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Modeling study of regional severe hazes over mid-eastern China in January 2013 and its implications on pollution prevention and control 被引量:113
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作者 WANG ZiFa LI Jie +15 位作者 WANG Zhe YANG WenYi TANG Xiao GE BaoZhu YAN PinZhong ZHU LiLi CHEN XueShun CHEN HuanSheng WAND Wei LI JianJun LIU Bing WANG XiaoYan WAND Wei ZHAO YiLin LU Ning SU DeBin 《Science China Earth Sciences》 SCIE EI CAS 2014年第1期3-13,共11页
The Nested Air Quality Prediction Model System(NAQPMS)was used to investigate the temporal and spatial variations of PM2.5over tropospheric central eastern China in January 2013.The impact of regional transport and it... The Nested Air Quality Prediction Model System(NAQPMS)was used to investigate the temporal and spatial variations of PM2.5over tropospheric central eastern China in January 2013.The impact of regional transport and its implications on pollution prevention and control were also examined.Comparison between simulated and observed PM2.5showed NAQPMS was able to reproduce the evolution of PM2.5during heavy haze episodes.The results indicated that regional transport of PM2.5played an important role in regional haze episodes in the city cluster including Hebei,Beijing and Tianjin(HBT).The cross-city clusters transport outside HBT and transport among cities inside HBT contributed 20%–35%and 26%–35%of PM2.5as compared with local emission,in HBT respectively.To meet the Air Quality Standards for Grade II,90%,90%and65%of emissions would have to be cut down in Hebei,Tianjin and Beijing,if non-control strategy was taken in the surrounding city clusters of HBT.This implicated that control of emissions in one city cluster is not sufficient to reduce regional haze events,and joint efforts among city clusters are essential.Besides regional transports,two-way feedback between boundary-layer evolution and PM2.5also significantly contributed to the formation of heavy hazes,which contributed 30%of monthly average PM2.5concentration in HBT. 展开更多
关键词 regional hazes trans-boundary transport feedback between boundary-layer evolution and PM2.5 pollution preventionand control
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Topical losartan for treating corneal haze after Pseudomonas keratitis:a case report
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作者 Fabrizio D’Ancona Pier Luigi Surico +4 位作者 Rosario Alfio Umberto Lizzio Gabriele D’Ancona Luca Marelli Stefano Mattioli Paolo Nucci 《Annals of Eye Science》 2025年第1期14-21,共8页
Background:Corneal scarring following bacterial keratitis,particularly from Pseudomonas infections,poses significant challenges in ophthalmic care.Current treatments often fall short in effectively reducing corneal ha... Background:Corneal scarring following bacterial keratitis,particularly from Pseudomonas infections,poses significant challenges in ophthalmic care.Current treatments often fall short in effectively reducing corneal haze and restoring vision.To our knowledge,this is the first report documenting the use of topical losartan,an angiotensin II receptor antagonist known to inhibit the transforming growth factor-β(TGF-β)pathway,for treating corneal haze resulting from bacterial keratitis.Case Description:A 30-year-old male presented with a persistent corneal scar in his right eye,178 days post-Pseudomonas keratitis.Despite a prolonged course of topical corticosteroids,his best-corrected visual acuity(BCVA)stabilized at 20/40 with a hybrid contact lens