The lipophilic hydroxyapatite(HA)nanorods were firstly synthesized by the solvothermal method using calcium oleate as the precursor.As-synthesized HA nanorods had an average aspect ratio of 11.4 with 18.4 wt%oleic aci...The lipophilic hydroxyapatite(HA)nanorods were firstly synthesized by the solvothermal method using calcium oleate as the precursor.As-synthesized HA nanorods had an average aspect ratio of 11.4 with 18.4 wt%oleic acid attached on the surface.Then the hydroxyapatite/polylactic acid(HA/PLA)nanocomposites were prepared by dispersing the HA nanorods in PLA using dichloromethane(CH_(2)Cl_(2))as the volatile solvent.The influence of the HA content on the properties of the HA/PLA nanocomposites was investigated.It is found that the nanocomposite with 2 wt%HA exhibits the optimal mechanical properties.The tensile strength and elongation at break are 59.4 MPa and 18.19%,respectively.The values are enhanced by 13%and 184.2%compared with that of the pure PLA.The higher HA addition results in the decrease in the mechanical properties due to the aggregation of HA nanorods.The thermal properties of the HA/PLA nanocomposites were also examined.It is found that the thermal stability and crystallization transition temperature are decreased while the glass transition temperature and melting temperature remain basically unchanged with the increasing HA content up to 10 wt%.展开更多
Biphasic calcium phosphate （BCP） nanopowders were synthesized by using microwave and non-microwave irradiation assisted processes. The synthesized powders were pressed under a pressure of 90 MPa, and then were sinte...Biphasic calcium phosphate （BCP） nanopowders were synthesized by using microwave and non-microwave irradiation assisted processes. The synthesized powders were pressed under a pressure of 90 MPa, and then were sintered at 1000-1200℃ for 1 h. The mechanical properties of the samples were investigated. The formed phases and microstructures were characterized by X-ray diffraction （XRD） and scanning electron microscopy （SEM）. The results showed that the synthesis time was shorter, along with a more homogeneous microstructure, when the microwave irradiation assisted method was applied. The compression strength and the Young＇s modulus of the samples synthesized with microwave irradiation were about 60 MPa and 3 GPa, but those of the samples synthesized without microwave irradiation were about 30 MPa and 2 GPa, respectively. XRD patterns of the microwave irradiation assisted and non-microwave irradiation assisted nanopowders showed the coexistence of hydroxyapatite （HA） and lricalcium phosphate （TCP） phases in the system.展开更多
A型流感病毒(influenza A virus,IAV)极易发生突变和重组,导致现有疫苗和抗流感药物失效。因此,开发有效的广谱抗流感病毒疫苗和药物是我国乃至全球的重要需求。2025年1月9日,中国农业科学院兰州兽医研究所/兰州大学动物医学与生物安全...A型流感病毒(influenza A virus,IAV)极易发生突变和重组,导致现有疫苗和抗流感药物失效。因此,开发有效的广谱抗流感病毒疫苗和药物是我国乃至全球的重要需求。2025年1月9日,中国农业科学院兰州兽医研究所/兰州大学动物医学与生物安全学院朱启运研究员团队在Nature Communications杂志发表了题为“Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection”的研究论文。该研究分离并纯化了一株特异性识别A型流感病毒血凝素(HA)的纳米抗体E10,该抗体对不同亚型流感病毒具有跨组中和和体内保护效应。研究鉴定E10靶向HA头部结构域的保守氨基酸位点(K166/S167),并且含有E10表位的多肽分子能够诱导交叉反应性抗体,能够对小鼠提供部分交叉免疫保护。该研究不仅为流感防治提供了新的手段,也为广谱流感疫苗研发提供了新的靶点和希望。展开更多
基金the Foundation of Hubei Province Key Laboratory of Green Materials for Light Industry,Hubei University of Technology。
文摘The lipophilic hydroxyapatite(HA)nanorods were firstly synthesized by the solvothermal method using calcium oleate as the precursor.As-synthesized HA nanorods had an average aspect ratio of 11.4 with 18.4 wt%oleic acid attached on the surface.Then the hydroxyapatite/polylactic acid(HA/PLA)nanocomposites were prepared by dispersing the HA nanorods in PLA using dichloromethane(CH_(2)Cl_(2))as the volatile solvent.The influence of the HA content on the properties of the HA/PLA nanocomposites was investigated.It is found that the nanocomposite with 2 wt%HA exhibits the optimal mechanical properties.The tensile strength and elongation at break are 59.4 MPa and 18.19%,respectively.The values are enhanced by 13%and 184.2%compared with that of the pure PLA.The higher HA addition results in the decrease in the mechanical properties due to the aggregation of HA nanorods.The thermal properties of the HA/PLA nanocomposites were also examined.It is found that the thermal stability and crystallization transition temperature are decreased while the glass transition temperature and melting temperature remain basically unchanged with the increasing HA content up to 10 wt%.
文摘Biphasic calcium phosphate （BCP） nanopowders were synthesized by using microwave and non-microwave irradiation assisted processes. The synthesized powders were pressed under a pressure of 90 MPa, and then were sintered at 1000-1200℃ for 1 h. The mechanical properties of the samples were investigated. The formed phases and microstructures were characterized by X-ray diffraction （XRD） and scanning electron microscopy （SEM）. The results showed that the synthesis time was shorter, along with a more homogeneous microstructure, when the microwave irradiation assisted method was applied. The compression strength and the Young＇s modulus of the samples synthesized with microwave irradiation were about 60 MPa and 3 GPa, but those of the samples synthesized without microwave irradiation were about 30 MPa and 2 GPa, respectively. XRD patterns of the microwave irradiation assisted and non-microwave irradiation assisted nanopowders showed the coexistence of hydroxyapatite （HA） and lricalcium phosphate （TCP） phases in the system.
文摘A型流感病毒(influenza A virus,IAV)极易发生突变和重组,导致现有疫苗和抗流感药物失效。因此,开发有效的广谱抗流感病毒疫苗和药物是我国乃至全球的重要需求。2025年1月9日,中国农业科学院兰州兽医研究所/兰州大学动物医学与生物安全学院朱启运研究员团队在Nature Communications杂志发表了题为“Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection”的研究论文。该研究分离并纯化了一株特异性识别A型流感病毒血凝素(HA)的纳米抗体E10,该抗体对不同亚型流感病毒具有跨组中和和体内保护效应。研究鉴定E10靶向HA头部结构域的保守氨基酸位点(K166/S167),并且含有E10表位的多肽分子能够诱导交叉反应性抗体,能够对小鼠提供部分交叉免疫保护。该研究不仅为流感防治提供了新的手段,也为广谱流感疫苗研发提供了新的靶点和希望。
