Four alternative functions are used for lilting tree height and diameter growth models for mongolian oak(Quercus mongolica Fisch et Turcz)The data set includes 1250 random trees and 755 dominant trees coming from 510l...Four alternative functions are used for lilting tree height and diameter growth models for mongolian oak(Quercus mongolica Fisch et Turcz)The data set includes 1250 random trees and 755 dominant trees coming from 510lemporary plots The resultsshow that the Richads function is the best model for predicting height diameter at breast height(DBH) and dominant height from age The average growth curveof domnant height is used as a guide curve for the construction of a site index table which is partially validated using an independent data set The Mischerlic function is the bestmodel for estimating height and dominam height from DBH展开更多
Objective:To discuss the effect of Glycyrrhiza uralensis(G.uralensis) Fisch polysaccharide on growth performance and immunologic function in mice in Ural City,Xinjiang and to provide important data supporting the appl...Objective:To discuss the effect of Glycyrrhiza uralensis(G.uralensis) Fisch polysaccharide on growth performance and immunologic function in mice in Ural City,Xinjiang and to provide important data supporting the application of Glycyrrhiza polysaccharide.Methods:A total of100 Kunming mice aged 3 weeks old were randomly divided into 5 groups with 20 mice in each group(10 were females and 10 were males).About 0.5 mL normal saline was given to the mice of control group every day and 0.5 mL G.uralensis Fisch polysaccharide was given to the mice of other groups at the concentration of 1,20,50 and 100 mg/mL respectively.The growth performance(average body weight,average daily feed intake and feed efficiency),immune organ indexes(spleen index and thymus index) and immunologic function(serum IL-2,CD4^+/CD8^+ and the activity of NK cells) of mice in each group were detected continuously.Results:The average body weight,feed efficiency,serum IL-2,CD4^+/CD8^+ and the activity of NK cells of mice were increased with the increase of administrated time after administrating G.uralensis Fisch polysaccharide and were reached up the largest level on Day 28.At the same time,each index was proportional to the given dose and was significantly higher than those of control group and reached up the largest level at the administrated dose of 100 mg/mL.After administrating G.uralensis Fisch polysaccharide,the spleen index and thymus index of mice were increased with the increase of administrated dose and the spleen index and thymus index of mice administrated with the dose of 100 mg/mL were maximum which was more than 1.51 times and 1.43 times of that in control group respectively and the comparative differences showed statistical significance(P<0.05).The average daily feed intake of mice in each group was increased with the passage of lime and at the same time,the comparison of average daily feed intake of mice in each group was not significantly different(P>0.05).Conclusions:G.uralensis Fisch polysaccharide can significantly improve the growth performance and immunologic function of mice and laid a research basis for the clinical application of G.uralensis Fisch polysaccharide.展开更多
Covariance functions have been proposed as an alternative to model longitudinal data in animal breeding because of their various merits in comparison to the classical analytical methods.In practical estimation,differe...Covariance functions have been proposed as an alternative to model longitudinal data in animal breeding because of their various merits in comparison to the classical analytical methods.In practical estimation,different models and polynomial orders fitted can influence the estimates of covariance functions and thus genetic parameters.The objective of this study was to select model for estimation of covariance functions for body weights of Angora goats at 7 time points.Covariance functions were estimated by fitting 6 random regression models with birth year,birth month,sex,age of dam,birth type,and relative birth date as fixed effects.Random effects involved were direct and maternal additive genetic,and animal and maternal permanent environmental effects with different orders of fit.Selection of model and orders of fit were carried out by likelihood ratio test and 4 types of information criteria.The results showed that model with 6 orders of polynomial fit for direct additive genetic and animal permanent environmental effects and 4 and 5 orders for maternal genetic and permanent environmental effects,respectively,were preferable for estimation of covariance functions.Models with and without maternal effects influenced the estimates of covariance functions greatly.Maternal permanent environmental effect does not explain the variation of all permanent environments,well suggesting different sources of permanent environmental effects also has large influence on covariance function estimates.展开更多
