Objective To develop an onset risk prediction nomogram for patients with homocysteine-type(H-type)hypertension(HTH)based on pulse diagram parameters to assist early clinical prediction and diagnosis of HTH.Methods Pat...Objective To develop an onset risk prediction nomogram for patients with homocysteine-type(H-type)hypertension(HTH)based on pulse diagram parameters to assist early clinical prediction and diagnosis of HTH.Methods Patients diagnosed with essential hypertension and admitted to Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shang-hai Hospital of Traditional Chinese Medicine,and Shanghai Hospital of Integrated Tradition-al Chinese and Western Medicine from July 6th 2020 to June 16th 2021,and from August 11th 2023 to January 22nd 2024,were enrolled in this retrospective research.The baselines and clinical biochemical indicators of patients were collected.The SMART-I TCM pulse instru-ment was applied to gather pulse diagram parameters.Multivariate logistic regression was adopted to analyze the risk factors for HTH.RStudio was employed to construct the nomo-gram model,receiver operating characteristic(ROC)curve,and calibration curve(bootstrap self-sampling 200 times),and clinical decision curve were drawn to evaluate the model’s dis-crimination and clinical effectiveness.Results A total of 168 hospitalized patients with essential hypertension were selected and di-vided into non-HTH group(n=29)and HTH group(n=139).Compared with non-HTH group,HTH group had a lower body mass index(BMI),and higher proportions of male pa-tients and drinkers(P<0.05).The ventricular wall thickening(VWT)could not be deter-mined.The proportions of left common carotid intima-media wall thickness(LCCIMWT)and serum creatinine(SCR)were higher in HTH group(P<0.05).The pulse diagram parameter As was significantly higher,and H4/H1 and T1/T were lower in HTH group(P<0.05).Gender,al-cohol consumption,serum creatinine,and the pulse diagram parameter H4/H1 were identi-fied as independent risk factors for HTH(P<0.05).The nomogram’s area under the ROC curve(AUC)was 0.795[95%confidence interval(CI):(0.7066,0.8828)],with a specificity of 0.724 and sensitivity of 0.799.After 200 times repeated bootstrap self-samplings,the calibra-tion curve showed that the simulated curve fits well with the actual curve(x^(2)=9.5002,P=0.3019).The clinical decision curve indicated that the nomogram’s applicability was optimal when the threshold for predicting HTH was between 0.38 and 1.00.Conclusion The nomogram model could be valuable for predicting the onset risk of HTH and pulse diagram parameters can facilitate early screening and prevention of HTH.展开更多
目的探究老年H型高血压患者颈动脉血管超声参数与血管性认知功能障碍的关系。方法选取2022年10月至2024年12月在承德市中心医院诊治的老年H型高血压患者180例为研究对象(研究组),根据患者是否合并血管性认知功能障碍,分为认知功能障碍组...目的探究老年H型高血压患者颈动脉血管超声参数与血管性认知功能障碍的关系。方法选取2022年10月至2024年12月在承德市中心医院诊治的老年H型高血压患者180例为研究对象(研究组),根据患者是否合并血管性认知功能障碍,分为认知功能障碍组(82例)和无认知功能障碍组(98例)。采用简易精神状态检查量表(mini-mental state examination,MMSE)评估患者是否存在认知功能障碍。另募集同期健康体检者80例作为对照组。收集受试者一般资料,均接受颈动脉血管超声检查,比较各组颈动脉血管超声参数颈动脉内膜中层厚度(intima-media thickness,IMT)和阻力指数(resistance index,RI)。采用logistic回归分析老年H型高血压患者发生血管性认知功能障碍的影响因素。结果研究组患者IMT、RI和认知功能障碍发生率显著高于对照组,MMSE评分显著低于对照组(P<0.01)。认知功能障碍组患者收缩压、舒张压、同型半胱氨酸(homocysteine,Hcy)、IMT、RI、斑块检出率、斑块厚度、斑块低回声/混合回声比例、斑块不规则比例、中度和重度狭窄比例显著高于无认知功能障碍组,血尿酸低于无认知功能障碍组,差异均有统计学意义(P<0.01)。Logistic回归分析显示,收缩压、Hcy、IMT和RI高均是老年H型高血压患者发生血管性认知功能障碍的危险因素,血尿酸低是独立保护因素(P<0.01)。ROC曲线分析显示,IMT、RI联合诊断老年H型高血压患者发生血管性认知功能障碍的曲线下面积为0.855(95%CI:0.798~0.911),高于各单一指标(P<0.01)。结论颈动脉血管超声参数IMT、RI与老年H型高血压患者合并血管性认知功能障碍相关,二者联合诊断价值较高。展开更多
