1|INTRODUCTION Black adults living in the United States experience shorter sleep durations,lower sleep efficiencies,and less slow‐wave sleep(SWS)than peers in other racial groups.^(1–3)As a social stressor that disp...1|INTRODUCTION Black adults living in the United States experience shorter sleep durations,lower sleep efficiencies,and less slow‐wave sleep(SWS)than peers in other racial groups.^(1–3)As a social stressor that disproportionately affects Black adults,racial discrimination is likely a contributor to racial disparities in sleep.^(4)展开更多
With the increasing efforts to protect the safety of drinking water in rural areas,brackish groundwater,as a drinking water resource,needed desalinating urgently in the western region of China.In response to this prob...With the increasing efforts to protect the safety of drinking water in rural areas,brackish groundwater,as a drinking water resource,needed desalinating urgently in the western region of China.In response to this problem,static and dynamic single stacked tray and two stacked tray distillation experiments were researched on steady-state conditions.Results reflected the way how the efficiency of展开更多
To The Editor:1.INTRODUCTION Fanconi anemia(FA)is a hereditary disorder characterized by genomic instability and increased sensitivity to DNA cross-linking agents.FA is typically diagnosed in childhood,with an average...To The Editor:1.INTRODUCTION Fanconi anemia(FA)is a hereditary disorder characterized by genomic instability and increased sensitivity to DNA cross-linking agents.FA is typically diagnosed in childhood,with an average age at diagnosis of 7 years.Mutations in any of the 23 genes associated with the FA/BRCA pathway can lead to the onset of FA.The clinical manifestations of FA primar-ily include congenital abnormalities,progressive bone marrow failure,and heightened susceptibility to malignancies.展开更多
Radiotherapy(RT)serves as the primary treatment for solid tumors.Its potential to incite an immune response against tumors both locally and distally profoundly impacts clinical outcomes.However,RT may also promote the...Radiotherapy(RT)serves as the primary treatment for solid tumors.Its potential to incite an immune response against tumors both locally and distally profoundly impacts clinical outcomes.However,RT may also promote the accumulation of immunosuppressive cytokines and immunosuppressive cells,greatly impeding the activation of antitumor immune responses and substantially limiting the effectiveness of RT.Therefore,regulating post-RT immunosuppression to steer the immune milieu toward heightened activation potentially enhances RT's therapeutic potential.Cytokines,potent orchestrators of diverse cellular responses,play a pivotal role in regulating this immunosuppressive response.Identifying and promptly neutralizing early released immunosuppressive cytokines are a crucial development in augmenting RT's immunomodulatory effects.To this end,we conducted a screen of immunosuppressive cytokines following RT and identified macrophage colony-stimulating factor(MCSF)as an early up-regulated and persistent immune suppressor.Single-cell sequencing revealed that the main source of up-regulated McSF derived from tumor cells.Mechanistic exploration revealed that irradiation-dependent phosphorylation of the p65 protein facilitated its binding to the McSF gene promoter,enhancing transcription.Knockdown and chemical inhibitor experiments conclusively demonstrated that suppressing tumor cell-derived McSF amplifies RT's immune-activating effects,with optimal results achieved by early MCSF blockade after irradiation.Additionally,we validated that MCSF acted on macrophages,inducing the secretion of a large number of inhibitory cytokines.In summary,we propose a novel approach to enhance the immune activation effects of RT by blocking the MCSF-CSF1R signaling pathway early after irradiation.展开更多
The global ecological crisis encompasses a variety of effects on the environment caused by humans.This encompasses severe climatic conditions,escalating sea levels,permanent biodiversity decline,and a heightened disea...The global ecological crisis encompasses a variety of effects on the environment caused by humans.This encompasses severe climatic conditions,escalating sea levels,permanent biodiversity decline,and a heightened disease risk due to greenhouse gas emissions elevating global average temperatures in water and air from industrial and consumer waste,along with soil pollution.The primary cause of greenhouse gas emissions is the overreliance on fossil fuels to satisfy escalating energy needs.展开更多
