Amyotrophic lateral sclerosis(ALS)is a fatal,late-onset neurodegenerative disorder characterized by the progressive degeneration of motor neurons in the motor cortex,brainstem,and spinal cord(Feldman et al.,2022).
Quinoxalin-2(1H)-ones are unique nitrogen-containing organic compounds with wide applications in the agrochemical,pharmaceutical,and chemical industries as well as in material science.During the last decades,visible-l...Quinoxalin-2(1H)-ones are unique nitrogen-containing organic compounds with wide applications in the agrochemical,pharmaceutical,and chemical industries as well as in material science.During the last decades,visible-light-promoted photoredox catalysis has emerged as a versatile platform for constructing quinoxalin-2(1H)-one scaffolds under exceptionally mild conditions.In this review,we provide an overview of recent advances in photocatalytic direct C(3)–H functionalization of quinoxaline-2(1H)-ones,including the construction of C(3)–C bonds and C(3)–R_(F)/C/O/N/Cl/S/D bonds,as well as the related reaction mechanisms.We aim to enhance the methods for the reaction of quinoxalin-2(1H)-ones at the C-3 position,which have extensive applications in organic synthesis and medicinal chemistry.展开更多
Efficient alkaline hydrogen evolution reaction(HER)catalysts are critical for anion exchange membrane water electrolysis(AEMWE).However,the intrinsic scaling relationship between water dissociation and OH desorption f...Efficient alkaline hydrogen evolution reaction(HER)catalysts are critical for anion exchange membrane water electrolysis(AEMWE).However,the intrinsic scaling relationship between water dissociation and OH desorption fundamentally impedes designing catalysts requiring concurrent superior water dissociation and facile OH desorption.Here,we engineer a superhydrophilic Ru/Cr_(2)O_(3) heterostructured electrocatalyst through in situ confinement of Ru nanoparticles(5-10 nm)within a Cr_(2)O_(3) matrix.Acting as a Lewis acid,the Cr_(2)O_(3) component provides alternative sites for water dissociation,accelerating the Volmer step kinetics and downshifting the Ru d-band center via interfacial charge transfer,while simultaneously adsorbing OH-to form a surface-bound Lewis base that repels excess OH-from Ru sites,thereby suppressing hydroxyl over-adsorption.Concurrently,the superhydrophilic surface architecture promotes efficient hydrogen bubble release,thereby reducing mass transport resistance.As a result,the Ru/Cr_(2)O_(3) heterostructured electrocatalyst exhibits an ultralow overpotential of 36.7 mV at 10 mA cm^(-2) and a Tafel slope of 33.2 mV dec^(-1).Integrated into an AEMWE device,the electrode delivers500 mA cm^(-2) for 2000 h in 1.0 M KOH,underscoring its industrial viability(hydrogen production energy consumption per cubic meter(EW):3.94 kW h m^(-3);electricity-to-hydrogen energy conversion efficiency(η_(ETH)):89%@80℃).展开更多
This study employed tri-component continuous monitoring data from 10 measurement points on both sides of a base isolation layer in the basement of a large-span high-rise building in Beijing,as well as from a free-fiel...This study employed tri-component continuous monitoring data from 10 measurement points on both sides of a base isolation layer in the basement of a large-span high-rise building in Beijing,as well as from a free-field station and roof frame,during a Mw 5.5 magnitude earthquake in Pingyuan,Shandong,in 2023.The H/V spectral ratio method was used to evaluate the structural dynamic response characteristics of the building and analyze the regulatory effect of the base-isolation layer on seismic waves.The results indicate that during the earthquake,the peak frequency of the free-field and the measurement points below the base-isolation layer was stable at 0.17 Hz,whereas the main frequency of the measurement points above the base-isolation layer increased to 0.75–1.18 Hz,which is 4–6 times greater than that of the points below.The amplitude was suppressed by more than 70%,confirming that the base isolation layer effectively isolated the low-frequency energy from the ground and increased the response frequency of the building.When the building was excited by an earthquake,a three-tier frequency gradient was formed throughout the building:“base-isolation layer(0.17 Hz)-main body(1.18 Hz)-roof frame(3.83 Hz)”,which can effectively avoid resonance of the entire building.In addition,the composite base-isolation device changed the dynamic characteristics of the structure.The resonance period was extended from 0.74 s(theoretical value without base isolation)to 5.9 s(calculated value),and the resonance frequency was reduced from 1.35 to 0.17 Hz.This finding indicates that the base-isolation layer can enhance seismic performance by increasing flexibility and damping.展开更多
