Recently,Prevotella spp.,a major genus of gram-negative commensal bacteria in humans,have emerged as a key microbial contributor to host metabolism due to its ability to ferment dietary fibers,produce beneficial short...Recently,Prevotella spp.,a major genus of gram-negative commensal bacteria in humans,have emerged as a key microbial contributor to host metabolism due to its ability to ferment dietary fibers,produce beneficial short-chain fatty acids,and influence immune responses.However,their diversity and functional differences have created challenges for their development and therapeutic use.Recent studies have shown that specific Prevotella species,such as P.copri,P.intestinalis,and P.histicola,can strengthen gut barrier integrity and reduce metabolic imbalances.Notably,Prevotella populations can be increased through high-fiber or herbal-based treatments.Traditional herbal medicines,including fiber-rich decoctions,also demonstrate the potential to boost endogenous Prevotella communities,enhance microbial fermentation,and improve glucose and lipid balance.This perspective examines the context-dependent roles of Prevotella spp.,with emphasis on the functional heterogeneity of key species such as P.copri,suggests a framework for combining herbal modulation with species-level microbiota profiling,and outlines a research plan to explore microbe-herb synergy in treating obesity,type 2 diabetes,and related metabolic disorders.This strategy offers a new,ecology-based approach to complement standard metabolic interventions.展开更多
Background Meat originating from the spent hen is an important source of poultry meat production;however,multiple factors cause the decline in the meat quality of spent hens.Chinese herbs have been widely used as medi...Background Meat originating from the spent hen is an important source of poultry meat production;however,multiple factors cause the decline in the meat quality of spent hens.Chinese herbs have been widely used as medi-cine for a long time to prevent diseases and as nutrient supplements to improve the product quality.This experi-ment explored the effects of adding 1.0%Chinese herbal formula(CHF,including 0.30%Leonurus japonicus Houtt.,0.20%Salvia miltiorrhiza Bge.,0.25%Ligustrum lucidum Ait.,and 0.25%Taraxacum mongolicum Hand.-Mazz.)for 120 d to the spent hens’diet through metabolomics,network pharmacology,and microbiome strategies.Results The results indicated that CHF supplementation improved the meat quality by reducing drip loss(P<0.05),b*value(P=0.058),and shear force(P=0.099)and increasing cooked meat percentage(P=0.054)and dry matter(P<0.05)of breast muscle.The addition of CHF improved the nutritional value of breast muscle by increasing(P<0.05)the content of C18:2n-6,n-6/n-3 polyunsaturated fatty acids(PUFA),total PUFA,PUFA-to-saturated fatty acids(SFA)ratio,and hypocholesterolemic-to-hypercholesterolemic ratio,and tending to increase serine content(P=0.069).The targeted metabolomics analysis revealed that the biosynthesis of SFA,linoleic acid metabolism,fatty acid degradation,fatty acid elongation,and fatty acid biosynthesis pathways were enriched by CHF supplementation.Furthermore,the network pharmacology analysis indicated that CHF was closely associated with oxidative stress and lipid metabo-lism.The CHF supplementation increased the glutathione peroxidase level(P<0.05)and upregulated gene expres-sion related to the Nrf2 pathway(including HO-1,P<0.05;Nrf2,P=0.098;CAT,P=0.060;GPX1,P=0.063;and SOD2,P=0.052)and lipid metabolism(including PPARγ,P<0.05;SREBP1,P=0.059;and CPT1A,P=0.058).Additionally,CHF supplementation increased Firmicutes and decreased Bacteroidetes,Spirochaetes,and Synergistetes abundances(P<0.05),which may contribute to better meat quality.Conclusions Our results suggest that CHF supplementation improved the quality and nutritional value of meat,which will provide a theoretical basis for the utilization of CHF as a feed additive in spent hens’diets.展开更多
This paper first analyzes the complexity of pathological processes involved in acute hemorrhagic or ischemic stroke,including primary and secondary brain injury manifestations and mechanisms,potential transformations ...This paper first analyzes the complexity of pathological processes involved in acute hemorrhagic or ischemic stroke,including primary and secondary brain injury manifestations and mechanisms,potential transformations between hemorrhage and infarction,and the impact of postbrain injury inflammation on disease progression.Based on decades of extensive clinical and pharmacological research on the usage of Chinese herbal medicine(CHM)monomers or formulas that promote blood circulation and remove blood stasis(such as Angong Niuhuang Wan,Buyang Huanwu Tang,Dahuoluo Wan,and Dushen Tang)for stroke treatment,it proposes that tonifying qi,promoting blood circulation,removing blood stasis,and detoxifying are rational treatment principles of CHM.These principles correspond to the following Western medical implications:tonifying qi corresponds to neuroprotection effects,promoting blood circulation corresponds to anticoagulation and thrombolysis,removing blood stasis addresses hematoma absorption and cerebral edema reduction,and detoxifying corresponds to anti-inflammatory actions.This paper further proposes from a systems medicine perspective that acute stroke is a complex disease requiring individualized CHM treatment with timely modifications rather than a one-sizefits-all approach.CHM monomers or formulas for promoting blood circulation and removing blood stasis,which have various effects such as lowering blood pressure,hemostasis,anticoagulation,antiplatelet,anti-inflammatory,promoting fibrinolysis,and edema reduction,must align with disease progression and be applied within appropriate therapeutic time windows to ensure efficacy and safety.Finally,this paper suggests that a combined use of acupuncture and CHM can potentially synergistically leverage their respective therapeutic strengths.Additionally,acupuncture shows clear benefits in the acute phase of intracerebral hemorrhage(ICH),such as stimulating the vagus nerve to enhance cerebral blood flow,reducing inflammation,as well as triggering hemostatic effects.By applying these rational treatment principles in an integrated approach,better CHM treatment outcomes and higher efficacy of stroke management may be attained.展开更多