背景:H型血管(CD31hiEmcnhi)因独特的功能为深入理解血管介导的骨代谢调控机制提供了新的视角和切入点,引发了骨科学研究范式从“骨本位”向“骨-血管整合”的重要转变。目的:基于H型血管领域的文献数据进行可视化分析,探讨该领域的研...背景:H型血管(CD31hiEmcnhi)因独特的功能为深入理解血管介导的骨代谢调控机制提供了新的视角和切入点,引发了骨科学研究范式从“骨本位”向“骨-血管整合”的重要转变。目的:基于H型血管领域的文献数据进行可视化分析,探讨该领域的研究热点和前沿趋势。方法:系统检索CNKI和Web of Science核心合集中与H型血管相关的中英文文献,文献检索时限为2014-2024年。采用CiteSpace 6.2.R4信息可视化软件对文献的发表国家、作者、机构、关键词、时间线视图等进行可视化分析。结果与结论:①共纳入中文文献59篇、英文文献185篇。自2014年提出H型血管概念以来,相关研究文献数量逐年增加,中国在该领域的研究处于领先地位,主要研究机构包括南方医科大学、四川大学和上海交通大学等。关键词分析揭示,当前研究热点主要集中在H型血管的生成与调控机制、H型血管在骨生成和骨重塑过程中的作用以及H型血管与骨质代谢相关疾病的关系;此外,出现“诱导膜”“软骨修复”“中医药”等新兴关键词,表明研究正在向多样化和多学科交叉的方向发展。②H型血管在骨骼疾病的发生发展中发挥着关键作用,相关研究对深入理解骨组织的生理与病理过程具有重要意义。未来应进一步探讨H型血管在不同疾病背景下的具体作用机制,推动基础研究成果的临床转化,为骨骼疾病的预防和治疗提供新的思路与策略。展开更多
背景:H型血管因其独特的功能为深入理解血管介导的骨代谢调控机制提供了新的视角和切入点。目的:探讨H型血管在不同骨骼疾病动物模型中的生成机制及对骨代谢的影响。方法:系统检索CNKI、维普、万方、PubMed、Scopus和Web of Science数...背景:H型血管因其独特的功能为深入理解血管介导的骨代谢调控机制提供了新的视角和切入点。目的:探讨H型血管在不同骨骼疾病动物模型中的生成机制及对骨代谢的影响。方法:系统检索CNKI、维普、万方、PubMed、Scopus和Web of Science数据库中2014年1月至2025年2月收录的H型血管相关中英文文献。剔除重复及不符合纳入标准的文献,对141篇涉及不同骨骼疾病动物模型中H型血管生成的文献进行系统分析。结果与结论:研究表明,H型血管在不同的骨骼疾病模型中表现出特定的生成机制和生物学功能。H型血管不仅在骨内血管生成中发挥重要作用,还与骨代谢密切相关,能够作为评估骨量水平的早期标志物。不同骨骼疾病动物模型中H型血管生成及作用不尽相同。在骨质疏松症、骨折、骨坏死等骨骼疾病中,通过促进H型血管表达,可显著改善血管重塑与骨再生能力;而在骨关节炎、骨肿瘤等恶性骨骼疾病中,选择性抑制H型血管表达则成为潜在的治疗干预策略。研究还揭示了多条关键信号通路在H型血管生成中的重要作用,如缺氧诱导因子1α/血管内皮生长因子、血小板源性生长因子BB、Wnt/β-catenin等,为理解血管介导的骨代谢调控机制提供了新的科学视角,同时为H型血管作为潜在治疗靶点的临床应用价值提供了重要理论基础。通过分析不同骨骼疾病动物模型中H型血管生成的作用,将为进一步深入探究人类骨关节疾病机制及治疗靶点提供重要依据。展开更多
The bent double-ridged rectangular tube(DRRT)with high forming quality is helpful to improve the microwave transmission accuracy.For reducing the cross-sectional deformation in the H-typed bending process,in addition ...The bent double-ridged rectangular tube(DRRT)with high forming quality is helpful to improve the microwave transmission accuracy.For reducing the cross-sectional deformation in the H-typed bending process,in addition to using rigid mandrel to support the inside of tube,ridge groove fillers are also added to restrict the deformation of ridge grooves.Because of the change of stress and strain state of bent tube in bending,rigid mandrel retracting and specially twicespringback stages,and the springback of fillers,the cross-sectional deformation of tube in each stage may be different.Therefore,based on the ABAQUS platform,the finite element models(FEM)for H-typed bending,mandrel retracting and twice-springback stages of H96 DRRT with fillers were established and validated.It is found that,for the height and width deformation of tube and spacing deformation of ridge grooves,retraction of mandrel can make the distribution of these deformations more uniform along the bending direction.The first springback can reduce these deformations significantly,which should be emphasized.But the second springback only increases them by less amount,which can be ignored.The smaller height deformation of ridge groove and filler can be neglected.展开更多