Let G=(V,E)be a connected graph.For an integer h≥0,a subset F■V(G)(resp.F■E(G))of G,if any,is called an h-restricted vertex cut(resp.h-restricted edge cut)of G,if G-F is disconnected and every vertex in G-F has at ...Let G=(V,E)be a connected graph.For an integer h≥0,a subset F■V(G)(resp.F■E(G))of G,if any,is called an h-restricted vertex cut(resp.h-restricted edge cut)of G,if G-F is disconnected and every vertex in G-F has at least h neighbors.The cardinality of a minimum h-restricted vertex-cut(resp.h-restricted edge cut)of G is the h-restricted connectivity(resp.h-restricted edge connectivity)of G,and denoted by κ^(h)(G)(resp.λ^(h)(G)).The enhanced hypercube Q_(n,κ)(1≤k≤n)is a variant of the hypercube Q_(n).In this paper,we consider the h-restricted connectivity of Q_(n,κ) for 2≤k≤n-1.Our main results are as follows:(1)κ^(h)(Q_(n,κ))=2^(h)(n-h+1)for 4≤k≤n-1 and 0≤h≤n-3,λ^(h)(Q_(n,κ))=2^(h)(n-h+1)for 2≤k≤n-1 and 0≤h≤n-2.(2)κ^(h)(Q_(n,3))=2^(h-1)(n-h+1)for n≥5 and 4≤h≤n-1,κ^(h)(Q_(n,2))=2^(h-1)(n-h+1)for n≥4 and 3≤h≤n-1.(3)κ^(3)(Q_(n,3))=6n-16 for n≥5,κ^(2)(Q_(n,3))=4n-8 for n≥4 and κ^(2)(Q_(n,2))=3n-5 for n≥3,κ^(1)(Q_(n,3))=2n and κ^(3)(Q_(n,2))=2n-2 for n≥3.展开更多
Introduction: Disaster damage to health systems is a human and health tragedy, results in huge economic losses, deals devastating blows to development goals, and shakes social confidence. Hospital disaster preparednes...Introduction: Disaster damage to health systems is a human and health tragedy, results in huge economic losses, deals devastating blows to development goals, and shakes social confidence. Hospital disaster preparedness presents complex clinical operation. It is difficult philosophical challenge. It is difficult to determine how much time, money, and effort should be spent in preparing for an event that may not occur. Health facilities whether hospitals or rural health clinics, should be a source of strength during emergencies and disasters. They should be ready to save lives and to continue providing essential emergencies and disasters. Jeddah has relatively a level of disaster risk which is attributable to its geographical location, climate variability, topography, etc. This study investigates the hospital disaster preparedness (HDP) in Jeddah. Methods: Questionnaire was designed according to five Likert scales. It was divided into eight fields of 33 indicators: structure, architectural and furnishings, lifeline facilities’ safety, hospital location, utilities maintenance, surge capacity, emergency and disaster plan, and control of communication and coordination. Sample of six hospitals participated in the study and rated to the extent of disaster preparedness for each hospital disaster preparedness indicators. Two hazard tools were used to find out the hazards for each hospital. An assessment tool was designed to monitor progress and effectiveness of the hospitals’ improvement. Weakness was found in HDP level in the surveyed hospitals. Disaster mitigation needs more action including: risk assessment, structural and non-structural prevention, and preparedness for contingency planning and warning and evacuation. Conclusion: The finding shows that hospitals included in this study have tools and indicators in hospital preparedness but with lack of training and management during disaster. So the research shed light on hospital disaster preparedness. Considering the importance of preparedness in disaster, it is necessary for hospitals to understand that most of hospital disaster preparedness is built in the hospital system.展开更多
Influenza A virus(IAV) has a wide host range,including wild birds,poultry,various mammals,and even humans(Xu et al.2024).Currently,two subtypes of canine influenza virus(CIV),H3N8 and H3N2,are primarily circulating in...Influenza A virus(IAV) has a wide host range,including wild birds,poultry,various mammals,and even humans(Xu et al.2024).Currently,two subtypes of canine influenza virus(CIV),H3N8 and H3N2,are primarily circulating in dogs.The H3N8 CIV was introduced from horses into dogs in 2004(Crawford et al.2005),while the H3N2 CIV originated from chickens in Asia in 2007(Song et al.2008).In China,H3N2 is the predominant CIV subtype,with a prevalence rate of up to 5.63% in the canine population,as reported by Chen et al.(2023).CIV infection typically manifests with symptoms such as coughing,sneezing,runny nose,and fever but is rarely fatal.However,co-infection with other pathogens(e.g.,Streptococcus,Mycoplasma or canine parainfluenza virus) can exacerbate symptoms and lead to lethal outcomes(Yondo et al.2023).展开更多
