Objective To study the key technologies in the field of ginsenosides and to offer a guide for the future development ginsenosides through the main path identification method based on genetic knowledge persistence algo...Objective To study the key technologies in the field of ginsenosides and to offer a guide for the future development ginsenosides through the main path identification method based on genetic knowledge persistence algorithm(GKPA).Methods The global ginsenoside invention authorized patents were used as the data source to construct a ginsenoside patent self-citation network,and to identify high knowledge persistent patents(HKPP)of ginsenoside technology based on the GKPA,and extract its high knowledge persistence main path(HKPMP).Finally,the genetic forward and backward path(GFBP)was used to search the nodes on the main path,and draw the genetic forward and backward main path(GFBMP)of ginsenoside technology.Results and Conclusion The algorithm was applied to the field of ginsenosides.The research results show the milestone patents in ginsenosides technology and the main evolution process of three key technologies,which points out the future direction for the technological development of ginsenosides.The results obtained by this algorithm are more interpretable,comprehensive and scientific.展开更多
Torque teno virus(TTV) has been found to be prevalent world-wide in healthy populations and in patients with various diseases, but its etiological role has not yet been determined. Using high-throughput unbiased seque...Torque teno virus(TTV) has been found to be prevalent world-wide in healthy populations and in patients with various diseases, but its etiological role has not yet been determined. Using high-throughput unbiased sequencing to screen for viruses in the serum of a patient with persistent high fever who died of suspected viral infection and prolonged weakness, we identified the complete genome sequence of a TTV(isolate Hebei-1). The genome of TTV-Hebei-1 is 3649 bp in length, encoding four putative open reading frames, and it has a G+C content of 49%. Genomic comparison and a BLASTN search revealed that the assembled genome of TTV-Hebei-1 represented a novel isolate, with a genome sequence that was highly heterologous to the sequences of other reported TTV strains. A phylogenetic tree constructed using the complete genome sequence showed that TTV-Hebei-1 and an uncharacterized Taiwan Residents strain, TW53A37, constitute a new TTV genotype. The patient was strongly suspected of carrying a viral infection and died eventually without any other possible causes being apparent. No virus other than the novel TTV was identified in his serum sample. Although a direct causal link between the novel TTV genotype infection and the patient's disease could not be confirmed, the findings suggest that surveillance of this novel TTV genotype is necessary and that its role in disease deserves to be explored.展开更多
On June 19th,2017,the registration system of ITMA ASIA＋CITME 2018 came online officially.In the past five months,the exhibition recruitment work has obtained the general concentration of the industry.What is the bigg...On June 19th,2017,the registration system of ITMA ASIA＋CITME 2018 came online officially.In the past five months,the exhibition recruitment work has obtained the general concentration of the industry.What is the biggest difference of this exhibition with the previous ones？What will the audiences and exhibitors get from this exhibition？展开更多
This paper highlights some recent developments in testing predictability of asset returns with focuses on linear mean regressions, quantile regressions and nonlinear regression models. For these models, when predictor...This paper highlights some recent developments in testing predictability of asset returns with focuses on linear mean regressions, quantile regressions and nonlinear regression models. For these models, when predictors are highly persistent and their innovations are contemporarily correlated with dependent variable, the ordinary least squares estimator has a finite-sample bias, and its limiting distribution relies on some unknown nuisance parameter, which is not consistently estimable. Without correcting these issues, conventional test statistics are subject to a serious size distortion and generate a misleading conclusion in testing pre- dictability of asset returns in real applications. In the past two decades, sequential studies have contributed to this subject and proposed various kinds of solutions, including, but not limit to, the bias-correction procedures, the linear projection approach, the IVX filtering idea, the variable addition approaches, the weighted empirical likelihood method, and the double-weight robust approach. Particularly, to catch up with the fast-growing literature in the recent decade, we offer a selective overview of these methods. Finally, some future research topics, such as the econometric theory for predictive regressions with structural changes, and nonparametric predictive models, and predictive models under a more general data setting, are also discussed.展开更多