over a 2-month period.Given the lack of improvement,we initiated treatment with topical losartan at a concentration of 0.8 mg/mL,administered six times daily.After 4 months of therapy,the patient’s BCVA improved to 20/25.Slit-lamp examination and corneal tomography revealed a significant reduction in corneal haze,indicating a positive response to the treatment.Conclusions:This case suggests that topical losartan may be a promising therapeutic option for reducing corneal opacity following bacterial keratitis by inhibiting the TGF-βpathway.However,further clinical studies are necessary to confirm its efficacy and safety in broader patient populations. 展开更多
关键词 Pseudomonas kerititis corneal scar HAZE topical losartan case report
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Displacement Feature Mapping for Vehicle License Plate Recognition Influenced by Haze Weather
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作者 Mohammed Albekairi Radhia Khdhir +3 位作者 Amina Magdich Somia Asklany Ghulam Abbas Amr Yousef 《Computer Modeling in Engineering & Sciences》 2025年第9期3607-3644,共38页
License plate recognition in haze-affected images is challenging due to feature distortions such as blurring and elongation,which lead to pixel displacements.This article introduces a Displacement Region Recognition M... License plate recognition in haze-affected images is challenging due to feature distortions such as blurring and elongation,which lead to pixel displacements.This article introduces a Displacement Region Recognition Method(DR2M)to address such a problem.This method operates on displaced features compared to the training input observed throughout definite time frames.The technique focuses on detecting features that remain relatively stable under haze,using a frame-based analysis to isolate edges minimally affected by visual noise.The edge detection failures are identified using a bilateral neural network through displaced feature training.The training converges bilaterally towards the minimum edges from the maximum region.Thus,the training input and detected edges are used to identify the displacement between observed image frames to extract and differentiate the license plate region from the other vehicle regions.The proposed method maps the similarity feature between the detected and identified vehicle regions.This aids in leveraging the plate recognition precision with a high F1 score.Thus,this technique achieves a 10.27%improvement in identification precision,a 10.57%increase in F1 score,and a 9.73%reduction in false positive rate compared to baseline methods under maximum displacement conditions caused by haze.The technique attains an identification precision of 95.68%,an F1 score of 94.68%,and a false positive rate of 4.32%,indicating robust performance under haze-affected settings. 展开更多
关键词 Neural network machine learning edge detection feature displacement haze weather
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Changes in the urban dew chemical composition in Northeast China from 2013 to 2023
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作者 Yingying Xu Haodong Hou +2 位作者 Yachao Zhang Yunze Zhao Xiaoteng Liu 《Journal of Environmental Sciences》 2025年第11期633-644,共12页
