BACKGROUND Advanced gastric cancer is characterized by fast tumor growth and aggressive biological behavior.During neoadjuvant chemotherapy,patients are at risk of distant metastasis or local progression.Anemia is a f...BACKGROUND Advanced gastric cancer is characterized by fast tumor growth and aggressive biological behavior.During neoadjuvant chemotherapy,patients are at risk of distant metastasis or local progression.Anemia is a frequent complication in these patients.AIM To analyze whether changes in hemoglobin and hematocrit can predict the survival and efficacy of neoadjuvant chemotherapy in patients with advanced gastric cancer.METHODS The clinical data of 185 patients with advanced gastric cancer admitted to the Third Affiliated Hospital of Chengdu Medical College,Pidu District People’s Hospital,Chengdu,China,between January 2016 and January 2021,were retrospectively analyzed.All patients underwent a tegafur+oxaliplatin+apatinib chemotherapy regimen.According to the efficacy of chemotherapy,they were divided into an effective group(complete or partial response,n=121)and an ineffective group(stable disease or disease progression,n=64).The factors related to chemotherapy efficacy in patients with advanced gastric cancer were analyzed by univariate and logistic multivariate analyses.The 3-year survival rates of the patients with different hemoglobin and hematocrit levels were compared.RESULTS Univariate analysis showed that the proportion of patients with a tumor diameter>5 cm,non-tubular adenocarcinoma,lymph node metastasis,hematocrit<33%,low mean red blood cell(RBC)protein content,low RBC distribution width,hemoglobin<107 g/L,and platelets>266×109/L in the ineffective group were significantly higher than those in the effective group(P<0.05).Logistic multivariate analysis showed that a tumor diameter>5 cm,lymph node metastasis,≤3 chemotherapy cycles,hematocrit<33%,and hemoglobin<107 g/L are risk factors for neoadjuvant chemotherapy failure in advanced gastric cancer(P<0.05).The 1-year,2-year,and 3-year survival rates in the effective group were 93.39%,83.47%,and 60.33%,respectively.These rates were significantly higher than those in the ineffective group(P<0.05).The 1-year,2-year,and 3-year survival rates of patients with hematocrit<33%were 74.67%,49.33%,and 29.33%,respectively,which were significantly lower than those of patients with hematocrit≥33%(P<0.05).The 1-year,2-year,and 3-year survival rates of patients with hemoglobin<107 g/L were 80.39%,58.82%,and 39.22%,respectively,which were significantly lower than those of patients with hemoglobin≥107 g/L(P<0.05).CONCLUSION Hematocrit<33%and hemoglobin<107 g/L are risk factors for chemotherapy failure in patients with advanced gastric cancer.They are associated with poorer prognosis and reduced 3-year survival rates.展开更多
Cryopreservation of red blood cells(RBCs)provides great potential benefits for providing transfusion timely in emergencies.High concentrations of glycerol(20%or 40%)are used for RBC cryopreservation in current clinica...Cryopreservation of red blood cells(RBCs)provides great potential benefits for providing transfusion timely in emergencies.High concentrations of glycerol(20%or 40%)are used for RBC cryopreservation in current clinical practice,which results in cytotoxicity and osmotic injuries that must be carefully controlled.However,existing studies on the low-glycerol cryopreservation of RBCs still suffer from the bottleneck of low hematocrit levels,which require relatively large storage space and an extra concentration process before transfusion,making it inconvenient(time-consuming,and also may cause injury and sample lose)for clinical applications.To this end,we develop a novel method for the glycerol-free cryopreservation of human RBCs with a high final hematocrit by using trehalose as the sole cryoprotectant to dehydrate RBCs and using core–shell alginate hydrogel microfibers to enhance heat transfer during cryopreservation.Different from previous studies,we achieve the cryopreservation of human RBCs at high hematocrit(>40%)with high recovery(up to 95%).Additionally,the washed RBCs post-cryopreserved are proved to maintain their morphology,mechanics,and functional properties.This may provide a nontoxic,high-efficiency,and glycerol-free approach for RBC cryopreservation,along with potential clinical transfusion benefits.展开更多
