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On Construction and Wovenness of K-frame Generators for Unitary Systems
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作者 XIANG Zhongqi CHEN Yuxian +1 位作者 LIN Chunxia WAN Mingxiu 《数学进展》 北大核心 2025年第3期591-602,共12页
We give a new result on the construction of K-frame generators for unitary systems by using the pseudo-inverses of involved operators,which provides an improvement to one known result on this topic.We also introduce t... We give a new result on the construction of K-frame generators for unitary systems by using the pseudo-inverses of involved operators,which provides an improvement to one known result on this topic.We also introduce the concept of K-woven generators for unitary systems,by means of which we investigate the weaving properties of K-frame generators for unitary systems. 展开更多
关键词 K-frame generator unitary system K-woven PSEUDO-INVERSE
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Comparison of Reflectivity Consistency between Spaceborne Precipitation Radar and Ground-based Weather Radar in China and the United States
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作者 Peng CHEN Lin CHEN +3 位作者 Gang WANG Qiong WU Huiying WANG Peng ZHANG 《Advances in Atmospheric Sciences》 2025年第7期1376-1394,共19页
The Global Precipitation Measurement(GPM)dual-frequency precipitation radar(DPR)products(Version 07A)are employed for a rigorous comparative analysis with ground-based operational weather radar(GR)networks.The reflect... The Global Precipitation Measurement(GPM)dual-frequency precipitation radar(DPR)products(Version 07A)are employed for a rigorous comparative analysis with ground-based operational weather radar(GR)networks.The reflectivity observed by GPM Ku PR is compared quantitatively against GR networks from CINRAD of China and NEXRAD of the United States,and the volume matching method is used for spatial matching.Additionally,a novel frequency correction method for all phases as well as precipitation types is used to correct the GPM Ku PR radar frequency to the GR frequency.A total of 20 GRs(including 10 from CINRAD and 10 from NEXRAD)are included in this comparative analysis.The results indicate that,compared with CINRAD matched data,NEXRAD exhibits larger biases in reflectivity when compared with the frequency-corrected Ku PR.The root-mean-square difference for CINRAD is calculated at 2.38 d B,whereas for NEXRAD it is 3.23 d B.The mean bias of CINRAD matched data is-0.16 d B,while the mean bias of NEXRAD is-2.10 d B.The mean standard deviation of bias for CINRAD is 2.15 d B,while for NEXRAD it is 2.29 d B.This study effectively assesses weather radar data in both the United States and China,which is crucial for improving the overall consistency of global precipitation estimates. 展开更多
关键词 GPM DPR volume matching REFLECTIVITY ground-based radar
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CloudViT:A Lightweight Ground-Based Cloud Image Classification Model with the Ability to Capture Global Features
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作者 Daoming Wei Fangyan Ge +5 位作者 Bopeng Zhang Zhiqiang Zhao Dequan Li Lizong Xi Jinrong Hu Xin Wang 《Computers, Materials & Continua》 2025年第6期5729-5746,共18页
Accurate cloud classification plays a crucial role in aviation safety,climate monitoring,and localized weather forecasting.Current research has been focusing on machine learning techniques,particularly deep learning b... Accurate cloud classification plays a crucial role in aviation safety,climate monitoring,and localized weather forecasting.Current research has been focusing on machine learning techniques,particularly deep learning based model,for the types identification.However,traditional approaches such as convolutional neural networks(CNNs)encounter difficulties in capturing global contextual information.In addition,they are computationally expensive,which restricts their usability in resource-limited environments.To tackle these issues,we present the Cloud Vision Transformer(CloudViT),a lightweight model that integrates CNNs with Transformers.The integration enables an effective balance between local and global feature extraction.To be specific,CloudViT comprises two innovative modules:Feature Extraction(E_Module)and Downsampling(D_Module).These modules are able to significantly reduce the number of model parameters and computational complexity while maintaining translation invariance and enhancing contextual comprehension.Overall,the CloudViT includes 0.93×10^(6)parameters,which decreases more than ten times compared to the SOTA(State-of-the-Art)model CloudNet.Comprehensive evaluations conducted on the HBMCD and SWIMCAT datasets showcase the outstanding performance of CloudViT.It achieves classification accuracies of 98.45%and 100%,respectively.Moreover,the efficiency and scalability of CloudViT make it an ideal candidate for deployment inmobile cloud observation systems,enabling real-time cloud image classification.The proposed hybrid architecture of CloudViT offers a promising approach for advancing ground-based cloud image classification.It holds significant potential for both optimizing performance and facilitating practical deployment scenarios. 展开更多
关键词 Image classification ground-based cloud images lightweight neural networks attention mechanism deep learning vision transformer
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Different Types of Electrical Generators for Converting Wave Energy into Electrical Energy–A Review
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作者 Jawad Faiz Shahryar Haghvirdiloo Ali Ghaffarpour 《哈尔滨工程大学学报(英文版)》 2025年第1期76-97,共22页
