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C_3-Symmetric Molecules with Axial Chirality and Handed Arrangement of Dipole Fields 被引量:1
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作者 XU Wei JIN Lan +3 位作者 ZHOU Hui LU Yin-xiang LAN Bi-jian ZOU Zhen-guang 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2007年第5期628-630,共3页
Introduction Chirality is defined as the absence of inversion symmetry,however,it is actually a pseudo-scalar of objects or figures,and does not depend for its definition on any connection to the physical world[1-5]. ... Introduction Chirality is defined as the absence of inversion symmetry,however,it is actually a pseudo-scalar of objects or figures,and does not depend for its definition on any connection to the physical world[1-5]. Logically,chiral molecules may possess other inherent physical quantity that guarantees the connection to the physical world[6,7]. 展开更多
关键词 C3 symmetry Axial chirality Electric dipole handed vortex field Two-state system
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Science Letters:Dual structure of composite right/left-handed transmission line 被引量:1
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作者 HU Xin ZHANG Pu HE Sailing 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2006年第10期1777-1780,共4页
A dual structure of composite right/left handed (CRLH) transmission line (TL) is analyzed in which an inductance LR is in parallel with a capacitance CL and a shunt capacitance CR is in series with an inductance LL. B... A dual structure of composite right/left handed (CRLH) transmission line (TL) is analyzed in which an inductance LR is in parallel with a capacitance CL and a shunt capacitance CR is in series with an inductance LL. Both the distributed and lumped cases are considered. The dispersion diagram and transmission properties of the dual CRLH TL are given and compared with those of a standard CRLH TL. Contrary to the frequency response of a standard CRLH TL, a dual CRLH TL has a left-handed (negative phase shift) band at higher frequencies and a right-handed (positive phase shift) band at lower frequencies. A novel dual-band balun is presented as an application. 展开更多
关键词 Dual structure Composite fight/left handed transmission line (CRLH TL) Dual band balun
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Opto propeller effect on Micro–Rotors with different handedness
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作者 Yiwen Tang Zhibing Li 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第8期212-219,共8页
Manipulating biomacromolecules and micro-devices with light is highly appealing.Opto driving torque can propel micro-rotors to translational motion in viscous liquid,and then separate microsystems according to their h... Manipulating biomacromolecules and micro-devices with light is highly appealing.Opto driving torque can propel micro-rotors to translational motion in viscous liquid,and then separate microsystems according to their handedness.We study the torque of dielectric loss generated by circular polarized lasers.The unwanted axial force which causes the handedness independent translational motion is cancelled by the counter propagating reflection beams.The propelling efficiency and the friction torque of water are obtained by solving the Navier-Stokes equation.In the interesting range of parameters,the numerical friction torque is found to be linear to the angular velocity with a slope depending on the radius of rotor as r^3.The time-dependent distribution of angular velocity is obtained as a solution of the Fokker-Planck equation,with which the thermal fluctuation is accounted.The results shed light on the micro-torque measurement and suggest a controllable micro-carrier. 展开更多
关键词 micro-rotors with DIFFERENT handedNESS PROPELLER EFFECT dielectric loss
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Handedness inversion of chiral mesoporous silica: A diffuse-reflectance circular dichroism study
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作者 Nan Wang Ruiyu Lin +2 位作者 Minzhao Xue Yingying Duan Shun'ai Che 《Chinese Chemical Letters》 SCIE CAS CSCD 2019年第1期139-142,共4页