Objective To evaluate the effect of point-of-care hemoglobin/hematocrit(POC HGB/HCT) devices and intraoperative blood salvage on the amount of perioperative allogeneic blood transfusion and blood conservation in clini...Objective To evaluate the effect of point-of-care hemoglobin/hematocrit(POC HGB/HCT) devices and intraoperative blood salvage on the amount of perioperative allogeneic blood transfusion and blood conservation in clinical practice. Methods A total of 46 378 medical records of 22 selected hospitals were reviewed. The volume of allogeneic red blood cell and plasma, number of patients transfused, number of intraoperative autologous blood salvage, total volume of autologous blood transfusion, and amount of surgery in the year of 2011 and 2013 were tracked. Paired t-test was used in intra-group comparison, while t-test of two isolated samples carried out in inter-group comparison. P<0.05 was defined as statistically significant difference. Results In the hospitals where POC HGB/HCT device was used(n=9), the average allogeneic blood transfusion volume per 100 surgical cases in 2013 was significantly lower than that in 2011(39.86±20.20 vs. 30.49±17.50 Units, t=3.522, P=0.008). In the hospitals without POC HGB/HCT meter, the index was not significantly different between 2013 and 2011. The average allogeneic blood transfusion volume was significantly reduced in 2013 than in 2011 in the hospitals where intraoperative autologous blood salvage ratio [autologous transfusion volume/(autologous transfusion volume+allogeneic transfusion volume)] was increased(n=12, t=2.290, P=0.042). No significant difference of the above index was found in the hospitals whose autologous transfusion ratio did not grow. Conclusion Intraoperative usage of POC HGB/HCT devices and increasing autologous transfusion ratio could reduce perioperative allogeneic blood transfusion.展开更多
A theoretical investigation concerning hematocrit and slip velocity influence on the flow of blood and heat transfer by taking into account the externally applied magnetic field has been carried out. The mathematical ...A theoretical investigation concerning hematocrit and slip velocity influence on the flow of blood and heat transfer by taking into account the externally applied magnetic field has been carried out. The mathematical models considered in this work treated blood as a non-Newtonian fluid obeying the third grade fluid model. A suitable geometry of the stenosis is taken into account. Galerkin weighted residual and Newton Raphson methods are used to solve the equations that govern the flow of blood and heat transfer. Analytical expression for the velocity profile, temperature profile, volume flow rate, wall shear stress and resistance to flow were obtained. Graphical representation of results shows that the flow velocity, volumetric flow rate and shear stress increase while resistance to flow and heat transfer rate decrease when the slip velocity increases. Also, flow velocity and volume flow rate decrease while shear stress, heat transfer rate, and resistance to flow increase when the hematocrit parameter increases. Finally, increases in magnetic field parameter lead to decrease in flow velocity, flow rate and shear stress but increase the flow resistance.展开更多
This paper is written in order to provide a scientific basis for a unified standard of the reference value of Chinese healthy old people's hematocrit. It studies the relationship between the reference values of he...This paper is written in order to provide a scientific basis for a unified standard of the reference value of Chinese healthy old people's hematocrit. It studies the relationship between the reference values of healthy old people's hematocrit, tested according to the Wintrobe Laws and five geographical factors. It is found that the altitude is the most important factor affecting the reference value of old people's hematocrit. As the altitude gradually increases, the reference value of their hematocrit also increases, the relationship is quite significant. By using the method of stepwise regression analysis, two multivariate regression equations are deduced:1=50.2+0.00248X1-0.0534X3-0.388X4+0.00383X5±2.2, 2=44.5+0.00231X1-0.0600X3-0.260X4+0.00341X5±2.1. If the geographical index values in a particular area in China are known, the reference value of old people's hematocrit in this area can be established by means of the regression equations. Furthermore, according to the dependent relationship of the reference value of old people's hematocrit on geographical factors, China can be divided into six regions: Qinghai-Tibet, Plateau, Southwest, Northwest, Southeast, North and Northeast.展开更多