The use of traditional herbal drugs derived from natural sources is on the rise due to their minimal side effects and numerous health benefits.However,a major limitation is the lack of standardized knowledge for ident...The use of traditional herbal drugs derived from natural sources is on the rise due to their minimal side effects and numerous health benefits.However,a major limitation is the lack of standardized knowledge for identifying and mapping the quality of these herbal medicines.This article aims to provide practical insights into the application of artificial intelligence for quality-based commercialization of raw herbal drugs.It focuses on feature extraction methods,image processing techniques,and the preparation of herbal images for compatibility with machine learning models.The article discusses commonly used image processing tools such as normalization,slicing,cropping,and augmentation to prepare images for artificial intelligence-based models.It also provides an overview of global herbal image databases and the models employed for herbal plant/drug identification.Readers will gain a comprehensive understanding of the potential application of various machine learning models,including artificial neural networks and convolutional neural networks.The article delves into suitable validation parameters like true positive rates,accuracy,precision,and more for the development of artificial intelligence-based identification and authentication techniques for herbal drugs.This article offers valuable insights and a conclusive platform for the further exploration of artificial intelligence in the field of herbal drugs,paving the way for smarter identification and authentication methods.展开更多
The herbal drink “Attoté” has been widely used in the Abidjan district to treat a number of illnesses, notably erectile dysfunction. Despite the popularity of its therapeutic effects, very few studies have been...The herbal drink “Attoté” has been widely used in the Abidjan district to treat a number of illnesses, notably erectile dysfunction. Despite the popularity of its therapeutic effects, very few studies have been carried out on its effects on the health of users. The aim of this study was to identify the constituents contained in the phytomedicinal product and to assess their potential adverse effects in vivo. Phytochemical screening was conducted to identify the bioactive molecules in “Attoté” and to evaluate its hepatic effects in vivo. Forty (40) Wistar rats, randomly divided into 4 groups, with 10 animals per group (5 males and 5 females) were used to study potential hepatotoxic effects. Group 1 animals (control group) received distilled water. Batches I, II and III received by gavage a volume of Attoté extract corresponding to 1 ml/100 g body weight at 200 mg/kg, 400 mg/kg and 800 mg/kg, respectively. Attoté extract was administered daily at the same time for 28 days, and serum was collected every two weeks to assess hepatic biochemical markers by spectrophotometry using a Cobas C311® HITACHI biochemistry system. After one month of study, the rats were euthanized by ether overdose and the livers were harvested for morphological and histopathological analysis. Phytochemical screening revealed the presence of alkaloids, polyphenols, leucoanthocyanes, anthraquinones and quinones. Hepatic biochemical and hematological parameters such as red globular, hemoglobin, alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), alkaline phosphatase (ALPs) and gamma glutamyl transferase (GGT) showed no significant change (p > 0.05) in the treated rat group compared with controls. However, these variations were moderate and transient, with values remaining almost within their standard limits. Microscopic observations of liver tissue sections from treated rats showed no liver damage or dysfunction. This study merits further investigation, with a view to gaining a better understanding of the cytotoxic mechanisms of herbal medicinal beverages, with a view to their reformulation as improved traditional medicines (ITMs).展开更多
[Objectives]To systematically evaluate the clinical efficacy of head massage combined with Chinese herbal bath in treating insomnia and analyze its herbal medication patterns.[Methods]Clinical data of 200 chronic inso...[Objectives]To systematically evaluate the clinical efficacy of head massage combined with Chinese herbal bath in treating insomnia and analyze its herbal medication patterns.[Methods]Clinical data of 200 chronic insomnia patients treated at the Sleep Disorder Center of Taihe Hospital from January 2020 to December 2024 were retrospectively analyzed.Patients were randomly divided into observation group and control group(n=100 each).The observation group received head massage combined with Chinese herbal bath therapy,while the control group received Chinese herbal bath alone.The Pittsburgh Sleep Quality Index(PSQI)was used for efficacy evaluation,and statistical analysis was performed on the frequency of herbal medications in herbal herbal bath formulas.[Results]The PSQI score improvement in the observation group(8.44±1.87)was significantly better than that in the control group(5.74±1.93)(P<0.01).Herbal formulas for external bath primarily contained mind-calming and heart-nourishing herbs(fried Ziziphi Spinosae Semen,Concha Margaritifera)and heat-clearing herbs(Rhizoma Coptidis,Radix Scutellariae).[Conclusions]The combination of head massage and Chinese herbal bath can significantly improve sleep quality in insomnia patients,demonstrating superior clinical efficacy compared with Chinese herbal bath alone.This combined therapy shows good safety and operability,warranting promotion in primary and specialized medical institutions.展开更多
