees of interlocking.In addition,2D-SAXS analysis revealed that KSK tubes have higher tensile strength due to smaller crystal sizes and larger shish dimensions,forming dense interlocking structures.In contrast,the SKS and TSK tubes had thicker amorphous regions and smaller shish sizes,resulting in reduced interlocking and mechanical performance.展开更多
Evaluation of backfilling effectiveness plays a crucial role in the geological environment management and restoration of abandoned open-pit quarries,providing a scientific basis for subsequent greening efforts.Backfil...Evaluation of backfilling effectiveness plays a crucial role in the geological environment management and restoration of abandoned open-pit quarries,providing a scientific basis for subsequent greening efforts.Backfill soil,predominantly composed of silty clay,demonstrates high water retention capacity and elevated moisture content,leading to a pronounced resistivity contrast with the bedrock exposed by quarrying activities.To investigate the distribution of backfill soil subsurface and assess backfilling effectiveness in the study area,this study conducted a comprehensive geophysical investigation utilizing the high-density electrical resistivity tomography(ERT).A total of 19 ERT survey lines were deployed across three distinct areas in Liuyao Village,Huaibei City,Anhui Province,China.The inversion results,derived from both two-dimensional(2D)and three-dimensional(3D),reveal distinct electrical properties of the subsurface materials:the backfill soil layer shows low resistivity features,the fill stone layer exhibits medium to high resistivity,and the bedrock shows the highest resistivity.The 2D inversion results,from the data measured using the Wenner array effectively capture the spatial distribution and structural features of the backfill soil layer.The findings indicate a gradual east-west thinning of the clay layer within the quarry.Furthermore,the northern pit area exhibits a uniform distribution of backfill soil layer,indicative of effective backfilling operations.In contrast,the southern pit area lacks a well-defined clay layer,suggesting suboptimal backfilling effectiveness.展开更多
High-density interconnect(HDI)soft electronics that can integrate multiple individual functions into one miniaturized monolithic system is promising for applications related to smart healthcare,soft robotics,and human...High-density interconnect(HDI)soft electronics that can integrate multiple individual functions into one miniaturized monolithic system is promising for applications related to smart healthcare,soft robotics,and human-machine interactions.However,despite the recent advances,the development of three-dimensional(3D)soft electronics with both high resolution and high integration is still challenging because of the lack of efficient manufacturing methods to guarantee interlayer alignment of the high-density vias and reliable interlayer electrical conductivity.Here,an advanced 3D laser printing pathway,based on femtosecond laser direct writing(FLDW),is demonstrated for preparing liquid metal(LM)-based any layer HDI soft electronics.FLDW technology,with the characteristics of high spatial resolution and high precision,allows the maskless fabrication of high-resolution embedded LM microchannels and high-density vertical interconnect accesses for 3D integrated circuits.High-aspect-ratio blind/through LM microstructures are formed inside the elastomer due to the supermetalphobicity induced during laser ablation.The LM-based HDI circuit featuring high resolution(~1.5μm)and high integration(10-layer electrical interconnection)is achieved for customized soft electronics,including various customized multilayer passive electric components,soft multilayer circuit,and cross-scale multimode sensors.The 3D laser printing method provides a versatile approach for developing chip-level soft electronics.展开更多
Dislocation strengthening,as one of the methods to simultaneously enhance the room temperature strength and ductility of alloys,does not achieve the desired strengthening and plasticity effect during elevated-temperat...Dislocation strengthening,as one of the methods to simultaneously enhance the room temperature strength and ductility of alloys,does not achieve the desired strengthening and plasticity effect during elevated-temperature deformation.Here,we report a novel strategy to boost the dislocation multiplication and accumulation during deformation at elevated temperatures through dynamic strain aging(DSA).With the introduction of the rare-earth element Ho in Mg-Y-Zn alloy,Ho atoms diffuse toward dislocations during deformation at elevated temperatures,provoking the DSA effect,which increases the dislocation density significantly via the interactions of mobile dislocations and Ho atoms.The resulting alloy achieves a great enhancement of dislocation hardening and obtains the dual benefits of high strength and good ductility simultaneously at high homologous temperatures.The present work provides an effective strategy to enhancing the strength and ductility for elevated-temperature materials.展开更多
In the context of rapid urbanization,high-density construction areas face significant challenges,including the reduction of ecological spaces and the deterioration of their functions.Planning and managing ecological s...In the context of rapid urbanization,high-density construction areas face significant challenges,including the reduction of ecological spaces and the deterioration of their functions.Planning and managing ecological spaces have emerged as essential strategies to address the conflict between urban development and ecological conservation.Using Jinjiang City,Fujian Province as the case study,this paper systematically examines the significance and primary challenges of ecological space planning in highdensity construction areas.It also identifies prevailing issues within the current research domain,including“an overemphasis on top-level design at the expense of implementation,a focus on isolated aspects rather than systemic integration,and prioritization of control over coordination”.This study proposes the key aspects of ecological space planning and management in high-density construction areas,focusing on three fundamental dimensions:human-centered demand orientation,the integration of top-down and bottomup linkage mechanisms,and a differentiated control system.Drawing on the full-element assessment of the ecosystem,ecological network construction,and full-process control system implemented in Jinjiang City,an integrated approach to ecological space governance,encompassing assessment,planning,and control,has been developed.This approach offers both theoretical insights and practical guidance for optimizing ecological spaces in comparable urban contexts.展开更多