Abnormal hematocrit(Hct)is associated with an increased risk of pre-hypertension and all-cause death in general population,and people with a high Hct value are susceptible to arterial cardiovascular disease and venous...Abnormal hematocrit(Hct)is associated with an increased risk of pre-hypertension and all-cause death in general population,and people with a high Hct value are susceptible to arterial cardiovascular disease and venous thromboembolism.In this study,we report for the first time on the ability of thermoacoustic imaging(TAI)for in vivo evaluating Hct changes in human forearms.In vitro blood samples with different Hct values from healthy volunteers(n=3)were prepared after centrifugation.TAI was performed using these samples in comparison with the direct measurements of conductivity.In vivo TAI was conducted in the forearm of healthy volunteers(n=7)where Hct changes were produced through a vascular occlusion stimulation over a period of time.The results of in vitro blood samples obtained from the 3 healthy subjects show that the thermoacoustic(TA)signals changes due to the variation of blood conductivity are closely related to the changes in Hct.In addition,the in vivo TA signals obtained from the 7 healthy subjects consistently increase in the artery/muscle and decrease in the vein during venous or arterial occlusion because of the changed Hct value in their forearms.These findings suggest that TAI has the potential to become a new tool for monitoring Hct changes for a variety of pre-clinical and clinical applications.展开更多
Regular monitoring of pulmonary congestion in car-diogenic pulmonary edema (CPE) patients is neces-sary for its adequate management via pharmaceuti-cal treatment. It is well known that the development of CPE is accomp...Regular monitoring of pulmonary congestion in car-diogenic pulmonary edema (CPE) patients is neces-sary for its adequate management via pharmaceuti-cal treatment. It is well known that the development of CPE is accompanied with an increase in hema-tocrit, plasma protein concentration and colloid os-motic pressure due to the decrease in the plasma volume. In the present study the mean left and right lung resistivity values taken pre- and post treatment with diuretics using a hybrid bio-impedance electri-cal impedance tomography system were correlate to the measured changes in hematocrit level. A marginal significant correlation was found between the abso-lute mean lung resistivity and hematocrit levels (Pearson’s correlation coefficient of R = 0.4, p-value = 0.057). When the change in the mean lung resistivity of a patient was plotted vs. the change in hematocrit readout, a significant linear correlation was found (R = 0.7, p-value = 0.02). These results support the validity of the resistivity measurements using bio-impedance system in monitoring changes of pulmonary edema in CPE patients.展开更多
Objective: to investigate the role of blood lipid, hematocrit (HCT), coagulation function and hemorheology in pregnancy induced hypertension (PIH). Methods: the diagnosis time was from January 2020 to January 2022. A ...Objective: to investigate the role of blood lipid, hematocrit (HCT), coagulation function and hemorheology in pregnancy induced hypertension (PIH). Methods: the diagnosis time was from January 2020 to January 2022. A total of 67 pregnant women with PIH (group A) were divided into mild group (38 cases) and severe group (29 cases) according to the severity of the disease;at the same time, 67 healthy pregnant women (group B) were selected. The blood lipid, HCT, coagulation function index and hemorheology were detected, and the test results and pregnancy outcomes were compared. Results: compared with the levels of blood lipid and HCT among the three groups, the difference was significant, as shown by P0.05. The blood coagulation function indexes of mild group and severe group were different from those of group B (P0.05). There were also differences in coagulation function between mild and severe groups (P>0.05). Compared with the three groups, the indexes of hemorheology were different (P0.05). Compared with mild and severe groups, there was a difference in adverse pregnancy outcomes, as shown by P0.05. Conclusion: the detection of blood lipid, HCT, coagulation function and hemorheology can detect PIH, judge the severity of the disease, and predict the pregnancy outcome. The above indicators can ensure the safety of pregnancy.展开更多
Objective: To investigate the effect of high altitude span transportation on the change of hematocrit and electrocardiogram of the crew in the plateau construction, and discuss their relationship. Method: By SPSS 11.0...Objective: To investigate the effect of high altitude span transportation on the change of hematocrit and electrocardiogram of the crew in the plateau construction, and discuss their relationship. Method: By SPSS 11.0 statistical software, to treat hematocrit and electrocardiogram in the examination data of the the crew, who took part in the construction of Qinghai-Tibetan railway in 2003, before, during and after the construction. Then, we compared the data among the constructors in the fixed altitude during the same period. Result: The hematocrit of the crew slowly and continually rose to