Background Studies of highly exposed persistently seronegative （HEPS） individuals may provide valuable information on mechanisms of protection and on vaccine design. Cellular immune responses play a critical role in...Background Studies of highly exposed persistently seronegative （HEPS） individuals may provide valuable information on mechanisms of protection and on vaccine design. Cellular immune responses play a critical role in containing human immunodeficiency virus. However, the cellular immune responses in HEPS individuals have not been thoroughly assessed at the entire viral genome level. Methods Ten HEPS Chinese with a history of frequent penetrative vaginal intercourse （mean frequency, at least once a week）, with some unprotected sexual contact occurring in the weeks or days immediately before enrollment, 25 HIV-1 seropositive individuals, 10 HIV-1-seronegative healthy individuals with low-risk sexual behavior and no history suggestive of exposure to HIV-1 infection were enrolled. HIV-1-specific T cell responses were comprehensively analyzed by an interferon- 7 Elispot assay against 770 overlapping peptides spanning all HIV-1 proteins. Results HIV-1-specific T-cell responses of interferon- 7 secretion were identified in 3 （30%） out of 10 HEPS individuals; the specific cytotoxic T lymphocytes were targeted at Pol （2/10）, Env （2/10）, and Tat （1/10）. HIV-1-specific T-cell responses of interferon- ~ secretion were identified in 20 （80%） out of 25 seropositive intravenous drug users （IDUs）, revealing that all HIV-1 proteins and protein subunits could serve as targets for HIV-1-specific CD8^＋ T cell responses with 85% recognizing Gag, 80% recognizing Nef, 75% recognizing Pol, 60% recognizing Env, 55% recognizing Vpu, 45% recognizing Vpr, 20% recognizing Vif, 20% recognizing Tat and 15% recognizing Rev in these seropositive individuals. None of the seronegative healthy individuals gave the positive T-cell responses. Conclusions About 30% of HEPS Chinese mounted HIV-1 specific T cell immune responses. Cell-mediated immunity against HIV-1 may be developed through non-productive infections.展开更多
Two persistent heavy rainfall（PHR） events in the middle and lower reaches of Yangtze River（MLYR）occurring in June 1982 and 1998 are studied in this paper.Though both events happened in the Meiyu season,their large...Two persistent heavy rainfall（PHR） events in the middle and lower reaches of Yangtze River（MLYR）occurring in June 1982 and 1998 are studied in this paper.Though both events happened in the Meiyu season,their large-scale background and developing processes were quite different.During the PHR event in 1982,the Lake Baikal area was occupied by a strong westerly trough and the western Pacific subtropical high（WPSH） was stronger and more westward-extending than the normal years.Under such a condition,the cold dry air and warm moist air were continuously transported to the MLYR and favored the PHR there.For the event in 1998,the WPSH was similar to that in 1982,while the westerly trough in the Lake Baikal area was comparatively weak and a shortwave trough situating in East China contributed to advect cold dry air to the MLYR.It is found that the high-latitude trough was closely related to the 1030-day low-frequency oscillation while the anomaly of WPSH was linked with the combined effect of both30 60- and 10 30-day low-frequency oscillations in the PHR event in 1982.By contrast,the 60-day low-pass perturbation demonstrated positive impact on the westward extension of WPSH and development of the Baikal trough while the 30 60-day oscillation played a role in strengthening the shortwave trough in East China and the WPSH in the case of 1998.Though the low-latitude 30 60-day oscillations contributed to the intensification and westward extension of the WPSH in both PHR events,their evolution exhibited evident differences.In the 1982 case,the 30 60-day anomalies originated from the western Indian Ocean were much more like the Madden Julian Oscillation,while its counterpart in the 1998 case was much more similar to the first mode of the boreal summer intraseasonal oscillation.展开更多
文摘Objective To study the key technologies in the field of ginsenosides and to offer a guide for the future development ginsenosides through the main path identification method based on genetic knowledge persistence algorithm(GKPA).Methods The global ginsenoside invention authorized patents were used as the data source to construct a ginsenoside patent self-citation network,and to identify high knowledge persistent patents(HKPP)of ginsenoside technology based on the GKPA,and extract its high knowledge persistence main path(HKPMP).Finally,the genetic forward and backward path(GFBP)was used to search the nodes on the main path,and draw the genetic forward and backward main path(GFBMP)of ginsenoside technology.Results and Conclusion The algorithm was applied to the field of ginsenosides.The research results show the milestone patents in ginsenosides technology and the main evolution process of three key technologies,which points out the future direction for the technological development of ginsenosides.The results obtained by this algorithm are more interpretable,comprehensive and scientific.