Let △ be full Laplacian on H-type group G. Then for every compact set D Ga local estimate of the Schrodinger maximal operator holds, that is,∫D^sup0〈t〈1｜e^it△f（x）｜^2dx≤｜｜f｜｜^2H^s,s〉1/2We also show that ...Let △ be full Laplacian on H-type group G. Then for every compact set D Ga local estimate of the Schrodinger maximal operator holds, that is,∫D^sup0〈t〈1｜e^it△f（x）｜^2dx≤｜｜f｜｜^2H^s,s〉1/2We also show that the above inequality fails when s 〈 1/4.展开更多
基金National Natural Science Foundation of China (81973749 and 8143594)State Administration of Traditional Chinese Medicine High-level Chinese Medicine Key Discipline Construction Project (zyyzdxk-2023069)。
文摘Objective To develop an onset risk prediction nomogram for patients with homocysteine-type(H-type)hypertension(HTH)based on pulse diagram parameters to assist early clinical prediction and diagnosis of HTH.Methods Patients diagnosed with essential hypertension and admitted to Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shang-hai Hospital of Traditional Chinese Medicine,and Shanghai Hospital of Integrated Tradition-al Chinese and Western Medicine from July 6th 2020 to June 16th 2021,and from August 11th 2023 to January 22nd 2024,were enrolled in this retrospective research.The baselines and clinical biochemical indicators of patients were collected.The SMART-I TCM pulse instru-ment was applied to gather pulse diagram parameters.Multivariate logistic regression was adopted to analyze the risk factors for HTH.RStudio was employed to construct the nomo-gram model,receiver operating characteristic(ROC)curve,and calibration curve(bootstrap self-sampling 200 times),and clinical decision curve were drawn to evaluate the model’s dis-crimination and clinical effectiveness.Results A total of 168 hospitalized patients with essential hypertension were selected and di-vided into non-HTH group(n=29)and HTH group(n=139).Compared with non-HTH group,HTH group had a lower body mass index(BMI),and higher proportions of male pa-tients and drinkers(P<0.05).The ventricular wall thickening(VWT)could not be deter-mined.The proportions of left common carotid intima-media wall thickness(LCCIMWT)and serum creatinine(SCR)were higher in HTH group(P<0.05).The pulse diagram parameter As was significantly higher,and H4/H1 and T1/T were lower in HTH group(P<0.05).Gender,al-cohol consumption,serum creatinine,and the pulse diagram parameter H4/H1 were identi-fied as independent risk factors for HTH(P<0.05).The nomogram’s area under the ROC curve(AUC)was 0.795[95%confidence interval(CI):(0.7066,0.8828)],with a specificity of 0.724 and sensitivity of 0.799.After 200 times repeated bootstrap self-samplings,the calibra-tion curve showed that the simulated curve fits well with the actual curve(x^(2)=9.5002,P=0.3019).The clinical decision curve indicated that the nomogram’s applicability was optimal when the threshold for predicting HTH was between 0.38 and 1.00.Conclusion The nomogram model could be valuable for predicting the onset risk of HTH and pulse diagram parameters can facilitate early screening and prevention of HTH.
文摘目的探究老年H型高血压患者颈动脉血管超声参数与血管性认知功能障碍的关系。方法选取2022年10月至2024年12月在承德市中心医院诊治的老年H型高血压患者180例为研究对象(研究组),根据患者是否合并血管性认知功能障碍,分为认知功能障碍组(82例)和无认知功能障碍组(98例)。采用简易精神状态检查量表(mini-mental state examination,MMSE)评估患者是否存在认知功能障碍。另募集同期健康体检者80例作为对照组。收集受试者一般资料,均接受颈动脉血管超声检查,比较各组颈动脉血管超声参数颈动脉内膜中层厚度(intima-media thickness,IMT)和阻力指数(resistance index,RI)。采用logistic回归分析老年H型高血压患者发生血管性认知功能障碍的影响因素。结果研究组患者IMT、RI和认知功能障碍发生率显著高于对照组,MMSE评分显著低于对照组(P<0.01)。认知功能障碍组患者收缩压、舒张压、同型半胱氨酸(homocysteine,Hcy)、IMT、RI、斑块检出率、斑块厚度、斑块低回声/混合回声比例、斑块不规则比例、中度和重度狭窄比例显著高于无认知功能障碍组,血尿酸低于无认知功能障碍组,差异均有统计学意义(P<0.01)。Logistic回归分析显示,收缩压、Hcy、IMT和RI高均是老年H型高血压患者发生血管性认知功能障碍的危险因素,血尿酸低是独立保护因素(P<0.01)。ROC曲线分析显示,IMT、RI联合诊断老年H型高血压患者发生血管性认知功能障碍的曲线下面积为0.855(95%CI:0.798~0.911),高于各单一指标(P<0.01)。结论颈动脉血管超声参数IMT、RI与老年H型高血压患者合并血管性认知功能障碍相关,二者联合诊断价值较高。
