Let p be a prime. For any finite p-group G, the deep transfers T H,G ' : H / H ' → G ' / G " from the maximal subgroups H of index (G:H) = p in G to the derived subgroup G ' are introduced as an ...Let p be a prime. For any finite p-group G, the deep transfers T H,G ' : H / H ' → G ' / G " from the maximal subgroups H of index (G:H) = p in G to the derived subgroup G ' are introduced as an innovative tool for identifying G uniquely by means of the family of kernels ùd(G) =(ker(T H,G ')) (G: H) = p. For all finite 3-groups G of coclass cc(G) = 1, the family ùd(G) is determined explicitly. The results are applied to the Galois groups G =Gal(F3 (∞)/ F) of the Hilbert 3-class towers of all real quadratic fields F = Q(√d) with fundamental discriminants d > 1, 3-class group Cl3(F) □ C3 × C3, and total 3-principalization in each of their four unramified cyclic cubic extensions E/F. A systematic statistical evaluation is given for the complete range 1 d 7, and a few exceptional cases are pointed out for 1 d 8.展开更多
Based on a general theory of descendant trees of finite p-groups and the virtual periodicity isomorphisms between the branches of a coclass subtree, the behavior of algebraic invariants of the tree vertices and their ...Based on a general theory of descendant trees of finite p-groups and the virtual periodicity isomorphisms between the branches of a coclass subtree, the behavior of algebraic invariants of the tree vertices and their automorphism groups under these isomorphisms is described with simple transformation laws. For the tree of finite 3-groups with elementary bicyclic commutator qu-otient, the information content of each coclass subtree with metabelian main-line is shown to be finite. As a striking novelty in this paper, evidence is provided of co-periodicity isomorphisms between coclass forests which reduce the information content of the entire metabelian skeleton and a significant part of non-metabelian vertices to a finite amount of data.展开更多
Let 0<γ<π be a fixed pythagorean angle. We study the abelian group Hr of primitive integral triangles (a,b,c) for which the angle opposite side c is γ. Addition in Hr is defined by adding the angles β opposi...Let 0<γ<π be a fixed pythagorean angle. We study the abelian group Hr of primitive integral triangles (a,b,c) for which the angle opposite side c is γ. Addition in Hr is defined by adding the angles β opposite side b and modding out by π-γ. The only Hr for which the structure is known is Hπ/2, which is free abelian. We prove that for generalγ, Hr has an element of order two iff 2(1- cosγ) is a rational square, and it has elements of order three iff the cubic (2cosγ)x3-3x2+1=0 has a rational solution 0<x<1. This shows that the set of values ofγ for which Hr has two-torsion is dense in [0, π], and similarly for three-torsion. We also show that there is at most one copy of either Z2 or Z3 in Hr. Finally, we give some examples of higher order torsion elements in Hr.展开更多
Theoretical background and an implementation of the p-group generation algorithm by Newman and O’Brien are used to provide computational evidence of a new type of periodically repeating patterns in pruned descendant ...Theoretical background and an implementation of the p-group generation algorithm by Newman and O’Brien are used to provide computational evidence of a new type of periodically repeating patterns in pruned descendant trees of finite p-groups.展开更多
The present note is concerned with two connected and highly important fundamental questions of physics and cosmology, namely if E8E8 Lie symmetry group describes the universe and where cosmic dark energy comes from. F...The present note is concerned with two connected and highly important fundamental questions of physics and cosmology, namely if E8E8 Lie symmetry group describes the universe and where cosmic dark energy comes from. Furthermore, we reason following Wheeler, Hartle and Hawking that since the boundary of a boundary is an empty set which models the quantum wave of the cosmos, then it follows that dark energy is a fundamental physical phenomenon associated with the boundary of the holographic boundary. This leads directly to a clopen universe which is its own Penrose tiling-like multiverse with energy density in full agreement with COBE, WMAP and Type 1a supernova cosmic measurements.展开更多
In order to generalize the relativistic notion of boost to the case of non inertial particles and to general relativity, we look closer into the definition of the Lie group of Lorentz matrices and its Lie algebra and ...In order to generalize the relativistic notion of boost to the case of non inertial particles and to general relativity, we look closer into the definition of the Lie group of Lorentz matrices and its Lie algebra and we study how this group acts on the Minskowski space. We thus define the notion of tangent boost along a worldline. This very general notion gives a useful tool both in special relativity (for non inertial particles or/and for non rectilinear coordinates) and in general relativity. We also introduce a matrix of the Lie algebra