Artificial photosynthesis presents a sustainable and cost-effective approach to harnessing solar energy to produce value-added chemicals[1,2].In particular,the simultaneous photocatalytic conversion of CO_(2)and H_(2)...Artificial photosynthesis presents a sustainable and cost-effective approach to harnessing solar energy to produce value-added chemicals[1,2].In particular,the simultaneous photocatalytic conversion of CO_(2)and H_(2)O into formic acid(HCOOH)and hydrogen peroxide(H2O2)has emerged as a promising strategy to mitigate global warming driven by CO_(2)emissions.HCOOH is a versatile chemical and hydrogen carrier,offering economic and practical advantages due to its compatibility with existing industrial processes and energy storage/conversion systems.Meanwhile,H_(2)O_(2)is among the world’s top 100 essential chemicals,with a global market valued at$4.0 billion in 2020 and projected to grow to$5.2 billion by 2026.展开更多
Cognitive impairment is a complex neurodegenerative disorder,and increased homocysteine levels are recognized as a major risk factor for this condition.Epigenetic modifications,particularly histone acetylation,have be...Cognitive impairment is a complex neurodegenerative disorder,and increased homocysteine levels are recognized as a major risk factor for this condition.Epigenetic modifications,particularly histone acetylation,have been implicated in the progression of cognitive impairment;however,the mechanisms underlying hyperhomocysteinemia-induced cognitive impairment remain unclear.In this study,we developed an hyperhomocysteinemia-induced cognitive impairment model by feeding mice a high-methionine diet and conducted behavioral and molecular analyses to elucidate the mechanisms involved in cognitive impairment.Behavioral experiments revealed significant cognitive deficits and neuroinflammation accompanied by a marked decrease in histone H3 lysine 27 acetylation in the hippocampus and cortex.Furthermore,metabolomic profiling and chromatin immunoprecipitation sequencing demonstrated substantial shifts in the levels of homocysteine metabolites and identified histone H3 lysine 27 acetylation-targeted genes involved in synaptic long-term potentiation,including Gria1,Gria3,Grin2a,Grin2b,Slc1a1,Slc24a2,Ptk2b,and Src.RNA sequencing confirmed that hyperhomocysteinemia induced neurodegeneration.In vitro experiments confirmed that decreased histone H3 lysine 27 acetylation downregulates the expression of these target genes in homocysteine-treated HT-22 cells,thereby impairing synaptic plasticity.Collectively,these findings suggest that aberrant expression of long-term potentiation-related genes regulated by histone H3 lysine 27 acetylation is a key driver of hyperhomocysteinemia-induced cognitive impairment.Targeting histone H3 lysine 27 acetylation-mediated epigenetic dysregulation may be a promising therapeutic strategy,offering potential avenues for intervention in individuals with cognitive impairment and neurodegenerative disorders.展开更多
At present,there is currently a lack of unified standard methods for the determination of antimony content in groundwater in China.The precision and trueness of related detection technologies have not yet been systema...At present,there is currently a lack of unified standard methods for the determination of antimony content in groundwater in China.The precision and trueness of related detection technologies have not yet been systematically and quantitatively evaluated,which limits the effective implementation of environmental monitoring.In response to this key technical gap,this study aimed to establish a standardized method for determining antimony in groundwater using Hydride Generation–Atomic Fluorescence Spectrometry(HG-AFS).Ten laboratories participated in inter-laboratory collaborative tests,and the statistical analysis of the test data was carried out in strict accordance with the technical specifications of GB/T 6379.2—2004 and GB/T 6379.4—2006.The consistency and outliers of the data were tested by Mandel's h and k statistics,the Grubbs test and the Cochran test,and the outliers were removed to optimize the data,thereby significantly improving the reliability and accuracy.Based on the optimized data,parameters such as the repeatability limit(r),reproducibility limit(R),and method bias value(δ)were determined,and the trueness of the method was statistically evaluated.At the same time,precision-function relationships were established,and all results met the requirements.The results show that the lower the antimony content,the lower the repeatability limit(r)and reproducibility limit(R),indicating that the measurement error mainly originates from the detection limit of the method and instrument sensitivity.Therefore,improving the instrument sensitivity and reducing the detection limit are the keys to controlling the analytical error and improving precision.This study provides reliable data support and a solid technical foundation for the establishment and evaluation of standardized methods for the determination of antimony content in groundwater.展开更多
基金supported by the Else Kröner-Fresenius-Stiftung(2021-EKSE.95)the Deutsche Forschungsgemeinschaft(CRC1678 and Germany’s Excellence Strategy-CECAD,EXC 2030-390661388)(to DV).