For a continuous,increasing functionω:[0,∞)→C of finite exponential type,we establish a Hille-Yosida type theorem for strongly continuous α-times(α>0)integrated cosine operator functions with O(ω).It includes...For a continuous,increasing functionω:[0,∞)→C of finite exponential type,we establish a Hille-Yosida type theorem for strongly continuous α-times(α>0)integrated cosine operator functions with O(ω).It includes the corresponding results for n-times integrated cosine operator functions that are polynomially bounded and exponentially bounded.展开更多
Phytochrome family mainly senses red and far-red light to regulate a range of developmental processes throughout the life cycle of plants. Rice phytochrome gene family is composed of three members known as PHYA, PHYB ...Phytochrome family mainly senses red and far-red light to regulate a range of developmental processes throughout the life cycle of plants. Rice phytochrome gene family is composed of three members known as PHYA, PHYB and PHYC. It has been elucidated that individual phytochromes display both unique and overlapping roles in rice photomorphogenesis by characterization of all rice phytochrome mutants including single mutants, all combinations of double mutants as well as triple mutants. Based on the published data and authors’ ongoing studies, current knowledge of rice phytochrome functions in regulating seedling de-etiolation, root gravitropic response and elongation, plant architecture, flowering time and fertility is summarized. Additionally, the important issues in the field of rice phytochromes are proposed.展开更多
The expression and function in growth and apoptosis of the renin-angiotensin system(RAS)was evaluated inhuman glioblastoma.Renin and angiotensinogen(AGT)mRNAs and proteins were found by in situ hybridisationand immuno...The expression and function in growth and apoptosis of the renin-angiotensin system(RAS)was evaluated inhuman glioblastoma.Renin and angiotensinogen(AGT)mRNAs and proteins were found by in situ hybridisationand immunohistochemistry in glioblastoma cells.Angiotensinogen was present in glioblastoma cystic fluids.Thus,human glioblastoma cells produce renin and AGT and secrete AGT.Human glioblastoma and glioblastoma cellsexpressed renin,AGT,renin receptor,AT(2)and/or AT(1)mRNAs and proteins determined by RT-PCR and/展开更多
In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint （DU 20）. Motor and sensory function was tested...In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint （DU 20）. Motor and sensory function was tested using Garcia’s scale and motor weakness grading, and the expression of vascular endothelial growth factor in the brain was quantified using immunoblotting and immunohistochemistry. We found that scalp electroacupuncture at DU 20 significantly improved motor performance and sensory function in rats with stroke, and this was accompanied by an increased expression of vascular endothelial growth factor in the ischemic brain tissue and peri-ischemic area. In addition, Pearson correlation analysis showed that the improvements in functional recovery were correlated with the increased expression of vascular endothelial growth factor.展开更多
No attempt has been made to date to model growth in girth of rubber tree （Hevea brasiliansis）. We evaluated the few widely used growth functions to identify the most parsimonious and biologically reasonable model fo...No attempt has been made to date to model growth in girth of rubber tree （Hevea brasiliansis）. We evaluated the few widely used growth functions to identify the most parsimonious and biologically reasonable model for describing the girth growth of young rubber trees based on an incomplete set of young age measurements. Monthly data for girth of immature trees （age 2 to 12 yearsi from two locations were sub- jected to modelling. Re-parameterized, unconstrained and constrained growth functions,of Richards （RM）, Gompertz （GM） and the monomo- lecular ＇model ^（MM） were fitted to data. Duration of growth was the firsf constraint introduced. In the stagel We attempted a population aver- age （PA） model to capture the trend in growth. The best PA model was fitted as a subject specific （SS） model. We used appropriate error vari- ance-covariance structure to account for correlation due to repeated measurements over time. Unconstrainecl functions underestimated the asymptotic maximum that did not reflective carrying capacity of the locations. Underestimafions were