which, together with the tangent boost, gives the whole dynamical description of the considered system (acceleration and Thomas rotation). After studying the properties of Lie algebra matrices and their reduced forms, we show that the Lie group of special Lorentz matrices has four one-parameter subgroups. These tools lead us to introduce the Thomas rotation in a quite general way. At the end of the paper, we present some examples using these tools and we consider the case of an electron rotating on a circular orbit around an atom nucleus. We then discuss the twin paradox and we show that when the one who made a journey into space in a high-speed rocket returns home, he is not only younger than the twin who stayed on Earth but he is also disorientated because his gyroscope has turned with respect to earth referential frame.展开更多
'Acompany shall have its commitment to build a century-old business if it hopes to continue operation for a long time.'John Soo is the third generation of Chinese immigrants in Malaysia and CEO of Ally Biz Int...'Acompany shall have its commitment to build a century-old business if it hopes to continue operation for a long time.'John Soo is the third generation of Chinese immigrants in Malaysia and CEO of Ally Biz International Group. His forefathers were engaged in traditional plantation business. As a new-generation Malaysian Chinese who have received higher education and worked in many international companies as accountant or CEO, John Soo found that the business opportunities in traditional plantation industry has becoming slim. The challenge is to seek a better business project for new breakthroughs.展开更多
BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung inju...BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis.展开更多
AIM: To investigate the molecular mechanisms underlying the reversal effect of emodin on platinum resistance in hepatocellular carcinoma. METHODS: After the addition of 10 μmol/L emodin to HepG2/oxaliplatin (OXA) cel...AIM: To investigate the molecular mechanisms underlying the reversal effect of emodin on platinum resistance in hepatocellular carcinoma. METHODS: After the addition of 10 μmol/L emodin to HepG2/oxaliplatin (OXA) cells, the inhibition rate (IR), 50% inhibitory concentration (IC 50 ) and reversal index (IC 50 in experimental group/IC 50 in control group) were calculated. For HepG2, HepG2/OXA, HepG2/OXA/T, each cell line was divided into a control group, OXA group, OXA + fibroblast growth factor 7 (FGF7) group and OXA + emodin group, and the final concentrations of FGF7, emodin and OXA in each group were 5 ng/mL, 10 μg/mL and 10 μmol/L, respectively. Single-cell gel electrophoresis was conducted to detect DNA damage, and the fibroblast growth factor receptor 2 (FGFR2), phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2) and excision repair cross-complementing gene 1 (ERCC1) protein expression levels in each group were examined by Western blotting. RESULTS: Compared with the IC50 of 120.78 μmol/L in HepG2/OXA cells, the IC 50 decreased to 39.65 μmol/L after treatment with 10 μmol/L emodin; thus, the reversal index was 3.05. Compared with the control group, the tail length and Olive tail length in the OXA group, OXA + FGF7 group and OXA + emodin group were significantly increased, and the differences were statistically significant (P < 0.01). The tail length and Olive tail length were lower in the OXA + FGF7 group than in the OXA group, and this difference was also statistically significant. Compared with the OXA + FGF7 group, the tail extent, the Olive tail moment and the percentage of tail DNA were significantly increased in the OXA + emodin group, and these differences were statistically significant (P < 0.01). In comparison with its parental cell line HepG2, the HepG2/OXA cells demonstrated significantly increased FGFR2, p-ERK1/2 and ERCC1 expression levels, whereas the expression of all three molecules was significantly inhibited in HepG2/ OXA/T cells, in which FGFR2 was silenced by FGFR2 shRNA. In the examined HepG2 cells, the FGFR2, p-ERK1/2 and ERCC1 expression levels demonstrated increasing trends in the OXA group and OXA + FGF7 group. Compared with the OXA group and OXA + FGF7 group, the FGFR2, p-ERK1/2, and ERCC1 expression levels were significantly lower in the OXA + emodin group, and these differences were statistically significant. In the HepG2/OXA/T cell line that was transfected with FGFR2 shRNA, the FGFR2, p-ERK1/2 and ERCC1 expression levels were significantly inhibited, but there were no significant differences in these expression levels among the OXA, OXA + FGF7 and OXA + emodin groups. CONCLUSION: Emodin markedly reversed OXA resistance by enhancing OXA DNA damage in HepG2/OXA cells, and the molecular mechanism was related to the inhibitory effect on ERCC1 expression being mediated by the FGFR2/ERK1/2 signaling pathway.展开更多