文摘Amyotrophic lateral sclerosis(ALS)is a fatal,late-onset neurodegenerative disorder characterized by the progressive degeneration of motor neurons in the motor cortex,brainstem,and spinal cord(Feldman et al.,2022).
基金support from the National Natural Science Foundation of China(No.22101267)the China Postdoctoral Science Foundation(Nos.2021M692905 and 2024T170832)+2 种基金Natural Science Foundation of Henan Province,China(No.242300421123)Scientific Research Project of Hubei Provincial Education Department,China(No.Q20233104)Hubei Provincial Natural Science Foundation,China(No.2024AFB946).
文摘Quinoxalin-2(1H)-ones are unique nitrogen-containing organic compounds with wide applications in the agrochemical,pharmaceutical,and chemical industries as well as in material science.During the last decades,visible-light-promoted photoredox catalysis has emerged as a versatile platform for constructing quinoxalin-2(1H)-one scaffolds under exceptionally mild conditions.In this review,we provide an overview of recent advances in photocatalytic direct C(3)–H functionalization of quinoxaline-2(1H)-ones,including the construction of C(3)–C bonds and C(3)–R_(F)/C/O/N/Cl/S/D bonds,as well as the related reaction mechanisms.We aim to enhance the methods for the reaction of quinoxalin-2(1H)-ones at the C-3 position,which have extensive applications in organic synthesis and medicinal chemistry.
基金supported by the National Natural Science Foundation of China(22479113,52101268)the Fundamental Research Funds for the Central Universities(buctrc202323)。
文摘Efficient alkaline hydrogen evolution reaction(HER)catalysts are critical for anion exchange membrane water electrolysis(AEMWE).However,the intrinsic scaling relationship between water dissociation and OH desorption fundamentally impedes designing catalysts requiring concurrent superior water dissociation and facile OH desorption.Here,we engineer a superhydrophilic Ru/Cr_(2)O_(3) heterostructured electrocatalyst through in situ confinement of Ru nanoparticles(5-10 nm)within a Cr_(2)O_(3) matrix.Acting as a Lewis acid,the Cr_(2)O_(3) component provides alternative sites for water dissociation,accelerating the Volmer step kinetics and downshifting the Ru d-band center via interfacial charge transfer,while simultaneously adsorbing OH-to form a surface-bound Lewis base that repels excess OH-from Ru sites,thereby suppressing hydroxyl over-adsorption.Concurrently,the superhydrophilic surface architecture promotes efficient hydrogen bubble release,thereby reducing mass transport resistance.As a result,the Ru/Cr_(2)O_(3) heterostructured electrocatalyst exhibits an ultralow overpotential of 36.7 mV at 10 mA cm^(-2) and a Tafel slope of 33.2 mV dec^(-1).Integrated into an AEMWE device,the electrode delivers500 mA cm^(-2) for 2000 h in 1.0 M KOH,underscoring its industrial viability(hydrogen production energy consumption per cubic meter(EW):3.94 kW h m^(-3);electricity-to-hydrogen energy conversion efficiency(η_(ETH)):89%@80℃).
基金supported by the Deep Earth Probe and Mineral Resources Exploration-National Science and Technology Major Project(Grant No.2025ZD005100)by Beijing Geolight Technology Co.,Ltd.under the project“The Impact of Strong Ground Motion on Buildings”(YF-202520).
