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枯草菌HemAT蛋白质结合配基O_2的构象变化——紫外共振拉曼光谱研究
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作者 顾玉宗 张放 +2 位作者 皇甫昱 王超 毛艳丽 《生物物理学报》 CAS CSCD 北大核心 2007年第6期443-447,共5页
枯草菌HemAT蛋白质是新近发现的一种基于血红素的趋氧性同型二聚体蛋白质。作者对此蛋白质进行了表达和提纯。用紫外共振拉曼光谱研究了全分子和传感域HemAT在与配基O2结合时的构象变化。发现O2配基与HemAT蛋白质的结合使传感域中Trp和... 枯草菌HemAT蛋白质是新近发现的一种基于血红素的趋氧性同型二聚体蛋白质。作者对此蛋白质进行了表达和提纯。用紫外共振拉曼光谱研究了全分子和传感域HemAT在与配基O2结合时的构象变化。发现O2配基与HemAT蛋白质的结合使传感域中Trp和Tyr的环境发生变化,而对连接域中Tyr的环境影响可忽略不计。信号发送域对O2配基引起的Trp和Tyr的环境变化不产生影响。O2配基与HemAT蛋白质的结合使得G-螺旋发生位移,传感域与信号发送域通过某种互感方式把O2结合信号从传感域传递到信号发送域。 展开更多
关键词 枯草菌 HemAT 蛋白质 紫外共振拉曼
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Journal of Mathematical Research with Applications Guide for Authors
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《Journal of Mathematical Research with Applications》 CSCD 2019年第4期F0003-F0003,共1页
Journal overview: Journal of Mathematical Research with Applications (JMRA), formerly Journal of Mat hematical Research and Exposition (JMRE) created in 1981, one of the t ransac tions of China Society for Industrial ... Journal overview: Journal of Mathematical Research with Applications (JMRA), formerly Journal of Mat hematical Research and Exposition (JMRE) created in 1981, one of the t ransac tions of China Society for Industrial and Applied Mathematics, is a home for original research papers of the highes t quality in all areas of mat hematics with applications. The target audience comprises: pure and applied mathematicians, graduate students in broad fields of sciences and technology, scientists and engineers interes ted in mat hematics. 展开更多
关键词 RESEARCH EXPOSITION hematics
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基于Mathematica 10的通用导轨选型软件的设计
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作者 徐娜 莫堃 《装备制造与教育》 2017年第1期43-46,共4页
导轨选型与设计是直线运动机构的关键组成部分。如今市面上的导轨选型工具均受限于各商业产品手册,他们对选型过程做了大量封装或简化,不能完全实现从需求出发并依据运动学和动力学原理进行设计,效率较低。本文在计算软件Mat hemat ica1... 导轨选型与设计是直线运动机构的关键组成部分。如今市面上的导轨选型工具均受限于各商业产品手册,他们对选型过程做了大量封装或简化,不能完全实现从需求出发并依据运动学和动力学原理进行设计,效率较低。本文在计算软件Mat hemat ica10的环境下,实现了用于选型的导轨主要性能参数的快速计算。首先根据运动学、动力学原理,综合考虑多种影响因素,总结并提出了一套具有普适性、以承受载荷和使用寿命为主要指标选型流程;然后基于Mat hemat ica动态模块和符号推导技术实现了该软件并与现有各种商业软件进行了对比,获得良好的使用效果。 展开更多
关键词 导轨 选型 承受载荷 使用寿命 MAT hemat I CA
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一个基于RBAC的权限管理系统的设计和实现 被引量:1
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作者 张宏丽 《科技视界》 2012年第19期160-162,共3页
介绍了一个MVC模式下基于角色的权限管理(RBAC)的权限管理系统的设计,通过对角色授权的方式使得用户获得相应的权限和操作,提高了系统的安全性,简化了系统的权限分配和管理工作;并利用J2EE主流技术:Struts2+Hibernate+Spring框架和dhtml... 介绍了一个MVC模式下基于角色的权限管理(RBAC)的权限管理系统的设计,通过对角色授权的方式使得用户获得相应的权限和操作,提高了系统的安全性,简化了系统的权限分配和管理工作;并利用J2EE主流技术:Struts2+Hibernate+Spring框架和dhtmlxtree实现了信息系统中用户权限树形结构管理。 展开更多
关键词 MVC 角色权限管理 J2EE stnlts2+H.hemate+Sing框架 dhtmlxtree
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Semi-Conducting Behavior of Plio-Quaternary Basaltic Lava Flows from Hemat Madam Volcano, Sana’a-Amran Volcanic Field, Yemen
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作者 M. R. Eraky Mohamed Th. S. Heikal 《Journal of Applied Mathematics and Physics》 2015年第12期1610-1618,共9页
Electric DC and AC measurements and dielectric investigations have been carried out on some Plio-Qaternary basalt of Hemat Madam volcano from Sana’a-Amran volcanic field (SAVF). In this article we focus primarily on ... Electric DC and AC measurements and dielectric investigations have been carried out on some Plio-Qaternary basalt of Hemat Madam volcano from Sana’a-Amran volcanic field (SAVF). In this article we focus primarily on the field aspects and the main characteristic mineralogical and petrographic features of this inactive volcano. Using DC and AC experimental arrangements we discovered excellent electrical characteristics for this inactive volcano. The results