The planning site was divided into a spatial structure of"one center,one corridor,two axes,two belts and three communities"and traffic system designed to a 3-grade road system of"artery,secondary artery...The planning site was divided into a spatial structure of"one center,one corridor,two axes,two belts and three communities"and traffic system designed to a 3-grade road system of"artery,secondary artery and by-pass".Meanwhile,a 3-ring structure of the planning site was constructed:diffusion waterfront landscape belt,waterfront pathway and core eco-green island.Finally,the planning concepts for major ecological constructions were given.This study tried to explore the group eco-landscape pattern in urban core areas so as to provide a strategic instruction for the regional sustainable development.展开更多
In 1986, G.X. Viennot introduced the theory of heaps of pieces as a visualization of Cartier and Foata’s “partially commutative monoids”. These are essentially labeled posets satisfying a few additional properties,...In 1986, G.X. Viennot introduced the theory of heaps of pieces as a visualization of Cartier and Foata’s “partially commutative monoids”. These are essentially labeled posets satisfying a few additional properties, and one natural setting where they arise is as models of reduced words in Coxeter groups. In this paper, we introduce a cyclic version of a heap, which loosely speaking, can be thought of as taking a heap and wrapping it into a cylinder. We call this object a toric heap, because we formalize it as a labeled toric poset, which is a cyclic version of an ordinary poset. Defining the category of toric heaps leads to the notion of certain morphisms such as toric extensions. We study toric heaps in Coxeter theory, because a cyclic shift of a reduced word is simply a conjugate by an initial or terminal generator. As such, we formalize and study a framework that we call cyclic reducibility in Coxeter theory, which is closely related to conjugacy. We introduce what it means for elements to be torically reduced, which is a stronger condition than simply being cyclically reduced. Along the way, we encounter a new class of elements that we call torically fully commutative (TFC), which are those that have a unique cyclic commutativity class, and comprise a strictly bigger class than the cyclically fully commutative (CFC) elements. We prove several cyclic analogues of results on fully commutative (FC) elements due to Stembridge. We conclude with how this framework fits into recent work in Coxeter groups, and we correct a minor flaw in a few recently published theorems.展开更多
The Interconnected River System Network (IRSN) plays a crucial role in water resource allocation, water ecological restoration and water quality improvement. It has become a key part of the urban lake management. An e...The Interconnected River System Network (IRSN) plays a crucial role in water resource allocation, water ecological restoration and water quality improvement. It has become a key part of the urban lake management. An evaluation methodology system for IRSN project can provide important guidance for the selection of different water diversion schemes. However, few if any comprehensive evaluation systems have been developed to evaluate the hydrodynamics and water quality of connected lakes. This study developed a comprehensive evaluation system based on multi-indexes including aspects of water hydrodynamics, water quality and socioeconomics. A two-dimensional (2-D) mathematical hydrodynamics and water quality model was built, using NH<sub>3</sub>-N, TN and TP as water quality index. The IRSN project in Tangxun Lake group was used as a testbed here, and five water diversion schemes were simulated and evaluated. Results showed that the IRSN project can improve the water fluidity and the water quality obviously after a short time of water diversion, while the improvement rates decreased gradually as the water diversion went on. Among these five schemes, Scheme V showed the most noticeable improvement in hydrodynamics and water quality, and brought the most economic benefits. This comprehensive evaluation method can provide useful reference for the implementation of other similar IRSN projects.展开更多
A new method using group-induced second-order long waves (GSLW) to describe wave groups is presented in this paper on the basis of the GSLW theory by Longuet- Higgins and Steward (1964) . In the method , the parabolic...A new method using group-induced second-order long waves (GSLW) to describe wave groups is presented in this paper on the basis of the GSLW theory by Longuet- Higgins and Steward (1964) . In the method , the parabolic relationship between GSLW and the wave envelope is first deduced , and then the distribution function of GSLW amplitude is derived . Thus, the formulae in terms of the moments of GSLW and short wave spectra for the average time duration and the mean length of runs of wave heights exceeding a certain level can be derived . A new groupiness factor equivalent to half the mean wave number in wave groups is defined by taking into account the widths of spectra of GSLW and short waves . Compared with theoretical results of others , ours are closer to measured wave data .展开更多