The chemical composition of dew is closely related to the air quality.Since 2013,China has promulgated a series of laws and regulations focused on air pollution control,and remarkable results have been achieved over t... The chemical composition of dew is closely related to the air quality.Since 2013,China has promulgated a series of laws and regulations focused on air pollution control,and remarkable results have been achieved over the past decade.As an indicator of near-surface air quality,the chemical composition of dew obviously changes.The dew quality was affected mainly by the local air quality.The mean dew pH was 6.3±0.4(n=186)from 2013 to 2023,and the order of ions was SO_(4)^(2-)(3180.7±3592.0μeq/L)>NH_(4)^(+)(2552.3±2971.8μeq/L)>Ca^(2+)(1006.2±945.5μeq/L)>NO_(3)^(-)(397.2±511.0μeq/L)>Cl^(-)(152.3±133.4μeq/L)>K^(+)(149.4±191.6μeq/L)>F^(-)(133.0±110.3μeq/L)>Na^(+)(123.8±94.9μeq/L)>Mg^(2+)(83.3±65.6μeq/L).The dew quality deteriorated on hazy days.There were no haze events during the condensation period after 2020,which caused a significant reduction in the concentration of the main ions in the dew.Over the past decade,electrical conductivity(EC),total dissolved solids(TDS),PM_(2.5) and PM_(10),as well as major ions(SO_(4)^(2-),NO_(3)^(-),NH_(4)^(+),Ca^(2+),Cl^(-),Na^(+),F^(-),K^(+)and Mg^(2+))in dew,have all tended to decrease.The annualmean NO_(3)^(-)concentration in 2023 was 86.5%lower than that in 2013,with values of 79.3%for SO_(4)^(2-),77.3%for Ca^(2+),76.7%for NH_(4)^(+),74.6%for K^(+),65.4%for Mg^(2+),63.4%for Na^(+),61.7%for Cl^(-),and 60.3%for F^(-). 展开更多
关键词 Dew chemical composition Ionic component Air quality Emission reduction Haze event
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角膜光密度定量评价散光TPRK术后haze的临床特点
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作者 李帅飞 游昌涛 +3 位作者 徐玲玲 陈东栋 马宏杰 李庚 《国际眼科杂志》 2025年第9期1420-1424,共5页
目的:采用角膜光密度定量评价散光经上皮准分子激光角膜切削术(TPRK)术后角膜上皮下混浊(haze)的临床特点。方法:回顾性临床研究。连续性收集2022年10月至2024年12月在我院行TPRK的屈光不正(散光≥1.25 D)患者74例106眼,根据术后是否出... 目的:采用角膜光密度定量评价散光经上皮准分子激光角膜切削术(TPRK)术后角膜上皮下混浊(haze)的临床特点。方法:回顾性临床研究。连续性收集2022年10月至2024年12月在我院行TPRK的屈光不正(散光≥1.25 D)患者74例106眼,根据术后是否出现haze将其分为透明组(65眼)和haze组(41眼),术前及术后复查均行Pentacam眼前节分析仪检查,记录术前及透明组术后1 mo、haze组术后haze程度最重时间点的角膜中央2 mm圆形、2-6 mm环形和6-10 mm环形各区域的角膜全层平均光密度,及散光轴(散光以负柱镜形式表示)和正交轴(与散光轴垂直的轴向)切面中央6 mm的角膜切面全层平均光密度,及haze组顺规散光患者散光轴鼻侧和颞侧2-6 mm区域内的角膜切面全层平均光密度,并计算术后较术前角膜光密度变化量。结果:透明组和haze组间性别、年龄、等效球镜等基线资料均无差异(均P>0.05);角膜2-6 mm区域haze组角膜光密度变化量大于透明组(Z=-2.226,P=0.026),中央2 mm及6-10 mm区域两组间角膜光密度变化量均无差异(均P>0.05);两组在正交轴角膜光密度变化量均无差异(均P>0.05),而在散光轴haze组的角膜光密度变化量大于透明组(Z=-2.371,P=0.018);haze组顺规散光患者术后颞侧角膜光密度大于鼻侧,且角膜光密度变化量亦大于鼻侧(Z=-4.288,P<0.001;Z=-4.043,P<0.001)。结论:不同于近视和远视的球镜矫正,散光TPRK术后haze主要表现在散光轴的周边切削区,且顺规散光患者在散光轴的颞侧较鼻侧发生haze的几率更高或程度更重。 展开更多
关键词 经上皮准分子激光角膜切削术(TPRK) 角膜上皮下混浊(haze) 散光 角膜光密度
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Elaborations of the influencing factors on the formation of secondary inorganic aerosols in a heavily polluted urban area of China 被引量:2
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作者 Shuang Wang Qiyuan Wang +8 位作者 Ting Zhang Suixin Liu Steven Sai Hang Ho Jie Tian Hui Su Yong Zhang Luyao Wang Tingting Wu Junji Cao 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2024年第4期406-417,共12页
In this study,online water-soluble inorganic ions were detected to deduce the formation mechanism of secondary inorganic aerosol in Xianyang,China during wintertime.The dominant inorganic ions of sulfate(SO_(4)^(2-)),... In this study,online water-soluble inorganic ions were detected to deduce the formation mechanism of secondary inorganic aerosol in Xianyang,China during wintertime.The dominant inorganic ions of sulfate(SO_(4)^(2-)),nitrate(NO_(3)^(-)),and ammonium(NH_(4)^(+))(the sum of those is abbreviated as SNA)accounted for 17%,21%,and 12% of PM_(2.5)mass,respectively.While the air quality deteriorated