Extended defects such as dislocation networks and general grain boundaries are ubiquitous in metals,and accurate modeling these extensive defects is crucial to elucidate their deformation mechanisms.However,existing m...Extended defects such as dislocation networks and general grain boundaries are ubiquitous in metals,and accurate modeling these extensive defects is crucial to elucidate their deformation mechanisms.However,existing machine learning interatomic potentials(MLIPs)often fall short in adequately describing these defects,as their large characteristic scales exceed the computational limits of firstprinciples calculations.To address this challenge,wepresent acomputational frameworkcombining a defect genome constructed via empirical interatomic potential-guided sampling,with an automated reconstruction technique that enables accurate first-principles modeling of general defects by converting atomic clusters into periodic configurations.The effectiveness of this approach was validated through simulations of nanoindentation,tensile deformation,and fracture in BCC tungsten.This framework enhances the modeling accuracy of extended defects in crystalline materials and provides a robust foundation for advancing MLIP development by leveraging defect genomes strategically.展开更多
Since its introduction,endoscopic ultrasound(EUS)guided fine needle aspiration and fine needle biopsy have become an indispensable tool for the diagnosis of lesions within the gastrointestinal tract and surrounding or...Since its introduction,endoscopic ultrasound(EUS)guided fine needle aspiration and fine needle biopsy have become an indispensable tool for the diagnosis of lesions within the gastrointestinal tract and surrounding organs.It has proved to be an effective diagnostic method with high accuracy and low complication rates.Several factors can influence the accuracy and the diagnostic yield of this procedure including experience of the endosonographer,availability of onsite cytopathology services,the method of cytopathology preparation,the location and physical characteristics of the lesion,sampling techniques and the type and size of the needle used.In this review we will outline the recent studies evaluating EUS-guided tissue acquisition and will provide practical recommendations to maximize tissue yield.展开更多
基金sponsored by Nederlandse Organisatie voor WetenschappelijkOnderzoek(The Netherlands Organization for Scientific Research,NWO)domain Science for the use of supercomputer facilities.
文摘Extended defects such as dislocation networks and general grain boundaries are ubiquitous in metals,and accurate modeling these extensive defects is crucial to elucidate their deformation mechanisms.However,existing machine learning interatomic potentials(MLIPs)often fall short in adequately describing these defects,as their large characteristic scales exceed the computational limits of firstprinciples calculations.To address this challenge,wepresent acomputational frameworkcombining a defect genome constructed via empirical interatomic potential-guided sampling,with an automated reconstruction technique that enables accurate first-principles modeling of general defects by converting atomic clusters into periodic configurations.The effectiveness of this approach was validated through simulations of nanoindentation,tensile deformation,and fracture in BCC tungsten.This framework enhances the modeling accuracy of extended defects in crystalline materials and provides a robust foundation for advancing MLIP development by leveraging defect genomes strategically.
文摘Since its introduction,endoscopic ultrasound(EUS)guided fine needle aspiration and fine needle biopsy have become an indispensable tool for the diagnosis of lesions within the gastrointestinal tract and surrounding organs.It has proved to be an effective diagnostic method with high accuracy and low complication rates.Several factors can influence the accuracy and the diagnostic yield of this procedure including experience of the endosonographer,availability of onsite cytopathology services,the method of cytopathology preparation,the location and physical characteristics of the lesion,sampling techniques and the type and size of the needle used.In this review we will outline the recent studies evaluating EUS-guided tissue acquisition and will provide practical recommendations to maximize tissue yield.