Chiral mesoporous silica ribbons and rods with inversed handedness have been synthesized with the same enantio pure N-acylaminoacidat temperatures of 0℃and 20℃ respectively. With involving Cu^(2+)and meso-tetra(4-su... Chiral mesoporous silica ribbons and rods with inversed handedness have been synthesized with the same enantio pure N-acylaminoacidat temperatures of 0℃and 20℃ respectively. With involving Cu^(2+)and meso-tetra(4-sulfonatophenyl)porphyrin(TPPS) as probes, ribbons and rods revealed opposite signals in diffuse-reflectance circular dichroism(DRCD) spectra, indicating the existence of inversed supramolecular chiral imprintings through helical stacking of amphiphiles. The structural evolution was systematically studied by the freeze-dried products sampled at different time after the addition of silica precursors. The H-bonding-depended molecular orientation probably controls the chiral sense upon forming chiral molecular stacking, which would be the origin of such handedness inversion 展开更多
关键词 Chirality handedNESS INVERSION Circular DICHROISM Mesoporous AMPHIPHILE Self-assembly
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Handedness found in a wild group of moor monkeys Macaca maurus in the Karaenta Nature Reserve, South Sulawesi,Indonesia
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作者 Kunio WATANABE 《Current Zoology》 SCIE CAS CSCD 北大核心 2010年第2期209-212,共4页
Hand preference of wild moor monkeys Macaca maurus was investigated in food reaching situations at the Karaenta Nature Reserve, South Sulawesi, Indonesia. The frequency picking up sweet-corn grains to take into the mo... Hand preference of wild moor monkeys Macaca maurus was investigated in food reaching situations at the Karaenta Nature Reserve, South Sulawesi, Indonesia. The frequency picking up sweet-corn grains to take into the mouth by either hand of monkeys was counted directly at the feeding ground where sweet-corn grains were scattered for monkeys. Among the 20 monkeys examined, 8 were right-handed, 8 were left-handed, and 4 were ambilateral. The results indicated the prevailed hand preference on individual level but not either trends of left- or right-hand preference on population level. The trend toward a higher proportion of left-handed monkeys found in Japanese and rhesus monkeys was not found. Some other characteristics found in moor monkeys are discussed in comparison with those previous findings in Japanese and Tibetan macaques in order to evaluate variations within the genus Macaca 展开更多
关键词 Moor macaque Macaca maurus handedNESS LATERALITY SULAWESI
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The Effect of Handedness on Supplementary Motor Area Activation during Complex Motor Tasks
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作者 Amauri Dalla-Corte Carlos M. M. das Neves +2 位作者 Maurício Anés Mirna W. Portuguez Jaderson C. Dacosta 《Journal of Behavioral and Brain Science》 2015年第10期458-469,共12页
Functional magnetic resonance imaging (fMRI) was used to assess the activity of supplementary motor area (SMA) in six right-handed and six left-handed healthy volunteers. Two manual tasks (self-initiated previously pr... Functional magnetic resonance imaging (fMRI) was used to assess the activity of supplementary motor area (SMA) in six right-handed and six left-handed healthy volunteers. Two manual tasks (self-initiated previously practiced and unpredictable visually guided) were used. Quantitative analysis of hemispheric and bilateral SMA activation was described as mean ± standard deviation of hot spots/total spots. The two tasks induced bilateral SMA activation. The laterality of SMA activation was affected by manual dominance. Left SMA was significantly more activated in right- and left-handers while performing the motor tasks with the right hand. Right SMA was more activated in the left-handers when the left hand was used. Task complexity was the most important factor influencing the degree of SMA activation. 展开更多
关键词 Functional Magnetic RESONANCE Imaging MOTOR Control SUPPLEMENTARY MOTOR Area LATERALITY handedNESS
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A Left-Handed, Stem-Twining Plant from the Miocene Shanwang Formation of Eastern China
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作者 Qi Wang Si Shen Zhenyu Li 《American Journal of Plant Sciences》 2013年第5期18-22,共5页