This paper investigates the approach of presenting groups by generators and relations from an original angle. It starts by interpreting this familiar concept with the novel notion of “formal words” created by juxtap...This paper investigates the approach of presenting groups by generators and relations from an original angle. It starts by interpreting this familiar concept with the novel notion of “formal words” created by juxtaposing letters in a set. Taking that as basis, several fundamental results related to free groups, such as Dyck’s Theorem, are proven. Then, the paper highlights three creative applications of the concept in classifying finite groups of a fixed order, representing all dihedral groups geometrically, and analyzing knots topologically. All three applications are of considerable significance in their respective topic areas and serve to illustrate the advantages and certain limitations of the approach flexibly and comprehensively.展开更多
AlCl3-mediated cleavage of ethereal methyl–oxygen bond in aroylated 2,7-dimethoxynaphthalene compounds proceeds chemospecifically and regioselectively. The ethereal bond at the β(2)-position of 1-monoaroylated 2,7-d...AlCl3-mediated cleavage of ethereal methyl–oxygen bond in aroylated 2,7-dimethoxynaphthalene compounds proceeds chemospecifically and regioselectively. The ethereal bond at the β(2)-position of 1-monoaroylated 2,7-dimethoxynaphthalene is cleaved readily and predominantly against the β(7)-position, whereas scission of β-ethereal bonds of 1,8-diaroylated 2,7-dimethoxynaphthalene hardly undergoes like the non-aroylated mother frame compound of 2,7-dimethoxynaphthalene.展开更多
Recent examples of periodic bifurcations in descendant trees of finite p-groups with ?are used to show that the possible p-class tower groups G of certain multiquadratic fields K with p- class group of type (2,2,2) , ...Recent examples of periodic bifurcations in descendant trees of finite p-groups with ?are used to show that the possible p-class tower groups G of certain multiquadratic fields K with p- class group of type (2,2,2) , resp. (3,3), form periodic sequences in the descendant tree of the elementary Abelian root , resp. . The particular vertex of the periodic sequence which occurs as the p-class tower group G of an assigned field K is determined uniquely by the p-class number of a quadratic, resp. cubic, auxiliary field k, associated unambiguously to K. Consequently, the hard problem of identifying the p-class tower group G is reduced to an easy computation of low degree arithmetical invariants.展开更多
This paper proposes a group synchronization control scheme with prediction in work using haptic media. The scheme adjusts the output timing among multiple terminals and keeps the interactivity high. It outputs positio...This paper proposes a group synchronization control scheme with prediction in work using haptic media. The scheme adjusts the output timing among multiple terminals and keeps the interactivity high. It outputs position information by predicting the future position later than the position included in the last-received information by a fixed amount of time. It also advances the output time of position information at each local terminal by the same amount of time. We deal with two different types of work using haptic media so as to demonstrate the effectiveness of the scheme. We assess the output quality of haptic media for the two types of work subjectively and objectively by Quality of Experience (QoE) assessment. We further clarify the relationship between subjective and objective assessment results.展开更多
Based on isotopic, lithologic and electrical data and logging cycle analysis technique, stratigraphic sequences in the Middle-Upper Cambrian Xixiangchi Group in the Sichuan Basin and its adjacent area are divided, and...Based on isotopic, lithologic and electrical data and logging cycle analysis technique, stratigraphic sequences in the Middle-Upper Cambrian Xixiangchi Group in the Sichuan Basin and its adjacent area are divided, and its sedimentary characteristics and evolution are analyzed. The Xixiangchi Group can be divided into 5 third-order sequences(Sql-Sq5), of which sequences Ⅰ to Ⅲ(Sql-Sq3) are relatively complete, sequences Ⅳ and Ⅴ are denuded in the Late Cambrian because of the Dian-Chuan paleo-uplifts.Third-order sequences of the Xixiangchi Group in this area have the characteristics of thin in the west and thick in the east, showing that the Caledonian paleo-uplift is a synsedimentary paleo-uplift and the paleogeomorphology in the platform is a gentle slope. Sequence Ⅰdevelops high stand systems tract and transgressive systems tract. The other third-order sequences are dominated by highstand systems tracts, and the transgressive systems tracts last shortly in time and are limited in area. The basic features of evaporative-restricted platform of gentle slope type developed continuously in the sedimentary period of the Xixiangchi Group, its sedimentary environment of "high in west and low in east" and the change of micro paleogeomorphology in the platform control the continuous development of sedimentary facies. Open platform is developed only in sequence Ⅰ and sequence Ⅱ, and the inner beach of the platform and the edge beach of the platform are mostly developed in sequence Ⅱ and sequence Ⅲ. It indicates that there are two platform margin zones in the study area,a relatively stable, large-scale platform marginal zone in NE Guizhou-Western Hunan and Hubei, and a moving and small-scale platform marginal zone in North Chongqing-Western Hubei.展开更多