attributed to the partial set＇ of meas- urements made during the early growth phase of the trees. MM proved superior to RM and GM. In the randomcoefficient models, both Gf and Go appeared to be influenced by tree level effects. Inclusion of diagonal definite positive matrix removed the correlation between random effects. The results were similar at both locations. In the overall assessment MM appeared as the candidate model for studying the girth-age relationships in Hevea trees. Based on the fitted model we conclude that, in Hevea trees, growth rate is maintained at maximum value at to, then decreases until the final state at dG/dt 〉 0, resulting in yield curve with no period of accelerating growth. One physiological explanation is that photosynthetic activity in Hevea trees decreases as girth increases and constructive metabolism is larger than destructive metabolism.展开更多
For a continuous increasing function ω ： [0, ∞） → （0, ∞） of finite exponetial type, we establish a Hille-Yosida type theorem for strongly continuous integrated cosine operator functions with O（ω）. It includ...For a continuous increasing function ω ： [0, ∞） → （0, ∞） of finite exponetial type, we establish a Hille-Yosida type theorem for strongly continuous integrated cosine operator functions with O（ω）. It includes the well-known polynomially bounded and exponentially bounded cases.展开更多
The Chapman-Richards Function and its two exception cases in applications were discussed and compared with the Schnute model in stand growth studies. Compared from all perspective, it was found that the Schnute model ...The Chapman-Richards Function and its two exception cases in applications were discussed and compared with the Schnute model in stand growth studies. Compared from all perspective, it was found that the Schnute model commonly used in foreitry was identical to the Chapman-Richards function. If some parameter in the Chapman-Richdrds Function was unconstraint, the function could also be very versatile to fit some exceptional growth curves, the fitted function should be identical to that the Schnute model.展开更多
Previous molecular analyses of human astrocytomas have identified many genetic changes associated with astrocy-toma formation and progression.In an effort to identify novel gene expression changes associated with astr...Previous molecular analyses of human astrocytomas have identified many genetic changes associated with astrocy-toma formation and progression.In an effort to identify novel gene expression changes associated with astrocytomaformation,which might reveal new potential targets for glioma therapeutic drug design,we used the B8-RAS-transgenic mouse astrocytoma model.Using multiplex gene expression profiling,we found that展开更多
Mr.Jiang Zcmin,Gencral-Seerctary of the Cen-tral Committee of the Chincse Communist Party and.Chairman of the People's Republic of China,in a rC-ccnt spcech cm phasized that the family planning pro-gramme should b...Mr.Jiang Zcmin,Gencral-Seerctary of the Cen-tral Committee of the Chincse Communist Party and.Chairman of the People's Republic of China,in a rC-ccnt spcech cm phasized that the family planning pro-gramme should be strictly and effectively im plemented in 1994,a year of crucial importance for promoting re-form and opening and thc drive lowards.modernization.To makc continucd contributions to the sociocconomic development in the country,we must fulfil the plan for controlling population growth..The spcech was delivcred at the anua!National Fo-rum on Family Planning Work convened jointly by the Party's Central Committcc and the Statc Council.展开更多
In this paper, we obtain an estimate for the lower bound for the dimensions of harmonic functions with polynomial growth and a Liouville type theorem on manifolds with nonnegative Ricci curvature whose tangent cone at...In this paper, we obtain an estimate for the lower bound for the dimensions of harmonic functions with polynomial growth and a Liouville type theorem on manifolds with nonnegative Ricci curvature whose tangent cone at infinity is a unique metric cone with a conic measure.展开更多