the maximum(p<0.01) after the construction in the high altitude span during one construction year, and the abnormal rate of electrocardiogram obviously decreased(p<0.05). The abnormal rate of electrocardiogram apparently improved when hematocrit reached 52% among the range from 45.12% to 52.24%, and the correlation analysis showed that the electrocardiographic change was closely and negatively correlated with the hematocrit among the range of hematocrit(p<0.05). Conclusion: Although the higher-level stress state of the crew made the hematocrit in the blood continually increase in the long-term high altitude span construction, the hematocrit reached the more reasonable hematocrit compensation and made it the optimum state of Hct in the end. As a result, the perfusion of tissues and organs was improved. The abnormal rate of electrocardiogram apparently improved because the oxygen delivery of the myocardium reached the optimum compensation.展开更多
Objective:The main objective is to determine the normal physiological values of heart rate,respiratory rate,oxygen saturation,blood pressure,and hemato-crit in populations living at altitudes between 1,000 and 3,500 m...Objective:The main objective is to determine the normal physiological values of heart rate,respiratory rate,oxygen saturation,blood pressure,and hemato-crit in populations living at altitudes between 1,000 and 3,500 meters above sea level in the Cajamarca Region during the year 2023.Methods:The study de-sign was a descriptive observational cross-sectional study with a non-proba-bilistic sampling method.Inclusion criteria considered inhabitants aged 1 to 70 years,of both sexes,both native and non-native,who had resided for more than one year at the measured altitude and agreed to participate by signing the informed consent form.In the case of minors,consent was obtained from their parents.Exclusion criteria included a history of cardiovascular,pulmonary,or hematological disease;presence of respiratory symptoms at the time of the test such as cough,sputum,or dyspnea;diagnosis of obesity;body mass index greater than or equal to 30;and regular smoking.The total population included 476 individuals.Statistical analysis was performed using R Project software,and non-parametric statistical tests such as the Kruskal-Wallis test were applied.Results:Significant differences were found by sex in heart rate,respiratory rate,and hematocrit.Additionally,all physiological variables measured showed statistically significant differences according to sex,altitude,and life course.Conclusion:This study is relevant as it establishes a baseline for vital signs and hem-atocrit values in high-altitude populations.It is the first study of its kind con-ducted in the Cajamarca Region and represents a starting point for future research in high-altitude medicine.展开更多
Objective:To validate the hematocrit percentage drop cutoff points for blood loss in patients with postpartum hemorrhage(PPH)using the automated gravimetric method.Methods:A prospective cohort study was conducted from...Objective:To validate the hematocrit percentage drop cutoff points for blood loss in patients with postpartum hemorrhage(PPH)using the automated gravimetric method.Methods:A prospective cohort study was conducted from January 2023 to July 2023,in which 107 patients 18 years of age and above were scheduled for elective cesarean with obstetrical indications.We excluded cases with difficulty quantifying blood loss,those with incomplete data,and those of patients who did not consent to participate.Blood loss was measured by an automated gravimetric system integrated into a suction blood collector and surgical gauze weighing systems to automatically sum up blood loss immediately after hysterectomy and fetal delivery.The percentage drop in hematocrit was determined by subtracting the 8-hour postsurgical from presurgical hematocrit,divided by presurgical hematocrit.We performed the Pearson correlation test,and the receiver operating characteristic curve was used to determine cutoff points,their sensitivity,and their specificity.Theκindex was used to determine the diagnostic agreement between the two methods.Results:A positive correlation was observed between the volume of blood loss and the percentage drop in hematocrit,with a Pearson correlation index of 0.70 and P<0.0001.A 14%decrease in hematocrit had an 81.7%agreement rate,with a goodκindex of 0.602,a sensitivity of 82.5%,and a specificity of 80.0%.A 10%drop in hemoglobin was sensitive(93.0%)but not very specific(56.0%)for blood loss greater than 1000 mL.Conclusion:The automated gravimetric method strongly correlates with hematocrit changes,providing an accurate real-time diagnosis of PPH.Additionally,a hematocrit percentage drop can retrospectively indicate significant blood loss,aiding in managing patients at risk for long-term PPH complications.展开更多