High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the ex...High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain injury.Several drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system disorders.Although it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system disorders.In this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory role.Research targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.展开更多
A method using group-induced second-order long waves(GSLW) to represent statistical properties of wave groups with double-peaked spectra is put forward in this paper on the basis of the GSLW theory. The GSLW is regard...A method using group-induced second-order long waves(GSLW) to represent statistical properties of wave groups with double-peaked spectra is put forward in this paper on the basis of the GSLW theory. The GSLW is regarded as a weighted linear superimposition of the second-order long Wave induced by the low peak frequency section and that induced by the high peak frequency section. There is a parabolic relationship between the GSLW and the wave envelope. Then the probability density function and the distribution function of the GSLW amplitude are derived. Thus the formulas for the average time duration and the mean length of runs can be derived. Good agreement between theoretical results and measured values was achieved. as verified with the measured double-peaked spectra in different regions.展开更多
文摘Let p be a prime. For any finite p-group G, the deep transfers T H,G ' : H / H ' → G ' / G " from the maximal subgroups H of index (G:H) = p in G to the derived subgroup G ' are introduced as an innovative tool for identifying G uniquely by means of the family of kernels ùd(G) =(ker(T H,G ')) (G: H) = p. For all finite 3-groups G of coclass cc(G) = 1, the family ùd(G) is determined explicitly. The results are applied to the Galois groups G =Gal(F3 (∞)/ F) of the Hilbert 3-class towers of all real quadratic fields F = Q(√d) with fundamental discriminants d > 1, 3-class group Cl3(F) □ C3 × C3, and total 3-principalization in each of their four unramified cyclic cubic extensions E/F. A systematic statistical evaluation is given for the complete range 1 d 7, and a few exceptional cases are pointed out for 1 d 8.
文摘Based on a general theory of descendant trees of finite p-groups and the virtual periodicity isomorphisms between the branches of a coclass subtree, the behavior of algebraic invariants of the tree vertices and their automorphism groups under these isomorphisms is described with simple transformation laws. For the tree of finite 3-groups with elementary bicyclic commutator qu-otient, the information content of each coclass subtree with metabelian main-line is shown to be finite. As a striking novelty in this paper, evidence is provided of co-periodicity isomorphisms between coclass forests which reduce the information content of the entire metabelian skeleton and a significant part of non-metabelian vertices to a finite amount of data.
文摘Let 0<γ<π be a fixed pythagorean angle. We study the abelian group Hr of primitive integral triangles (a,b,c) for which the angle opposite side c is γ. Addition in Hr is defined by adding the angles β opposite side b and modding out by π-γ. The only Hr for which the structure is known is Hπ/2, which is free abelian. We prove that for generalγ, Hr has an element of order two iff 2(1- cosγ) is a rational square, and it has elements of order three iff the cubic (2cosγ)x3-3x2+1=0 has a rational solution 0<x<1. This shows that the set of values ofγ for which Hr has two-torsion is dense in [0, π], and similarly for three-torsion. We also show that there is at most one copy of either Z2 or Z3 in Hr. Finally, we give some examples of higher order torsion elements in Hr.
文摘Theoretical background and an implementation of the p-group generation algorithm by Newman and O’Brien are used to provide computational evidence of a new type of periodically repeating patterns in pruned descendant trees of finite p-groups.
文摘The present note is concerned with two connected and highly important fundamental questions of physics and cosmology, namely if E8E8 Lie symmetry group describes the universe and where cosmic dark energy comes from. Furthermore, we reason following Wheeler, Hartle and Hawking that since the boundary of a boundary is an empty set which models the quantum wave of the cosmos, then it follows that dark energy is a fundamental physical phenomenon associated with the boundary of the holographic boundary. This leads directly to a clopen universe which is its own Penrose tiling-like multiverse with energy density in full agreement with COBE, WMAP and Type 1a supernova cosmic measurements.