BACKGROUND The association between the uric acid-to-high-density lipoprotein cholesterol ratio(UHR)and mental health among individuals with type 2 diabetes mellitus(T2DM)has not been thoroughly investigated.AIM To exa...BACKGROUND The association between the uric acid-to-high-density lipoprotein cholesterol ratio(UHR)and mental health among individuals with type 2 diabetes mellitus(T2DM)has not been thoroughly investigated.AIM To examine the link between UHR and symptoms of depression and anxiety in patients with T2DM.METHODS A cross-sectional analysis was carried out from March 2023 to April 2024,involving participants diagnosed with T2DM.Data on sociodemographic characteristics,clinical parameters,and UHR values were systematically gathered.The Self-Rating Depression Scale(SDS)and Self-Rating Anxiety Scale(SAS)were utilized to evaluate depressive and anxiety symptoms,respectively.To assess the relationships between UHR and SDS/SAS scores,linear regression models were employed,incorporating adjustments for potential confounding variables.Additionally,smooth curve fitting and threshold effect analyses were conducted to explore potential nonlinear relationships.RESULTS A total of 285 patients with T2DM were included.Initial univariate analysis demonstrated a significant positive correlation between elevated UHR levels and higher SDS and SAS scores.Multivariate regression analysis revealed that a one-unit rise in UHR was associated with a 1.13-point increase in SDS scores(95%CI:0.69-1.58)and a 0.57-point increase in SAS scores(95%CI:0.20-0.93).After controlling for confounders,UHR remained positively correlated with SDS(β=1.55,95%CI:0.57-2.53)and SAS(β=0.72,95%CI:0.35-1.09).Nonlinear analysis identified critical thresholds at UHR values of 5.02 for SDS and 4.00 for SAS,beyond which the relationships between UHR and psychological symptom scores became markedly stronger(P<0.05).CONCLUSION Higher UHR levels are significantly linked to exacerbated depressive and anxiety symptoms in patients with T2DM.These results indicate that UHR may function as a promising biomarker to identify individuals at greater risk of mental health complications within this population.展开更多
Rapeseed mustard(Brassica juncea L.) is the third most important oilseed crop in the world, but the geneticmechanism underlying its massive phenotypic variation remains largely unexplored. In this study, specific leng...Rapeseed mustard(Brassica juncea L.) is the third most important oilseed crop in the world, but the geneticmechanism underlying its massive phenotypic variation remains largely unexplored. In this study, specific length amplified fragment sequencing(SLAF-Seq) was used to resequence a population comprising 197 F8recombinantinbred lines(RILs) derived from a cross between vegetable-type Qichi881 and oilseed-type YufengZC of B. juncea. In total, 438,895 high-quality SLAFs were discovered, 47,644 of which were polymorphic, and 3,887 of the polymorphic markers met the requirements for genetic map construction. The final map included 3,887 markers on 18 linkage groups and was 1,830.23 centiMorgan(cM) in length, with an average distance of 0.47 cM between adjacent markers. Using the newly constructed high-density genetic map, a total of 53 QTLs for erucicacid(EA), oleic acid(OA), and linolenic acid(LNA) were detected and integrated into eight consensus QTLswith two for each of these traits. For each of these three traits, two candidate genes were cloned and sequence analysis indicated colocalization with their respective consensus QTLs. The co-dominant allele-specific markers for Bju.FAD3.A03 and Bju.FAD3.B07 were developed and showed co-localization with their consensus QTLs andco-segregation with LNA content, further supporting the results of QTL mapping and bioinformatic analysis. Theexpression levels of the cloned homologous genes were also determined, and the genes were tightly correlatedwith the EA, OA and LNA contents of different lines. The results of this study will facilitate the improvement offatty acid traits and molecular breeding of B. juncea. Further uses of the high-density genetic map created in this study are also discussed.展开更多
Stroke survivors often face significant challenges when performing daily self-care activities due to upper limb motor impairments.Traditional surface electromyography(sEMG)analysis typically focuses on isolated hand p...Stroke survivors often face significant challenges when performing daily self-care activities due to upper limb motor impairments.Traditional surface electromyography(sEMG)analysis typically focuses on isolated hand postures,overlooking the complexity of object-interactive behaviors that are crucial for promoting patient independence.This study introduces a novel framework that combines high-density sEMG(HD-sEMG)signals with an improved Whale Optimization Algorithm(IWOA)-optimized Long Short-Term Memory(LSTM)network to address this limitation.The key contributions of this work include:(1)the creation of a specialized HD-sEMG dataset that captures nine continuous self-care behaviors,along with time and posture markers,to better reflect real-world patient interactions;(2)the development of a multi-channel feature fusion module based on Pascal’s theorem,which enables efficient signal segmentation and spatial–temporal feature extraction;and(3)the enhancement of the IWOA algorithm,which integrates optimal point set initialization,a diversity-driven pooling mechanism,and cosine-based differential evolution to optimize LSTM hyperparameters,thereby improving convergence and global search capabilities.Experimental results demonstrate superior performance,achieving 99.58%accuracy in self-care behavior recognition and 86.19%accuracy for 17 continuous gestures on the Ninapro db2 benchmark.The framework operates with low latency,meeting the real-time requirements for assistive devices.By enabling precise,context-aware recognition of daily activities,this work advances personalized rehabilitation technologies,empowering stroke patients to regain autonomy in self-care tasks.The proposed methodology offers a robust,scalable solution for clinical applications,bridging the gap between laboratory-based gesture recognition and practical,patient-centered care.展开更多
Objective Uric acid(UA)to high-density lipoprotein(HDL)ratio(UHR)has recently been proposed as a novel biomarker of inflammation.This study aimed to investigate the association between the UHR and carotid atherosclero...Objective Uric acid(UA)to high-density lipoprotein(HDL)ratio(UHR)has recently been proposed as a novel biomarker of inflammation.This study aimed to investigate the association between the UHR and carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).Methods In this single-center,retrospective cross-sectional study,379 patients with T2DM were enrolled and categorized into two groups:259 T2DM patients with CAS(T2DM-CAS)and 120 T2DM patients without CAS(T2DM-WCAS).Carotid intima‒media thickness(CIMT)and carotid atheromatous plaques(CAPs)were assessed via Doppler ultrasound.UHR values were compared between the groups,and receiver operating characteristic(ROC)curve analysis was employed to evaluate their diagnostic performance.Results The UHR was significantly greater in the T2DM-CAS group than in the T2DM-WCAS group(P<0.001).Multivariate logistic regression analysis identified the UHR as an independent risk factor for T2DM-CAS(P<0.001).The area under the ROC curve(AUC)for UHR to detect CAS was 0.750,with an optimal cut-off value of 0.35.Conclusion The UHR is an independent risk factor for CAS in patients with T2DM and may serve as a valuable biomarker for predicting CAS in this population.展开更多