Background Streptococcus pneumoniae,as a respiratory tract common pathogen,can cause invasive disease and sepsis.This study aimed to investigate the association of factors with clinical outcomes in sepsis with strepto...Background Streptococcus pneumoniae,as a respiratory tract common pathogen,can cause invasive disease and sepsis.This study aimed to investigate the association of factors with clinical outcomes in sepsis with streptococcus pneumoniae infection based on MIMIC-IV database.Methods The sepsis patients with streptococcus pneumoniae infection were included.Different variables between the survivor group and the non-survivor group were analyzed.Multivariable logistic regression was applied to identify the factors which were associated with clinical outcomes.Results A total of 80 sepsis patients with streptococcus pneumoniae infection were included.The in-hospital mortality was 23.75%(n=19).Significant differences were found in heart rate,white blood cell,RDW,MCV and hematocrit between the survivor group and the non-survivor group.The area under the ROC curve of hematocrit was 0.758 with a sensitivity of 73.7%and a specificity of 72.1%.The cut-off value of hematocrit was 30.8%.Conclusions Hematocrit level was identified to be negatively associated with in-hospital mortality in sepsis with streptococcus pneumoniae infection.展开更多
INTRODUCTION Total hip arthroplasty （THA） and total knee arthroplasty （TKA） are currently two effective treatments for many diseases of the hip and knee. Despite the ability to minimize intraoperative blood loss, ...INTRODUCTION Total hip arthroplasty （THA） and total knee arthroplasty （TKA） are currently two effective treatments for many diseases of the hip and knee. Despite the ability to minimize intraoperative blood loss, postoperative hemoglobin （Hgb） loss is expected, and a number of studies have reported on hidden blood loss after THA and TKA.展开更多
文摘BACKGROUND Advanced gastric cancer is characterized by fast tumor growth and aggressive biological behavior.During neoadjuvant chemotherapy,patients are at risk of distant metastasis or local progression.Anemia is a frequent complication in these patients.AIM To analyze whether changes in hemoglobin and hematocrit can predict the survival and efficacy of neoadjuvant chemotherapy in patients with advanced gastric cancer.METHODS The clinical data of 185 patients with advanced gastric cancer admitted to the Third Affiliated Hospital of Chengdu Medical College,Pidu District People’s Hospital,Chengdu,China,between January 2016 and January 2021,were retrospectively analyzed.All patients underwent a tegafur+oxaliplatin+apatinib chemotherapy regimen.According to the efficacy of chemotherapy,they were divided into an effective group(complete or partial response,n=121)and an ineffective group(stable disease or disease progression,n=64).The factors related to chemotherapy efficacy in patients with advanced gastric cancer were analyzed by univariate and logistic multivariate analyses.The 3-year survival rates of the patients with different hemoglobin and hematocrit levels were compared.RESULTS Univariate analysis showed that the proportion of patients with a tumor diameter>5 cm,non-tubular adenocarcinoma,lymph node metastasis,hematocrit<33%,low mean red blood cell(RBC)protein content,low RBC distribution width,hemoglobin<107 g/L,and platelets>266×109/L in the ineffective group were significantly higher than those in the effective group(P<0.05).Logistic multivariate analysis showed that a tumor diameter>5 cm,lymph node metastasis,≤3 chemotherapy cycles,hematocrit<33%,and hemoglobin<107 g/L are risk factors for neoadjuvant chemotherapy failure in advanced gastric cancer(P<0.05).The 1-year,2-year,and 3-year survival rates in the effective group were 93.39%,83.47%,and 60.33%,respectively.These rates were significantly higher than those in the ineffective group(P<0.05).The 1-year,2-year,and 3-year survival rates of patients with hematocrit<33%were 74.67%,49.33%,and 29.33%,respectively,which were significantly lower than those of patients with hematocrit≥33%(P<0.05).The 1-year,2-year,and 3-year survival rates of patients with hemoglobin<107 g/L were 80.39%,58.82%,and 39.22%,respectively,which were significantly lower than those of patients with hemoglobin≥107 g/L(P<0.05).CONCLUSION Hematocrit<33%and hemoglobin<107 g/L are risk factors for chemotherapy failure in patients with advanced gastric cancer.They are associated with poorer prognosis and reduced 3-year survival rates.
基金the National Natural Science Foundation of China(No.82172114)the Anhui Provincial Natural Science Foundation for Distinguished Young Scholars(No.2108085J37).