文摘In order to generalize the relativistic notion of boost to the case of non inertial particles and to general relativity, we look closer into the definition of the Lie group of Lorentz matrices and its Lie algebra and we study how this group acts on the Minskowski space. We thus define the notion of tangent boost along a worldline. This very general notion gives a useful tool both in special relativity (for non inertial particles or/and for non rectilinear coordinates) and in general relativity. We also introduce a matrix of the Lie algebra which, together with the tangent boost, gives the whole dynamical description of the considered system (acceleration and Thomas rotation). After studying the properties of Lie algebra matrices and their reduced forms, we show that the Lie group of special Lorentz matrices has four one-parameter subgroups. These tools lead us to introduce the Thomas rotation in a quite general way. At the end of the paper, we present some examples using these tools and we consider the case of an electron rotating on a circular orbit around an atom nucleus. We then discuss the twin paradox and we show that when the one who made a journey into space in a high-speed rocket returns home, he is not only younger than the twin who stayed on Earth but he is also disorientated because his gyroscope has turned with respect to earth referential frame.
文摘'Acompany shall have its commitment to build a century-old business if it hopes to continue operation for a long time.'John Soo is the third generation of Chinese immigrants in Malaysia and CEO of Ally Biz International Group. His forefathers were engaged in traditional plantation business. As a new-generation Malaysian Chinese who have received higher education and worked in many international companies as accountant or CEO, John Soo found that the business opportunities in traditional plantation industry has becoming slim. The challenge is to seek a better business project for new breakthroughs.
文摘BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis.
基金Supported by National Natural Sciences Foundation of China,No. 81001067the Ministry of Science and Technology International Cooperation Project, No. 2010DFA31870the AstraZeneca Special Research Foundation for Targeted Therapy of the Wu Jieping Medical Foundation, No. 320.6700.09068
文摘AIM: To investigate the molecular mechanisms underlying the reversal effect of emodin on platinum resistance in hepatocellular carcinoma. METHODS: After the addition of 10 μmol/L emodin to HepG2/oxaliplatin (OXA) cells, the inhibition rate (IR), 50% inhibitory concentration (IC 50 ) and reversal index (IC 50 in experimental group/IC 50 in control group) were calculated. For HepG2, HepG2/OXA, HepG2/OXA/T, each cell line was divided into a control group, OXA group, OXA + fibroblast growth factor 7 (FGF7) group and OXA + emodin group, and the final concentrations of FGF7, emodin and OXA in each group were 5 ng/mL, 10 μg/mL and 10 μmol/L, respectively. Single-cell gel electrophoresis was conducted to detect DNA damage, and the fibroblast growth factor receptor 2 (FGFR2), phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2) and excision repair cross-complementing gene 1 (ERCC1) protein expression levels in each group were examined by Western blotting. RESULTS: Compared with the IC50 of 120.78 μmol/L in HepG2/OXA cells, the IC 50 decreased to 39.65 μmol/L after treatment with 10 μmol/L emodin; thus, the reversal index was 3.05. Compared with the control group, the tail length and Olive tail length in the OXA group, OXA + FGF7 group and OXA + emodin group were significantly increased, and the differences were statistically significant (P < 0.01). The tail length and Olive tail length were lower in the OXA + FGF7 group than in the OXA group, and this difference was also statistically significant. Compared with the OXA + FGF7 group, the tail extent, the Olive tail moment and the percentage of tail DNA were significantly increased in the OXA + emodin group, and these differences were statistically significant (P < 0.01). In comparison with its parental cell line HepG2, the HepG2/OXA cells demonstrated significantly increased FGFR2, p-ERK1/2 and ERCC1 expression levels, whereas the expression of all three molecules was significantly inhibited in HepG2/ OXA/T cells, in which FGFR2 was silenced by FGFR2 shRNA. In the examined HepG2 cells, the FGFR2, p-ERK1/2 and ERCC1 expression levels demonstrated increasing trends in the OXA group and OXA + FGF7 group. Compared with the OXA group and OXA + FGF7 group, the FGFR2, p-ERK1/2, and ERCC1 expression levels were significantly lower in the OXA + emodin group, and these differences were statistically significant. In the HepG2/OXA/T cell line that was transfected with FGFR2 shRNA, the FGFR2, p-ERK1/2 and ERCC1 expression levels were significantly inhibited, but there were no significant differences in these expression levels among the OXA, OXA + FGF7 and OXA + emodin groups. CONCLUSION: Emodin markedly reversed OXA resistance by enhancing OXA DNA damage in HepG2/OXA cells, and the molecular mechanism was related to the inhibitory effect on ERCC1 expression being mediated by the FGFR2/ERK1/2 signaling pathway.