of DC electrical resistivity versus a temperature reveal that all the samples have semiconductor characters. Moreover, the measurements showed that these samples have high resistive extrinsic semiconductors (ρDC ~ 109 Ω·m). AC and dielectric measurements were ensured the semi-conductivity and normal dielectric behavior of these samples. AC measurements reveal that the classical barrier hopping model (CBH) is the predominant conduction mechanism, while at low temperature region small polarons may contribute to the conduction in the samples. The samples have low values for dielectric constant ε' and low loss factor tanδ (ε' ~ 27 and tanδ ~ 0.7 at 200 Hz for the sample BA7). Then, the semicodutor behavior, the high values of DC/AC resistivity and low loss dissipation factor considered a very good characterization for magnetic semiconductor materials. So, we can predict that, the studied natural materials represent newborn promising material sciences for many more technological applications. 展开更多
关键词 Hemat Madam VOLCANO Semiconductor BASALTIC ROCKS Electrical Properties
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SELECTED TITLES OF RECENT JOURNALS
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《外科研究与新技术》 1995年第2期127-127,共1页
950430 Study on point mutations of factor IX genewith PCR and DsDNA cycle sequencing.WANG Ning-sui(王宁遂),et al.Instit of pediatrics.Chongqing U-niv Med Sciences,Chongqing,630014.Chin J Hemat1995;16(5):227-22S.950431... 950430 Study on point mutations of factor IX genewith PCR and DsDNA cycle sequencing.WANG Ning-sui(王宁遂),et al.Instit of pediatrics.Chongqing U-niv Med Sciences,Chongqing,630014.Chin J Hemat1995;16(5):227-22S.950431 The double(Tri-) lumen catheter for perma-nent hemodialysis access.MA Jan(马骏),et al.DeptMed,Hua Shah Hosp shanghai Med Univ 200040 ChinJ Nephol 1995;11(2):66-68. 展开更多
关键词 CHONGQING SEQUENCING HEMODIALYSIS Hemat cycle LUMEN MIRROR 卜工 王新 Neurol
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Expression and significance of IL-18 in the bone marrow of patients with hematological diseases 被引量:4
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作者 张斌 饶青 +6 位作者 郑国光 曹震宇 马小彤 李戈 林永敏 耿以琪 吴克复 《Chinese Medical Journal》 SCIE CAS CSCD 2003年第2期218-221,共4页
To investigate the levels of IL 18 in the bone marrow of both normal subjects a nd patients with hematological diseases and to determine the possible significan ce of IL 18 in pathogenesis of some hematological mali... To investigate the levels of IL 18 in the bone marrow of both normal subjects a nd patients with hematological diseases and to determine the possible significan ce of IL 18 in pathogenesis of some hematological malignancies Methods The IL 18 mRNA levels in the bone marrow of 140 patients with hematological dis eases and 15 normal donors were determined by the semi quantitative reverse tra nscriptase polymerase chain reaction (RT PCR) Immunohistochemical method was used to detect IL 18 protein in 12 patients with acute myeloid leukemia (AML) The possible regulation of IL 18 for proliferation of some leukemia cells was investigated using antisense techniques Results IL 18 mRNA levels were obviously higher in the patients with leukemia or other malignant hematological diseases (OMHD) than in normal donors However, no sign ificant difference was found in the level of transcription between patients with iron deficiency anemia (IDA) and normal controls Immunohistochemical method c onfirmed the presence of IL 18 protein in 10 out of 12 AML cases with positive transcription By 3 (4,5 dimethylthiazol 2 yl) 2,5 diphenyl tetrazolium b romide (MTT) assay, IL 18 antisense oligodeoxynucleotides (ASON) clearly inhibi ted the growth of J6 1 and HL 60 cells (42% and 12% inhibited, respectively) i n a dose dependant manner Conclusions IL 18 was detected at elevated levels in the bone marrow of patients with some hematological malignancies, and might be involved in the proliferation of certai n leukemic cells in vivo through an autocrine mechanism 展开更多