文摘Cryopreservation of red blood cells(RBCs)provides great potential benefits for providing transfusion timely in emergencies.High concentrations of glycerol(20%or 40%)are used for RBC cryopreservation in current clinical practice,which results in cytotoxicity and osmotic injuries that must be carefully controlled.However,existing studies on the low-glycerol cryopreservation of RBCs still suffer from the bottleneck of low hematocrit levels,which require relatively large storage space and an extra concentration process before transfusion,making it inconvenient(time-consuming,and also may cause injury and sample lose)for clinical applications.To this end,we develop a novel method for the glycerol-free cryopreservation of human RBCs with a high final hematocrit by using trehalose as the sole cryoprotectant to dehydrate RBCs and using core–shell alginate hydrogel microfibers to enhance heat transfer during cryopreservation.Different from previous studies,we achieve the cryopreservation of human RBCs at high hematocrit(>40%)with high recovery(up to 95%).Additionally,the washed RBCs post-cryopreserved are proved to maintain their morphology,mechanics,and functional properties.This may provide a nontoxic,high-efficiency,and glycerol-free approach for RBC cryopreservation,along with potential clinical transfusion benefits.
文摘Objective To evaluate the effect of point-of-care hemoglobin/hematocrit(POC HGB/HCT) devices and intraoperative blood salvage on the amount of perioperative allogeneic blood transfusion and blood conservation in clinical practice. Methods A total of 46 378 medical records of 22 selected hospitals were reviewed. The volume of allogeneic red blood cell and plasma, number of patients transfused, number of intraoperative autologous blood salvage, total volume of autologous blood transfusion, and amount of surgery in the year of 2011 and 2013 were tracked. Paired t-test was used in intra-group comparison, while t-test of two isolated samples carried out in inter-group comparison. P<0.05 was defined as statistically significant difference. Results In the hospitals where POC HGB/HCT device was used(n=9), the average allogeneic blood transfusion volume per 100 surgical cases in 2013 was significantly lower than that in 2011(39.86±20.20 vs. 30.49±17.50 Units, t=3.522, P=0.008). In the hospitals without POC HGB/HCT meter, the index was not significantly different between 2013 and 2011. The average allogeneic blood transfusion volume was significantly reduced in 2013 than in 2011 in the hospitals where intraoperative autologous blood salvage ratio [autologous transfusion volume/(autologous transfusion volume+allogeneic transfusion volume)] was increased(n=12, t=2.290, P=0.042). No significant difference of the above index was found in the hospitals whose autologous transfusion ratio did not grow. Conclusion Intraoperative usage of POC HGB/HCT devices and increasing autologous transfusion ratio could reduce perioperative allogeneic blood transfusion.
文摘A theoretical investigation concerning hematocrit and slip velocity influence on the flow of blood and heat transfer by taking into account the externally applied magnetic field has been carried out. The mathematical models considered in this work treated blood as a non-Newtonian fluid obeying the third grade fluid model. A suitable geometry of the stenosis is taken into account. Galerkin weighted residual and Newton Raphson methods are used to solve the equations that govern the flow of blood and heat transfer. Analytical expression for the velocity profile, temperature profile, volume flow rate, wall shear stress and resistance to flow were obtained. Graphical representation of results shows that the flow velocity, volumetric flow rate and shear stress increase while resistance to flow and heat transfer rate decrease when the slip velocity increases. Also, flow velocity and volume flow rate decrease while shear stress, heat transfer rate, and resistance to flow increase when the hematocrit parameter increases. Finally, increases in magnetic field parameter lead to decrease in flow velocity, flow rate and shear stress but increase the flow resistance.
基金Under the auspices of National Natural Science Foundation of China (49771007)
文摘This paper is written in order to provide a scientific basis for a unified standard of the reference value of Chinese healthy old people's hematocrit. It studies the relationship between the reference values of healthy old people's hematocrit, tested according to the Wintrobe Laws and five geographical factors. It is found that the altitude is the most important factor affecting the reference value of old people's hematocrit. As the altitude gradually increases, the reference value of their hematocrit also increases, the relationship is quite significant. By using the method of stepwise regression analysis, two multivariate regression equations are deduced:1=50.2+0.00248X1-0.0534X3-0.388X4+0.00383X5±2.2, 2=44.5+0.00231X1-0.0600X3-0.260X4+0.00341X5±2.1. If the geographical index values in a particular area in China are known, the reference value of old people's hematocrit in this area can be established by means of the regression equations. Furthermore, according to the dependent relationship of the reference value of old people's hematocrit on geographical factors, China can be divided into six regions: Qinghai-Tibet, Plateau, Southwest, Northwest, Southeast, North and Northeast.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61701076,82071940,and 62001075).