Earthquakes are highly destructive spatio-temporal phenomena whose analysis is essential for disaster preparedness and risk mitigation.Modern seismological research produces vast volumes of heterogeneous data from sei...Earthquakes are highly destructive spatio-temporal phenomena whose analysis is essential for disaster preparedness and risk mitigation.Modern seismological research produces vast volumes of heterogeneous data from seismic networks,satellite observations,and geospatial repositories,creating the need for scalable infrastructures capable of integrating and analyzing such data to support intelligent decision-making.Data warehousing technologies provide a robust foundation for this purpose;however,existing earthquake-oriented data warehouses remain limited,often relying on simplified schemas,domain-specific analytics,or cataloguing efforts.This paper presents the design and implementation of a spatio-temporal data warehouse for seismic activity.The framework integrates spatial and temporal dimensions in a unified schema and introduces a novel array-based approach for managing many-to-many relationships between facts and dimensions without intermediate bridge tables.A comparative evaluation against a conventional bridge-table schema demonstrates that the array-based design improves fact-centric query performance,while the bridge-table schema remains advantageous for dimension-centric queries.To reconcile these trade-offs,a hybrid schema is proposed that retains both representations,ensuring balanced efficiency across heterogeneous workloads.The proposed framework demonstrates how spatio-temporal data warehousing can address schema complexity,improve query performance,and support multidimensional visualization.In doing so,it provides a foundation for integrating seismic analysis into broader big data-driven intelligent decision systems for disaster resilience,risk mitigation,and emergency management.展开更多
The scientific goal of the Anninghe seismic array is to investigate the detailed geometry of the Anninghe fault and the velocity structure of the fault zone.This 2D seismic array is composed of 161 stations forming su...The scientific goal of the Anninghe seismic array is to investigate the detailed geometry of the Anninghe fault and the velocity structure of the fault zone.This 2D seismic array is composed of 161 stations forming sub-rectangular geometry along the Anninghe fault,which covers 50 km and 150 km in the fault normal and strike directions,respectively,with~5 km intervals.The data were collected between June 2020 and June 2021,with some level of temporal gaps.Two types of instruments,i.e.QS-05A and SmartSolo,are used in this array.Data quality and examples of seismograms are provided in this paper.After the data protection period ends(expected in June 2024),researchers can request a dataset from the National Earthquake Science Data Center.展开更多
This work contributes to the theoretical foundation for pricing in data markets and offers practical insights for managing digital data exchanges in the era of big data.We propose a structured pricing model for data e...This work contributes to the theoretical foundation for pricing in data markets and offers practical insights for managing digital data exchanges in the era of big data.We propose a structured pricing model for data exchanges transitioning from quasi-public to marketoriented operations.To address the complex dynamics among data exchanges,suppliers,and consumers,the authors develop a threestage Stackelberg game framework.In this model,the data exchange acts as a leader setting transaction commission rates,suppliers are intermediate leaders determining unit prices,and consumers are followers making purchasing decisions.Two pricing strategies are examined:the Independent Pricing Approach(IPA)and the novel Perfectly Competitive Pricing Approach(PCPA),which accounts for competition among data providers.Using backward induction,the study derives subgame-perfect equilibria and proves the existence and uniqueness of Stackelberg equilibria under both approaches.Extensive numerical simulations are carried out in the model,demonstrating that PCPA enhances data demander utility,encourages supplier competition,increases transaction volume,and improves the overall profitability and sustainability of data exchanges.Social welfare analysis further confirms PCPA’s superiority in promoting efficient and fair data markets.展开更多
Ovarian cancer(OC)is one of the leading causes of death related to gynecological cancer,with the main difficulty of its early diagnosis and a heterogeneous nature of tumor biomarkers.Machine learning(ML)has the potent...Ovarian cancer(OC)is one of the leading causes of death related to gynecological cancer,with the main difficulty of its early diagnosis and a heterogeneous nature of tumor biomarkers.Machine learning(ML)has the potential to process complex datasets and support decision-making in OC diagnosis.Nevertheless,traditional ML models tend to be biased,overfitting,noisy,and less generalized.Moreover,their black-box nature reduces interpretability and limits their practical clinical applicability.In this study,we introduce an explainable ensemble learning(EL)model,TreeX-Stack,based on a stacking architecture that employs tree-based learners such as Decision Tree(DT),Random Forest(RF),Gradient Boosting(GB),and Extreme Gradient Boosting(XGBoost)as base learners,and Logistic Regression(LR)as the meta-learner to enhance ovarian cancer(OC)diagnosis.Local Interpretable ModelAgnostic Explanations(LIME)are used to explain individual predictions,making the model outputs more clinically interpretable and applicable.The model is trained on the dataset that includes demographic information,blood test,general chemistry,and tumor markers.Extensive preprocessing includes handling missing data using iterative imputation with Bayesian Ridge and addressing multicollinearity by removing features with correlation coefficients above 0.7.Relevant features are then selected using the Boruta feature selection method.To obtain robust and unbiased performance estimates during hyperparameter tuning,nested cross-validation(CV)with grid search is employed,and all experiments are repeated five times to ensure statistical reliability.TreeX-Stack demonstrates excellent diagnostic performance,achieving an accuracy of 0.9027,a precision of 0.8673,a recall of 0.9391,and an F1-score of 0.9012.Feature-importance analyses using LIME and permutation importance highlight Human Epididymis Protein 4(HE4)as the most significant biomarker for OC.The combination of high predictive performance and interpretability makes TreeX-Stack a reliable tool for clinical decision support in OC diagnosis.展开更多
Accurately assessing the relationship between tree growth and climatic factors is of great importance in dendrochronology.This study evaluated the consistency between alternative climate datasets(including station and...Accurately assessing the relationship between tree growth and climatic factors is of great importance in dendrochronology.This study evaluated the consistency between alternative climate datasets(including station and gridded data)and actual climate data(fixed-point observations near the sampling sites),in northeastern China’s warm temperate zone and analyzed differences in their correlations with tree-ring width index.The results were:(1)Gridded temperature data,as well as precipitation and relative humidity data from the Huailai meteorological station,was more consistent with the actual climate data;in contrast,gridded soil moisture content data showed significant discrepancies.(2)Horizontal distance had a greater impact on the representativeness of actual climate conditions than vertical elevation differences.(3)Differences in consistency between alternative and actual climate data also affected their correlations with tree-ring width indices.In some growing season months,correlation coefficients,both in magnitude and sign,differed significantly from those based on actual data.The selection of different alternative climate datasets can lead to biased results in assessing forest responses to climate change,which is detrimental to the management of forest ecosystems in harsh environments.Therefore,the scientific and rational selection of alternative climate data is essential for dendroecological and climatological research.展开更多