This review examines the distinct mechanisms of Tuina massage and topical herbal medicine in pediatric diarrhea management,focusing on their independent regulation of gastrointestinal metabolism and barrier function.T...This review examines the distinct mechanisms of Tuina massage and topical herbal medicine in pediatric diarrhea management,focusing on their independent regulation of gastrointestinal metabolism and barrier function.Tuina therapy primarily enhances gastrointestinal motility through the stimulation of targeted acupoints such as Tianshu(ST25)and Shenque(CV8),activating vagal efferent pathways to normalize motility hormones including motilin while suppressing pro-inflammatory cytokines such interleukin-6 and tumor necrosis factor-alpha.It further reinforces mucosal defense by inhibiting mast cell degranulation and augmenting microcirculation via nitric oxide-mediated vasodilation.Herbal medicine containing bioactive compounds from Atractylodes macrocephala and Poria cocos directly restores intestinal barrier integrity by upregulating tight junction proteins occludin and zonula occludens-1,inhibiting epithelial apoptosis,and stimulating MUC2 production.These formulations additionally reprogram enterocyte metabolism by reactivating mitochondrial tricarboxylic acid cycle flux and modulating short-chain fatty acid profiles,with the independent prebiotic effects enhancing commensal butyrate production.Tuina primarily modulates neuroimmune pathways and motility,and herbal medicine directly targets epithelial repair and metabolism.These therapeutic pathways may address core diarrhea pathophysiology,providing holistic complementary therapies.Standardized protocols and interdisciplinary research are urgently needed for clinical translation.展开更多
[Objectives]This study was conducted to investigate the effects of a compound Chinese herbal medicine pig gut microbiota and metabolic ecology.[Methods]Through 16S rRNA high-throughput sequencing and metabolomics,the ...[Objectives]This study was conducted to investigate the effects of a compound Chinese herbal medicine pig gut microbiota and metabolic ecology.[Methods]Through 16S rRNA high-throughput sequencing and metabolomics,the effects of administing a 5%compound mixture of Pseudostellaria heterophylla,Uncaria rhynchophylla and Lonicera japonica for 60 d on the intestinal microbiota and metabolites of three-way crossbred pigs were evaluated.[Results]The Chinese herbal medicine(CHM)group exhibited improvedα-diversity indices(Ace=541.22,Shannon=3.36,Simpson=0.10),though not significant(P>0.05),compared with the CK group(Ace=511.46,Shannon=2.75,Simpson=0.12).β-diversity analysis revealed a clear separation between the groups.At the phylum level,the overall differences in gut microbiota composition were minor.However,the CHM group showed a substantial increase in Bacteroidota in the cecum and a significant rise in Myxobacteria,which have anti-inflammatory and anti-obesity potential,suggesting a positive effect on intestinal health.Meanwhile,the CHM group exhibited 67 unique OTUs,higher than 27 in the CK group,primarily concentrated in the ileum and cecum.Additionally,metabolomic analysis revealed 210 unique metabolites in the CHM group,surpassing 77 in the CK group.A total of 653 metabolites showed significant changes,involving 11 metabolic pathways.Correlation analysis revealed that metabolites such as PC,PE,LysoPC,LysoPE and dehydrocarpaine were closely associated with microbiota.In the CHM group,key metabolites exhibited complex interactions with gut microbiota.Dehydrocarpaine showed positive correlations with probiotics such as Lactobacillus and Bifidobacterium.[Conclusions]These results demonstrated that CHM potentially enhanced pig gut health by improving microbial diversity and regulating metabolic networks,providing a scientific basis for further optimization of swine farming strategies.展开更多
A novel low molecular weight compound polysaccharide(LMW-CPS) was identified from a specific combination of Chinese herb ingredients.The monosaccharide composition of LMW-CPS was consisted of single arabinose,which ha...A novel low molecular weight compound polysaccharide(LMW-CPS) was identified from a specific combination of Chinese herb ingredients.The monosaccharide composition of LMW-CPS was consisted of single arabinose,which had an α-L-furanose configuration with an average molecular weight of 2.06 kDa.NMR spectra and monosaccharide constitution analyses revealed that it had a backbone of→5)-α-L-Araf-(1→with α-L-Araf(1→as the terminal residue.In vitro experiments found that it could lead to apoptosis and inhibit hepatocellular carcinoma cell proliferation by arresting them in the S phase.In vivo experiments showed that it protected immune organs such as the thymus and spleen,enhanced immune cell activities,stimulated cytokine release,augmented the abundance of CD8,CD3,CD4,and CD 19 positive lymphocytes,and markedly impeded solid hepatocellular carcinoma progression in mice.Hematoxylin and eosin staining and cell cycle examination also indicated that LMW-CPS arrested hepatocellular carcinoma cells at the S phase to induce apoptosis.These findings indicated its promising potential for the treatment of hepatocellular carcinoma.展开更多
The amalgamation of herbal medicine and nanoformulation technology presents a compelling avenue for the advancement of pharmaceutical and health food products.This synergy capitalizes on the inherent therapeutic prope...The amalgamation of herbal medicine and nanoformulation technology presents a compelling avenue for the advancement of pharmaceutical and health food products.This synergy capitalizes on the inherent therapeutic properties of herbal extracts while harnessing the innovative capabilities of nano-scale formulation.Nano-technology has revolutionized drug delivery systems,offering enhanced bioavailability and targeted delivery of active compounds.The global research landscape reflects a burgeoning interest in nano-based pharmaceuticals,driven by their potential to overcome traditional limitations and optimize therapeutic outcomes.Vietnam,with its rich biodiversity and burgeoning nano-industry,stands at the forefront of this convergence.Vietlife,a prominent player in health product research and manufacturing,is poised to capitalize on this convergence.By leveraging indigenous herbal knowledge and cutting-edge nanoformulation techniques,Vietlife can pioneer the development of novel pharmaceutical and health food solutions.In conclusion,the integration of herbal medicine and nanoformulation technology opens up promising opportunities for the development of pharmaceuticals and healthcare products.Vietnam and Vietlife can capitalize on this trend to drive sustainable development and establish their presence in the international market.展开更多