[Objectives]To investigate the effect of diet with Picria fel-tarrae Lour particle(PFLp)on growth performance,blood biochemical indexes,immune and antioxidant function of Hongguang yellow chickens(HYC).[Methods]80 HYC...[Objectives]To investigate the effect of diet with Picria fel-tarrae Lour particle(PFLp)on growth performance,blood biochemical indexes,immune and antioxidant function of Hongguang yellow chickens(HYC).[Methods]80 HYC in age of 1 d were divided into 4 groups randomly and each group was assigned to 5 replicates with 24 chicks in each replicate.Group A was control group fed only basal diet.Group B,C and D were treatment groups and fed diets with 0.125%,0.25%and 0.50%of PFLp respectively during the trial of 49 d.Serum samples were taken from 10 chicks in each group in the age of 21,35 and 49 d respectively and analyzed for biochemical,immune and antioxidant parameters in blood.[Results]ADG from group C in 21 d was increased significantly than that from group A,B and D(P<0.01),and ADG in 35 d from group C was also significantly greater than that from group A,B and D(P<0.05),but not much difference was found on ADG among the 4 groups in 49 d(P>0.05);ADFI from group C in 35 d was significantly higher than that from group A,B and D(P<0.05).ADFI from group C in 21 and 49 d were also higher than that from group A(P>0.05).FCR from group C in 21 d was much better than that from the other three groups(P<0.01).Death rate of group C was 50 percent lower than group A;There was no difference occurred in serum biochemical and immune parameters among the 4 groups during the trial(P>0.05).However,the T-AOC from group C and D in 21 d was enhanced significantly than that from group A and B(P<0.01),and the one from group C in 35 d was also increased greatly than that from group A,B and D(P<0.05).GSH from group C and D in 21 d was much higher than that from group A and B(P<0.05),and the ones from group C and D in 35 d were also significantly higher than those from group A and B(P<0.01).T-SOD in three stages trended up also in group C and D(P>0.05).[Conclusions]The diet with 0.25%PFLp in 21 and 35 d could dramatically improve the growth performance,significantly increase the antioxidant capacity and effectively reduce death rate.Diet with 0.25%PFLp is the most appropriate among the three different additions.展开更多
We review the biology and role of transforming growth factor beta 1 （TGF-β1） in peripheral nerve injury and regeneration, as it relates to injuries to large nerve trunks （i.e., sciatic nerve, brachial plexus）, wh...We review the biology and role of transforming growth factor beta 1 （TGF-β1） in peripheral nerve injury and regeneration, as it relates to injuries to large nerve trunks （i.e., sciatic nerve, brachial plexus）, which often leads to suboptimal functional recovery. Experimental studies have suggested that the reason for the lack of functional recovery resides in the lack of sufficient mature axons reaching their targets, which is a result of the loss of the growth-supportive environment provided by the Schwann cells in the distal stump of injured nerves. Using an established chronic nerve injury and delayed repair animal model that accu- rately mimics chronic nerve injuries in humans, we summarize our key findings as well as others to better understand the pathophysiology of poor functional recovery. We demonstrated that 6 month TGF-β1 treat- ment for chronic nerve injury significantly improved Schwann cell capacity to support axonal regeneration. When combined with forskolin, the effect was additive, as evidenced by a near doubling of regenerated axons proximal to the repair site. We showed that in vivo application of TGF-β1 and forskolin directly onto chronically injured nerves reactivated chronically denervated Schwann cells, induced their proliferation, and upregulated the expression of regeneration-associated proteins. The effect of TGF-β1 and forskolin on old nerve injuries is quite impressive and the treatment regiment appears to mediate a growth-supportive milieu in the injured peripheral nerves. In summary, TGF-β1 and forskolin treatment reactivates chronical- ly denervated Schwann cells and could potentially be used to extend and prolong the regenerative responses to promote axonal regeneration.展开更多
OBJECTIVE: To investigate the effect of brain functional recovery decoction(BFRD) on expression of vascular endothelial growth factor(VEGF) and angiopoietin-1(Ang-1) protein in rats with cerebral ischemia reperfusion ...OBJECTIVE: To investigate the effect of brain functional recovery decoction(BFRD) on expression of vascular endothelial growth factor(VEGF) and angiopoietin-1(Ang-1) protein in rats with cerebral ischemia reperfusion injury, and to explore the mechanism of action of BFRD.METHODS: Using the suture-occlusion method, a Wistar rat model of focal cerebral ischemia reperfusion was established. The rats were randomly divided into treatment group, model group, and sham operation group. The treatment group was administered BFRD. In situ hybridization was used to detect VEGF m RNA expression. Immunohistochemistry was used to observe expression of Ang-1 protein.RESULTS: VEGF mRNA expression was greater in the model group compared with the sham operation group(P < 0.05); Ang-1 protein expression was more obvious in the treatment group than the model group(P < 0.05).CONCLUSION: BFRD promoted VEGF m RNA and Ang-1 protein expression in the brains of rats with cerebral ischemia, suggesting increased angiogenesis.展开更多