文摘This study employed tri-component continuous monitoring data from 10 measurement points on both sides of a base isolation layer in the basement of a large-span high-rise building in Beijing,as well as from a free-field station and roof frame,during a Mw 5.5 magnitude earthquake in Pingyuan,Shandong,in 2023.The H/V spectral ratio method was used to evaluate the structural dynamic response characteristics of the building and analyze the regulatory effect of the base-isolation layer on seismic waves.The results indicate that during the earthquake,the peak frequency of the free-field and the measurement points below the base-isolation layer was stable at 0.17 Hz,whereas the main frequency of the measurement points above the base-isolation layer increased to 0.75–1.18 Hz,which is 4–6 times greater than that of the points below.The amplitude was suppressed by more than 70%,confirming that the base isolation layer effectively isolated the low-frequency energy from the ground and increased the response frequency of the building.When the building was excited by an earthquake,a three-tier frequency gradient was formed throughout the building:“base-isolation layer(0.17 Hz)-main body(1.18 Hz)-roof frame(3.83 Hz)”,which can effectively avoid resonance of the entire building.In addition,the composite base-isolation device changed the dynamic characteristics of the structure.The resonance period was extended from 0.74 s(theoretical value without base isolation)to 5.9 s(calculated value),and the resonance frequency was reduced from 1.35 to 0.17 Hz.This finding indicates that the base-isolation layer can enhance seismic performance by increasing flexibility and damping.
文摘Let G=(V,E)be a connected graph.For an integer h≥0,a subset F■V(G)(resp.F■E(G))of G,if any,is called an h-restricted vertex cut(resp.h-restricted edge cut)of G,if G-F is disconnected and every vertex in G-F has at least h neighbors.The cardinality of a minimum h-restricted vertex-cut(resp.h-restricted edge cut)of G is the h-restricted connectivity(resp.h-restricted edge connectivity)of G,and denoted by κ^(h)(G)(resp.λ^(h)(G)).The enhanced hypercube Q_(n,κ)(1≤k≤n)is a variant of the hypercube Q_(n).In this paper,we consider the h-restricted connectivity of Q_(n,κ) for 2≤k≤n-1.Our main results are as follows:(1)κ^(h)(Q_(n,κ))=2^(h)(n-h+1)for 4≤k≤n-1 and 0≤h≤n-3,λ^(h)(Q_(n,κ))=2^(h)(n-h+1)for 2≤k≤n-1 and 0≤h≤n-2.(2)κ^(h)(Q_(n,3))=2^(h-1)(n-h+1)for n≥5 and 4≤h≤n-1,κ^(h)(Q_(n,2))=2^(h-1)(n-h+1)for n≥4 and 3≤h≤n-1.(3)κ^(3)(Q_(n,3))=6n-16 for n≥5,κ^(2)(Q_(n,3))=4n-8 for n≥4 and κ^(2)(Q_(n,2))=3n-5 for n≥3,κ^(1)(Q_(n,3))=2n and κ^(3)(Q_(n,2))=2n-2 for n≥3.
文摘Introduction: Disaster damage to health systems is a human and health tragedy, results in huge economic losses, deals devastating blows to development goals, and shakes social confidence. Hospital disaster preparedness presents complex clinical operation. It is difficult philosophical challenge. It is difficult to determine how much time, money, and effort should be spent in preparing for an event that may not occur. Health facilities whether hospitals or rural health clinics, should be a source of strength during emergencies and disasters. They should be ready to save lives and to continue providing essential emergencies and disasters. Jeddah has relatively a level of disaster risk which is attributable to its geographical location, climate variability, topography, etc. This study investigates the hospital disaster preparedness (HDP) in Jeddah. Methods: Questionnaire was designed according to five Likert scales. It was divided into eight fields of 33 indicators: structure, architectural and furnishings, lifeline facilities’ safety, hospital location, utilities maintenance, surge capacity, emergency and disaster plan, and control of communication and coordination. Sample of six hospitals participated in the study and rated to the extent of disaster preparedness for each hospital disaster preparedness indicators. Two hazard tools were used to find out the hazards for each hospital. An assessment tool was designed to monitor progress and effectiveness of the hospitals’ improvement. Weakness was found in HDP level in the surveyed hospitals. Disaster mitigation needs more action including: risk assessment, structural and non-structural prevention, and preparedness for contingency planning and warning and evacuation. Conclusion: The finding shows that hospitals included in this study have tools and indicators in hospital preparedness but with lack of training and management during disaster. So the research shed light on hospital disaster preparedness. Considering the importance of preparedness in disaster, it is necessary for hospitals to understand that most of hospital disaster preparedness is built in the hospital system.
基金supported by the National Key Research and Development Program of China (2021YFD1800200)the National Natural Science Foundation of China (32170539)。
文摘Influenza A virus(IAV) has a wide host range,including wild birds,poultry,various mammals,and even humans(Xu et al.2024).Currently,two subtypes of canine influenza virus(CIV),H3N8 and H3N2,are primarily circulating in dogs.The H3N8 CIV was introduced from horses into dogs in 2004(Crawford et al.2005),while the H3N2 CIV originated from chickens in Asia in 2007(Song et al.2008).In China,H3N2 is the predominant CIV subtype,with a prevalence rate of up to 5.63% in the canine population,as reported by Chen et al.(2023).CIV infection typically manifests with symptoms such as coughing,sneezing,runny nose,and fever but is rarely fatal.However,co-infection with other pathogens(e.g.,Streptococcus,Mycoplasma or canine parainfluenza virus) can exacerbate symptoms and lead to lethal outcomes(Yondo et al.2023).