from excellent to poor grades,the precursor gas sulfur dioxide(SO_(2))of SO_(4)^(2-)increased and then decreased with a fluctuation,while nitrogen dioxide(NO_(2))and ammonia(NH_(3)),precursors of NO_(3)^(-)and NH_(4)^(+),and SNA show increasing trends.Meteorological factors including boundary layer height(BLH),temperature,and wind speed also show decline trends,except relative humidity(RH).Meanwhile,the secondary conversion ratio shows a remarkable increasing trend,indicating that there was a strong secondary transformation.From the perspective of chemical mechanisms,RH is positively correlated with sulfur oxidation ratios(SOR),nitrogen oxidation ratios(NOR),and ammonia conversion ratios,representing that the increase of humidity could promote the generation of SNA.Notably,SOR and NOR were also positively related to the ammonia.On the one hand,the low wind speed and BLH led to the accumulation of pollutants.On the other hand,the increases of RH and ammonia promoted more formations of SNA and PM_(2.5).The results advance our identification of the contributors to the haze episodes and assist to establish more efficient emission controls in Xianyang,in addition to other cities with similar emission and geographical characteristics. 展开更多
关键词 Haze episodes Secondary inorganic aerosol Secondary conversion ratio Meteorological factors
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角膜光密度评价复性近视散光Trans-PRK术后haze特点1例 被引量:1
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作者 李帅飞 游昌涛 +1 位作者 徐玲玲 陈东栋 《实用防盲技术》 2024年第4期168-170,F0002,F0004,共5页
1例复性近视散光女性患者在经上皮准分子激光角膜表面切削(Trans-PRK)术后早期因发现怀孕停用糖皮质激素滴眼液,随访过程中出现角膜上皮下混浊(haze),并使用Pentacam眼前节分析仪测量角膜光密度进行haze程度和特点的评价。
关键词 Trans-PRK HAZE 角膜光密度 近视 散光
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A super sandstorm altered the abundance and composition of airborne bacteria in Beijing
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作者 Fanxuan Xia Zhuo Chen +1 位作者 Enze Tian Jinhan Mo 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2024年第10期35-44,共10页
Sandstorm,which injects generous newly emerging microbes into the atmosphere covering cities,adversely affects the air quality in built environments.However,few studies have examined the change of airborne bacteria du... Sandstorm,which injects generous newly emerging microbes into the atmosphere covering cities,adversely affects the air quality in built environments.However,few studies have examined the change of airborne bacteria during severe sandstorm events.In this work,we analyzed the airborne bacteria during one of the strongest sandstorms in East Asia onMarch 15th,2021,which affected large areas of China and Mongolia.The characteristics of the sandstorm were compared with those of the subsequent clean and haze days.The composition of the bacterial community of air samples was investigated using quantitative polymerase chain reaction(qPCR)and high-throughput sequencing technology.During the sandstorm,the particulate matter(PM)concentration and bacterial richnesswere extremely high(PM_(2.5):207μg/m^(3);PM_(10):1630μg/m^(3);5700 amplicon sequence variants/m^(3)).In addition,the sandstorm brought 10 pathogenic bacterial genera to the atmosphere,posing a grave hazard to human health.As the sandstorm subsided,small bioaerosols(0.65–1.1μm)with a similar bacterial community remained suspended in the atmosphere,bringing possible long-lasting health risks. 展开更多
关键词 Airborne bacteria SANDSTORM BIOAEROSOL HAZE PATHOGEN