文摘The planning site was divided into a spatial structure of"one center,one corridor,two axes,two belts and three communities"and traffic system designed to a 3-grade road system of"artery,secondary artery and by-pass".Meanwhile,a 3-ring structure of the planning site was constructed:diffusion waterfront landscape belt,waterfront pathway and core eco-green island.Finally,the planning concepts for major ecological constructions were given.This study tried to explore the group eco-landscape pattern in urban core areas so as to provide a strategic instruction for the regional sustainable development.
文摘In 1986, G.X. Viennot introduced the theory of heaps of pieces as a visualization of Cartier and Foata’s “partially commutative monoids”. These are essentially labeled posets satisfying a few additional properties, and one natural setting where they arise is as models of reduced words in Coxeter groups. In this paper, we introduce a cyclic version of a heap, which loosely speaking, can be thought of as taking a heap and wrapping it into a cylinder. We call this object a toric heap, because we formalize it as a labeled toric poset, which is a cyclic version of an ordinary poset. Defining the category of toric heaps leads to the notion of certain morphisms such as toric extensions. We study toric heaps in Coxeter theory, because a cyclic shift of a reduced word is simply a conjugate by an initial or terminal generator. As such, we formalize and study a framework that we call cyclic reducibility in Coxeter theory, which is closely related to conjugacy. We introduce what it means for elements to be torically reduced, which is a stronger condition than simply being cyclically reduced. Along the way, we encounter a new class of elements that we call torically fully commutative (TFC), which are those that have a unique cyclic commutativity class, and comprise a strictly bigger class than the cyclically fully commutative (CFC) elements. We prove several cyclic analogues of results on fully commutative (FC) elements due to Stembridge. We conclude with how this framework fits into recent work in Coxeter groups, and we correct a minor flaw in a few recently published theorems.
基金National Key Research and Development Program,No.2017YFA0603704,No.2017YFC1502500
文摘The Interconnected River System Network (IRSN) plays a crucial role in water resource allocation, water ecological restoration and water quality improvement. It has become a key part of the urban lake management. An evaluation methodology system for IRSN project can provide important guidance for the selection of different water diversion schemes. However, few if any comprehensive evaluation systems have been developed to evaluate the hydrodynamics and water quality of connected lakes. This study developed a comprehensive evaluation system based on multi-indexes including aspects of water hydrodynamics, water quality and socioeconomics. A two-dimensional (2-D) mathematical hydrodynamics and water quality model was built, using NH<sub>3</sub>-N, TN and TP as water quality index. The IRSN project in Tangxun Lake group was used as a testbed here, and five water diversion schemes were simulated and evaluated. Results showed that the IRSN project can improve the water fluidity and the water quality obviously after a short time of water diversion, while the improvement rates decreased gradually as the water diversion went on. Among these five schemes, Scheme V showed the most noticeable improvement in hydrodynamics and water quality, and brought the most economic benefits. This comprehensive evaluation method can provide useful reference for the implementation of other similar IRSN projects.
基金This project was funded by the National Natural Science Foundation of China
文摘A new method using group-induced second-order long waves (GSLW) to describe wave groups is presented in this paper on the basis of the GSLW theory by Longuet- Higgins and Steward (1964) . In the method , the parabolic relationship between GSLW and the wave envelope is first deduced , and then the distribution function of GSLW amplitude is derived . Thus, the formulae in terms of the moments of GSLW and short wave spectra for the average time duration and the mean length of runs of wave heights exceeding a certain level can be derived . A new groupiness factor equivalent to half the mean wave number in wave groups is defined by taking into account the widths of spectra of GSLW and short waves . Compared with theoretical results of others , ours are closer to measured wave data .
文摘This paper investigates the approach of presenting groups by generators and relations from an original angle. It starts by interpreting this familiar concept with the novel notion of “formal words” created by juxtaposing letters in a set. Taking that as basis, several fundamental results related to free groups, such as Dyck’s Theorem, are proven. Then, the paper highlights three creative applications of the concept in classifying finite groups of a fixed order, representing all dihedral groups geometrically, and analyzing knots topologically. All three applications are of considerable significance in their respective topic areas and serve to illustrate the advantages and certain limitations of the approach flexibly and comprehensively.
文摘AlCl3-mediated cleavage of ethereal methyl–oxygen bond in aroylated 2,7-dimethoxynaphthalene compounds proceeds chemospecifically and regioselectively. The ethereal bond at the β(2)-position of 1-monoaroylated 2,7-dimethoxynaphthalene is cleaved readily and predominantly against the β(7)-position, whereas scission of β-ethereal bonds of 1,8-diaroylated 2,7-dimethoxynaphthalene hardly undergoes like the non-aroylated mother frame compound of 2,7-dimethoxynaphthalene.