To address the severe challenges of PM_(2.5) and ozone co-control during the"14^(th) Five-Year Plan"period and to enhance the precision and intelligence level of air environment governance,it is imperative t...To address the severe challenges of PM_(2.5) and ozone co-control during the"14^(th) Five-Year Plan"period and to enhance the precision and intelligence level of air environment governance,it is imperative to build an efficient comprehensive management platform for regional air quality.In this paper,the specific practice in Zibo City,Shandong Province is as an example to systematically analyze the top-level design,technical implementation,and innovative application of a comprehensive management platform for regional air quality integrating"perception monitoring,data fusion,research judgment of early warnings,analysis of sources,collaborative dispatching,and evaluation assessment".Through the construction of an"sky-air-ground"integrated three-dimensional monitoring network,the platform integrates multi-source heterogeneous environmental data,and employs big data,cloud computing,artificial intelligence,CALPUFF/CMAQ,and other numerical model technologies to achieve comprehensive perception,precise prediction,intelligent source tracing,and closed-loop management of air pollution.The platform innovatively establishes a full-process closed-loop management mechanism of"data-early warning-disposition-evaluation",and achieves a fundamental transformation from passive response to active anticipation and from experience-based judgment to data driving in environmental supervision.The application results show that this platform significantly improves the scientific decision-making ability and collaborative execution efficiency of air pollution governance in Zibo City,providing a replicable and scalable comprehensive solution for similar industrial cities to achieve the continuous improvement of air quality.展开更多
tRNA-derived small RNAs(tsRNAs),as a class of regulatory small noncoding RNA,have been implicated in a wide variety of human diseases.Large amounts of tsRNA–disease associations have been identified in recent years f...tRNA-derived small RNAs(tsRNAs),as a class of regulatory small noncoding RNA,have been implicated in a wide variety of human diseases.Large amounts of tsRNA–disease associations have been identified in recent years from accumulating studies.However,repositories for cataloging the detailed information on tsRNA–disease associations are scarce.In this study,we provide a tsRNADisease database by integrating experimentally and computationally supported tsRNA–disease associations from manual curation of literatures and other related resources.tsRNADisease contains 5571 manually curated associations between 4759 tsRNAs and 166 diseases with experimental evidence from 346 studies.In addition,it also contains 5013 predicted associations between 1297 tsRNAs and 111 diseases.tsRNADisease provides a user-friendly interface to browse,retrieve,and download data conveniently.This database can improve our understanding of tsRNA deregulation in diseases and serve as a valuable resource for investigating the mechanism of disease-related tsRNAs.tsRNADisease is freely available at http://www.compgenelab.info/tsRNADisease.展开更多
0 INTRODUCTION Earth science is a natural science concerned with the composition,dynamics,spatiotemporal evolution,and formation mechanisms of Earth materials(Chen and Yang,2023).Traditional Earth science research has...0 INTRODUCTION Earth science is a natural science concerned with the composition,dynamics,spatiotemporal evolution,and formation mechanisms of Earth materials(Chen and Yang,2023).Traditional Earth science research has largely been discipline-based,relying on field investigations,data collection,experimental analyses,and data interpretation to study individual components of the Earth system.展开更多
基金financially supported by the Key R&D Program of Shandong Province(2022SFGC0801)the National Natural Science Foundation of China(No.22005162 and 22175009)the Natural Science Foundation of Shandong Province(No.ZR2020QE093)。
文摘Osmotic energy,existing between the seawater and river water,is a renewable energy source,which can be directly converted into electricity by ion-exchange membranes(IEM).In traditional IEMs,the ion transport channels are formed by nanophase separation of hydrophilic ion carriers and hydrophobic segments.It is difficult to realize high-density ion channels with controlled spatial arrangement and length scale of ion carriers.Herein,we construct high-density 1D ion wires as transmission channels.Through molecular design,hydrophilic imidazole groups and hydrophobic alkyl tails were introduced into the repeat units,which self-assembled into 1D ion transporting core and protecting shell along the main chains.The areal density of the ionic wire arrays is up to~10^(12)cm^(-2),which is the highest value.The ionic wires ensure both high ion flux transport and high selectivity,achieving an ultrahigh-power density of 40.5 W m^(-2)at a 500-fold salinity gradient.Besides,the ionic wire array membrane is well recyclable and antibacterial.The ionic wires provide novel concept for next generation of high-performance membranes.
基金Projects(41074085,41374118)supported by the National Natural Science Foundation of ChinaProject(20120162110015)supported by Doctoral Fund of Ministry of Education of ChinaProject(NCET-12-0551)supported by Program for New Century Excellent Talents in University,China
文摘The 2D data processing adopted by the high-density resistivity method regards the geological structures as two degrees, which makes the results of the 2D data inversion only an approximate interpretation;the accuracy and effect can not meet the precise requirement of the inversion. Two typical models of the geological bodies were designed, and forward calculation was carried out using finite element method. The forward-modeled profiles were obtained. 1% Gaussian random error was added in the forward models and then 2D and 3D inversions using a high-density resistivity method were undertaken to realistically simulate field data and analyze the sensitivity of the 2D and 3D inversion algorithms to noise. Contrast between the 2D and 3D inversion results of least squares inversion shows that two inversion results of high-density resistivity method all can basically reflect the spatial position of an anomalous body. However, the 3D inversion can more effectively eliminate the influence of interference from Gaussian random error and better reflect the distribution of resistivity in the anomalous bodies. Overall, the 3D inversion was better than 2D inversion in terms of embodying anomalous body positions, morphology and resistivity properties.
