It was Father’s Day 1978,and Doug Heir,abrawny 18-year-old,was working as a lifeguard ata pool in Fairfield,N.J.Suddenly he spotted astruggling child crying for help.Doug dived offthe nine-foot lifeguard stand into t...It was Father’s Day 1978,and Doug Heir,abrawny 18-year-old,was working as a lifeguard ata pool in Fairfield,N.J.Suddenly he spotted astruggling child crying for help.Doug dived offthe nine-foot lifeguard stand into the pool.Thenext thing he saw was a white flash as his head struckthe concrete bottom.The water turned red around him,and Dougfelt he was drowning.Then he saw his brother,Brian,pulling him to the surface."Somebody’s in trouble over there,"Doug sput-tered,blood gushing from his head.展开更多
Background and purpose The low-field MRI is a promising tool to accurately diagnose strokes.We here report our study on the accuracy of a 0.23-Tesla(0.23-T)MRI using the haematoma enhanced inversion recovery(HEIR)sequ...Background and purpose The low-field MRI is a promising tool to accurately diagnose strokes.We here report our study on the accuracy of a 0.23-Tesla(0.23-T)MRI using the haematoma enhanced inversion recovery(HEIR)sequence to detect acute ischaemic stroke(AIS)and intracerebral haemorrhage(ICH)within 24 hours of symptom onset.Methods A novel HEIR sequence based on fluid-attenuated inversion recovery T1-weighted,with a scanning time of 1 min and 17 s,was developed using an ICH and AIS pig model on a 0.23-T MRI.Images of the pig model were obtained hourly for 24 hours in order to monitor value changes on T1/T2 and verify the differential diagnosis of AIS and ICH.Then,30 patients with AIS and 30 patients with ICH with confirmed diagnoses by 3T-MRI/CT were included.Diagnostic criteria on a 0.23-T MRI for ICH was the hyperintensity signal on both the diffusion-weighted imaging(DWI)and HEIR sequence,while for AIS was the hyperintensity on DWI and isointensity on the HEIR sequence.Two blinded raters independently assessed the images obtained by the 0.23-T MRI for the presence of ICH/AIS.Results In the pig model,setting the inversion time to 800 ms enabled clear differentiation of ICH from brain parenchymal tissue and AIS.In real patients,a correct 0.23-T MRI diagnosis of either an AIS or ICH was made in all 60 patients within 24 hours of symptom onset(100%overall accuracy).No adverse events occurred.Conclusions The 0.23-T MRI may have the potential to differentiate cerebral haemorrhage from cerebral infarction with both speed and accuracy,making brain MRI scans easier,faster and cheaper.It might be possible to improve the screening imaging process for strokes in the emergency room.Further multicentre studies are needed to validate our findings.展开更多
文摘It was Father’s Day 1978,and Doug Heir,abrawny 18-year-old,was working as a lifeguard ata pool in Fairfield,N.J.Suddenly he spotted astruggling child crying for help.Doug dived offthe nine-foot lifeguard stand into the pool.Thenext thing he saw was a white flash as his head struckthe concrete bottom.The water turned red around him,and Dougfelt he was drowning.Then he saw his brother,Brian,pulling him to the surface."Somebody’s in trouble over there,"Doug sput-tered,blood gushing from his head.
基金National Natural Science Foundation of China(grant no.82271329grant no.82471356).
文摘Background and purpose The low-field MRI is a promising tool to accurately diagnose strokes.We here report our study on the accuracy of a 0.23-Tesla(0.23-T)MRI using the haematoma enhanced inversion recovery(HEIR)sequence to detect acute ischaemic stroke(AIS)and intracerebral haemorrhage(ICH)within 24 hours of symptom onset.Methods A novel HEIR sequence based on fluid-attenuated inversion recovery T1-weighted,with a scanning time of 1 min and 17 s,was developed using an ICH and AIS pig model on a 0.23-T MRI.Images of the pig model were obtained hourly for 24 hours in order to monitor value changes on T1/T2 and verify the differential diagnosis of AIS and ICH.Then,30 patients with AIS and 30 patients with ICH with confirmed diagnoses by 3T-MRI/CT were included.Diagnostic criteria on a 0.23-T MRI for ICH was the hyperintensity signal on both the diffusion-weighted imaging(DWI)and HEIR sequence,while for AIS was the hyperintensity on DWI and isointensity on the HEIR sequence.Two blinded raters independently assessed the images obtained by the 0.23-T MRI for the presence of ICH/AIS.Results In the pig model,setting the inversion time to 800 ms enabled clear differentiation of ICH from brain parenchymal tissue and AIS.In real patients,a correct 0.23-T MRI diagnosis of either an AIS or ICH was made in all 60 patients within 24 hours of symptom onset(100%overall accuracy).No adverse events occurred.Conclusions The 0.23-T MRI may have the potential to differentiate cerebral haemorrhage from cerebral infarction with both speed and accuracy,making brain MRI scans easier,faster and cheaper.It might be possible to improve the screening imaging process for strokes in the emergency room.Further multicentre studies are needed to validate our findings.