Background:Over 65 million people have long COVID.Evidence for using Chinese herbal medicine(CHM)to treat long COVID is growing.A systematic review of evidence for guiding clinical decision is warranted.Objective:To e...Background:Over 65 million people have long COVID.Evidence for using Chinese herbal medicine(CHM)to treat long COVID is growing.A systematic review of evidence for guiding clinical decision is warranted.Objective:To examine the effects and safety of CHM in alleviating the severity of dyspnea,fatigue,exercise intolerance,depression,anxiety and insomnia in long COVID adults based on registered randomized clinical trials(RCT).Search strategy:World Health Organization International Clinical Trials Registry Platform and Chinese Clinical Trial Registry were searched for registered trial protocols from database inception to February 10,2023.English(PubM ed,Embase,AMED and CINAHL)and Chinese databases(CNKI,Wanfang Data and CQVIP)were then searched to identify relevant publications from December 2019 through April 6,2023.Inclusion criteria:Registered RCTs that compared the effects of Chinese herbal medicines or Chinese herbal formulas against a control treatment(i.e.,the placebo or usual care)in adults with persistent symptoms of long COVID.The primary outcome of dyspnea,and secondary outcomes of fatigue,exercise intolerance,depression,anxiety and insomnia were measured using validated tools at the end of the treatment.Data extraction and analysis:Data were extracted,and eligible RCTs were evaluated using version 2 of the Cochrane risk-of-bias tool for randomized trials and Grading of Recommendations,Assessment,Development and Evaluations independently by two researchers.Effect sizes were estimated by randomeffects modelling and mean difference(MD).Heterogeneity between trials was quantified by I^(2).Results:Among the 38 registered clinical trials we identified,seven RCTs(1,519 patients)were included in the systematic review.One RCT had a low overall risk of bias.Compared to the control,CHM reduces dyspnea on the Borg Dyspnea Scale score(MD=–0.2,95%confidence interval[CI]=–0.65 to 0.25)with moderate certainty,and reduces fatigue on the Borg Scale(MD=–0.48,95%CI=–0.74 to–0.22)with low certainty.CHM clinically reduces depression on Hamilton Depression Rating Scale score(MD=–6.00,95%CI=–7.56 to–4.44)and anxiety on Hamilton Anxiety Rating Scale score(MD=–6.10,95%CI=–7.67 to–4.53),and reduces insomnia on the Insomnia Severity Index(MD=–4.86,95%CI=–12.50 to 2.79)with moderate certainty.Meta-analysis of two RCTs(517 patients)showed that CHM clinically improves exercise intolerance by increasing 6-minute walking distance(MD=–15.92,95%CI=–10.20 to 42.05)with substantial heterogeneity(I^(2)=68%)and low certainty.Conclusion:CHM is associated with a post-treatment clinical reduction in depression and anxiety in long COVID adults,compared to the control,but it does not have a strong treatment effect on dyspnea and insomnia.Effects of CHM on exercise intolerance and fatigue are uncertain,and the safety of using CHM remains questionable.展开更多
BACKGROUND The impact of psychiatric disorder,especially depression,on the prognosis of sarcopenic patients is gaining prominence.Yet,there have been very few studies focusing on this issue,let alone the related targe...BACKGROUND The impact of psychiatric disorder,especially depression,on the prognosis of sarcopenic patients is gaining prominence.Yet,there have been very few studies focusing on this issue,let alone the related targeted mental health prevention.This cohort-based nested case-control study is geared to compare risk of depression and the depression-related ambulatory care utilization for sarcopenia persons with and without receiving add-on Chinese herbal medicines(CHMs)treatment.AIM To compare risk of depression and the depression-related ambulatory care utili-zation for sarcopenia persons with and without receiving add-on CHMs treat-ment.METHODS In the beginning,we recruited those aged 20-70 years with newly diagnosed sarcopenia and free of depression between 2002 and 2010 from a nationwide insurance database.From them,we identified cases with depression onset occurring after sarcopenia until December 31,2013.To cautiously isolate the effect of CHMs,we established the matched sets of treated and untreated subjects with CHMs use by randomly frequency matching.A conditional logistic regression was executed to explore the association of CHMs to depression risk,and the frequency and costs of depression-related ambulatory care were compared using Mann-Whitney U test.RESULTS Addition of CHMs to routine care of sarcopenia notably correlated with a lower risk of depression.A remarkable effect of CHMs in reducing depression was detected when sarcopenia subjects received CHMs for more than three years,lowering depression risk by as much as 65%.As compared to CHMs users,the non-CHMs users indeed incurred higher frequency and costs of depression-related ambulatory care after depression attack(P<0.05).Notably,the costs for per depression-related ambulatory care profoundly increased with the years after depression attack.CONCLUSION Sarcopenic patients can greatly benefit from add-on CHMs treatment,underscoring the urgent need for interdisciplinary collaboration and proactive treatment planning.展开更多
基金supported by the National Research Foundation of Korea(2020R1F1A1074155).