Twining stems of plants are very common in extant tropical and subtropical forests, and the climbing growth habit of plants may be an evolutionary innovation and ecological adaptation to either closed, shady or open, ... Twining stems of plants are very common in extant tropical and subtropical forests, and the climbing growth habit of plants may be an evolutionary innovation and ecological adaptation to either closed, shady or open, edge environments. However, the origin of handedness in climbing plants remains unclear. Here we report a Miocene (ca. 16 million years ago) macrofossil from the Shanwang Formation of Shandong Province, Eastern China, unequivocally exhibiting the first direct fossil evidence for a left-handed, stem-twining growth habit in plants. This fossil plant bears a thicker, slightly curved supporting stem (2 - 3.5 mm wide), which is loosely, spirally twined by a thinner stem (1.5 - 2 mm wide), possibly representing part of distal branches from a liana or vine. 展开更多
关键词 Climbing Growth HABIT handedNESS LIANA MIOCENE SHANWANG Formation Stem-Twining Plants Vine
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Wider frequency domain for negative refraction index in a quantized composite right–left handed transmission line
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作者 Qi-Xuan Wu Shun-Cai Zhao 《Chinese Physics B》 SCIE EI CAS CSCD 2018年第6期468-472,共5页
The refraction index of the quantized lossy composite right-left handed transmission line(CRLH-TL) is deduced in the thermal coherence state. The results show that the negative refraction index(herein the left-hand... The refraction index of the quantized lossy composite right-left handed transmission line(CRLH-TL) is deduced in the thermal coherence state. The results show that the negative refraction index(herein the left-handedness) can be implemented by the electric circuit dissipative factors(i.e., the resistances R and conductances G) in a higher frequency band(1.446 GHz≤ ω ≤ 15 GHz), and flexibly adjusted by the left-handed circuit components(Cl, Ll) and the right-handed circuit components(Cr, Lr) at a lower frequency(ω = 0.995 GHz). The flexible adjustment for left-handedness in a wider bandwidth will be significant for the microscale circuit design of the CRLH-TL and may make the theoretical preparation for its compact applications. 展开更多
关键词 quantized composite right-left handed transmission line negative refraction index frequency do- main
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Left-handedness without absorption in the four-level Y-type atomic medium
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作者 赵顺才 刘正东 吴奇宣 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第1期350-354,共5页
In this paper we have investigated three external fields interacting with the four-level Y-type atomic system described by the density-matrix approach. The results show that left-handedness with zero absorption is ach... In this paper we have investigated three external fields interacting with the four-level Y-type atomic system described by the density-matrix approach. The results show that left-handedness with zero absorption is achieved. The zero absorption property displays the possibility of manipulation by varying the phase and the intensity of the coupling field. Also, the zero absorption property may be used to amplify the evanescent waves that have been lost in imaging by traditional lenses. We propose an approach to obtain a negative refractive medium with zero absorption and the possibility of enhaneeingthe imaging resolution in realizing 'superlenses'. 展开更多
关键词 zero absorption LEFT-handedNESS negative refractive index negative permittivity and permeability
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Asymmetry in Resting Alpha Activity: Effects of Handedness
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作者 Ruth E. Propper Jenna Pierce +2 位作者 Mark W. Geisler Stephen D. Christman Nathan Bellorado 《Open Journal of Medical Psychology》 2012年第4期86-90,共5页
Study Aim: Frontal electroencephalographic (EEG) alpha band power during rest shows increased right, and/or de-creased left, hemisphere activity under conditions of state or trait withdrawal-associated affect. Non-rig... Study Aim: Frontal electroencephalographic (EEG) alpha band power during rest shows increased right, and/or de-creased left, hemisphere activity under conditions of state or trait withdrawal-associated affect. Non-right-handers (NRH) are more likely to have mental illnesses and dispositions that involve such withdrawal-related affect. The aim of the study was to examine whether NRH might be characterized by increased right, relative to left, hemisphere activity during rest. Methods: The present research investigated that hypothesis by examining resting EEG alpha power in consistently-right-handed (CRH) and NRH individuals. Results: In support of the hypothesis, NRH demonstrated de-creased right hemisphere alpha power, and therefore increased right hemisphere activity, during rest, compared to CRH. Conclusions: The study demonstrates further support for an association between increased right hemisphere activity and negative affect via an association between such EEG activity and NRH. 展开更多
