Introduction:Internal heat-type acupuncture therapy is a new therapeutic method that integrates acupuncture and heat therapy and effectively reduces local muscle inflammation.It has a good effect on the clinical appli...Introduction:Internal heat-type acupuncture therapy is a new therapeutic method that integrates acupuncture and heat therapy and effectively reduces local muscle inflammation.It has a good effect on the clinical application of osteoporosis.The purpose of this study was to assess the improvement of glucocorticoid-induced osteoporosis(GIOP)after internal heat-type acupuncture treatment as well as its role in promoting the balance of bone remodeling in the GIOP rabbit model by regulating the triplet of osteoprotegerin(OPG)-receptor activator of nuclear factor-KB ligand(RANKL)-receptor activator of nuclear factor-KB(RANK).Methods:The rabbits were divided into the control,model(GIOP),GIOP+Alendronate,and GIOP+Internal heat-type acupuncture groups,with 8 rabbits in each group.At the end of the treatment,all rabbits were sacrificed.The pathologic changes of lumbar vertebrae were observed by x-ray,the morphology of lumbar trabecular bone was observed by HE staining,and the apoptosis of lumbar vertebrae was detected by Tunel.The protein expressions of OPG,RANKL,and RANK in lumbar vertebrae were detected by immunohistochemistry staining,immunofluorescence staining,and Western blotting.Results:Internal heat-type acupuncture partly prevented osteopenia among GIOP-induced rabbits,improved the morphology of lumbar vertebrae,and inhibited the apoptosis of lumbar vertebrae osteocytes.Moreover,by increasing the protein expression level of OPG and reducing the protein expression of RANKL and RANK,internal heat-type acupuncture effectively promoted the balance of bone remodeling and eventually achieved the treatment of GIOP.Conclusion:Internal heat-type acupuncture therapy may promote the balance of bone remodeling by regulating the triplet of osteoprotegerin-receptor activator of nuclear factor-KB ligand-receptor activator of nuclear factor-KB,thereby treating osteoporosis which was induced by glucocorticoid.展开更多
目的:分析黄连荷叶方联合度拉糖肽治疗2型糖尿病(T2DM)(湿热困脾证)肥胖患者疗效及对胰岛素抵抗和内脏脂肪指数的影响。方法:选取2023年1月—2024年12月佛山复星禅诚医院收治的T2DM(湿热困脾证)肥胖患者80例,随机数字表法分为对照组和...目的:分析黄连荷叶方联合度拉糖肽治疗2型糖尿病(T2DM)(湿热困脾证)肥胖患者疗效及对胰岛素抵抗和内脏脂肪指数的影响。方法:选取2023年1月—2024年12月佛山复星禅诚医院收治的T2DM(湿热困脾证)肥胖患者80例,随机数字表法分为对照组和联合组,每组40例。对照组采用度拉糖肽治疗,联合组加用黄连荷叶方治疗,均治疗12周。比较两组临床疗效,治疗前后血糖指标[餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A_(1)c)、空腹血糖(FPG)]、胰岛素抵抗指数(HOMA-IR)、中医证候积分、肥胖指标、不良反应。结果:联合组疗效高于对照组(P<0.05);治疗后,两组血糖指标、HOMAIR、中医证候积分、肥胖指标均低于治疗前(P<0.05),且联合组FPG、2 h PG、Hb A_(1)c、HOMA-IR、中医证候积分、体脂肪率、内脏脂肪指数均低于对照组(P<0.05,P<0.01);两组不良反应率差异无统计学意义(P>0.05)。结论:T2DM(湿热困脾证)肥胖患者应用黄连荷叶方联合度拉糖肽疗效较好,可降低血糖,改善胰岛素抵抗,改善患者中医证候,降低内脏脂肪指数。展开更多
基金supported by the National Natural Science Foundation of China(Nos.81860893 and 82360987)Ningxia Hui Autonomous Region key research and development project(Nos.2022BEG03134).
文摘Introduction:Internal heat-type acupuncture therapy is a new therapeutic method that integrates acupuncture and heat therapy and effectively reduces local muscle inflammation.It has a good effect on the clinical application of osteoporosis.The purpose of this study was to assess the improvement of glucocorticoid-induced osteoporosis(GIOP)after internal heat-type acupuncture treatment as well as its role in promoting the balance of bone remodeling in the GIOP rabbit model by regulating the triplet of osteoprotegerin(OPG)-receptor activator of nuclear factor-KB ligand(RANKL)-receptor activator of nuclear factor-KB(RANK).Methods:The rabbits were divided into the control,model(GIOP),GIOP+Alendronate,and GIOP+Internal heat-type acupuncture groups,with 8 rabbits in each group.At the end of the treatment,all rabbits were sacrificed.The pathologic changes of lumbar vertebrae were observed by x-ray,the morphology of lumbar trabecular bone was observed by HE staining,and the apoptosis of lumbar vertebrae was detected by Tunel.The protein expressions of OPG,RANKL,and RANK in lumbar vertebrae were detected by immunohistochemistry staining,immunofluorescence staining,and Western blotting.Results:Internal heat-type acupuncture partly prevented osteopenia among GIOP-induced rabbits,improved the morphology of lumbar vertebrae,and inhibited the apoptosis of lumbar vertebrae osteocytes.Moreover,by increasing the protein expression level of OPG and reducing the protein expression of RANKL and RANK,internal heat-type acupuncture effectively promoted the balance of bone remodeling and eventually achieved the treatment of GIOP.Conclusion:Internal heat-type acupuncture therapy may promote the balance of bone remodeling by regulating the triplet of osteoprotegerin-receptor activator of nuclear factor-KB ligand-receptor activator of nuclear factor-KB,thereby treating osteoporosis which was induced by glucocorticoid.
文摘目的:分析黄连荷叶方联合度拉糖肽治疗2型糖尿病(T2DM)(湿热困脾证)肥胖患者疗效及对胰岛素抵抗和内脏脂肪指数的影响。方法:选取2023年1月—2024年12月佛山复星禅诚医院收治的T2DM(湿热困脾证)肥胖患者80例,随机数字表法分为对照组和联合组,每组40例。对照组采用度拉糖肽治疗,联合组加用黄连荷叶方治疗,均治疗12周。比较两组临床疗效,治疗前后血糖指标[餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A_(1)c)、空腹血糖(FPG)]、胰岛素抵抗指数(HOMA-IR)、中医证候积分、肥胖指标、不良反应。结果:联合组疗效高于对照组(P<0.05);治疗后,两组血糖指标、HOMAIR、中医证候积分、肥胖指标均低于治疗前(P<0.05),且联合组FPG、2 h PG、Hb A_(1)c、HOMA-IR、中医证候积分、体脂肪率、内脏脂肪指数均低于对照组(P<0.05,P<0.01);两组不良反应率差异无统计学意义(P>0.05)。结论:T2DM(湿热困脾证)肥胖患者应用黄连荷叶方联合度拉糖肽疗效较好,可降低血糖,改善胰岛素抵抗,改善患者中医证候,降低内脏脂肪指数。