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Significant contribution of carbonyls to atmospheric oxidation capacity(AOC)during the winter haze pollution over North China Plain
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作者 Xue Yang Gen Zhang +4 位作者 Guang Pan Guolan Fan Houyong Zhang Xuan Ge Mingyue Du 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2024年第5期377-388,共12页
Atmospheric carbonyl compounds play significant roles in the cycling of radicals and have exhibited surprisingly high levels in winter that were well correlated to particulate matter,for which the reason have not been... Atmospheric carbonyl compounds play significant roles in the cycling of radicals and have exhibited surprisingly high levels in winter that were well correlated to particulate matter,for which the reason have not been clearly elucidated.Here we measured carbonyl compounds and other trace gasses together with PM_(2.5)over urban Jinan in North China Plain during the winter.Markedly higher carbonyl concentrations(average:14.63±4.21 ppbv)were found during wintertime haze pollution,about one to three-times relative to those on nonhaze days,with slight difference in chemical composition except formaldehyde(HCHO).HCHO(3.68 ppbv),acetone(3.17 ppbv),and acetaldehyde(CH_3CHO)(2.83 ppbv)were the three most abundant species,accounting for~75% of the total carbonylson both haze and non-haze days.Results from observational-based model(OBM)with atmospheric oxidation capacity(AOC)indicated that AOC significantly increased with the increasing carbonyls during the winter haze events.Carbonyl photolysis have supplied key oxidants such as RO_(2) and HO_(2),and thereby enhancing the formation of fine particles and secondary organic aerosols,elucidating the observed haze-carbonyls inter-correlation.Diurnal variation with carbonyls exhibiting peak values at early-noon and night highlighted the combined contribution of both secondary formation and primary diesel-fuel sources.1-butene was further confirmed to be the major precursor for HCHO.This study confirms the great contribution of carbonyls to AOC,and also suggests that reducing the emissions of carbonyls would be an effective way to mitigate haze pollution in urban area of the NCP region. 展开更多
关键词 CARBONYLS HAZE Observation-based model Source apportionment Atmospheric oxidation capacity
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Benefit of aerosol reduction to winter wheat during China's clean air action:A case study of Henan Province
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作者 Yang Bai Pengfei Zhao +4 位作者 Xueyang Chen Lijun Wang Wenjuan Chang Jianzhong Guo Jiayao Wang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2024年第7期90-101,共12页
A strongly declining aerosol radiative effect has been observed in China since 2013 after implementing the clean air action,yet its impact on wheat(Triticum aestivum L.)production remains unclear.We use satellite meas... A strongly declining aerosol radiative effect has been observed in China since 2013 after implementing the clean air action,yet its impact on wheat(Triticum aestivum L.)production remains unclear.We use satellite measures and a biophysical crop model to assess the impact of aerosol-induced radiative perturbations on winter wheat production in the agricultural belt of Henan province from 2013 to 2018.After calibrating parameters with the extended Fourier Amplitude Sensitivity Test(EFAST)and the generalized likelihood uncertainty estimation(GLUE)method,the DSSAT CERES-Wheat model was able to simulate crop biomass and yield more accurately.We found