文摘Four alternative functions are used for lilting tree height and diameter growth models for mongolian oak(Quercus mongolica Fisch et Turcz)The data set includes 1250 random trees and 755 dominant trees coming from 510lemporary plots The resultsshow that the Richads function is the best model for predicting height diameter at breast height(DBH) and dominant height from age The average growth curveof domnant height is used as a guide curve for the construction of a site index table which is partially validated using an independent data set The Mischerlic function is the bestmodel for estimating height and dominam height from DBH
基金supported by Scientific Research Innovation Project of Graduate Education Innovation Fund from Xinjiang(Grant No. XJGRI2014057)
文摘Objective:To discuss the effect of Glycyrrhiza uralensis(G.uralensis) Fisch polysaccharide on growth performance and immunologic function in mice in Ural City,Xinjiang and to provide important data supporting the application of Glycyrrhiza polysaccharide.Methods:A total of100 Kunming mice aged 3 weeks old were randomly divided into 5 groups with 20 mice in each group(10 were females and 10 were males).About 0.5 mL normal saline was given to the mice of control group every day and 0.5 mL G.uralensis Fisch polysaccharide was given to the mice of other groups at the concentration of 1,20,50 and 100 mg/mL respectively.The growth performance(average body weight,average daily feed intake and feed efficiency),immune organ indexes(spleen index and thymus index) and immunologic function(serum IL-2,CD4^+/CD8^+ and the activity of NK cells) of mice in each group were detected continuously.Results:The average body weight,feed efficiency,serum IL-2,CD4^+/CD8^+ and the activity of NK cells of mice were increased with the increase of administrated time after administrating G.uralensis Fisch polysaccharide and were reached up the largest level on Day 28.At the same time,each index was proportional to the given dose and was significantly higher than those of control group and reached up the largest level at the administrated dose of 100 mg/mL.After administrating G.uralensis Fisch polysaccharide,the spleen index and thymus index of mice were increased with the increase of administrated dose and the spleen index and thymus index of mice administrated with the dose of 100 mg/mL were maximum which was more than 1.51 times and 1.43 times of that in control group respectively and the comparative differences showed statistical significance(P<0.05).The average daily feed intake of mice in each group was increased with the passage of lime and at the same time,the comparison of average daily feed intake of mice in each group was not significantly different(P>0.05).Conclusions:G.uralensis Fisch polysaccharide can significantly improve the growth performance and immunologic function of mice and laid a research basis for the clinical application of G.uralensis Fisch polysaccharide.
基金funded by the Young Academic Leaders Supporting Project in Institutions of Higher Education of Shanxi Province,China
文摘Covariance functions have been proposed as an alternative to model longitudinal data in animal breeding because of their various merits in comparison to the classical analytical methods.In practical estimation,different models and polynomial orders fitted can influence the estimates of covariance functions and thus genetic parameters.The objective of this study was to select model for estimation of covariance functions for body weights of Angora goats at 7 time points.Covariance functions were estimated by fitting 6 random regression models with birth year,birth month,sex,age of dam,birth type,and relative birth date as fixed effects.Random effects involved were direct and maternal additive genetic,and animal and maternal permanent environmental effects with different orders of fit.Selection of model and orders of fit were carried out by likelihood ratio test and 4 types of information criteria.The results showed that model with 6 orders of polynomial fit for direct additive genetic and animal permanent environmental effects and 4 and 5 orders for maternal genetic and permanent environmental effects,respectively,were preferable for estimation of covariance functions.Models with and without maternal effects influenced the estimates of covariance functions greatly.Maternal permanent environmental effect does not explain the variation of all permanent environments,well suggesting different sources of permanent environmental effects also has large influence on covariance function estimates.