基金financially supported by the National Natural Science Foundation of China(Grant 22278439,21776313)the Shandong Province Higher Education Youth Innovation Technology Support Program(Grant 2022KJ074)。
文摘Metal-support interactions and hydrogen spillover effects in heterogeneous catalysts play a crucial role in aromatic hydrogenation reactions;however,these effects are limited by the metal dispersion on the catalyst and the number of acceptable H*receptors.This study prepares highly dispersed Ni nanoparticles(NPs)catalysts on a Beta substrate via precursor structure topology transformation.In contrast to traditional support materials,the coordination and electronic structure changes between the Ni NPs and the support were achieved,further optimizing the active interface sites and enhancing hydrogen activation and hydrogenation performance.Additionally,the-OH groups at the strong acid sites in zeolite effectively intensified the hydrogen spillover effect as receptors for H^(*)migration and anchoring,accelerating the hydrogenation rate of aromatic rings.Under solvent-free conditions,this catalyst was used for the hydrogenation reaction of aromatic-rich oils,directly producing a C_(8)-C_(14)branched cycloalkanes mixture with an aromatic conversion rate of>99%.The cycloalkanes mixture produced by this method features high density(0.92 g/mL)and a low freezing point(<-60℃),making it suitable for use as high-density aviation fuel or as an additive to enhance the volumetric heat value of conventional aviation fuels in practical applications.
基金supported by the National Natural Science Foundation of China(Nos.52373045 and 52033005).
文摘In rotationally extruded fittings,high-density polyethylene(HDPE)pipes prepared using conventional processing methods often suffer from poor pressure resistance and low toughness.This study introduces an innovative rotary shear system(RSS)to address these deficiencies through controlled mandrel rotation and cooling rates.We successfully prepared self-reinforced HDPE pipes with a three-layer structure combining spherical and shish-kebab crystals.Rotational processing aligned the molecular chains in the ring direction and formed shish-kebab crystals.As a result,the annular tensile strength of the rotationally processed three-layer shish-kebab structure(TSK)pipe increased from 26.7 MPa to 76.3 MPa,an enhancement of 185.8%.Notably,while maintaining excellent tensile strength(73.4 MPa),the elongation at break of the spherulite shishkebab spherulite(SKS)tubes was improved to 50.1%,as compared to 33.8%in the case of shish-kebab spherulite shish-kebab(KSK)tubes.This improvement can be attributed to the changes in the micro-morphology and polymer structure within the SKS tubes,specifically due to the formation of small-sized shish-kebab crystals and the low degrees of interlocking.In addition,2D-SAXS analysis revealed that KSK tubes have higher tensile strength due to smaller crystal sizes and larger shish dimensions,forming dense interlocking structures.In contrast,the SKS and TSK tubes had thicker amorphous regions and smaller shish sizes,resulting in reduced interlocking and mechanical performance.
基金Supported by National Key Research and Development Program of China(No.2023YFC3707901)。
文摘Evaluation of backfilling effectiveness plays a crucial role in the geological environment management and restoration of abandoned open-pit quarries,providing a scientific basis for subsequent greening efforts.Backfill soil,predominantly composed of silty clay,demonstrates high water retention capacity and elevated moisture content,leading to a pronounced resistivity contrast with the bedrock exposed by quarrying activities.To investigate the distribution of backfill soil subsurface and assess backfilling effectiveness in the study area,this study conducted a comprehensive geophysical investigation utilizing the high-density electrical resistivity tomography(ERT).A total of 19 ERT survey lines were deployed across three distinct areas in Liuyao Village,Huaibei City,Anhui Province,China.The inversion results,derived from both two-dimensional(2D)and three-dimensional(3D),reveal distinct electrical properties of the subsurface materials:the backfill soil layer shows low resistivity features,the fill stone layer exhibits medium to high resistivity,and the bedrock shows the highest resistivity.The 2D inversion results,from the data measured using the Wenner array effectively capture the spatial distribution and structural features of the backfill soil layer.The findings indicate a gradual east-west thinning of the clay layer within the quarry.Furthermore,the northern pit area exhibits a uniform distribution of backfill soil layer,indicative of effective backfilling operations.In contrast,the southern pit area lacks a well-defined clay layer,suggesting suboptimal backfilling effectiveness.
基金supported by the National Science Foundation of China under the Grant Nos.12127806 and 62175195the International Joint Research Laboratory for Micro/Nano Manufacturing and Measurement Technologies。
文摘High-density interconnect(HDI)soft electronics that can integrate multiple individual functions into one miniaturized monolithic system is promising for applications related to smart healthcare,soft robotics,and human-machine interactions.However,despite the recent advances,the development of three-dimensional(3D)soft electronics with both high resolution and high integration is still challenging because of the lack of efficient manufacturing methods to guarantee interlayer alignment of the high-density vias and reliable interlayer electrical conductivity.Here,an advanced 3D laser printing pathway,based on femtosecond laser direct writing(FLDW),is demonstrated for preparing liquid metal(LM)-based any layer HDI soft electronics.FLDW technology,with the characteristics of high spatial resolution and high precision,allows the maskless fabrication of high-resolution embedded LM microchannels and high-density vertical interconnect accesses for 3D integrated circuits.High-aspect-ratio blind/through LM microstructures are formed inside the elastomer due to the supermetalphobicity induced during laser ablation.The LM-based HDI circuit featuring high resolution(~1.5μm)and high integration(10-layer electrical interconnection)is achieved for customized soft electronics,including various customized multilayer passive electric components,soft multilayer circuit,and cross-scale multimode sensors.The 3D laser printing method provides a versatile approach for developing chip-level soft electronics.
基金supported by the National Key Research and Development Project(2023YFA1609100)the NSFC Funding(U2141207,52171111,52001083)+6 种基金Natural Science Foundation of Heilongjiang(YQ2023E026)China Postdoctoral Science foundation(2024M754149)Postdoctoral Fellowship Program of CPSF(GZC20242192)support from the National Science Foundation(DMR-1611180 and 1809640)with the program directors,DrsHKU Seed Fund for Collaborative Research(#2207101618)support by Croucher Senior Research Fellowship and City U Project(Project No.9229019)Shenzhen Science and Technology Program(Project No.JCYJ20220818101203007)。
文摘Dislocation strengthening,as one of the methods to simultaneously enhance the room temperature strength and ductility of alloys,does not achieve the desired strengthening and plasticity effect during elevated-temperature deformation.Here,we report a novel strategy to boost the dislocation multiplication and accumulation during deformation at elevated temperatures through dynamic strain aging(DSA).With the introduction of the rare-earth element Ho in Mg-Y-Zn alloy,Ho atoms diffuse toward dislocations during deformation at elevated temperatures,provoking the DSA effect,which increases the dislocation density significantly via the interactions of mobile dislocations and Ho atoms.The resulting alloy achieves a great enhancement of dislocation hardening and obtains the dual benefits of high strength and good ductility simultaneously at high homologous temperatures.The present work provides an effective strategy to enhancing the strength and ductility for elevated-temperature materials.