The dam heightening,which is an effective way to increase reservoir volume,has been paid close attention by engineers.Three problems should be dealt with when an arch dam needs to be heightened:stress state getting wo...The dam heightening,which is an effective way to increase reservoir volume,has been paid close attention by engineers.Three problems should be dealt with when an arch dam needs to be heightened:stress state getting worse at dam heel,cracking on new added concrete dam surface,and weak bonding between new added concrete and old dam.Taking Geba arch dam as an example,these problems are examined in details through simulation analysis by the finite element method.The tensile stresses on dam’s surface and joint face that have certain relations to the dam heightening can be controlled by some measures.展开更多
文摘1|INTRODUCTION Black adults living in the United States experience shorter sleep durations,lower sleep efficiencies,and less slow‐wave sleep(SWS)than peers in other racial groups.^(1–3)As a social stressor that disproportionately affects Black adults,racial discrimination is likely a contributor to racial disparities in sleep.^(4)
文摘With the increasing efforts to protect the safety of drinking water in rural areas,brackish groundwater,as a drinking water resource,needed desalinating urgently in the western region of China.In response to this problem,static and dynamic single stacked tray and two stacked tray distillation experiments were researched on steady-state conditions.Results reflected the way how the efficiency of
文摘To The Editor:1.INTRODUCTION Fanconi anemia(FA)is a hereditary disorder characterized by genomic instability and increased sensitivity to DNA cross-linking agents.FA is typically diagnosed in childhood,with an average age at diagnosis of 7 years.Mutations in any of the 23 genes associated with the FA/BRCA pathway can lead to the onset of FA.The clinical manifestations of FA primar-ily include congenital abnormalities,progressive bone marrow failure,and heightened susceptibility to malignancies.
基金supported by the National Natural Science Foundation of China(grant nos.82102931,82330085,82073354,and 82102201)Hubei Provincial Key Laboratory Open Project Fund for Precision Radiotherapy in Oncology(grant no.jzfs001).
文摘Radiotherapy(RT)serves as the primary treatment for solid tumors.Its potential to incite an immune response against tumors both locally and distally profoundly impacts clinical outcomes.However,RT may also promote the accumulation of immunosuppressive cytokines and immunosuppressive cells,greatly impeding the activation of antitumor immune responses and substantially limiting the effectiveness of RT.Therefore,regulating post-RT immunosuppression to steer the immune milieu toward heightened activation potentially enhances RT's therapeutic potential.Cytokines,potent orchestrators of diverse cellular responses,play a pivotal role in regulating this immunosuppressive response.Identifying and promptly neutralizing early released immunosuppressive cytokines are a crucial development in augmenting RT's immunomodulatory effects.To this end,we conducted a screen of immunosuppressive cytokines following RT and identified macrophage colony-stimulating factor(MCSF)as an early up-regulated and persistent immune suppressor.Single-cell sequencing revealed that the main source of up-regulated McSF derived from tumor cells.Mechanistic exploration revealed that irradiation-dependent phosphorylation of the p65 protein facilitated its binding to the McSF gene promoter,enhancing transcription.Knockdown and chemical inhibitor experiments conclusively demonstrated that suppressing tumor cell-derived McSF amplifies RT's immune-activating effects,with optimal results achieved by early MCSF blockade after irradiation.Additionally,we validated that MCSF acted on macrophages,inducing the secretion of a large number of inhibitory cytokines.In summary,we propose a novel approach to enhance the immune activation effects of RT by blocking the MCSF-CSF1R signaling pathway early after irradiation.
文摘The global ecological crisis encompasses a variety of effects on the environment caused by humans.This encompasses severe climatic conditions,escalating sea levels,permanent biodiversity decline,and a heightened disease risk due to greenhouse gas emissions elevating global average temperatures in water and air from industrial and consumer waste,along with soil pollution.The primary cause of greenhouse gas emissions is the overreliance on fossil fuels to satisfy escalating energy needs.
文摘The dam heightening,which is an effective way to increase reservoir volume,has been paid close attention by engineers.Three problems should be dealt with when an arch dam needs to be heightened:stress state getting worse at dam heel,cracking on new added concrete dam surface,and weak bonding between new added concrete and old dam.Taking Geba arch dam as an example,these problems are examined in details through simulation analysis by the finite element method.The tensile stresses on dam’s surface and joint face that have certain relations to the dam heightening can be controlled by some measures.