that the aerosol negatively impacted wheat biomass by 21.87%and yield by 22.48%from 2006 to 2018,and the biomass effects from planting to anthesis were more significant compared to anthesis to maturity.Due to the strict clean air action,under all-sky conditions,the surface solar shortwave radiation(SSR)in 2018 increased by about 7.08%over 2006-2013 during the wheat growing seasons.As a result of the improvement of crop photosynthesis,winter wheat biomass and yield increased by an average of 5.46%and 2.9%,respectively.Our findings show that crop carbon uptake and yield will benefit from the clean air action in China,helping to ensure national food and health security. 展开更多
关键词 Haze pollution Clean air action Aerosol-induced radiative perturbation Wheat production DSSAT model
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Control of fine particulate nitrate during severe winter haze in“2+26”cities
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作者 Chuang Qin Xiao Fu +2 位作者 Tao Wang Jian Gao Jiaqi Wang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2024年第2期261-269,共9页
The“2+26”cities,suffering the most severe winter haze pollution,have been the key region for air quality improvement in China.Increasing prominent nitrate pollution is one of the most challenging environmental issue... The“2+26”cities,suffering the most severe winter haze pollution,have been the key region for air quality improvement in China.Increasing prominent nitrate pollution is one of the most challenging environmental issues in this region,necessitating development of an effective control strategy.Herein,we use observations,and state-of-the-art model simulations with scenario analysis and process analysis to quantify the effectiveness of the future SO_(2)-NO_(X)-VOC-NH_(3) emission control on nitrate pollution mitigation in“2+26”cities.Focusing on a serious winter haze episode,we find that limited NO_(X)emission reduction alone in the short-term period is a less effective choice than VOC or NH_3emission reduction alone to decrease nitrate concentrations,due to the accelerated NO_(X)-HNO_(3)conversion by atmospheric oxidants and the enhanced HNO_(3)to NO_(3)^(-)partition by ammonia,although deep NO_(X)emission reduction is essential in the long-term period.The synergistic NH_(3) and VOC emission control is strongly recommended,which can counteract the adverse effects of nonlinear photochemistry and aerosol chemical feedback to decrease nitrate more.Such extra benefits will be reduced if the synergistic NH_(3) and VOC reduction is delayed,and thus reducing emission of multiple precursors is urgently required for the effective control of increasingly severe winter nitrate pollution in“2+26”cities. 展开更多
关键词 NITRATE Winter haze pollution Emission reduction “2+26”cities
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Analysis of the Haze Weather Process in the East of China from January 21 to 28, 2021
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作者 Ruicheng Zhang 《Journal of Geoscience and Environment Protection》 2024年第7期130-138,共9页
Haze is a pollution weather phenomenon that has been widely concerned by people in recent years. It has a significant impact on people’s production, life, and health. This study focuses on large-scale haze weather th... Haze is a pollution weather phenomenon that has been widely concerned by people in recent years. It has a significant impact on people’s production, life, and health. This study focuses on large-scale haze weather that happened in eastern China in late January 2021. The research uses multi-party data and synoptic analysis methods to analyze the occurrence, evolution, and end of the haze weather. The polar vortex, the change of the atmospheric circulation, the change of the cold air force, the temperature and humidity, and the rain and snow weather are the important reasons for this weathering process. It can be used for reference in future research on haze weather. 展开更多