文摘Abnormal hematocrit(Hct)is associated with an increased risk of pre-hypertension and all-cause death in general population,and people with a high Hct value are susceptible to arterial cardiovascular disease and venous thromboembolism.In this study,we report for the first time on the ability of thermoacoustic imaging(TAI)for in vivo evaluating Hct changes in human forearms.In vitro blood samples with different Hct values from healthy volunteers(n=3)were prepared after centrifugation.TAI was performed using these samples in comparison with the direct measurements of conductivity.In vivo TAI was conducted in the forearm of healthy volunteers(n=7)where Hct changes were produced through a vascular occlusion stimulation over a period of time.The results of in vitro blood samples obtained from the 3 healthy subjects show that the thermoacoustic(TA)signals changes due to the variation of blood conductivity are closely related to the changes in Hct.In addition,the in vivo TA signals obtained from the 7 healthy subjects consistently increase in the artery/muscle and decrease in the vein during venous or arterial occlusion because of the changed Hct value in their forearms.These findings suggest that TAI has the potential to become a new tool for monitoring Hct changes for a variety of pre-clinical and clinical applications.
文摘Regular monitoring of pulmonary congestion in car-diogenic pulmonary edema (CPE) patients is neces-sary for its adequate management via pharmaceuti-cal treatment. It is well known that the development of CPE is accompanied with an increase in hema-tocrit, plasma protein concentration and colloid os-motic pressure due to the decrease in the plasma volume. In the present study the mean left and right lung resistivity values taken pre- and post treatment with diuretics using a hybrid bio-impedance electri-cal impedance tomography system were correlate to the measured changes in hematocrit level. A marginal significant correlation was found between the abso-lute mean lung resistivity and hematocrit levels (Pearson’s correlation coefficient of R = 0.4, p-value = 0.057). When the change in the mean lung resistivity of a patient was plotted vs. the change in hematocrit readout, a significant linear correlation was found (R = 0.7, p-value = 0.02). These results support the validity of the resistivity measurements using bio-impedance system in monitoring changes of pulmonary edema in CPE patients.
文摘Objective: to investigate the role of blood lipid, hematocrit (HCT), coagulation function and hemorheology in pregnancy induced hypertension (PIH). Methods: the diagnosis time was from January 2020 to January 2022. A total of 67 pregnant women with PIH (group A) were divided into mild group (38 cases) and severe group (29 cases) according to the severity of the disease;at the same time, 67 healthy pregnant women (group B) were selected. The blood lipid, HCT, coagulation function index and hemorheology were detected, and the test results and pregnancy outcomes were compared. Results: compared with the levels of blood lipid and HCT among the three groups, the difference was significant, as shown by P0.05. The blood coagulation function indexes of mild group and severe group were different from those of group B (P0.05). There were also differences in coagulation function between mild and severe groups (P>0.05). Compared with the three groups, the indexes of hemorheology were different (P0.05). Compared with mild and severe groups, there was a difference in adverse pregnancy outcomes, as shown by P0.05. Conclusion: the detection of blood lipid, HCT, coagulation function and hemorheology can detect PIH, judge the severity of the disease, and predict the pregnancy outcome. The above indicators can ensure the safety of pregnancy.
文摘Objective: To investigate the effect of high altitude span transportation on the change of hematocrit and electrocardiogram of the crew in the plateau construction, and discuss their relationship. Method: By SPSS 11.0 statistical software, to treat hematocrit and electrocardiogram in the examination data of the the crew, who took part in the construction of Qinghai-Tibetan railway in 2003, before, during and after the construction. Then, we compared the data among the constructors in the fixed altitude during the same period. Result: The hematocrit of the crew slowly and continually rose to the maximum(p<0.01) after the construction in the high altitude span during one construction year, and the abnormal rate of electrocardiogram obviously decreased(p<0.05). The abnormal rate of electrocardiogram apparently improved when hematocrit reached 52% among the range from 45.12% to 52.24%, and the correlation analysis showed that the electrocardiographic change was closely and negatively correlated with the hematocrit among the range of hematocrit(p<0.05). Conclusion: Although the higher-level stress state of the crew made the hematocrit in the blood continually increase in the long-term high altitude span construction, the hematocrit reached the more reasonable hematocrit compensation and made it the optimum state of Hct in the end. As a result, the perfusion of tissues and organs was improved. The abnormal rate of electrocardiogram apparently improved because the oxygen delivery of the myocardium reached the optimum compensation.
