目的:通过计算机虚拟筛选金银花中具有抗人源手足口病毒Human Enterovirus 71(HEV71)的天然抑制剂。方法:以HEV71病毒衣壳蛋白为靶蛋白,通过PyRx运行Auto Dock Vina,对自建数据库中的金银花天然化合物进行虚拟筛选;用Discovery Studio V...目的:通过计算机虚拟筛选金银花中具有抗人源手足口病毒Human Enterovirus 71(HEV71)的天然抑制剂。方法:以HEV71病毒衣壳蛋白为靶蛋白,通过PyRx运行Auto Dock Vina,对自建数据库中的金银花天然化合物进行虚拟筛选;用Discovery Studio Visualizer对小分子抑制剂与HEV71的结合模式进行3D建模,分析了得到的小分子抑制剂与HEV71之间的结合情况。用同样的方法对茯苓中的化合物进行虚拟筛选,作为对照。结果:虚拟筛选出了3个金银花中具有潜在活性的化合物:loniflavone,3'-Omethyl loniflavone和3,5-dicaffeoylquinic acid。结论:虚拟筛选结果支持金银花具有抑制HEV71病毒活性,并且为金银花抗手足口病的分子机制研究提供了参考。展开更多
This research investigates a monopole patch antenna for Wi-Fi applications at 2.45 and 5.2 GHz,and WiMax at 3.5 GHz.A low-cost and flexible graphite sheet with good conductivity,base on graphite conductive powder and ...This research investigates a monopole patch antenna for Wi-Fi applications at 2.45 and 5.2 GHz,and WiMax at 3.5 GHz.A low-cost and flexible graphite sheet with good conductivity,base on graphite conductive powder and glue is used to create a radiator patch and ground plane.Instead of commercially available conductive inks or graphite sheets,we use our selfproduced graphite liquid to create the graphite sheet because it is easy to produce and inexpensive.The antenna structure is formed using a low-cost and easy hand-screen printing approach that involved placing graphite liquid on a bendable polyester substrate.This research focuses on designing and developing a low-cost,thin,light,and flexible patch antenna for wireless communication and smart glass applications.The proposed antenna utilizes CST microwave software for simulations to improve the parameters before fabrication and measurement.The simulation and measurement results for the reflection coefficients at 2.45 GHz,3.5 GHz,and 5.20 GHz are reliable and cover the required resonance frequencies,antennas gain are 1.91,1.98,and 1.87 dB,respectively.Additionally,the radiation patterns of both results are omnidirectional.In the experiments,bending the proposed patch antenna along with the cylinder with the radii of 60,40,and 25 mm yielded the same measurement results as the unbent patch antenna.展开更多
文摘目的:通过计算机虚拟筛选金银花中具有抗人源手足口病毒Human Enterovirus 71(HEV71)的天然抑制剂。方法:以HEV71病毒衣壳蛋白为靶蛋白,通过PyRx运行Auto Dock Vina,对自建数据库中的金银花天然化合物进行虚拟筛选;用Discovery Studio Visualizer对小分子抑制剂与HEV71的结合模式进行3D建模,分析了得到的小分子抑制剂与HEV71之间的结合情况。用同样的方法对茯苓中的化合物进行虚拟筛选,作为对照。结果:虚拟筛选出了3个金银花中具有潜在活性的化合物:loniflavone,3'-Omethyl loniflavone和3,5-dicaffeoylquinic acid。结论:虚拟筛选结果支持金银花具有抑制HEV71病毒活性,并且为金银花抗手足口病的分子机制研究提供了参考。
基金This work was supported by the RMUTT research and development fund。
文摘This research investigates a monopole patch antenna for Wi-Fi applications at 2.45 and 5.2 GHz,and WiMax at 3.5 GHz.A low-cost and flexible graphite sheet with good conductivity,base on graphite conductive powder and glue is used to create a radiator patch and ground plane.Instead of commercially available conductive inks or graphite sheets,we use our selfproduced graphite liquid to create the graphite sheet because it is easy to produce and inexpensive.The antenna structure is formed using a low-cost and easy hand-screen printing approach that involved placing graphite liquid on a bendable polyester substrate.This research focuses on designing and developing a low-cost,thin,light,and flexible patch antenna for wireless communication and smart glass applications.The proposed antenna utilizes CST microwave software for simulations to improve the parameters before fabrication and measurement.The simulation and measurement results for the reflection coefficients at 2.45 GHz,3.5 GHz,and 5.20 GHz are reliable and cover the required resonance frequencies,antennas gain are 1.91,1.98,and 1.87 dB,respectively.Additionally,the radiation patterns of both results are omnidirectional.In the experiments,bending the proposed patch antenna along with the cylinder with the radii of 60,40,and 25 mm yielded the same measurement results as the unbent patch antenna.