文摘Recently,Prevotella spp.,a major genus of gram-negative commensal bacteria in humans,have emerged as a key microbial contributor to host metabolism due to its ability to ferment dietary fibers,produce beneficial short-chain fatty acids,and influence immune responses.However,their diversity and functional differences have created challenges for their development and therapeutic use.Recent studies have shown that specific Prevotella species,such as P.copri,P.intestinalis,and P.histicola,can strengthen gut barrier integrity and reduce metabolic imbalances.Notably,Prevotella populations can be increased through high-fiber or herbal-based treatments.Traditional herbal medicines,including fiber-rich decoctions,also demonstrate the potential to boost endogenous Prevotella communities,enhance microbial fermentation,and improve glucose and lipid balance.This perspective examines the context-dependent roles of Prevotella spp.,with emphasis on the functional heterogeneity of key species such as P.copri,suggests a framework for combining herbal modulation with species-level microbiota profiling,and outlines a research plan to explore microbe-herb synergy in treating obesity,type 2 diabetes,and related metabolic disorders.This strategy offers a new,ecology-based approach to complement standard metabolic interventions.
基金supported by the National Key Research and Development Project(2022YFC3400700)the City-School Cooperation Project of the Fuyang Science and Technology Special Fund undertaken by Fuyang Normal University(SXHZ2020007)+1 种基金the Basic Research Program of Shenzhen Municipal Government(JCYJ20200109114242138)the Special Commissioner for Rural Science and Technology of Guangdong Province(KTP20210345).
文摘Background Meat originating from the spent hen is an important source of poultry meat production;however,multiple factors cause the decline in the meat quality of spent hens.Chinese herbs have been widely used as medi-cine for a long time to prevent diseases and as nutrient supplements to improve the product quality.This experi-ment explored the effects of adding 1.0%Chinese herbal formula(CHF,including 0.30%Leonurus japonicus Houtt.,0.20%Salvia miltiorrhiza Bge.,0.25%Ligustrum lucidum Ait.,and 0.25%Taraxacum mongolicum Hand.-Mazz.)for 120 d to the spent hens’diet through metabolomics,network pharmacology,and microbiome strategies.Results The results indicated that CHF supplementation improved the meat quality by reducing drip loss(P<0.05),b*value(P=0.058),and shear force(P=0.099)and increasing cooked meat percentage(P=0.054)and dry matter(P<0.05)of breast muscle.The addition of CHF improved the nutritional value of breast muscle by increasing(P<0.05)the content of C18:2n-6,n-6/n-3 polyunsaturated fatty acids(PUFA),total PUFA,PUFA-to-saturated fatty acids(SFA)ratio,and hypocholesterolemic-to-hypercholesterolemic ratio,and tending to increase serine content(P=0.069).The targeted metabolomics analysis revealed that the biosynthesis of SFA,linoleic acid metabolism,fatty acid degradation,fatty acid elongation,and fatty acid biosynthesis pathways were enriched by CHF supplementation.Furthermore,the network pharmacology analysis indicated that CHF was closely associated with oxidative stress and lipid metabo-lism.The CHF supplementation increased the glutathione peroxidase level(P<0.05)and upregulated gene expres-sion related to the Nrf2 pathway(including HO-1,P<0.05;Nrf2,P=0.098;CAT,P=0.060;GPX1,P=0.063;and SOD2,P=0.052)and lipid metabolism(including PPARγ,P<0.05;SREBP1,P=0.059;and CPT1A,P=0.058).Additionally,CHF supplementation increased Firmicutes and decreased Bacteroidetes,Spirochaetes,and Synergistetes abundances(P<0.05),which may contribute to better meat quality.Conclusions Our results suggest that CHF supplementation improved the quality and nutritional value of meat,which will provide a theoretical basis for the utilization of CHF as a feed additive in spent hens’diets.
文摘This paper first analyzes the complexity of pathological processes involved in acute hemorrhagic or ischemic stroke,including primary and secondary brain injury manifestations and mechanisms,potential transformations between hemorrhage and infarction,and the impact of postbrain injury inflammation on disease progression.Based on decades of extensive clinical and pharmacological research on the usage of Chinese herbal medicine(CHM)monomers or formulas that promote blood circulation and remove blood stasis(such as Angong Niuhuang Wan,Buyang Huanwu Tang,Dahuoluo Wan,and Dushen Tang)for stroke treatment,it proposes that tonifying qi,promoting blood circulation,removing blood stasis,and detoxifying are rational treatment principles of CHM.These principles correspond to the following Western medical implications:tonifying qi corresponds to neuroprotection effects,promoting blood circulation corresponds to anticoagulation and thrombolysis,removing blood stasis addresses hematoma absorption and cerebral edema reduction,and detoxifying corresponds to anti-inflammatory actions.This paper further proposes from a systems medicine perspective that acute stroke is a complex disease requiring individualized CHM treatment with timely modifications rather than a one-sizefits-all approach.CHM monomers or formulas for promoting blood circulation and removing blood stasis,which have various effects such as lowering blood pressure,hemostasis,anticoagulation,antiplatelet,anti-inflammatory,promoting fibrinolysis,and edema reduction,must align with disease progression and be applied within appropriate therapeutic time windows to ensure efficacy and safety.Finally,this paper suggests that a combined use of acupuncture and CHM can potentially synergistically leverage their respective therapeutic strengths.Additionally,acupuncture shows clear benefits in the acute phase of intracerebral hemorrhage(ICH),such as stimulating the vagus nerve to enhance cerebral blood flow,reducing inflammation,as well as triggering hemostatic effects.By applying these rational treatment principles in an integrated approach,better CHM treatment outcomes and higher efficacy of stroke management may be attained.