文摘Recent examples of periodic bifurcations in descendant trees of finite p-groups with ?are used to show that the possible p-class tower groups G of certain multiquadratic fields K with p- class group of type (2,2,2) , resp. (3,3), form periodic sequences in the descendant tree of the elementary Abelian root , resp. . The particular vertex of the periodic sequence which occurs as the p-class tower group G of an assigned field K is determined uniquely by the p-class number of a quadratic, resp. cubic, auxiliary field k, associated unambiguously to K. Consequently, the hard problem of identifying the p-class tower group G is reduced to an easy computation of low degree arithmetical invariants.
文摘This paper proposes a group synchronization control scheme with prediction in work using haptic media. The scheme adjusts the output timing among multiple terminals and keeps the interactivity high. It outputs position information by predicting the future position later than the position included in the last-received information by a fixed amount of time. It also advances the output time of position information at each local terminal by the same amount of time. We deal with two different types of work using haptic media so as to demonstrate the effectiveness of the scheme. We assess the output quality of haptic media for the two types of work subjectively and objectively by Quality of Experience (QoE) assessment. We further clarify the relationship between subjective and objective assessment results.
基金Supported by the PetroChina Science and Technology Major Project(2016E-0601)
文摘Based on isotopic, lithologic and electrical data and logging cycle analysis technique, stratigraphic sequences in the Middle-Upper Cambrian Xixiangchi Group in the Sichuan Basin and its adjacent area are divided, and its sedimentary characteristics and evolution are analyzed. The Xixiangchi Group can be divided into 5 third-order sequences(Sql-Sq5), of which sequences Ⅰ to Ⅲ(Sql-Sq3) are relatively complete, sequences Ⅳ and Ⅴ are denuded in the Late Cambrian because of the Dian-Chuan paleo-uplifts.Third-order sequences of the Xixiangchi Group in this area have the characteristics of thin in the west and thick in the east, showing that the Caledonian paleo-uplift is a synsedimentary paleo-uplift and the paleogeomorphology in the platform is a gentle slope. Sequence Ⅰdevelops high stand systems tract and transgressive systems tract. The other third-order sequences are dominated by highstand systems tracts, and the transgressive systems tracts last shortly in time and are limited in area. The basic features of evaporative-restricted platform of gentle slope type developed continuously in the sedimentary period of the Xixiangchi Group, its sedimentary environment of "high in west and low in east" and the change of micro paleogeomorphology in the platform control the continuous development of sedimentary facies. Open platform is developed only in sequence Ⅰ and sequence Ⅱ, and the inner beach of the platform and the edge beach of the platform are mostly developed in sequence Ⅱ and sequence Ⅲ. It indicates that there are two platform margin zones in the study area,a relatively stable, large-scale platform marginal zone in NE Guizhou-Western Hunan and Hubei, and a moving and small-scale platform marginal zone in North Chongqing-Western Hubei.
基金supported by a grant of the M.D.-Ph.D./Medical Scientist Training Program through the Korea Health Industry Development Institute(KHIDI)funded by the Ministry of Health&Welfare,Republic of Korea(to HK)+3 种基金supported by National Research Foundation of Korea(NRF)grants funded by the Korean government(MSITMinistry of Science and ICT)(NRF2019R1A5A2026045 and NRF-2021R1F1A1061819)a grant from the Korean Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health&Welfare,Republic of Korea(HR21C1003)New Faculty Research Fund of Ajou University School of Medicine(to JYC)。
文摘High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain injury.Several drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system disorders.Although it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system disorders.In this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory role.Research targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.
基金This project was funded by the National Natural Science Foundation of China
文摘A method using group-induced second-order long waves(GSLW) to represent statistical properties of wave groups with double-peaked spectra is put forward in this paper on the basis of the GSLW theory. The GSLW is regarded as a weighted linear superimposition of the second-order long Wave induced by the low peak frequency section and that induced by the high peak frequency section. There is a parabolic relationship between the GSLW and the wave envelope. Then the probability density function and the distribution function of the GSLW amplitude are derived. Thus the formulas for the average time duration and the mean length of runs can be derived. Good agreement between theoretical results and measured values was achieved. as verified with the measured double-peaked spectra in different regions.