基金supported by a grant from the National Natural Science Foundation of China (No. 81072350)the National Hi-Tech Research and Development (863) Program of China (No. 2012AA022-003)+2 种基金the China Mega-Project on Major Drug Development (No. 2011ZX09401-023)the China Mega-Project on Infectious Disease Prevention (No. 2013ZX10004-605, No. 2013ZX10004-607, No. 2013ZX10004-217, and No. 2011ZX10004-001) the State Key Laboratory of Pathogen and BioSecurity Program (No. SKLPBS1113)
文摘Torque teno virus(TTV) has been found to be prevalent world-wide in healthy populations and in patients with various diseases, but its etiological role has not yet been determined. Using high-throughput unbiased sequencing to screen for viruses in the serum of a patient with persistent high fever who died of suspected viral infection and prolonged weakness, we identified the complete genome sequence of a TTV(isolate Hebei-1). The genome of TTV-Hebei-1 is 3649 bp in length, encoding four putative open reading frames, and it has a G+C content of 49%. Genomic comparison and a BLASTN search revealed that the assembled genome of TTV-Hebei-1 represented a novel isolate, with a genome sequence that was highly heterologous to the sequences of other reported TTV strains. A phylogenetic tree constructed using the complete genome sequence showed that TTV-Hebei-1 and an uncharacterized Taiwan Residents strain, TW53A37, constitute a new TTV genotype. The patient was strongly suspected of carrying a viral infection and died eventually without any other possible causes being apparent. No virus other than the novel TTV was identified in his serum sample. Although a direct causal link between the novel TTV genotype infection and the patient's disease could not be confirmed, the findings suggest that surveillance of this novel TTV genotype is necessary and that its role in disease deserves to be explored.
文摘On June 19th,2017,the registration system of ITMA ASIA＋CITME 2018 came online officially.In the past five months,the exhibition recruitment work has obtained the general concentration of the industry.What is the biggest difference of this exhibition with the previous ones？What will the audiences and exhibitors get from this exhibition？
基金supported by the National Natural Science Foundation of China(71631004,71571152)the Fundamental Research Funds for the Central Universities(20720171002,20720170090)the Fok Ying-Tong Education Foundation(151084)
文摘This paper highlights some recent developments in testing predictability of asset returns with focuses on linear mean regressions, quantile regressions and nonlinear regression models. For these models, when predictors are highly persistent and their innovations are contemporarily correlated with dependent variable, the ordinary least squares estimator has a finite-sample bias, and its limiting distribution relies on some unknown nuisance parameter, which is not consistently estimable. Without correcting these issues, conventional test statistics are subject to a serious size distortion and generate a misleading conclusion in testing pre- dictability of asset returns in real applications. In the past two decades, sequential studies have contributed to this subject and proposed various kinds of solutions, including, but not limit to, the bias-correction procedures, the linear projection approach, the IVX filtering idea, the variable addition approaches, the weighted empirical likelihood method, and the double-weight robust approach. Particularly, to catch up with the fast-growing literature in the recent decade, we offer a selective overview of these methods. Finally, some future research topics, such as the econometric theory for predictive regressions with structural changes, and nonparametric predictive models, and predictive models under a more general data setting, are also discussed.