文摘The use of traditional herbal drugs derived from natural sources is on the rise due to their minimal side effects and numerous health benefits.However,a major limitation is the lack of standardized knowledge for identifying and mapping the quality of these herbal medicines.This article aims to provide practical insights into the application of artificial intelligence for quality-based commercialization of raw herbal drugs.It focuses on feature extraction methods,image processing techniques,and the preparation of herbal images for compatibility with machine learning models.The article discusses commonly used image processing tools such as normalization,slicing,cropping,and augmentation to prepare images for artificial intelligence-based models.It also provides an overview of global herbal image databases and the models employed for herbal plant/drug identification.Readers will gain a comprehensive understanding of the potential application of various machine learning models,including artificial neural networks and convolutional neural networks.The article delves into suitable validation parameters like true positive rates,accuracy,precision,and more for the development of artificial intelligence-based identification and authentication techniques for herbal drugs.This article offers valuable insights and a conclusive platform for the further exploration of artificial intelligence in the field of herbal drugs,paving the way for smarter identification and authentication methods.
文摘The herbal drink “Attoté” has been widely used in the Abidjan district to treat a number of illnesses, notably erectile dysfunction. Despite the popularity of its therapeutic effects, very few studies have been carried out on its effects on the health of users. The aim of this study was to identify the constituents contained in the phytomedicinal product and to assess their potential adverse effects in vivo. Phytochemical screening was conducted to identify the bioactive molecules in “Attoté” and to evaluate its hepatic effects in vivo. Forty (40) Wistar rats, randomly divided into 4 groups, with 10 animals per group (5 males and 5 females) were used to study potential hepatotoxic effects. Group 1 animals (control group) received distilled water. Batches I, II and III received by gavage a volume of Attoté extract corresponding to 1 ml/100 g body weight at 200 mg/kg, 400 mg/kg and 800 mg/kg, respectively. Attoté extract was administered daily at the same time for 28 days, and serum was collected every two weeks to assess hepatic biochemical markers by spectrophotometry using a Cobas C311® HITACHI biochemistry system. After one month of study, the rats were euthanized by ether overdose and the livers were harvested for morphological and histopathological analysis. Phytochemical screening revealed the presence of alkaloids, polyphenols, leucoanthocyanes, anthraquinones and quinones. Hepatic biochemical and hematological parameters such as red globular, hemoglobin, alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), alkaline phosphatase (ALPs) and gamma glutamyl transferase (GGT) showed no significant change (p > 0.05) in the treated rat group compared with controls. However, these variations were moderate and transient, with values remaining almost within their standard limits. Microscopic observations of liver tissue sections from treated rats showed no liver damage or dysfunction. This study merits further investigation, with a view to gaining a better understanding of the cytotoxic mechanisms of herbal medicinal beverages, with a view to their reformulation as improved traditional medicines (ITMs).
文摘[Objectives]To systematically evaluate the clinical efficacy of head massage combined with Chinese herbal bath in treating insomnia and analyze its herbal medication patterns.[Methods]Clinical data of 200 chronic insomnia patients treated at the Sleep Disorder Center of Taihe Hospital from January 2020 to December 2024 were retrospectively analyzed.Patients were randomly divided into observation group and control group(n=100 each).The observation group received head massage combined with Chinese herbal bath therapy,while the control group received Chinese herbal bath alone.The Pittsburgh Sleep Quality Index(PSQI)was used for efficacy evaluation,and statistical analysis was performed on the frequency of herbal medications in herbal herbal bath formulas.[Results]The PSQI score improvement in the observation group(8.44±1.87)was significantly better than that in the control group(5.74±1.93)(P<0.01).Herbal formulas for external bath primarily contained mind-calming and heart-nourishing herbs(fried Ziziphi Spinosae Semen,Concha Margaritifera)and heat-clearing herbs(Rhizoma Coptidis,Radix Scutellariae).[Conclusions]The combination of head massage and Chinese herbal bath can significantly improve sleep quality in insomnia patients,demonstrating superior clinical efficacy compared with Chinese herbal bath alone.This combined therapy shows good safety and operability,warranting promotion in primary and specialized medical institutions.
基金Supported by the Key Research and Development Program of Zhejiang Province,No.2024C03211the Traditional Chinese Medicine Science and Technology Plan Project of Zhejiang Province,No.2023ZL498.