基金Supported by the Natural Science Foundation of Department of Education of Jiangsu Province（06KJD110087） Supported by the Youth Foundation of NanJing Audit University（NSK2009/C04）
文摘For a continuous,increasing functionω:[0,∞)→C of finite exponential type,we establish a Hille-Yosida type theorem for strongly continuous α-times(α>0)integrated cosine operator functions with O(ω).It includes the corresponding results for n-times integrated cosine operator functions that are polynomially bounded and exponentially bounded.
基金supported by the grants from the Chinese National Natural Science Foundations (Grant Nos. 30870192 and 30971744)the National Major Science and Technology Project to Create New Crop Varieties Using Gene Transfer Technical (Grant No. 2009ZX08001-029B)the Open Research Program from the Key Laboratory of Crop Biology, China (Grant No. 2009KF04)
文摘Phytochrome family mainly senses red and far-red light to regulate a range of developmental processes throughout the life cycle of plants. Rice phytochrome gene family is composed of three members known as PHYA, PHYB and PHYC. It has been elucidated that individual phytochromes display both unique and overlapping roles in rice photomorphogenesis by characterization of all rice phytochrome mutants including single mutants, all combinations of double mutants as well as triple mutants. Based on the published data and authors’ ongoing studies, current knowledge of rice phytochrome functions in regulating seedling de-etiolation, root gravitropic response and elongation, plant architecture, flowering time and fertility is summarized. Additionally, the important issues in the field of rice phytochromes are proposed.
文摘The expression and function in growth and apoptosis of the renin-angiotensin system(RAS)was evaluated inhuman glioblastoma.Renin and angiotensinogen(AGT)mRNAs and proteins were found by in situ hybridisationand immunohistochemistry in glioblastoma cells.Angiotensinogen was present in glioblastoma cystic fluids.Thus,human glioblastoma cells produce renin and AGT and secrete AGT.Human glioblastoma and glioblastoma cellsexpressed renin,AGT,renin receptor,AT(2)and/or AT(1)mRNAs and proteins determined by RT-PCR and/
基金the Incheon St. Mary’s Hospital of the Catholic University of Korea, through the Clinical Research Laboratory Foundation Program, Korea Health 21 R&D Project, No. A092058, and WCU Neurocytomics
文摘In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint （DU 20）. Motor and sensory function was tested using Garcia’s scale and motor weakness grading, and the expression of vascular endothelial growth factor in the brain was quantified using immunoblotting and immunohistochemistry. We found that scalp electroacupuncture at DU 20 significantly improved motor performance and sensory function in rats with stroke, and this was accompanied by an increased expression of vascular endothelial growth factor in the ischemic brain tissue and peri-ischemic area. In addition, Pearson correlation analysis showed that the improvements in functional recovery were correlated with the increased expression of vascular endothelial growth factor.
