Lead-free halide double perovskites(HDPs)provide a promising platform for high-performance thermoelectric due to their intrinsically ultralow lattice thermal conductivity k_(l).In this study,we comprehensively investi...Lead-free halide double perovskites(HDPs)provide a promising platform for high-performance thermoelectric due to their intrinsically ultralow lattice thermal conductivity k_(l).In this study,we comprehensively investigate the lattice dynamics of Cs_(2)AgInCl_(6)using first-principles calculations.By explicitly incorporating four-phonon scattering and wave-like phonon tunneling,we predict a k_(l)of 0.52 W·m^(-1)·K^(-1)with a remarkably weak temperature dependence(k_(l)∝T^(-0.31)),confirming the intrinsically glass-like ultralow k_(l)in Cs_(2)AgInCl_(6).Further analyses reveal that hierarchical chemical bonds,loosely bonded rattling atoms and a mixed crystalline-liquid state collectively induce strong anharmonicity manifested in flat phonon modes.These factors dominate the glass-like thermal transport component of k_(l).This work uncovers the underlying mechanisms governing the unusual thermal transport properties in lead-free HDPs and offers guiding principles for designing novel energy conversion technologies.展开更多
妊娠期高血压疾病(hypertensive disorders in pregnancy,HDP)是孕妇中最常见的妊娠并发症,是孕产妇和新生儿发病及死亡的主要原因[1]。在全球有5%~10%的育龄女性在妊娠中经历过HDP[2],并且其发病率在过去几十年中仍不断增加[3-4]。2011...妊娠期高血压疾病(hypertensive disorders in pregnancy,HDP)是孕妇中最常见的妊娠并发症,是孕产妇和新生儿发病及死亡的主要原因[1]。在全球有5%~10%的育龄女性在妊娠中经历过HDP[2],并且其发病率在过去几十年中仍不断增加[3-4]。2011年,美国心脏协会已将HDP视为心血管疾病的独立危险因素[5],现已纳入女性风险评估和预防脑卒中及心血管疾病的指南[6],HDP可能导致不良妊娠结局的发生,如胎儿生长受限、胎儿窘迫、早产、胎儿宫内死亡、死产和新生儿窒息等[7],增加母子两代人患慢性高血压、外周动脉疾病、冠状动脉疾病、心力衰竭、心律失常等心血管疾病风险[8-9]。展开更多
妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)对于母胎的影响已较明确,但正常高值血压和HDP的关系以及和母胎不良妊娠结局间的关系尚不明确。本文对2021年1—12月期间在复旦大学附属妇产科医院单胎分娩的孕妇进行的回顾...妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)对于母胎的影响已较明确,但正常高值血压和HDP的关系以及和母胎不良妊娠结局间的关系尚不明确。本文对2021年1—12月期间在复旦大学附属妇产科医院单胎分娩的孕妇进行的回顾性研究,将产检到分娩入院前血压<130/80 mmHg的孕妇纳入正常血压组,血压在130~139/80~89 mmHg的孕妇纳入正常高值血压组,并根据血压开始升高的孕周分为正常高值血压(20周前)组及正常高值血压(20周后)组。分析这3组患者的基本资料、HDP发病情况及母胎不良结局,发现与正常血压组相比,20周前和20周后正常高值血压组的HDP发病率均显著增加,特别是正常高值血压(20周后)组增加更为明显。正常高值血压(20周前)组医疗性早产和小于胎龄儿(small for gestational age,SGA)的风险增加。本研究为制定更严格的血压监管策略提供了理论依据,有助于降低母儿的不良妊娠结局的发生率。展开更多
Objective:To explore the polymorphism of folate metabolism genes and its correlation with pregnancy-induced hypertension(PIH)in women of childbearing age in the Neijiang region.Methods:Forty-five pregnant women with h...Objective:To explore the polymorphism of folate metabolism genes and its correlation with pregnancy-induced hypertension(PIH)in women of childbearing age in the Neijiang region.Methods:Forty-five pregnant women with hypertension disorders who received prenatal care at the Maternal and Child Health Hospital in the Neijiang region from May 2023 to April 2025 were selected for the study and designated as the case group.Additionally,45 healthy pregnant women during the same period were selected as the control group.Venous blood samples were collected from both groups for folate metabolism gene testing,and the correlation with PIH was analyzed.Results:There were statistically significant differences in