关键词 EEG handedNESS Asymmetry EMOTION
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Strength, But Not Direction, of Handedness Is Related to Height
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作者 Ruth E. Propper Tad T. Brunye +1 位作者 Karly Hrank Sean E. McGraw 《Open Journal of Medical Psychology》 2013年第4期166-167,共2页
Left-handers are reputed to be shorter than right-handers. However, previous research has confounded handedness direction (left-versus right-handedness) with handedness strength (consistency with which one hand is cho... Left-handers are reputed to be shorter than right-handers. However, previous research has confounded handedness direction (left-versus right-handedness) with handedness strength (consistency with which one hand is chosen across a variety of tasks;consistent-versus inconsistent-handedness). Here, we support a relationship between handedness strength, but not direction, and stature, with increasing inconsistent-handedness associated with increasing self-reported height. 展开更多
关键词 handedNESS STATURE PRENATAL TESTOSTERONE
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Attenuation in a Cylindrical Left Handed Material (LHM) Wave-Guide Structure
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作者 Hana Mohammed Mousa 《Optics and Photonics Journal》 2012年第1期46-53,共8页
This paper tackles the wave attenuation along with a cylindrical waveguides composed of a left Handed material (LHM), surrounded by a superconducting or metal wall. I used the transcendental equations for both TE and ... This paper tackles the wave attenuation along with a cylindrical waveguides composed of a left Handed material (LHM), surrounded by a superconducting or metal wall. I used the transcendental equations for both TE and TM waves. I found out that the waveguide supports backward TE and backward TM waves since both permittivity and magnetic permeability of LHM are negative. I also illustrated the dependence of the TE and TM wave attenuation on the wave frequency and the reduced temperature of the superconducting wall (T/Tc). Attenuation constant increases by increasing the wave frequency and it shows higher values at higher T/Tc. Lowest wave attenuation and the best confinement are achieved for the thickest TE waveguide. LHM-superconductor waveguide shows lower wave attenuation than LHM-metal waveguide. 展开更多
关键词 LEFT handed Material TM WAVES TE WAVES ATTENUATION Constant WAVEGUIDES SUPERCONDUCTOR Metal
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TE Modal Dispersion in Dielectric Slab Waveguide with Lossy Left-Handed Metamaterial
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作者 Hassan S. Ashour 《Journal of Modern Physics》 2013年第9期1165-1170,共6页
In this work, we derived the modal dispersion relation for TEm modes for a symmetric slab waveguide constructed from SiO2 dielectric guiding core material with lossy left-handed material (LHM) as cladding and substrat... In this work, we derived the modal dispersion relation for TEm modes for a symmetric slab waveguide constructed from SiO2 dielectric guiding core material with lossy left-handed material (LHM) as cladding and substrate, and the power confinement factor. The dispersion relations and the power confinement factor were numerically solved for a given set of parameters: allowed frequency range;core’s thicknesses;and TEm mode order. We found that the real part of the effective refractive index decreased with thickness and frequency increase. Moreover, the imaginary part (extinction coefficient) of the effective refractive index has very small values for all thickness in the frequency ranges, which means the waveguide structure is transparent for the used frequencies. The waveguide structure offers good guiding power for all thickness in the frequency range with low power attenuation. The real part of the effective refractive index increases with the increase of mode order, and the power confinement factor decreases with the increase of mode order. 展开更多
关键词 Dispersion RELATION LEFT handed Material LHM Power CONFINEMENT TE Surface WAVES
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Acupuncture Techniques Handed Down from Dr.Zheng Kuishan's Family