文摘No attempt has been made to date to model growth in girth of rubber tree （Hevea brasiliansis）. We evaluated the few widely used growth functions to identify the most parsimonious and biologically reasonable model for describing the girth growth of young rubber trees based on an incomplete set of young age measurements. Monthly data for girth of immature trees （age 2 to 12 yearsi from two locations were sub- jected to modelling. Re-parameterized, unconstrained and constrained growth functions,of Richards （RM）, Gompertz （GM） and the monomo- lecular ＇model ^（MM） were fitted to data. Duration of growth was the firsf constraint introduced. In the stagel We attempted a population aver- age （PA） model to capture the trend in growth. The best PA model was fitted as a subject specific （SS） model. We used appropriate error vari- ance-covariance structure to account for correlation due to repeated measurements over time. Unconstrainecl functions underestimated the asymptotic maximum that did not reflective carrying capacity of the locations. Underestimafions were attributed to the partial set＇ of meas- urements made during the early growth phase of the trees. MM proved superior to RM and GM. In the randomcoefficient models, both Gf and Go appeared to be influenced by tree level effects. Inclusion of diagonal definite positive matrix removed the correlation between random effects. The results were similar at both locations. In the overall assessment MM appeared as the candidate model for studying the girth-age relationships in Hevea trees. Based on the fitted model we conclude that, in Hevea trees, growth rate is maintained at maximum value at to, then decreases until the final state at dG/dt 〉 0, resulting in yield curve with no period of accelerating growth. One physiological explanation is that photosynthetic activity in Hevea trees decreases as girth increases and constructive metabolism is larger than destructive metabolism.
文摘For a continuous increasing function ω ： [0, ∞） → （0, ∞） of finite exponetial type, we establish a Hille-Yosida type theorem for strongly continuous integrated cosine operator functions with O（ω）. It includes the well-known polynomially bounded and exponentially bounded cases.
文摘The Chapman-Richards Function and its two exception cases in applications were discussed and compared with the Schnute model in stand growth studies. Compared from all perspective, it was found that the Schnute model commonly used in foreitry was identical to the Chapman-Richards function. If some parameter in the Chapman-Richdrds Function was unconstraint, the function could also be very versatile to fit some exceptional growth curves, the fitted function should be identical to that the Schnute model.
文摘Previous molecular analyses of human astrocytomas have identified many genetic changes associated with astrocy-toma formation and progression.In an effort to identify novel gene expression changes associated with astrocytomaformation,which might reveal new potential targets for glioma therapeutic drug design,we used the B8-RAS-transgenic mouse astrocytoma model.Using multiplex gene expression profiling,we found that
文摘Mr.Jiang Zcmin,Gencral-Seerctary of the Cen-tral Committee of the Chincse Communist Party and.Chairman of the People's Republic of China,in a rC-ccnt spcech cm phasized that the family planning pro-gramme should be strictly and effectively im plemented in 1994,a year of crucial importance for promoting re-form and opening and thc drive lowards.modernization.To makc continucd contributions to the sociocconomic development in the country,we must fulfil the plan for controlling population growth..The spcech was delivcred at the anua!National Fo-rum on Family Planning Work convened jointly by the Party's Central Committcc and the Statc Council.
基金partially supported by NSFC(11701580and 11521101)the Fundamental Research Funds for the Central Universities(17lgpy13)
文摘In this paper, we obtain an estimate for the lower bound for the dimensions of harmonic functions with polynomial growth and a Liouville type theorem on manifolds with nonnegative Ricci curvature whose tangent cone at infinity is a unique metric cone with a conic measure.