BMI index,systolic blood pressure,diastolic blood pressure,serum folate levels,Hcy levels,and vitamin B12 levels between the case group and the control group(p<0.05).The proportions of MTHFR-wild type and MTRR-wild type in the case group were lower than those in the control group,while the proportions of MTHFR-heterozygous mutant type and MTRR-heterozygous mutant type were higher in the case group(p<0.05).The Logistic regression model showed that overweight/obesity,abnormal folate levels,abnormal Hcy levels,abnormal vitamin B12 levels,MTHFR-heterozygous mutant type,and(repeated entry corrected to another relevant factor if necessary,but assuming it’s a typo and should be another mutant type or omitted for clarity,here kept as is for direct translation)MTHFR-heterozygous mutant type(note:this repetition should likely be corrected in the original text,e.g.,to MTRR-heterozygous mutant type or another relevant factor)were independent risk factors for the occurrence of HDP(p<0.05),while MTHFR-wild type and MTRR-wild type were protective factors against HDP(p<0.05).Conclusion:The polymorphism distribution of key genes involved in folate metabolism among women of childbearing age in Neijiang is significantly associated with the occurrence of Hypertensive Disorders of Pregnancy(HDP).Mutant genotypes of MTHFR and MTRR serve as independent risk factors for HDP,while the wild-type acts as a protective factor.Additionally,overweight/obesity,reduced serum folate levels,hyperhomocysteinemia,and vitamin B12 deficiency are also important risk indicators for the onset of HDP.展开更多
妊娠期高血压疾病(hypertensive disorders in pregnancy,HDP)是妊娠与血压升高并存的一组疾病。孕期血压的管理,是预防子痫前期、改善母胎结局的关键。要做到'宽'、'严'相济,血压目标值可适当放宽,而血压监测、降压药...妊娠期高血压疾病(hypertensive disorders in pregnancy,HDP)是妊娠与血压升高并存的一组疾病。孕期血压的管理,是预防子痫前期、改善母胎结局的关键。要做到'宽'、'严'相济,血压目标值可适当放宽,而血压监测、降压药物选择、生活方式干预等方面,都需更为严格。展开更多
基金supported by the National Natural Science Foundation of China(Grant No.12204482),the Natural Science Foundation of Shanxi Province(Grant No.202403021221164)Higher education teaching reform and innovation project of Shanxi Province(Grant No.J20220480)the Natural Science Foundation of Hainan Province(Grant Nos.525MS080 and 225MS076).
文摘Lead-free halide double perovskites(HDPs)provide a promising platform for high-performance thermoelectric due to their intrinsically ultralow lattice thermal conductivity k_(l).In this study,we comprehensively investigate the lattice dynamics of Cs_(2)AgInCl_(6)using first-principles calculations.By explicitly incorporating four-phonon scattering and wave-like phonon tunneling,we predict a k_(l)of 0.52 W·m^(-1)·K^(-1)with a remarkably weak temperature dependence(k_(l)∝T^(-0.31)),confirming the intrinsically glass-like ultralow k_(l)in Cs_(2)AgInCl_(6).Further analyses reveal that hierarchical chemical bonds,loosely bonded rattling atoms and a mixed crystalline-liquid state collectively induce strong anharmonicity manifested in flat phonon modes.These factors dominate the glass-like thermal transport component of k_(l).This work uncovers the underlying mechanisms governing the unusual thermal transport properties in lead-free HDPs and offers guiding principles for designing novel energy conversion technologies.