关键词 Haze Forming Atmospheric Diffusion Conditions Eastern China
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晶片表面Haze值研究 被引量:5
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作者 张伟才 宋晶 +1 位作者 杨洪星 赵权 《半导体技术》 CAS CSCD 北大核心 2011年第9期681-683,共3页
介绍了晶片表面Haze值的定义和理论依据,通过对SSIS系统的原理分析,揭示了Haze是一种间接反映晶片表面状态的光学信号。通过对不同表面状态抛光片的光学扫描,研究了晶片表面粗糙度与Haze值的关系;通过对Si抛光片和砷化镓抛光片的扫描对... 介绍了晶片表面Haze值的定义和理论依据,通过对SSIS系统的原理分析,揭示了Haze是一种间接反映晶片表面状态的光学信号。通过对不同表面状态抛光片的光学扫描,研究了晶片表面粗糙度与Haze值的关系;通过对Si抛光片和砷化镓抛光片的扫描对比,研究了晶片本体反射系数对Haze值的影响。研究结果表明,同种材料的Haze值随着表面粗糙度的增大而增大,而不同的材料即使拥有相似的表面粗糙度,Haze值也会因本体反射系数的不同而呈现很大差异。通过对Haze扫描图的特征分析,研究了Haze值分布与晶片表面均匀性的关系,成功地利用Haze值分布将表面性状化,为化学机械抛光和湿法清洗工艺提供了一个新的反馈手段。 展开更多
关键词 Haze值 光散射 表面粗糙度 一致性 扫描表面检查系统
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丝裂霉素预防准分子激光屈光性角膜切削术后角膜混浊的临床研究 被引量:11
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作者 杨浩江 窦晓燕 司马晶 《国际眼科杂志》 CAS 2008年第7期1483-1485,共3页
目的:探讨准分子激光屈光性角膜切削术中使用0.2g/L丝裂霉素(MMC)预防术后角膜上皮下混浊(haze)的安全性、有效性。方法:对120例(240眼)屈光不正的患者进行准分子激光屈光性角膜切削术,术中使用0.2g/L丝裂霉素,作用时间为20~9... 目的:探讨准分子激光屈光性角膜切削术中使用0.2g/L丝裂霉素(MMC)预防术后角膜上皮下混浊(haze)的安全性、有效性。方法:对120例(240眼)屈光不正的患者进行准分子激光屈光性角膜切削术,术中使用0.2g/L丝裂霉素,作用时间为20~90s,观察术后角膜上皮愈合时间、观察术后1,3,6,12mo时裸眼视力、矫正视力、屈光状态、haze形成情况及并发症、角膜内皮细胞计数等。结果:角膜上皮愈合时间为3.01±0.72d;手术前后角膜内皮细胞计数统计学上无显著性差异(P=0.62);术后1,3,6,12mo时裸眼视力、矫正视力、屈光状态统计学上无显著性差异;术后6mo0~0.5级haze218眼(90.8%),1级haze21眼(8.75%),2级haze1眼(0.83%),术后12mo1级haze12眼(5%);术后未见丝裂霉素毒性反应及并发症。结论:使用0.2g/L丝裂霉素预防准分子激光屈光性角膜切削术后角膜上皮下混浊安全、有效。 展开更多
关键词 丝裂霉素 准分子激光屈光性角膜切削术 HAZE
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激光共焦显微镜对近视激光术后haze结构的研究 被引量:4
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作者 吴艳 杨丽萍 +2 位作者 薛春燕 黄振平 石尧 《眼科新进展》 CAS 北大核心 2013年第3期240-242,共3页
目的利用激光共焦显微镜观察近视激光术后的haze结构。方法选取Epi-LASIK术后发生haze患者12例(24眼)设为A组,另选择接受Epi-LASIK但无并发症发生患者10例(20眼)设为B组,行双眼激光共焦显微镜检查,观察A组患者角膜上皮层、前基质层、中... 目的利用激光共焦显微镜观察近视激光术后的haze结构。方法选取Epi-LASIK术后发生haze患者12例(24眼)设为A组,另选择接受Epi-LASIK但无并发症发生患者10例(20眼)设为B组,行双眼激光共焦显微镜检查,观察A组患者角膜上皮层、前基质层、中后基质层变化,并比较两组各层细胞密度。结果 A组角膜上皮基底膜缺如,上皮下散在斑点状瘢痕及高反光白色小点,瓣边缘见环形瘢痕,周边上皮细胞核呈高反光。角膜前基质层纤维紊乱,局部见空泡样改变及大量点状、斑片状瘢痕组织,近上皮瓣基底部大片瘢痕,其间可见细小皱褶;瘢痕间少量神经末梢走行,神经组织纤细,局部可见断裂、扭曲。中、后基质层见正常网状结构,内皮细胞"六边形"结构正常。A组角膜上皮层细胞密度为(6381.9±290.1)mm(-2),前基质层细胞密度为(482.6±53.3)mm(-2),对照组分别为(4729.1±319.2)mm(-2)和(372.4±41.2)mm(-2),两组相比差异均有统计学意义(均为P<0.05);A组中、后基质层和内皮层的细胞密度分别为(278.0±41.1)mm(-2)、(188.2±22.0)mm(-2)、(3290.1±339.2)mm(-2),对照组分别为(301.3±49.3)mm(-2)、(197.6±28.1)mm(-2)、(3102.3±322.0)mm(-2),两组相比差异均无统计学意义(均为P>0.05)。结论激光共焦显微镜可用于近视激光术后haze结构的观察评估。 展开更多
关键词 激光共焦显微镜 HAZE Epi—LASIK 近视
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Epi-LASIK治疗中高度近视术后视觉质量的临床研究 被引量:5
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作者 杨飏 夏丽坤 +3 位作者 陆岩 曹哲瑶 杜长虹 张桂新 《国际眼科杂志》 CAS 2011年第6期1005-1008,共4页
