Oxygen is essential for sustaining life,maintaining physiological homeostasis,and supporting a wide range of therapeutic applications.Hemoglobin-based oxygen carriers(HBOCs)have long been explored as potential substit...Oxygen is essential for sustaining life,maintaining physiological homeostasis,and supporting a wide range of therapeutic applications.Hemoglobin-based oxygen carriers(HBOCs)have long been explored as potential substitutes for red blood cells(RBCs)due to their inherent oxygen transport capability.However,their clinical translation has been constrained by issues such as vasoactivity,oxidative stress-induced toxicity,and short circulation half-life.Recent advances in functional polymer science have provided new opportunities to overcome these barriers,with strategies including hemoglobin-polymer conjugation and encapsulation enabling the development of HBOCs with improved safety and efficacy.This review summarizes recent progress in the use of functional polymers for HBOC development,outlines key methods for performance evaluation,and discusses their current status and future prospects in diverse biomedical contexts,including blood substitution,ischemia-reperfusion injury and ischemic stroke therapy,tissue engineering,and cancer treatment.展开更多
基金financially supported by the Major Scientific and Technological Infrastructure Cultivation Projects of Jiangsu Province,Chinathe National Natural Science Foundation of China(Grant No.32301189)+1 种基金the Natural Science Foundation of Jiangsu Province(Grant Nos.BK20220824,BK20222002)the Jiangsu Funding Program for Excellent Postdoctoral Talent(Grant No.2025ZB578)。
文摘Oxygen is essential for sustaining life,maintaining physiological homeostasis,and supporting a wide range of therapeutic applications.Hemoglobin-based oxygen carriers(HBOCs)have long been explored as potential substitutes for red blood cells(RBCs)due to their inherent oxygen transport capability.However,their clinical translation has been constrained by issues such as vasoactivity,oxidative stress-induced toxicity,and short circulation half-life.Recent advances in functional polymer science have provided new opportunities to overcome these barriers,with strategies including hemoglobin-polymer conjugation and encapsulation enabling the development of HBOCs with improved safety and efficacy.This review summarizes recent progress in the use of functional polymers for HBOC development,outlines key methods for performance evaluation,and discusses their current status and future prospects in diverse biomedical contexts,including blood substitution,ischemia-reperfusion injury and ischemic stroke therapy,tissue engineering,and cancer treatment.