文摘In the context of rapid urbanization,high-density construction areas face significant challenges,including the reduction of ecological spaces and the deterioration of their functions.Planning and managing ecological spaces have emerged as essential strategies to address the conflict between urban development and ecological conservation.Using Jinjiang City,Fujian Province as the case study,this paper systematically examines the significance and primary challenges of ecological space planning in highdensity construction areas.It also identifies prevailing issues within the current research domain,including“an overemphasis on top-level design at the expense of implementation,a focus on isolated aspects rather than systemic integration,and prioritization of control over coordination”.This study proposes the key aspects of ecological space planning and management in high-density construction areas,focusing on three fundamental dimensions:human-centered demand orientation,the integration of top-down and bottomup linkage mechanisms,and a differentiated control system.Drawing on the full-element assessment of the ecosystem,ecological network construction,and full-process control system implemented in Jinjiang City,an integrated approach to ecological space governance,encompassing assessment,planning,and control,has been developed.This approach offers both theoretical insights and practical guidance for optimizing ecological spaces in comparable urban contexts.
基金Supported by Science and Technology Program of Quzhou,China,No.2022K67Zhejiang Medical Association Clinical Research Fund Project,No.2024ZYC-A526and the Research Project of Quzhou People’s Hospital,No.KYQD2024-006.
文摘BACKGROUND The association between the uric acid-to-high-density lipoprotein cholesterol ratio(UHR)and mental health among individuals with type 2 diabetes mellitus(T2DM)has not been thoroughly investigated.AIM To examine the link between UHR and symptoms of depression and anxiety in patients with T2DM.METHODS A cross-sectional analysis was carried out from March 2023 to April 2024,involving participants diagnosed with T2DM.Data on sociodemographic characteristics,clinical parameters,and UHR values were systematically gathered.The Self-Rating Depression Scale(SDS)and Self-Rating Anxiety Scale(SAS)were utilized to evaluate depressive and anxiety symptoms,respectively.To assess the relationships between UHR and SDS/SAS scores,linear regression models were employed,incorporating adjustments for potential confounding variables.Additionally,smooth curve fitting and threshold effect analyses were conducted to explore potential nonlinear relationships.RESULTS A total of 285 patients with T2DM were included.Initial univariate analysis demonstrated a significant positive correlation between elevated UHR levels and higher SDS and SAS scores.Multivariate regression analysis revealed that a one-unit rise in UHR was associated with a 1.13-point increase in SDS scores(95%CI:0.69-1.58)and a 0.57-point increase in SAS scores(95%CI:0.20-0.93).After controlling for confounders,UHR remained positively correlated with SDS(β=1.55,95%CI:0.57-2.53)and SAS(β=0.72,95%CI:0.35-1.09).Nonlinear analysis identified critical thresholds at UHR values of 5.02 for SDS and 4.00 for SAS,beyond which the relationships between UHR and psychological symptom scores became markedly stronger(P<0.05).CONCLUSION Higher UHR levels are significantly linked to exacerbated depressive and anxiety symptoms in patients with T2DM.These results indicate that UHR may function as a promising biomarker to identify individuals at greater risk of mental health complications within this population.
基金funded by the Scientific and Technological Key Program of Guizhou Province, China (Qiankehezhicheng [2022] Key 031)the National Natural Science Foundation of China (32160483 and 32360497)+2 种基金the Post-Funded Project for the National Natural Science Foundation of China from Guizhou University ([2023]093)the Key Laboratory of Molecular Breeding for Grain and Oil Crops in Guizhou Province, China (Qiankehezhongyindi [2023]008)the Key Laboratory of Functional Agriculture of Guizhou Provincial Higher Education Institutions, China (Qianjiaoji [2023] 007)。
文摘Rapeseed mustard(Brassica juncea L.) is the third most important oilseed crop in the world, but the geneticmechanism underlying its massive phenotypic variation remains largely unexplored. In this study, specific length amplified fragment sequencing(SLAF-Seq) was used to resequence a population comprising 197 F8recombinantinbred lines(RILs) derived from a cross between vegetable-type Qichi881 and oilseed-type YufengZC of B. juncea. In total, 438,895 high-quality SLAFs were discovered, 47,644 of which were polymorphic, and 3,887 of the polymorphic markers met the requirements for genetic map construction. The final map included 3,887 markers on 18 linkage groups and was 1,830.23 centiMorgan(cM) in length, with an average distance of 0.47 cM between adjacent markers. Using the newly constructed high-density genetic map, a total of 53 QTLs for erucicacid(EA), oleic acid(OA), and linolenic acid(LNA) were detected and integrated into eight consensus QTLswith two for each of these traits. For each of these three traits, two candidate genes were cloned and sequence analysis indicated colocalization with their respective consensus QTLs. The co-dominant allele-specific markers for Bju.FAD3.A03 and Bju.FAD3.B07 were developed and showed co-localization with their consensus QTLs andco-segregation with LNA content, further supporting the results of QTL mapping and bioinformatic analysis. Theexpression levels of the cloned homologous genes were also determined, and the genes were tightly correlatedwith the EA, OA and LNA contents of different lines. The results of this study will facilitate the improvement offatty acid traits and molecular breeding of B. juncea. Further uses of the high-density genetic map created in this study are also discussed.
基金supported by the National Natural Science Foundation of China(72061006)the research on the auxiliary diagnosis system of chronic injury of levator scapulae based on the concept of digital twin(Contract No:Qian Kehe Support[2023]General 117)Research on indoor intelligent assisted walking robot for the rehabilitation of walking ability of the elderly(Contract No:Qian kehe Support[2023]General 124).