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作者 郝晋东 郑俊江 王新中 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2000年第2期115-118,共4页
It has been proved by the ancient and modemacupuncture practices that needling techniques are ofvital importance in the acupuncture treatment ofdiseases.At present,much has been reported aboutthe researches on acupunc... It has been proved by the ancient and modemacupuncture practices that needling techniques are ofvital importance in the acupuncture treatment ofdiseases.At present,much has been reported aboutthe researches on acupuncture techniques,which canbe roughly divided into the following three types:reinforcing,reducing,and even methods.Throughlong years of study and clinical practice,Dr. 展开更多
关键词 Acupuncture Techniques handed Down from Dr.Zheng Kuishan’s Family
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The Direction of Slant and Horizontal Stroke as Potential Suggestive Markers for the Determination of Handedness
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作者 Pawan Gupta Anu Singla +1 位作者 Baljeet Yadav Vartika Khare 《Journal of Forensic Science and Medicine》 2024年第3期165-170,共6页
Background:The task of document examiners is very challenging,as they need to gather all the relevant facts to make an informed decision regarding the questioned document.In the present study,a total of 300 handwritin... Background:The task of document examiners is very challenging,as they need to gather all the relevant facts to make an informed decision regarding the questioned document.In the present study,a total of 300 handwriting samples from 100 different writers(involving 50 right-handed and 50 left-handed)were collected at Bundelkhand University,Jhansi.Slant and stroke,as characteristic features of handwriting,were visually examined under a stereomicroscope to ascertain the handedness.Methods:Slants and Strokes as characteristic features were analyzed in a total of 300 handwriting samples collected from 50 left-handed and 50 right-handed writers of age 17–22 years.A reference text comprising three pangram sentences printed on A4 paper and a blue ball point pen was used for sampling.Results:The data collected during the study were analyzed using a statistical method(Chi-square test)and revealed that the left-handed writers(LHWs)had a significantly(P<0.05)different writing style than the right-handed ones.Results indicated that LHWs are more likely to make strokes in the right-to-left direction and slant of letters in the backward direction,while right-handed writers make strokes in the left-to-right direction and slant of letters in the forward direction.Conclusions:The findings of the study showed valuable insight and highlighted the significance of the direction of slant and horizontal stroke as potential indicators for the determination of handedness. 展开更多
关键词 Forensic science handedNESS handwriting stroke questioned document slant
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基于社交文本的洪涝信息抽取与时空演变分析 被引量:1
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作者 侯华伟 慎利 +1 位作者 贾嘉楠 徐柱 《地理与地理信息科学》 北大核心 2025年第2期1-9,共9页
以2018年寿光市水灾为例,基于深度学习和规则匹配相结合方法从微博数据中抽取关键灾情信息,通过时间序列分析提取洪涝事件的关键时间节点,利用核密度估计探索灾情的空间分布特征,应用HDBSCAN算法分析核心受灾区域;通过LDA算法对待响应... 以2018年寿光市水灾为例,基于深度学习和规则匹配相结合方法从微博数据中抽取关键灾情信息,通过时间序列分析提取洪涝事件的关键时间节点,利用核密度估计探索灾情的空间分布特征,应用HDBSCAN算法分析核心受灾区域;通过LDA算法对待响应点的文本进行主题分析,提取不同受灾区域面临的问题与需求;基于抽取的水情相关信息和DEM数据,利用HAND模型绘制洪水淹没范围,识别核心受灾区。实验结果表明,该框架的灾情信息抽取总体准确率达83%,高于其他对比方法,可为应急响应提供定向援助与资源配置的决策依据。 展开更多
关键词 社交文本 深度学习 规则匹配 LDA模型 HAND模型
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精神分裂症与孤独症患者利手分布的荟萃分析
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作者 马秀慧 杨梦怡 +4 位作者 吴曦 马成凤 马占兵 霍正浩 党洁 《解剖学杂志》 2025年第1期53-59,82,共8页
目的:系统分析精神分裂症及孤独症患者利手的分布特点,探讨利手左移现象与精神发育异常的相关性。方法:检索中国知网、万方医学数据库、维普期刊服务平台、PubMed数据库等公开发表的利手与精神分裂症和孤独症相关文献(1976年—2022年)... 目的:系统分析精神分裂症及孤独症患者利手的分布特点,探讨利手左移现象与精神发育异常的相关性。方法:检索中国知网、万方医学数据库、维普期刊服务平台、PubMed数据库等公开发表的利手与精神分裂症和孤独症相关文献(1976年—2022年)。利用Stata 14软件对纳入的研究做异质性检验及合并后结果分析,漏斗图和Egger检验评估发表偏倚,敏感性分析评估研究的稳定性,Meta回归检验影响文章异质性的来源。SPSS26.0进行聚类分析和χ2检验,探索不同人群非右利手分布可能的遗传学差异。结果:共纳入符合要求的29项研究,包含5950例精神分裂症患者及其对照24725人;孤独症患者94人及其对照331人。荟萃分析结果显示,精神分裂症组及孤独症组非右利手比率均显著高于对照组;男性精神分裂症患者非右利手比率显著高于对照组;孤独症组非右利手比率显著高于精神分裂症组及对照组,对照组非右利手比率最低。结论:利手在精神分裂症和孤独症中均出现明显左移现象,在精神分裂症中男性较女性更为明显,有望成为筛选精神发育异常类疾病的宏观生物学标记。 展开更多
关键词 利手 精神分裂症 孤独症 荟萃分析
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Miniaturized fractal-shaped branch-line coupler for dual-band applications based on composite right/left handed transmission lines 被引量:1