目的:研究机械法准分子激光角膜上皮瓣下磨镶术(Epi-LAS1K)矫治中、高度近视对视觉质量的影响。方法:回顾分析采用Epi-LAS1K手术矫治中、高度近视并随访1a的病例128例256眼的临床资料。患者根据术前等效球镜分为3组:A组:<-3.00D,均值... 目的:研究机械法准分子激光角膜上皮瓣下磨镶术(Epi-LAS1K)矫治中、高度近视对视觉质量的影响。方法:回顾分析采用Epi-LAS1K手术矫治中、高度近视并随访1a的病例128例256眼的临床资料。患者根据术前等效球镜分为3组:A组:<-3.00D,均值-2.11±0.35D(30例60眼);B组:-3.00D~-6.00D,均值-4.93±0.68D(46例92眼);C组:>-6.00D,均值-8.45±1.62D(52例104眼)。手术采用美国AMO公司AmadeusⅡ自动角膜板层刀制作上皮瓣,以德国ZEISS公司MEL80型准分子激光仪进行激光切削,术后配戴绷带式角膜接触镜7d,术后随访时间为1,7d;1,3,6mo;1a,研究术后视力和屈光状态、高阶像差及haze形成情况。结果:术后随访1a,A组58眼(97%)的UCVA>1.0,B组87眼(95%)的UCVA>1.0,C组89眼(86%)的UCVA>1.0;A组60眼(100%)等效球镜屈光度数在预期值的±1.00D内,B组92眼(100%)等效球镜屈光度数在预期值的±1.00D内,C组7眼(7%)等效球镜屈光度数大于预期值的±1.00D。术后高阶像差较术前增大(P<0.05),B组与C组各时间点与A组相比无统计学意义。A组术后1mo有3眼(5%)的患者有0.5级haze,术后3mo有1眼(2%)的患者有0.5级haze,术后6mo到1a,所有患者均无明显haze;B组术后1mo有6眼(7%)的患者有0.5级haze,术后3mo有4眼(4%)的患者有0.5级haze,术后6mo~1a,所有患者均无明显haze;C组术后1mo有10眼(10%)的患者有0.5级haze,2眼(2%)的患者有Ⅰ级haze,术后3mo有8眼(8%)的患者有0.5级haze,2眼(2%)的患者有Ⅰ级haze,术后6mo有5眼(5%)的患者有0.5级haze,术后1a所有患者均无明显haze。结论:Epi-LAS1K手术术后具有视力恢复满意,haze程度轻等优点,是治疗中、高度近视的一种安全、有效的手术方式。 展开更多
关键词 机械法准分子激光角膜上皮瓣下磨镶术 近视 HAZE
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丝裂霉素C在Epi-LASIK治疗高度近视术中的应用 被引量:4
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作者 陈静 韩苏宁 +3 位作者 龚小雪 吴军丽 唐谋玉 李欣 《眼科研究》 CSCD 北大核心 2009年第5期441-442,共2页
关键词 丝裂霉素C LASIK治疗 近视术 Epi HAZE形成 原位角膜磨镶术 近视患者 准分子激光
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丝裂霉素C对LASEK术后Haze形成及角膜基质细胞的影响 被引量:4
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作者 于海群 陶祥臣 +2 位作者 朱伟 原越 张泳 《山东大学耳鼻喉眼学报》 CAS 2012年第5期3-5,共3页
目的探讨在准分子激光角膜上皮瓣下磨镶术(LASEK)中,使用不同浓度丝裂霉素C(MMC)、作用不同时间,对Haze的形成及角膜基质细胞变化的影响。方法 40只兔(80眼),取随机一眼为实验眼,行LASEK术+MMC,对侧眼为手术对照组,仅行LASEK手术。实验... 目的探讨在准分子激光角膜上皮瓣下磨镶术(LASEK)中,使用不同浓度丝裂霉素C(MMC)、作用不同时间,对Haze的形成及角膜基质细胞变化的影响。方法 40只兔(80眼),取随机一眼为实验眼,行LASEK术+MMC,对侧眼为手术对照组,仅行LASEK手术。实验眼又随机分为4组:T1组为0.02%的MMC作用10 s,T2组为0.02%的MMC作用30 s,T3组为0.08%的MMC作用10 s,T4组为0.08%的MMC作用30s。另设5兔(10眼)为正常对照组,不做任何手术及药物处理。术后观察Haze形成情况及并发症,并对角膜基质细胞凋亡进行实验研究。结果术后1周内T1、T2、T3组角膜基本愈合,T4组仍有部分未愈合。术后1周,所有实验组的双眼角膜均有不同程度的Haze形成,其中T2、T3、T4组与手术对照组相比,差异有统计学意义(P<0.05),而此实验三组之间差异无统计学意义(P>0.05)。T1组与手术对照组相比差异无统计学意义(P>0.05)。各组之间的角膜基质TUNEL阳性细胞数量差异均具有统计学意义(P<0.05),PT4组>PT3组>PT2组>PT1组>P手术对照组。结论 MMC可以减少Haze形成,增加作用时间及浓度都会明显抑制Haze的形成,增强角膜基质细胞凋亡。浓度为0.08%,作用时间为30 s的MMC作用最明显,但其对于角膜的刺激作用较大,上皮修复时间较长。 展开更多
关键词 丝裂霉素C 准分子激光角膜上皮瓣下磨 镶术 HAZE 角膜基质细胞
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羊膜移植对激光角膜光学切除术后haze形成的影响 被引量:2
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作者 钟一声 周颖明 +3 位作者 丁侃 叶纹 廉井财 王康孙 《上海第二医科大学学报》 CSCD 2001年第5期390-392,396,共4页
目的探讨羊膜移植对激光角膜光学切除术 (photorefractivekeratectomy ,PRK)后上皮下混浊 (haze)的影响。 方法对 18只新西兰白兔双眼行PRK ,术后一眼立即行角膜表面羊膜移植术 ,另眼作为对照。术后 4周和 8周用裂隙灯检查角膜haze形... 目的探讨羊膜移植对激光角膜光学切除术 (photorefractivekeratectomy ,PRK)后上皮下混浊 (haze)的影响。 方法对 18只新西兰白兔双眼行PRK ,术后一眼立即行角膜表面羊膜移植术 ,另眼作为对照。术后 4周和 8周用裂隙灯检查角膜haze形成情况。将兔于术后 1、4、8周处死 ,取下角膜进行常规组织切片 ,分别进行HE染色、AgNORs染色和胶原染色检查。 结果术后 4周和 8周 ,羊膜移植组haze轻于对照组。术后 1、4、8周 ,羊膜移植组切削区中央上皮层厚度明显小于对照组 (P <0 .0 5 ) ,切削区边缘上皮层厚度两组间无显著差异 (P >0 .0 5 ) ;术后 4周和 8周 ,羊膜移植组术区前基质角膜细胞数较对照组少 (P <0 .0 5 ) ,且增殖活性较对照组低 ,Ⅲ型胶原形成少。 结论羊膜移植能抑制PRK后基质角膜细胞增殖和Ⅲ型胶原形成而有效的减轻haze的形成。 展开更多
关键词 羊膜移植 激光屈光性角膜切削术 上皮下混浊 HAZE形成
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PRK+MMC与LASEK治疗高度近视效果比较 被引量:8
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作者 张光明 张明昌 +1 位作者 胡燕华 聂绍松 《眼外伤职业眼病杂志》 北大核心 2005年第9期664-667,共4页
目的比较PRK术中预防性使用丝裂霉素C(MMC)治疗高度近视和LASEK治疗高度近视的疗效。方法将高度近视(-6.0^-10.0D)随机分为PRK+MMC组40例(80眼)和LASEK组38例(76眼)。另以早年PRK手术屈光状态与之相似的40例(80眼)作为对照。PRK+MMC组在... 目的比较PRK术中预防性使用丝裂霉素C(MMC)治疗高度近视和LASEK治疗高度近视的疗效。方法将高度近视(-6.0^-10.0D)随机分为PRK+MMC组40例(80眼)和LASEK组38例(76眼)。另以早年PRK手术屈光状态与之相似的40例(80眼)作为对照。PRK+MMC组在PRK术中使用0.02%MMC,LASEK组采用常规LASEK,评价术后角膜上皮下雾状浑浊(haze),屈光回退、视力及角膜内皮细胞改变等情况。结果PRK+MMC组未出现2级或2级以上haze,无术后矫正视力下降者,术后欠矫小于-0.5D者70眼;LASEK组有6眼出现2级及2级以上haze,有6眼出现术后矫正视力下降,术后欠矫小于-0.5D者56眼。两组的差异有显著性。使用MMC未见明显毒副作用。结论PRK术中预防性使用MMC,在术后减少haze、防止屈光回退、改善视力方面较LASEK为优。 展开更多
关键词 屈光性激光角膜切削术(PRK) 上皮下激光角膜切削术(LASEK) 丝裂霉素C 角膜上皮下混浊(haze)
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