文摘This review examines the distinct mechanisms of Tuina massage and topical herbal medicine in pediatric diarrhea management,focusing on their independent regulation of gastrointestinal metabolism and barrier function.Tuina therapy primarily enhances gastrointestinal motility through the stimulation of targeted acupoints such as Tianshu(ST25)and Shenque(CV8),activating vagal efferent pathways to normalize motility hormones including motilin while suppressing pro-inflammatory cytokines such interleukin-6 and tumor necrosis factor-alpha.It further reinforces mucosal defense by inhibiting mast cell degranulation and augmenting microcirculation via nitric oxide-mediated vasodilation.Herbal medicine containing bioactive compounds from Atractylodes macrocephala and Poria cocos directly restores intestinal barrier integrity by upregulating tight junction proteins occludin and zonula occludens-1,inhibiting epithelial apoptosis,and stimulating MUC2 production.These formulations additionally reprogram enterocyte metabolism by reactivating mitochondrial tricarboxylic acid cycle flux and modulating short-chain fatty acid profiles,with the independent prebiotic effects enhancing commensal butyrate production.Tuina primarily modulates neuroimmune pathways and motility,and herbal medicine directly targets epithelial repair and metabolism.These therapeutic pathways may address core diarrhea pathophysiology,providing holistic complementary therapies.Standardized protocols and interdisciplinary research are urgently needed for clinical translation.
基金Supported by Guizhou Provincial Department of Agriculture and Rural Affairs Project(QNYZZZ[2017]No.12,GZSZCYJSTX-04)2024 Quality Supervision and Sampling Project of Normal Temperature Semen for Breeding Pigs.
文摘[Objectives]This study was conducted to investigate the effects of a compound Chinese herbal medicine pig gut microbiota and metabolic ecology.[Methods]Through 16S rRNA high-throughput sequencing and metabolomics,the effects of administing a 5%compound mixture of Pseudostellaria heterophylla,Uncaria rhynchophylla and Lonicera japonica for 60 d on the intestinal microbiota and metabolites of three-way crossbred pigs were evaluated.[Results]The Chinese herbal medicine(CHM)group exhibited improvedα-diversity indices(Ace=541.22,Shannon=3.36,Simpson=0.10),though not significant(P>0.05),compared with the CK group(Ace=511.46,Shannon=2.75,Simpson=0.12).β-diversity analysis revealed a clear separation between the groups.At the phylum level,the overall differences in gut microbiota composition were minor.However,the CHM group showed a substantial increase in Bacteroidota in the cecum and a significant rise in Myxobacteria,which have anti-inflammatory and anti-obesity potential,suggesting a positive effect on intestinal health.Meanwhile,the CHM group exhibited 67 unique OTUs,higher than 27 in the CK group,primarily concentrated in the ileum and cecum.Additionally,metabolomic analysis revealed 210 unique metabolites in the CHM group,surpassing 77 in the CK group.A total of 653 metabolites showed significant changes,involving 11 metabolic pathways.Correlation analysis revealed that metabolites such as PC,PE,LysoPC,LysoPE and dehydrocarpaine were closely associated with microbiota.In the CHM group,key metabolites exhibited complex interactions with gut microbiota.Dehydrocarpaine showed positive correlations with probiotics such as Lactobacillus and Bifidobacterium.[Conclusions]These results demonstrated that CHM potentially enhanced pig gut health by improving microbial diversity and regulating metabolic networks,providing a scientific basis for further optimization of swine farming strategies.
基金supported by the National Key Research and Development Program of China (2022YFF1100904)the Tianjin Key R&D Program (21YFSNSN00110)+2 种基金the Science and Technology Planning Project of State Administration for Market Regulation (2019MK005, 2020MK010, 2022MK012)Tianjin Administration for Market Regulation (2019-W20)State Criteria for Food Safety (spaq-2020-08, spaq-2020-31, spaq-2021-07, spaq-2022-05)。
文摘A novel low molecular weight compound polysaccharide(LMW-CPS) was identified from a specific combination of Chinese herb ingredients.The monosaccharide composition of LMW-CPS was consisted of single arabinose,which had an α-L-furanose configuration with an average molecular weight of 2.06 kDa.NMR spectra and monosaccharide constitution analyses revealed that it had a backbone of→5)-α-L-Araf-(1→with α-L-Araf(1→as the terminal residue.In vitro experiments found that it could lead to apoptosis and inhibit hepatocellular carcinoma cell proliferation by arresting them in the S phase.In vivo experiments showed that it protected immune organs such as the thymus and spleen,enhanced immune cell activities,stimulated cytokine release,augmented the abundance of CD8,CD3,CD4,and CD 19 positive lymphocytes,and markedly impeded solid hepatocellular carcinoma progression in mice.Hematoxylin and eosin staining and cell cycle examination also indicated that LMW-CPS arrested hepatocellular carcinoma cells at the S phase to induce apoptosis.These findings indicated its promising potential for the treatment of hepatocellular carcinoma.