基金This work has been funded by the 10th Five-Year National Key Technologies R & D Program of China (No. 2004BA719A01).
文摘Background Studies of highly exposed persistently seronegative （HEPS） individuals may provide valuable information on mechanisms of protection and on vaccine design. Cellular immune responses play a critical role in containing human immunodeficiency virus. However, the cellular immune responses in HEPS individuals have not been thoroughly assessed at the entire viral genome level. Methods Ten HEPS Chinese with a history of frequent penetrative vaginal intercourse （mean frequency, at least once a week）, with some unprotected sexual contact occurring in the weeks or days immediately before enrollment, 25 HIV-1 seropositive individuals, 10 HIV-1-seronegative healthy individuals with low-risk sexual behavior and no history suggestive of exposure to HIV-1 infection were enrolled. HIV-1-specific T cell responses were comprehensively analyzed by an interferon- 7 Elispot assay against 770 overlapping peptides spanning all HIV-1 proteins. Results HIV-1-specific T-cell responses of interferon- 7 secretion were identified in 3 （30%） out of 10 HEPS individuals; the specific cytotoxic T lymphocytes were targeted at Pol （2/10）, Env （2/10）, and Tat （1/10）. HIV-1-specific T-cell responses of interferon- ~ secretion were identified in 20 （80%） out of 25 seropositive intravenous drug users （IDUs）, revealing that all HIV-1 proteins and protein subunits could serve as targets for HIV-1-specific CD8^＋ T cell responses with 85% recognizing Gag, 80% recognizing Nef, 75% recognizing Pol, 60% recognizing Env, 55% recognizing Vpu, 45% recognizing Vpr, 20% recognizing Vif, 20% recognizing Tat and 15% recognizing Rev in these seropositive individuals. None of the seronegative healthy individuals gave the positive T-cell responses. Conclusions About 30% of HEPS Chinese mounted HIV-1 specific T cell immune responses. Cell-mediated immunity against HIV-1 may be developed through non-productive infections.
基金Supported by the National(Key)Basic Research and Development(973)Program of China(2012CB417201)National Natural Science Foundation of China(41475046)
文摘Two persistent heavy rainfall（PHR） events in the middle and lower reaches of Yangtze River（MLYR）occurring in June 1982 and 1998 are studied in this paper.Though both events happened in the Meiyu season,their large-scale background and developing processes were quite different.During the PHR event in 1982,the Lake Baikal area was occupied by a strong westerly trough and the western Pacific subtropical high（WPSH） was stronger and more westward-extending than the normal years.Under such a condition,the cold dry air and warm moist air were continuously transported to the MLYR and favored the PHR there.For the event in 1998,the WPSH was similar to that in 1982,while the westerly trough in the Lake Baikal area was comparatively weak and a shortwave trough situating in East China contributed to advect cold dry air to the MLYR.It is found that the high-latitude trough was closely related to the 1030-day low-frequency oscillation while the anomaly of WPSH was linked with the combined effect of both30 60- and 10 30-day low-frequency oscillations in the PHR event in 1982.By contrast,the 60-day low-pass perturbation demonstrated positive impact on the westward extension of WPSH and development of the Baikal trough while the 30 60-day oscillation played a role in strengthening the shortwave trough in East China and the WPSH in the case of 1998.Though the low-latitude 30 60-day oscillations contributed to the intensification and westward extension of the WPSH in both PHR events,their evolution exhibited evident differences.In the 1982 case,the 30 60-day anomalies originated from the western Indian Ocean were much more like the Madden Julian Oscillation,while its counterpart in the 1998 case was much more similar to the first mode of the boreal summer intraseasonal oscillation.