文摘Stroke survivors often face significant challenges when performing daily self-care activities due to upper limb motor impairments.Traditional surface electromyography(sEMG)analysis typically focuses on isolated hand postures,overlooking the complexity of object-interactive behaviors that are crucial for promoting patient independence.This study introduces a novel framework that combines high-density sEMG(HD-sEMG)signals with an improved Whale Optimization Algorithm(IWOA)-optimized Long Short-Term Memory(LSTM)network to address this limitation.The key contributions of this work include:(1)the creation of a specialized HD-sEMG dataset that captures nine continuous self-care behaviors,along with time and posture markers,to better reflect real-world patient interactions;(2)the development of a multi-channel feature fusion module based on Pascal’s theorem,which enables efficient signal segmentation and spatial–temporal feature extraction;and(3)the enhancement of the IWOA algorithm,which integrates optimal point set initialization,a diversity-driven pooling mechanism,and cosine-based differential evolution to optimize LSTM hyperparameters,thereby improving convergence and global search capabilities.Experimental results demonstrate superior performance,achieving 99.58%accuracy in self-care behavior recognition and 86.19%accuracy for 17 continuous gestures on the Ninapro db2 benchmark.The framework operates with low latency,meeting the real-time requirements for assistive devices.By enabling precise,context-aware recognition of daily activities,this work advances personalized rehabilitation technologies,empowering stroke patients to regain autonomy in self-care tasks.The proposed methodology offers a robust,scalable solution for clinical applications,bridging the gap between laboratory-based gesture recognition and practical,patient-centered care.
基金supported by the National Natural Science Foundation of China(Grant No.82070862 and 82370840)the National Key R&D Program of China(Grant No.2020YFC2008900).
文摘Objective Uric acid(UA)to high-density lipoprotein(HDL)ratio(UHR)has recently been proposed as a novel biomarker of inflammation.This study aimed to investigate the association between the UHR and carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).Methods In this single-center,retrospective cross-sectional study,379 patients with T2DM were enrolled and categorized into two groups:259 T2DM patients with CAS(T2DM-CAS)and 120 T2DM patients without CAS(T2DM-WCAS).Carotid intima‒media thickness(CIMT)and carotid atheromatous plaques(CAPs)were assessed via Doppler ultrasound.UHR values were compared between the groups,and receiver operating characteristic(ROC)curve analysis was employed to evaluate their diagnostic performance.Results The UHR was significantly greater in the T2DM-CAS group than in the T2DM-WCAS group(P<0.001).Multivariate logistic regression analysis identified the UHR as an independent risk factor for T2DM-CAS(P<0.001).The area under the ROC curve(AUC)for UHR to detect CAS was 0.750,with an optimal cut-off value of 0.35.Conclusion The UHR is an independent risk factor for CAS in patients with T2DM and may serve as a valuable biomarker for predicting CAS in this population.
文摘Earthquakes are highly destructive spatio-temporal phenomena whose analysis is essential for disaster preparedness and risk mitigation.Modern seismological research produces vast volumes of heterogeneous data from seismic networks,satellite observations,and geospatial repositories,creating the need for scalable infrastructures capable of integrating and analyzing such data to support intelligent decision-making.Data warehousing technologies provide a robust foundation for this purpose;however,existing earthquake-oriented data warehouses remain limited,often relying on simplified schemas,domain-specific analytics,or cataloguing efforts.This paper presents the design and implementation of a spatio-temporal data warehouse for seismic activity.The framework integrates spatial and temporal dimensions in a unified schema and introduces a novel array-based approach for managing many-to-many relationships between facts and dimensions without intermediate bridge tables.A comparative evaluation against a conventional bridge-table schema demonstrates that the array-based design improves fact-centric query performance,while the bridge-table schema remains advantageous for dimension-centric queries.To reconcile these trade-offs,a hybrid schema is proposed that retains both representations,ensuring balanced efficiency across heterogeneous workloads.The proposed framework demonstrates how spatio-temporal data warehousing can address schema complexity,improve query performance,and support multidimensional visualization.In doing so,it provides a foundation for integrating seismic analysis into broader big data-driven intelligent decision systems for disaster resilience,risk mitigation,and emergency management.
基金supported by the National Key Research and Development Program of China(No.2018YFC1503401).
文摘The scientific goal of the Anninghe seismic array is to investigate the detailed geometry of the Anninghe fault and the velocity structure of the fault zone.This 2D seismic array is composed of 161 stations forming sub-rectangular geometry along the Anninghe fault,which covers 50 km and 150 km in the fault normal and strike directions,respectively,with~5 km intervals.The data were collected between June 2020 and June 2021,with some level of temporal gaps.Two types of instruments,i.e.QS-05A and SmartSolo,are used in this array.Data quality and examples of seismograms are provided in this paper.After the data protection period ends(expected in June 2024),researchers can request a dataset from the National Earthquake Science Data Center.
基金supported by the National Natural Science Foundation of China[grant numbers 12171158,12371474 and 12571510]Fundamental Research Funds for the Central Universities[grant number 2025ECNU-WLJC006].
文摘This work contributes to the theoretical foundation for pricing in data markets and offers practical insights for managing digital data exchanges in the era of big data.We propose a structured pricing model for data exchanges transitioning from quasi-public to marketoriented operations.To address the complex dynamics among data exchanges,suppliers,and consumers,the authors develop a threestage Stackelberg game framework.In this model,the data exchange acts as a leader setting transaction commission rates,suppliers are intermediate leaders determining unit prices,and consumers are followers making purchasing decisions.Two pricing strategies are examined:the Independent Pricing Approach(IPA)and the novel Perfectly Competitive Pricing Approach(PCPA),which accounts for competition among data providers.Using backward induction,the study derives subgame-perfect equilibria and proves the existence and uniqueness of Stackelberg equilibria under both approaches.Extensive numerical simulations are carried out in the model,demonstrating that PCPA enhances data demander utility,encourages supplier competition,increases transaction volume,and improves the overall profitability and sustainability of data exchanges.Social welfare analysis further confirms PCPA’s superiority in promoting efficient and fair data markets.
基金supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University(IMSIU)under the grant number IMSIU-DDRSP2601.