文摘Artificial photosynthesis presents a sustainable and cost-effective approach to harnessing solar energy to produce value-added chemicals[1,2].In particular,the simultaneous photocatalytic conversion of CO_(2)and H_(2)O into formic acid(HCOOH)and hydrogen peroxide(H2O2)has emerged as a promising strategy to mitigate global warming driven by CO_(2)emissions.HCOOH is a versatile chemical and hydrogen carrier,offering economic and practical advantages due to its compatibility with existing industrial processes and energy storage/conversion systems.Meanwhile,H_(2)O_(2)is among the world’s top 100 essential chemicals,with a global market valued at$4.0 billion in 2020 and projected to grow to$5.2 billion by 2026.
基金supported by the Science Research Start-up Fund for Doctor of Shanxi Medical University,No.SD2114(to JL).
文摘Cognitive impairment is a complex neurodegenerative disorder,and increased homocysteine levels are recognized as a major risk factor for this condition.Epigenetic modifications,particularly histone acetylation,have been implicated in the progression of cognitive impairment;however,the mechanisms underlying hyperhomocysteinemia-induced cognitive impairment remain unclear.In this study,we developed an hyperhomocysteinemia-induced cognitive impairment model by feeding mice a high-methionine diet and conducted behavioral and molecular analyses to elucidate the mechanisms involved in cognitive impairment.Behavioral experiments revealed significant cognitive deficits and neuroinflammation accompanied by a marked decrease in histone H3 lysine 27 acetylation in the hippocampus and cortex.Furthermore,metabolomic profiling and chromatin immunoprecipitation sequencing demonstrated substantial shifts in the levels of homocysteine metabolites and identified histone H3 lysine 27 acetylation-targeted genes involved in synaptic long-term potentiation,including Gria1,Gria3,Grin2a,Grin2b,Slc1a1,Slc24a2,Ptk2b,and Src.RNA sequencing confirmed that hyperhomocysteinemia induced neurodegeneration.In vitro experiments confirmed that decreased histone H3 lysine 27 acetylation downregulates the expression of these target genes in homocysteine-treated HT-22 cells,thereby impairing synaptic plasticity.Collectively,these findings suggest that aberrant expression of long-term potentiation-related genes regulated by histone H3 lysine 27 acetylation is a key driver of hyperhomocysteinemia-induced cognitive impairment.Targeting histone H3 lysine 27 acetylation-mediated epigenetic dysregulation may be a promising therapeutic strategy,offering potential avenues for intervention in individuals with cognitive impairment and neurodegenerative disorders.
基金supported by the National Natural Science Foundation of China(Project No.42307555).
文摘At present,there is currently a lack of unified standard methods for the determination of antimony content in groundwater in China.The precision and trueness of related detection technologies have not yet been systematically and quantitatively evaluated,which limits the effective implementation of environmental monitoring.In response to this key technical gap,this study aimed to establish a standardized method for determining antimony in groundwater using Hydride Generation–Atomic Fluorescence Spectrometry(HG-AFS).Ten laboratories participated in inter-laboratory collaborative tests,and the statistical analysis of the test data was carried out in strict accordance with the technical specifications of GB/T 6379.2—2004 and GB/T 6379.4—2006.The consistency and outliers of the data were tested by Mandel's h and k statistics,the Grubbs test and the Cochran test,and the outliers were removed to optimize the data,thereby significantly improving the reliability and accuracy.Based on the optimized data,parameters such as the repeatability limit(r),reproducibility limit(R),and method bias value(δ)were determined,and the trueness of the method was statistically evaluated.At the same time,precision-function relationships were established,and all results met the requirements.The results show that the lower the antimony content,the lower the repeatability limit(r)and reproducibility limit(R),indicating that the measurement error mainly originates from the detection limit of the method and instrument sensitivity.Therefore,improving the instrument sensitivity and reducing the detection limit are the keys to controlling the analytical error and improving precision.This study provides reliable data support and a solid technical foundation for the establishment and evaluation of standardized methods for the determination of antimony content in groundwater.