文摘Objective:The main objective is to determine the normal physiological values of heart rate,respiratory rate,oxygen saturation,blood pressure,and hemato-crit in populations living at altitudes between 1,000 and 3,500 meters above sea level in the Cajamarca Region during the year 2023.Methods:The study de-sign was a descriptive observational cross-sectional study with a non-proba-bilistic sampling method.Inclusion criteria considered inhabitants aged 1 to 70 years,of both sexes,both native and non-native,who had resided for more than one year at the measured altitude and agreed to participate by signing the informed consent form.In the case of minors,consent was obtained from their parents.Exclusion criteria included a history of cardiovascular,pulmonary,or hematological disease;presence of respiratory symptoms at the time of the test such as cough,sputum,or dyspnea;diagnosis of obesity;body mass index greater than or equal to 30;and regular smoking.The total population included 476 individuals.Statistical analysis was performed using R Project software,and non-parametric statistical tests such as the Kruskal-Wallis test were applied.Results:Significant differences were found by sex in heart rate,respiratory rate,and hematocrit.Additionally,all physiological variables measured showed statistically significant differences according to sex,altitude,and life course.Conclusion:This study is relevant as it establishes a baseline for vital signs and hem-atocrit values in high-altitude populations.It is the first study of its kind con-ducted in the Cajamarca Region and represents a starting point for future research in high-altitude medicine.
文摘Objective:To validate the hematocrit percentage drop cutoff points for blood loss in patients with postpartum hemorrhage(PPH)using the automated gravimetric method.Methods:A prospective cohort study was conducted from January 2023 to July 2023,in which 107 patients 18 years of age and above were scheduled for elective cesarean with obstetrical indications.We excluded cases with difficulty quantifying blood loss,those with incomplete data,and those of patients who did not consent to participate.Blood loss was measured by an automated gravimetric system integrated into a suction blood collector and surgical gauze weighing systems to automatically sum up blood loss immediately after hysterectomy and fetal delivery.The percentage drop in hematocrit was determined by subtracting the 8-hour postsurgical from presurgical hematocrit,divided by presurgical hematocrit.We performed the Pearson correlation test,and the receiver operating characteristic curve was used to determine cutoff points,their sensitivity,and their specificity.Theκindex was used to determine the diagnostic agreement between the two methods.Results:A positive correlation was observed between the volume of blood loss and the percentage drop in hematocrit,with a Pearson correlation index of 0.70 and P<0.0001.A 14%decrease in hematocrit had an 81.7%agreement rate,with a goodκindex of 0.602,a sensitivity of 82.5%,and a specificity of 80.0%.A 10%drop in hemoglobin was sensitive(93.0%)but not very specific(56.0%)for blood loss greater than 1000 mL.Conclusion:The automated gravimetric method strongly correlates with hematocrit changes,providing an accurate real-time diagnosis of PPH.Additionally,a hematocrit percentage drop can retrospectively indicate significant blood loss,aiding in managing patients at risk for long-term PPH complications.
文摘Background Streptococcus pneumoniae,as a respiratory tract common pathogen,can cause invasive disease and sepsis.This study aimed to investigate the association of factors with clinical outcomes in sepsis with streptococcus pneumoniae infection based on MIMIC-IV database.Methods The sepsis patients with streptococcus pneumoniae infection were included.Different variables between the survivor group and the non-survivor group were analyzed.Multivariable logistic regression was applied to identify the factors which were associated with clinical outcomes.Results A total of 80 sepsis patients with streptococcus pneumoniae infection were included.The in-hospital mortality was 23.75%(n=19).Significant differences were found in heart rate,white blood cell,RDW,MCV and hematocrit between the survivor group and the non-survivor group.The area under the ROC curve of hematocrit was 0.758 with a sensitivity of 73.7%and a specificity of 72.1%.The cut-off value of hematocrit was 30.8%.Conclusions Hematocrit level was identified to be negatively associated with in-hospital mortality in sepsis with streptococcus pneumoniae infection.
文摘INTRODUCTION Total hip arthroplasty （THA） and total knee arthroplasty （TKA） are currently two effective treatments for many diseases of the hip and knee. Despite the ability to minimize intraoperative blood loss, postoperative hemoglobin （Hgb） loss is expected, and a number of studies have reported on hidden blood loss after THA and TKA.