文摘The amalgamation of herbal medicine and nanoformulation technology presents a compelling avenue for the advancement of pharmaceutical and health food products.This synergy capitalizes on the inherent therapeutic properties of herbal extracts while harnessing the innovative capabilities of nano-scale formulation.Nano-technology has revolutionized drug delivery systems,offering enhanced bioavailability and targeted delivery of active compounds.The global research landscape reflects a burgeoning interest in nano-based pharmaceuticals,driven by their potential to overcome traditional limitations and optimize therapeutic outcomes.Vietnam,with its rich biodiversity and burgeoning nano-industry,stands at the forefront of this convergence.Vietlife,a prominent player in health product research and manufacturing,is poised to capitalize on this convergence.By leveraging indigenous herbal knowledge and cutting-edge nanoformulation techniques,Vietlife can pioneer the development of novel pharmaceutical and health food solutions.In conclusion,the integration of herbal medicine and nanoformulation technology opens up promising opportunities for the development of pharmaceuticals and healthcare products.Vietnam and Vietlife can capitalize on this trend to drive sustainable development and establish their presence in the international market.
文摘Background:Over 65 million people have long COVID.Evidence for using Chinese herbal medicine(CHM)to treat long COVID is growing.A systematic review of evidence for guiding clinical decision is warranted.Objective:To examine the effects and safety of CHM in alleviating the severity of dyspnea,fatigue,exercise intolerance,depression,anxiety and insomnia in long COVID adults based on registered randomized clinical trials(RCT).Search strategy:World Health Organization International Clinical Trials Registry Platform and Chinese Clinical Trial Registry were searched for registered trial protocols from database inception to February 10,2023.English(PubM ed,Embase,AMED and CINAHL)and Chinese databases(CNKI,Wanfang Data and CQVIP)were then searched to identify relevant publications from December 2019 through April 6,2023.Inclusion criteria:Registered RCTs that compared the effects of Chinese herbal medicines or Chinese herbal formulas against a control treatment(i.e.,the placebo or usual care)in adults with persistent symptoms of long COVID.The primary outcome of dyspnea,and secondary outcomes of fatigue,exercise intolerance,depression,anxiety and insomnia were measured using validated tools at the end of the treatment.Data extraction and analysis:Data were extracted,and eligible RCTs were evaluated using version 2 of the Cochrane risk-of-bias tool for randomized trials and Grading of Recommendations,Assessment,Development and Evaluations independently by two researchers.Effect sizes were estimated by randomeffects modelling and mean difference(MD).Heterogeneity between trials was quantified by I^(2).Results:Among the 38 registered clinical trials we identified,seven RCTs(1,519 patients)were included in the systematic review.One RCT had a low overall risk of bias.Compared to the control,CHM reduces dyspnea on the Borg Dyspnea Scale score(MD=–0.2,95%confidence interval[CI]=–0.65 to 0.25)with moderate certainty,and reduces fatigue on the Borg Scale(MD=–0.48,95%CI=–0.74 to–0.22)with low certainty.CHM clinically reduces depression on Hamilton Depression Rating Scale score(MD=–6.00,95%CI=–7.56 to–4.44)and anxiety on Hamilton Anxiety Rating Scale score(MD=–6.10,95%CI=–7.67 to–4.53),and reduces insomnia on the Insomnia Severity Index(MD=–4.86,95%CI=–12.50 to 2.79)with moderate certainty.Meta-analysis of two RCTs(517 patients)showed that CHM clinically improves exercise intolerance by increasing 6-minute walking distance(MD=–15.92,95%CI=–10.20 to 42.05)with substantial heterogeneity(I^(2)=68%)and low certainty.Conclusion:CHM is associated with a post-treatment clinical reduction in depression and anxiety in long COVID adults,compared to the control,but it does not have a strong treatment effect on dyspnea and insomnia.Effects of CHM on exercise intolerance and fatigue are uncertain,and the safety of using CHM remains questionable.
文摘BACKGROUND The impact of psychiatric disorder,especially depression,on the prognosis of sarcopenic patients is gaining prominence.Yet,there have been very few studies focusing on this issue,let alone the related targeted mental health prevention.This cohort-based nested case-control study is geared to compare risk of depression and the depression-related ambulatory care utilization for sarcopenia persons with and without receiving add-on Chinese herbal medicines(CHMs)treatment.AIM To compare risk of depression and the depression-related ambulatory care utili-zation for sarcopenia persons with and without receiving add-on CHMs treat-ment.METHODS In the beginning,we recruited those aged 20-70 years with newly diagnosed sarcopenia and free of depression between 2002 and 2010 from a nationwide insurance database.From them,we identified cases with depression onset occurring after sarcopenia until December 31,2013.To cautiously isolate the effect of CHMs,we established the matched sets of treated and untreated subjects with CHMs use by randomly frequency matching.A conditional logistic regression was executed to explore the association of CHMs to depression risk,and the frequency and costs of depression-related ambulatory care were compared using Mann-Whitney U test.RESULTS Addition of CHMs to routine care of sarcopenia notably correlated with a lower risk of depression.A remarkable effect of CHMs in reducing depression was detected when sarcopenia subjects received CHMs for more than three years,lowering depression risk by as much as 65%.As compared to CHMs users,the non-CHMs users indeed incurred higher frequency and costs of depression-related ambulatory care after depression attack(P<0.05).Notably,the costs for per depression-related ambulatory care profoundly increased with the years after depression attack.CONCLUSION Sarcopenic patients can greatly benefit from add-on CHMs treatment,underscoring the urgent need for interdisciplinary collaboration and proactive treatment planning.