基金Supported by Special Fund Project for Basic Research in Guangxi Public Welfare Research Special Project for Innovation in Guangxi(AA17204024)Scientific and Technological Research Project in Guangxi(14121003-3)Nanning Scientific Research and Technology Development Program(20155181)
文摘[Objectives]To investigate the effect of diet with Picria fel-tarrae Lour particle(PFLp)on growth performance,blood biochemical indexes,immune and antioxidant function of Hongguang yellow chickens(HYC).[Methods]80 HYC in age of 1 d were divided into 4 groups randomly and each group was assigned to 5 replicates with 24 chicks in each replicate.Group A was control group fed only basal diet.Group B,C and D were treatment groups and fed diets with 0.125%,0.25%and 0.50%of PFLp respectively during the trial of 49 d.Serum samples were taken from 10 chicks in each group in the age of 21,35 and 49 d respectively and analyzed for biochemical,immune and antioxidant parameters in blood.[Results]ADG from group C in 21 d was increased significantly than that from group A,B and D(P<0.01),and ADG in 35 d from group C was also significantly greater than that from group A,B and D(P<0.05),but not much difference was found on ADG among the 4 groups in 49 d(P>0.05);ADFI from group C in 35 d was significantly higher than that from group A,B and D(P<0.05).ADFI from group C in 21 and 49 d were also higher than that from group A(P>0.05).FCR from group C in 21 d was much better than that from the other three groups(P<0.01).Death rate of group C was 50 percent lower than group A;There was no difference occurred in serum biochemical and immune parameters among the 4 groups during the trial(P>0.05).However,the T-AOC from group C and D in 21 d was enhanced significantly than that from group A and B(P<0.01),and the one from group C in 35 d was also increased greatly than that from group A,B and D(P<0.05).GSH from group C and D in 21 d was much higher than that from group A and B(P<0.05),and the ones from group C and D in 35 d were also significantly higher than those from group A and B(P<0.01).T-SOD in three stages trended up also in group C and D(P>0.05).[Conclusions]The diet with 0.25%PFLp in 21 and 35 d could dramatically improve the growth performance,significantly increase the antioxidant capacity and effectively reduce death rate.Diet with 0.25%PFLp is the most appropriate among the three different additions.
文摘We review the biology and role of transforming growth factor beta 1 （TGF-β1） in peripheral nerve injury and regeneration, as it relates to injuries to large nerve trunks （i.e., sciatic nerve, brachial plexus）, which often leads to suboptimal functional recovery. Experimental studies have suggested that the reason for the lack of functional recovery resides in the lack of sufficient mature axons reaching their targets, which is a result of the loss of the growth-supportive environment provided by the Schwann cells in the distal stump of injured nerves. Using an established chronic nerve injury and delayed repair animal model that accu- rately mimics chronic nerve injuries in humans, we summarize our key findings as well as others to better understand the pathophysiology of poor functional recovery. We demonstrated that 6 month TGF-β1 treat- ment for chronic nerve injury significantly improved Schwann cell capacity to support axonal regeneration. When combined with forskolin, the effect was additive, as evidenced by a near doubling of regenerated axons proximal to the repair site. We showed that in vivo application of TGF-β1 and forskolin directly onto chronically injured nerves reactivated chronically denervated Schwann cells, induced their proliferation, and upregulated the expression of regeneration-associated proteins. The effect of TGF-β1 and forskolin on old nerve injuries is quite impressive and the treatment regiment appears to mediate a growth-supportive milieu in the injured peripheral nerves. In summary, TGF-β1 and forskolin treatment reactivates chronical- ly denervated Schwann cells and could potentially be used to extend and prolong the regenerative responses to promote axonal regeneration.
基金International Cooperation Projects of Shaanxi Province(The Protection on Ischemia-reperfusion Rats and the influence of VEGF RNA Expression of Brain Functional Recovery Decoction,No.2012-Kw-33-02)
文摘OBJECTIVE: To investigate the effect of brain functional recovery decoction(BFRD) on expression of vascular endothelial growth factor(VEGF) and angiopoietin-1(Ang-1) protein in rats with cerebral ischemia reperfusion injury, and to explore the mechanism of action of BFRD.METHODS: Using the suture-occlusion method, a Wistar rat model of focal cerebral ischemia reperfusion was established. The rats were randomly divided into treatment group, model group, and sham operation group. The treatment group was administered BFRD. In situ hybridization was used to detect VEGF m RNA expression. Immunohistochemistry was used to observe expression of Ang-1 protein.RESULTS: VEGF mRNA expression was greater in the model group compared with the sham operation group(P < 0.05); Ang-1 protein expression was more obvious in the treatment group than the model group(P < 0.05).CONCLUSION: BFRD promoted VEGF m RNA and Ang-1 protein expression in the brains of rats with cerebral ischemia, suggesting increased angiogenesis.