关键词 interleukin 18 · gene expression · hemat ological malignancies · autocrine
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Lymphatic system and lymphoma
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《China Medical Abstracts(Internal Medicine)》 2008年第1期55-56,共2页
2008108 Comparison of polyethylene glycol conjugated asparaginase and L-asparaginase for treatment of childhood acute lymphoblastic leukemia. ZHU Xiaofan(竺晓凡), et al. Instit Hemat & Blood Dis Hosp, CAMS & ... 2008108 Comparison of polyethylene glycol conjugated asparaginase and L-asparaginase for treatment of childhood acute lymphoblastic leukemia. ZHU Xiaofan(竺晓凡), et al. Instit Hemat & Blood Dis Hosp, CAMS & PUMC, Tianjin 300020. Chin J Hematol 2008;29(1):29-33. Objective To evaluate efficacy and side-effect of polyethylene glycol conjugated asparaginase (PEG-Asp) containing VDPAP regimen in newly diagnosed childhood acute lymphoblastic leukemia (ALL). 展开更多
关键词 LYMPHOBLASTIC CHILDHOOD conjugated polyethylene GLYCOL Tianjin REGIMEN Hemat CAMS Blood
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HEMOPOIETIC SYSTEM
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《China Medical Abstracts(Internal Medicine)》 1996年第3期182-185,共4页
关键词 INTERLEUKIN MOBILIZATION hemat REMISSION myelo PROGENITOR Immunol INFUSION UNRELATED 顾龙君
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Hematopoietic System
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《China Medical Abstracts(Internal Medicine)》 2020年第4期231-234,共4页
2020403 The clinical characteristics of patients with primary plasma cell leukemia and the efficacy of novel agents and hematopoietic stem cell transplantation.LI Wenjing(李文静),et al.Dept Hematol,Peking Univ People... 2020403 The clinical characteristics of patients with primary plasma cell leukemia and the efficacy of novel agents and hematopoietic stem cell transplantation.LI Wenjing(李文静),et al.Dept Hematol,Peking Univ People’s Hosp,Peking Univ Hematol Instit,Beijing 100044.Chin J Intern Med 2020;59(10):801-806. 展开更多
关键词 Hemat CLINICAL HEMATOPOIETIC
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Hematopoietic System
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《China Medical Abstracts(Internal Medicine)》 2020年第1期58-62,共5页
2020104 Analysis of correlation between plasma trough level and response of generic imatinib in the treatment of Chinese patients with chronic myeloid leukemia.YOU Jianhua(游建华),et al.Dept Hematol,Ruijin Hosp,Shangh... 2020104 Analysis of correlation between plasma trough level and response of generic imatinib in the treatment of Chinese patients with chronic myeloid leukemia.YOU Jianhua(游建华),et al.Dept Hematol,Ruijin Hosp,Shanghai Jiaotong Univ Med Sch,Shanghai 200025.Chin J Hematol 2019;40(11):939-942. 展开更多
关键词 Hemat leukemia. TROUGH
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Hematopoietic System
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《China Medical Abstracts(Internal Medicine)》 2022年第3期182-189,共8页
2022304 Influence of the number of high-risk cytogenetic abnormalities on the clinical characteristics and prognosis in 360 patients with newly diagnosed multiplemyeloma.CHENZhi(陈智),et al.Dept Hematol,1st Affil Hosp... 2022304 Influence of the number of high-risk cytogenetic abnormalities on the clinical characteristics and prognosis in 360 patients with newly diagnosed multiplemyeloma.CHENZhi(陈智),et al.Dept Hematol,1st Affil Hosp,Nanjing Med Univ,Nanjing 210029.Chin J Hematol 2022;43(5):408-413. 展开更多
关键词 Hemat PROGNOSIS
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