The pleiotropic functions of circulating high density lipoprotein（HDL） on peripheral vascular health are well established. HDL plays a pivotal role in reverse cholesterol transport and is also known to suppress infl...The pleiotropic functions of circulating high density lipoprotein（HDL） on peripheral vascular health are well established. HDL plays a pivotal role in reverse cholesterol transport and is also known to suppress inflammation,endothelial activation and apoptosis in peripheral vessels. Although not expressed in the central nervous system, HDL has nevertheless emerged as a potential resilience factor for dementia in multiple epidemiological studies. Animal model data specifically support a role for HDL in attenuating the accumulation of P-amyloid within cerebral vessels concomitant with reduced neuroinflammation and improved cognitive performance. As the vascular contributions to dementia are increasingly appreciated, this review seeks to summarize recent literature focused on the vasoprotective properties of HDL that may extend to cerebral vessels, discuss potential roles of HDL in dementia relative to brainderived lipoproteins, identify gaps in current knowledge, and highlight new opportunities for research and discovery.展开更多
The nitrate ester substitution derivatives of prismane were studied at the B3LYP/6-311G＊＊ level. The sublimation enthalpies and heats of formation in gas phase and solid state were calculated. The detonation perform...The nitrate ester substitution derivatives of prismane were studied at the B3LYP/6-311G＊＊ level. The sublimation enthalpies and heats of formation in gas phase and solid state were calculated. The detonation performances were also predicted by using the famous Kamlet-Jacbos equation. Our calculated results show that introducing nitrate ester group into prismane is helpful to enhance its detonation properties. Stabilities were evaluated through the bond dissociation energies, bond order, characteristic heights（H50） and band gap calculations. The trigger bonds in the pyrolysis process of prismane derivatives were confirmed as O–ON2 bond. The BDEs of all compounds were large, so these prismane derivatives have excellent stability consistent with the results of H50 and band gap.展开更多
Objective： To observe the effects of Xiongshao Capsule（芎芍胶囊, XSC） on anti-inflammatory properties of high-density lipoprotein（HDL）, myeloperoxidase（MPO） and paraoxonase 1（PON1） in serum of atherosclerosis...Objective： To observe the effects of Xiongshao Capsule（芎芍胶囊, XSC） on anti-inflammatory properties of high-density lipoprotein（HDL）, myeloperoxidase（MPO） and paraoxonase 1（PON1） in serum of atherosclerosis（AS） rabbit model and explore the anti-inflammatory protective effects of XSC on HDL. Methods： Sixty rabbits were randomized into the control, the model, XSC low-, medium-and high-dose（Rhizoma Chuanxiong ＋ Radix Paeoniae rubra ： 0.6＋0.3, 1.2＋0.6, 2.4＋1.2 g·kg-1·day-1, respectively）, and simvastatin（1 g·kg-1·day-1） groups. The model rabbits were fed with high-fat diet and respective drugs for 15 weeks. The blood and thoracic aortas samples were collected at the end of 15 weeks. The levels of serum MPO and PON1 as well as total cholesterol（TC） and free cholesterol（FC） in aorta wall cells were tested by enzyme linked immunosorbent assay. Results： TC and FC in the model group were significantly higher than those in the control group（P〈0.01）. Compared with the model group, TC and FC in the XSC groups were significantly lower（P〈0.05 or P〈0.01）, so was simvastatin group（P〈0.01）. There was no significant difference in PON1 level between groups（P〉0.05）, even between model and control groups（P〉0.05）. The serum MPO level in the model group was significantly higher than that in the control group（P〈0.05）, which was significantly lower in XSC groups as well as simvastatin group（P〈0.05 or P〈0.01）, and no difference was found between XSC groups and simvastatin group（P〉0.05）. Conclusions： XSC can reduce the serum MPO level in AS rabbits to protect the anti-inflammatory function of HDL, maintaining the normal lipid transport function. TC and FC levels in aorta cells decline, and this process initiated by XSC plays an anti-AS role.展开更多
文摘The pleiotropic functions of circulating high density lipoprotein（HDL） on peripheral vascular health are well established. HDL plays a pivotal role in reverse cholesterol transport and is also known to suppress inflammation,endothelial activation and apoptosis in peripheral vessels. Although not expressed in the central nervous system, HDL has nevertheless emerged as a potential resilience factor for dementia in multiple epidemiological studies. Animal model data specifically support a role for HDL in attenuating the accumulation of P-amyloid within cerebral vessels concomitant with reduced neuroinflammation and improved cognitive performance. As the vascular contributions to dementia are increasingly appreciated, this review seeks to summarize recent literature focused on the vasoprotective properties of HDL that may extend to cerebral vessels, discuss potential roles of HDL in dementia relative to brainderived lipoproteins, identify gaps in current knowledge, and highlight new opportunities for research and discovery.
基金supported by the Natural Science Foundation of Guizhou Province(QKJ[2014]2140 and QJTD[2012]052)
文摘The nitrate ester substitution derivatives of prismane were studied at the B3LYP/6-311G＊＊ level. The sublimation enthalpies and heats of formation in gas phase and solid state were calculated. The detonation performances were also predicted by using the famous Kamlet-Jacbos equation. Our calculated results show that introducing nitrate ester group into prismane is helpful to enhance its detonation properties. Stabilities were evaluated through the bond dissociation energies, bond order, characteristic heights（H50） and band gap calculations. The trigger bonds in the pyrolysis process of prismane derivatives were confirmed as O–ON2 bond. The BDEs of all compounds were large, so these prismane derivatives have excellent stability consistent with the results of H50 and band gap.
基金Supported by the National Natural Science Foundation of China(No.81173385)
文摘Objective： To observe the effects of Xiongshao Capsule（芎芍胶囊, XSC） on anti-inflammatory properties of high-density lipoprotein（HDL）, myeloperoxidase（MPO） and paraoxonase 1（PON1） in serum of atherosclerosis（AS） rabbit model and explore the anti-inflammatory protective effects of XSC on HDL. Methods： Sixty rabbits were randomized into the control, the model, XSC low-, medium-and high-dose（Rhizoma Chuanxiong ＋ Radix Paeoniae rubra ： 0.6＋0.3, 1.2＋0.6, 2.4＋1.2 g·kg-1·day-1, respectively）, and simvastatin（1 g·kg-1·day-1） groups. The model rabbits were fed with high-fat diet and respective drugs for 15 weeks. The blood and thoracic aortas samples were collected at the end of 15 weeks. The levels of serum MPO and PON1 as well as total cholesterol（TC） and free cholesterol（FC） in aorta wall cells were tested by enzyme linked immunosorbent assay. Results： TC and FC in the model group were significantly higher than those in the control group（P〈0.01）. Compared with the model group, TC and FC in the XSC groups were significantly lower（P〈0.05 or P〈0.01）, so was simvastatin group（P〈0.01）. There was no significant difference in PON1 level between groups（P〉0.05）, even between model and control groups（P〉0.05）. The serum MPO level in the model group was significantly higher than that in the control group（P〈0.05）, which was significantly lower in XSC groups as well as simvastatin group（P〈0.05 or P〈0.01）, and no difference was found between XSC groups and simvastatin group（P〉0.05）. Conclusions： XSC can reduce the serum MPO level in AS rabbits to protect the anti-inflammatory function of HDL, maintaining the normal lipid transport function. TC and FC levels in aorta cells decline, and this process initiated by XSC plays an anti-AS role.