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作者 He-xiu XU Guang-ming WANG +1 位作者 Pei-lin CHEN Tian-peng LI 《Journal of Zhejiang University-Science C(Computers and Electronics)》 SCIE EI 2011年第9期766-773,共8页
In this paper,novel dual-band (DB) branch-line couplers (BLCs) employing a composite right/left handed transmission line (CRLH TL) and fractal geometry are presented for the first time.The CRLH TL,with specified chara... In this paper,novel dual-band (DB) branch-line couplers (BLCs) employing a composite right/left handed transmission line (CRLH TL) and fractal geometry are presented for the first time.The CRLH TL,with specified characteristic impedance and phase shift,consists of lumped elements for the left handed (LH) part and fractal-shaped microstrip lines (MLs) for the right handed (RH) part,which can be designed separately.Two designed BLCs are involved in size reduction,one using a 3/2 fractal curve of first iteration,the other constructed based on a hybrid shape of fractal and meandered lines.A miniaturized principle for CRLH TL realization is derived and an exact design method for fractal implementation is developed.For verification,an example coupler was fabricated and measured.Consistent numerical and experimental results confirmed the design concept,showing that the BLCs obtain DB behavior centered at 0.9 GHz and 1.8 GHz respectively with good in-band performance,except for slightly larger coupled insertion loss for the hybrid-shaped BLC case.In addition,the proposed fractal-and hybrid-shaped BLCs obtained a 49.7% and 64.1% size reduction respectively relative to their conventional counterparts working in the lower band.The most important contributions of this article are the demonstration of compatibility between the fractal and CRLH TL techniques and the provision of an alternative approach and a new concept for designing devices. 展开更多
关键词 FRACTAL Composite right/left handed transmission line (CRLH TL) Dual-band (DB) MINIATURIZATION Branch-linecoupler (BLC)
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Harmonic suppressed bandpass filter using composite right/left handed transmission line 被引量:1
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作者 Jian-gang LIANG He-xiu XU 《Journal of Zhejiang University-Science C(Computers and Electronics)》 SCIE EI 2012年第7期552-558,共7页
A wideband composite right/left handed transmission line (CRLH TL) in conjunction with its corresponding equivalent circuit model is studied based on a cascaded complementary single split ring resonator (CCSSRR).The c... A wideband composite right/left handed transmission line (CRLH TL) in conjunction with its corresponding equivalent circuit model is studied based on a cascaded complementary single split ring resonator (CCSSRR).The characterization is performed by theory analysis,circuit simulation,and full-wave electromagnetic (EM) simulation.The negative refractive index (NRI) and backward wave propagation performance of the CRLH TL are demonstrated.For application,a bandpass filter (BPF) with enhanced out-of-band selectivity and harmonic suppression operating at the wireless local area network (WLAN) band is designed,fabricated,and measured by combining the CRLH TL with a complementary electric inductive-capacitive resonator (CELC).Three CELC cells with wideband stopband performance in the conductor strip and ground plane,respectively,are utilized in terms of single negative permeability.The design concept has been verified by the measurement data. 展开更多
关键词 Composite right/left handed transmission line Cascaded complementary split single ring resonator Bandpass filter Complementary electric inductive-capacitive resonator (CELC) Negative permeability
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NECAB family of neuronal calcium-binding proteins in health and disease
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作者 Diones Bueno Michael K.E.Schafer +2 位作者 Sudena Wang Michael J.Schmeisser Axel Methner 《Neural Regeneration Research》 SCIE CAS 2025年第5期1236-1243,共8页
The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally le... The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interaction partners, and the physiological and pathophysiological role of the NECAB family. 展开更多
关键词 CALCIUM EF hand MITOCHONDRIA nervous system signal transduction
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