文摘Ovarian cancer(OC)is one of the leading causes of death related to gynecological cancer,with the main difficulty of its early diagnosis and a heterogeneous nature of tumor biomarkers.Machine learning(ML)has the potential to process complex datasets and support decision-making in OC diagnosis.Nevertheless,traditional ML models tend to be biased,overfitting,noisy,and less generalized.Moreover,their black-box nature reduces interpretability and limits their practical clinical applicability.In this study,we introduce an explainable ensemble learning(EL)model,TreeX-Stack,based on a stacking architecture that employs tree-based learners such as Decision Tree(DT),Random Forest(RF),Gradient Boosting(GB),and Extreme Gradient Boosting(XGBoost)as base learners,and Logistic Regression(LR)as the meta-learner to enhance ovarian cancer(OC)diagnosis.Local Interpretable ModelAgnostic Explanations(LIME)are used to explain individual predictions,making the model outputs more clinically interpretable and applicable.The model is trained on the dataset that includes demographic information,blood test,general chemistry,and tumor markers.Extensive preprocessing includes handling missing data using iterative imputation with Bayesian Ridge and addressing multicollinearity by removing features with correlation coefficients above 0.7.Relevant features are then selected using the Boruta feature selection method.To obtain robust and unbiased performance estimates during hyperparameter tuning,nested cross-validation(CV)with grid search is employed,and all experiments are repeated five times to ensure statistical reliability.TreeX-Stack demonstrates excellent diagnostic performance,achieving an accuracy of 0.9027,a precision of 0.8673,a recall of 0.9391,and an F1-score of 0.9012.Feature-importance analyses using LIME and permutation importance highlight Human Epididymis Protein 4(HE4)as the most significant biomarker for OC.The combination of high predictive performance and interpretability makes TreeX-Stack a reliable tool for clinical decision support in OC diagnosis.
基金supported by the International Partnership program of the Chinese Academy of Sciences(170GJHZ2023074GC)National Natural Science Foundation of China(42425706 and 42488201)+1 种基金National Key Research and Development Program of China(2024YFF0807902)Beijing Natural Science Foundation(8242041),and China Postdoctoral Science Foundation(2025M770353).
文摘Accurately assessing the relationship between tree growth and climatic factors is of great importance in dendrochronology.This study evaluated the consistency between alternative climate datasets(including station and gridded data)and actual climate data(fixed-point observations near the sampling sites),in northeastern China’s warm temperate zone and analyzed differences in their correlations with tree-ring width index.The results were:(1)Gridded temperature data,as well as precipitation and relative humidity data from the Huailai meteorological station,was more consistent with the actual climate data;in contrast,gridded soil moisture content data showed significant discrepancies.(2)Horizontal distance had a greater impact on the representativeness of actual climate conditions than vertical elevation differences.(3)Differences in consistency between alternative and actual climate data also affected their correlations with tree-ring width indices.In some growing season months,correlation coefficients,both in magnitude and sign,differed significantly from those based on actual data.The selection of different alternative climate datasets can lead to biased results in assessing forest responses to climate change,which is detrimental to the management of forest ecosystems in harsh environments.Therefore,the scientific and rational selection of alternative climate data is essential for dendroecological and climatological research.
文摘To address the severe challenges of PM_(2.5) and ozone co-control during the"14^(th) Five-Year Plan"period and to enhance the precision and intelligence level of air environment governance,it is imperative to build an efficient comprehensive management platform for regional air quality.In this paper,the specific practice in Zibo City,Shandong Province is as an example to systematically analyze the top-level design,technical implementation,and innovative application of a comprehensive management platform for regional air quality integrating"perception monitoring,data fusion,research judgment of early warnings,analysis of sources,collaborative dispatching,and evaluation assessment".Through the construction of an"sky-air-ground"integrated three-dimensional monitoring network,the platform integrates multi-source heterogeneous environmental data,and employs big data,cloud computing,artificial intelligence,CALPUFF/CMAQ,and other numerical model technologies to achieve comprehensive perception,precise prediction,intelligent source tracing,and closed-loop management of air pollution.The platform innovatively establishes a full-process closed-loop management mechanism of"data-early warning-disposition-evaluation",and achieves a fundamental transformation from passive response to active anticipation and from experience-based judgment to data driving in environmental supervision.The application results show that this platform significantly improves the scientific decision-making ability and collaborative execution efficiency of air pollution governance in Zibo City,providing a replicable and scalable comprehensive solution for similar industrial cities to achieve the continuous improvement of air quality.
基金supported by the National Natural Science Foundation of China(91959106)the Foundation of the Shanghai Municipal Education Commission(24RGZNC02)+4 种基金Shanghai Key Laboratory of Intelligent Information Processing,Fudan University(IIPL-2025-RD3-02)Key University Science Research Project of Anhui Province(2023AH030108)Climbing Peak Training Program for Innovative Technology team of Yijishan Hospital,Wannan Medical College(PF201904)Peak Training Program for Scientific Research of Yijishan Hospital,Wannan Medical College(GF2019G15)the talent project of the First Affiliated Hospital of Wannan Medical College(Yijishan Hospital of Wannan Medical College)(YR202422).
文摘tRNA-derived small RNAs(tsRNAs),as a class of regulatory small noncoding RNA,have been implicated in a wide variety of human diseases.Large amounts of tsRNA–disease associations have been identified in recent years from accumulating studies.However,repositories for cataloging the detailed information on tsRNA–disease associations are scarce.In this study,we provide a tsRNADisease database by integrating experimentally and computationally supported tsRNA–disease associations from manual curation of literatures and other related resources.tsRNADisease contains 5571 manually curated associations between 4759 tsRNAs and 166 diseases with experimental evidence from 346 studies.In addition,it also contains 5013 predicted associations between 1297 tsRNAs and 111 diseases.tsRNADisease provides a user-friendly interface to browse,retrieve,and download data conveniently.This database can improve our understanding of tsRNA deregulation in diseases and serve as a valuable resource for investigating the mechanism of disease-related tsRNAs.tsRNADisease is freely available at http://www.compgenelab.info/tsRNADisease.
基金supported by National Key R&D Program of China(No.2021YFF0501301)the National Natural Science Foundation of China(No.42172231)。
文摘0 INTRODUCTION Earth science is a natural science concerned with the composition,dynamics,spatiotemporal evolution,and formation mechanisms of Earth materials(Chen and Yang,2023).Traditional Earth science research has largely been discipline-based,relying on field investigations,data collection,experimental analyses,and data interpretation to study individual components of the Earth system.