文摘妊娠期高血压疾病(hypertensive disorders in pregnancy,HDP)是孕妇中最常见的妊娠并发症,是孕产妇和新生儿发病及死亡的主要原因[1]。在全球有5%~10%的育龄女性在妊娠中经历过HDP[2],并且其发病率在过去几十年中仍不断增加[3-4]。2011年,美国心脏协会已将HDP视为心血管疾病的独立危险因素[5],现已纳入女性风险评估和预防脑卒中及心血管疾病的指南[6],HDP可能导致不良妊娠结局的发生,如胎儿生长受限、胎儿窘迫、早产、胎儿宫内死亡、死产和新生儿窒息等[7],增加母子两代人患慢性高血压、外周动脉疾病、冠状动脉疾病、心力衰竭、心律失常等心血管疾病风险[8-9]。
文摘妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)对于母胎的影响已较明确,但正常高值血压和HDP的关系以及和母胎不良妊娠结局间的关系尚不明确。本文对2021年1—12月期间在复旦大学附属妇产科医院单胎分娩的孕妇进行的回顾性研究,将产检到分娩入院前血压<130/80 mmHg的孕妇纳入正常血压组,血压在130~139/80~89 mmHg的孕妇纳入正常高值血压组,并根据血压开始升高的孕周分为正常高值血压(20周前)组及正常高值血压(20周后)组。分析这3组患者的基本资料、HDP发病情况及母胎不良结局,发现与正常血压组相比,20周前和20周后正常高值血压组的HDP发病率均显著增加,特别是正常高值血压(20周后)组增加更为明显。正常高值血压(20周前)组医疗性早产和小于胎龄儿(small for gestational age,SGA)的风险增加。本研究为制定更严格的血压监管策略提供了理论依据,有助于降低母儿的不良妊娠结局的发生率。
文摘Objective:To explore the polymorphism of folate metabolism genes and its correlation with pregnancy-induced hypertension(PIH)in women of childbearing age in the Neijiang region.Methods:Forty-five pregnant women with hypertension disorders who received prenatal care at the Maternal and Child Health Hospital in the Neijiang region from May 2023 to April 2025 were selected for the study and designated as the case group.Additionally,45 healthy pregnant women during the same period were selected as the control group.Venous blood samples were collected from both groups for folate metabolism gene testing,and the correlation with PIH was analyzed.Results:There were statistically significant differences in BMI index,systolic blood pressure,diastolic blood pressure,serum folate levels,Hcy levels,and vitamin B12 levels between the case group and the control group(p<0.05).The proportions of MTHFR-wild type and MTRR-wild type in the case group were lower than those in the control group,while the proportions of MTHFR-heterozygous mutant type and MTRR-heterozygous mutant type were higher in the case group(p<0.05).The Logistic regression model showed that overweight/obesity,abnormal folate levels,abnormal Hcy levels,abnormal vitamin B12 levels,MTHFR-heterozygous mutant type,and(repeated entry corrected to another relevant factor if necessary,but assuming it’s a typo and should be another mutant type or omitted for clarity,here kept as is for direct translation)MTHFR-heterozygous mutant type(note:this repetition should likely be corrected in the original text,e.g.,to MTRR-heterozygous mutant type or another relevant factor)were independent risk factors for the occurrence of HDP(p<0.05),while MTHFR-wild type and MTRR-wild type were protective factors against HDP(p<0.05).Conclusion:The polymorphism distribution of key genes involved in folate metabolism among women of childbearing age in Neijiang is significantly associated with the occurrence of Hypertensive Disorders of Pregnancy(HDP).Mutant genotypes of MTHFR and MTRR serve as independent risk factors for HDP,while the wild-type acts as a protective factor.Additionally,overweight/obesity,reduced serum folate levels,hyperhomocysteinemia,and vitamin B12 deficiency are also important risk indicators for the onset of HDP.
