A heterogeneous wireless sensor network comprises a number of inexpensive energy constrained wireless sensor nodes which collect data from the sensing environment and transmit them toward the improved cluster head in ...A heterogeneous wireless sensor network comprises a number of inexpensive energy constrained wireless sensor nodes which collect data from the sensing environment and transmit them toward the improved cluster head in a coordinated way. Employing clustering techniques in such networks can achieve balanced energy consumption of member nodes and prolong the network lifetimes.In classical clustering techniques, clustering and in-cluster data routes are usually separated into independent operations. Although separate considerations of these two issues simplify the system design, it is often the non-optimal lifetime expectancy for wireless sensor networks. This paper proposes an integral framework that integrates these two correlated items in an interactive entirety. For that,we develop the clustering problems using nonlinear programming. Evolution process of clustering is provided in simulations. Results show that our joint-design proposal reaches the near optimal match between member nodes and cluster heads.展开更多
Gastrointestinal cancers,including esophageal,gastric,colorectal,liver,gallbladder,cholangiocarcinoma,and pancreatic cancers,pose a significant global health challenge due to their high mortality rates and poor progno...Gastrointestinal cancers,including esophageal,gastric,colorectal,liver,gallbladder,cholangiocarcinoma,and pancreatic cancers,pose a significant global health challenge due to their high mortality rates and poor prognosis,particularly when diagnosed at advanced stages.These malignancies,characterized by diverse clinical presentations and etiologies,require innovative approaches for improved management.Bayesian networks(BN)have emerged as a powerful tool in this field,offering the ability to manage uncertainty,integrate heterogeneous data sources,and support clinical decision-making.This review explores the application of BN in addressing critical challenges in gastrointestinal cancers,including the identification of risk factors,early detection,treatment optimization,and prognosis prediction.By integrating genetic predispositions,lifestyle factors,and clinical data,BN hold the potential to enhance survival rates and improve quality of life through personalized treatment strategies.Despite their promise,the widespread adoption of BN is hindered by challenges such as data quality limitations,computational complexities,and the need for greater clinical acceptance.The review concludes with future research directions,emphasizing the development of advanced BN algorithms,the integration of multi-omics data,and strategies to ensure clinical applicability,aiming to fully realize the potential of BN in personalized medicine for gastrointestinal cancers.展开更多
Alpha-synuclein plays an important role in Parkinson's disease(PD).The current study of alpha-synuclein mainly concentrates at the gene level.However, it is found that the study at the protein level has special si...Alpha-synuclein plays an important role in Parkinson's disease(PD).The current study of alpha-synuclein mainly concentrates at the gene level.However, it is found that the study at the protein level has special significance.Meanwhile, there is free information on the Internet, such as databases and algorithms of protein-protein interactions(PPIs).In this paper, a novel method which integrates distributed heterogeneous data sources and algorithms to predict PPIs for alpha-synuclein in silico is proposed.The PPIs generated by the method take advantage of various experimental data, and indicate new information about PPIs for alpha-synuclein.In the end of this paper, the result illustrates that the method is practical.It is hoped that the prediction result obtained by this method can provide guidance for biological experiments of PPIs for alpha-synuclein to reveal possible mechanisms of PD.展开更多
基金supported by National Natural Science Foundation of China(Nos.61304131 and 61402147)Grant of China Scholarship Council(No.201608130174)+2 种基金Natural Science Foundation of Hebei Province(Nos.F2016402054 and F2014402075)the Scientific Research Plan Projects of Hebei Education Department(Nos.BJ2014019,ZD2015087 and QN2015046)the Research Program of Talent Cultivation Project in Hebei Province(No.A2016002023)
文摘A heterogeneous wireless sensor network comprises a number of inexpensive energy constrained wireless sensor nodes which collect data from the sensing environment and transmit them toward the improved cluster head in a coordinated way. Employing clustering techniques in such networks can achieve balanced energy consumption of member nodes and prolong the network lifetimes.In classical clustering techniques, clustering and in-cluster data routes are usually separated into independent operations. Although separate considerations of these two issues simplify the system design, it is often the non-optimal lifetime expectancy for wireless sensor networks. This paper proposes an integral framework that integrates these two correlated items in an interactive entirety. For that,we develop the clustering problems using nonlinear programming. Evolution process of clustering is provided in simulations. Results show that our joint-design proposal reaches the near optimal match between member nodes and cluster heads.
基金Supported by Open Funds for Shaanxi Provincial Key Laboratory of Infection and Immune Diseases,No.2023-KFMS-1.
文摘Gastrointestinal cancers,including esophageal,gastric,colorectal,liver,gallbladder,cholangiocarcinoma,and pancreatic cancers,pose a significant global health challenge due to their high mortality rates and poor prognosis,particularly when diagnosed at advanced stages.These malignancies,characterized by diverse clinical presentations and etiologies,require innovative approaches for improved management.Bayesian networks(BN)have emerged as a powerful tool in this field,offering the ability to manage uncertainty,integrate heterogeneous data sources,and support clinical decision-making.This review explores the application of BN in addressing critical challenges in gastrointestinal cancers,including the identification of risk factors,early detection,treatment optimization,and prognosis prediction.By integrating genetic predispositions,lifestyle factors,and clinical data,BN hold the potential to enhance survival rates and improve quality of life through personalized treatment strategies.Despite their promise,the widespread adoption of BN is hindered by challenges such as data quality limitations,computational complexities,and the need for greater clinical acceptance.The review concludes with future research directions,emphasizing the development of advanced BN algorithms,the integration of multi-omics data,and strategies to ensure clinical applicability,aiming to fully realize the potential of BN in personalized medicine for gastrointestinal cancers.
基金supported by the National Basic Research Program of China (Grant No.2006CB500702)the Shanghai Lead-ing Academic Discipline Project (Grant No.J50103)Shanghai University Systems Biology Reasearch Funding (GrantNo.SBR08001)
文摘Alpha-synuclein plays an important role in Parkinson's disease(PD).The current study of alpha-synuclein mainly concentrates at the gene level.However, it is found that the study at the protein level has special significance.Meanwhile, there is free information on the Internet, such as databases and algorithms of protein-protein interactions(PPIs).In this paper, a novel method which integrates distributed heterogeneous data sources and algorithms to predict PPIs for alpha-synuclein in silico is proposed.The PPIs generated by the method take advantage of various experimental data, and indicate new information about PPIs for alpha-synuclein.In the end of this paper, the result illustrates that the method is practical.It is hoped that the prediction result obtained by this method can provide guidance for biological experiments of PPIs for alpha-synuclein to reveal possible mechanisms of PD.