文摘背景:H型血管(CD31hiEmcnhi)因独特的功能为深入理解血管介导的骨代谢调控机制提供了新的视角和切入点,引发了骨科学研究范式从“骨本位”向“骨-血管整合”的重要转变。目的:基于H型血管领域的文献数据进行可视化分析,探讨该领域的研究热点和前沿趋势。方法:系统检索CNKI和Web of Science核心合集中与H型血管相关的中英文文献,文献检索时限为2014-2024年。采用CiteSpace 6.2.R4信息可视化软件对文献的发表国家、作者、机构、关键词、时间线视图等进行可视化分析。结果与结论:①共纳入中文文献59篇、英文文献185篇。自2014年提出H型血管概念以来,相关研究文献数量逐年增加,中国在该领域的研究处于领先地位,主要研究机构包括南方医科大学、四川大学和上海交通大学等。关键词分析揭示,当前研究热点主要集中在H型血管的生成与调控机制、H型血管在骨生成和骨重塑过程中的作用以及H型血管与骨质代谢相关疾病的关系;此外,出现“诱导膜”“软骨修复”“中医药”等新兴关键词,表明研究正在向多样化和多学科交叉的方向发展。②H型血管在骨骼疾病的发生发展中发挥着关键作用,相关研究对深入理解骨组织的生理与病理过程具有重要意义。未来应进一步探讨H型血管在不同疾病背景下的具体作用机制,推动基础研究成果的临床转化,为骨骼疾病的预防和治疗提供新的思路与策略。
文摘背景:H型血管因其独特的功能为深入理解血管介导的骨代谢调控机制提供了新的视角和切入点。目的:探讨H型血管在不同骨骼疾病动物模型中的生成机制及对骨代谢的影响。方法:系统检索CNKI、维普、万方、PubMed、Scopus和Web of Science数据库中2014年1月至2025年2月收录的H型血管相关中英文文献。剔除重复及不符合纳入标准的文献,对141篇涉及不同骨骼疾病动物模型中H型血管生成的文献进行系统分析。结果与结论:研究表明,H型血管在不同的骨骼疾病模型中表现出特定的生成机制和生物学功能。H型血管不仅在骨内血管生成中发挥重要作用,还与骨代谢密切相关,能够作为评估骨量水平的早期标志物。不同骨骼疾病动物模型中H型血管生成及作用不尽相同。在骨质疏松症、骨折、骨坏死等骨骼疾病中,通过促进H型血管表达,可显著改善血管重塑与骨再生能力;而在骨关节炎、骨肿瘤等恶性骨骼疾病中,选择性抑制H型血管表达则成为潜在的治疗干预策略。研究还揭示了多条关键信号通路在H型血管生成中的重要作用,如缺氧诱导因子1α/血管内皮生长因子、血小板源性生长因子BB、Wnt/β-catenin等,为理解血管介导的骨代谢调控机制提供了新的科学视角,同时为H型血管作为潜在治疗靶点的临床应用价值提供了重要理论基础。通过分析不同骨骼疾病动物模型中H型血管生成的作用,将为进一步深入探究人类骨关节疾病机制及治疗靶点提供重要依据。
基金the Science,Technology and Innovation Commission of Shenzhen Municipality of China(Nos.JCYJ20170306160003433 and JCYJ20180306171058717)111 Project of China(No.B08040)for the support given to this research。
文摘The bent double-ridged rectangular tube(DRRT)with high forming quality is helpful to improve the microwave transmission accuracy.For reducing the cross-sectional deformation in the H-typed bending process,in addition to using rigid mandrel to support the inside of tube,ridge groove fillers are also added to restrict the deformation of ridge grooves.Because of the change of stress and strain state of bent tube in bending,rigid mandrel retracting and specially twicespringback stages,and the springback of fillers,the cross-sectional deformation of tube in each stage may be different.Therefore,based on the ABAQUS platform,the finite element models(FEM)for H-typed bending,mandrel retracting and twice-springback stages of H96 DRRT with fillers were established and validated.It is found that,for the height and width deformation of tube and spacing deformation of ridge grooves,retraction of mandrel can make the distribution of these deformations more uniform along the bending direction.The first springback can reduce these deformations significantly,which should be emphasized.But the second springback only increases them by less amount,which can be ignored.The smaller height deformation of ridge groove and filler can be neglected.
基金supported by National Nature Science Foundation of China(11371036)
文摘Let △ be full Laplacian on H-type group G. Then for every compact set D Ga local estimate of the Schrodinger maximal operator holds, that is,∫D^sup0〈t〈1｜e^it△f（x）｜^2dx≤｜｜f｜｜^2H^s,s〉1/2We also show that the above inequality fails when s 〈 1/4.