This review paper examines the various types of electrical generators used to convert wave energy into electrical energy.The focus is on both linear and rotary generators,including their design principles,operational ... This review paper examines the various types of electrical generators used to convert wave energy into electrical energy.The focus is on both linear and rotary generators,including their design principles,operational efficiencies,and technological advancements.Linear generators,such as Induction,permanent magnet synchronous,and switched reluctance types,are highlighted for their direct conversion capability,eliminating the need for mechanical gearboxes.Rotary Induction generators,permanent magnet synchronous generators,and doubly-fed Induction generators are evaluated for their established engineering principles and integration with existing grid infrastructure.The paper discusses the historical development,environmental benefits,and ongoing advancements in wave energy technologies,emphasizing the increasing feasibility and scalability of wave energy as a renewable source.Through a comprehensive analysis,this review provides insights into the current state and future prospects of electrical generators in wave energy conversion,underscoring their potential to significantly reduce reliance on fossil fuels and mitigate environmental impacts. 展开更多
关键词 Wave energy Rotary generators Linear generators Control systems Wave energy converters
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A target imaging simulation method for ground-based system based on signal-to-noise ratio
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作者 Chunxu Ren Yun Li +3 位作者 Yanzhao Li Weihua Gao Wenlong Niu Xiaodong Peng 《Astronomical Techniques and Instruments》 2025年第5期288-298,共11页
Space target imaging simulation technology is an important tool for space target detection and identification,with advantages that include high flexibility and low cost.However,existing space target imaging simulation... Space target imaging simulation technology is an important tool for space target detection and identification,with advantages that include high flexibility and low cost.However,existing space target imaging simulation technologies are mostly based on target magnitudes for simulations,making it difficult to meet image simulation requirements for different signal-to-noise ratio(SNR)needs.Therefore,design of a simulation method that generates target image sequences with various SNRs based on the optical detection system parameters will be important for faint space target detection research.Addressing the SNR calculation issue in optical observation systems,this paper proposes a ground-based detection image SNR calculation method using the optical system parameters.This method calculates the SNR of an observed image precisely using radiative transfer theory,the optical system parameters,and the observation environment parameters.An SNR-based target sequence image simulation method for ground-based detection scenarios is proposed.This method calculates the imaging SNR using the optical system parameters and establishes a model for conversion between the target’s apparent magnitude and image grayscale values,thereby enabling generation of target sequence simulation images with corresponding SNRs for different system parameters.Experiments show that the SNR obtained using this calculation method has an average calculation error of<1 dB when compared with the theoretical SNR of the actual optical system.Additionally,the simulation images generated by the imaging simulation method show high consistency with real images,which meets the requirements of faint space target detection algorithm research and provides reliable data support for development of related technologies. 展开更多
关键词 Image SNR calculation Imaging simulation ground-based optical detection system Space target image sequence
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Monthly Reduced Time-Period Scheduling of Thermal Generators and Energy Storage Considering Daily Minimum Chargeable Energy of Energy Storage
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作者 Xingxu Zhu Shiye Wang +3 位作者 Gangui Yan Junhui Li Hongda Dong Chenggang Li 《Energy Engineering》 2025年第4期1469-1489,共21页
To address the excessive complexity of monthly scheduling and the impact of uncertain net load on the chargeable energy of storage,a reduced time-period monthly scheduling model for thermal generators and energy stora... To address the excessive complexity of monthly scheduling and the impact of uncertain net load on the chargeable energy of storage,a reduced time-period monthly scheduling model for thermal generators and energy storage,incorporating daily minimum chargeable energy constraints,was developed.Firstly,considering the variations in the frequency of unit start-ups and shutdowns under different levels of net load fluctuation,a method was proposed to reduce decision time periods for unit start-up and shut-down operations.This approach,based on the characteristics of net load fluctuations,minimizes the decision variables of units,thereby simplifying the monthly schedulingmodel.Secondly,the relationship between energy storage charging and discharging power,net load,and the total maximum/minimum output of units was analyzed.Based on this,daily minimum chargeable energy constraints were established to ensure the energy storage system meets charging requirements under extreme net load scenarios.Finally,taking into account the operational costs of thermal generators and energy storage,load loss costs,and operational constraints,the reduced time-period monthly schedulingmodel was constructed.Case studies demonstrate that the proposedmethod effectively generates economical monthly operation plans for thermal generators and energy storage,significantly reduces model solution time,and satisfies the charging requirements of energy storage under extreme net load conditions. 展开更多
关键词 Monthly scheduling thermal generators energy storage daily minimum chargeable energy decision time-period reduction unit start-up and shut-down unit commitment renewable energy
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Ground-based and additional science support for SMILE 被引量:2
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作者 J.A.Carter M.Dunlop +46 位作者 C.Forsyth K.Oksavik E.Donovon A.Kavanagh S.E.Milan T.Sergienko R.C.Fear D.G.Sibeck M.Connors T.Yeoman X.Tan M.G.G.T.Taylor K.McWilliams J.Gjerloev R.Barnes D.D.Billet G.Chisham A.Dimmock M.P.Freeman D.-S.Han M.D.Hartinger S.-Y.W.Hsieh Z.-J.Hu M.K.James L.Juusola K.Kauristie E.A.Kronberg M.Lester J.Manuel J.Matzka I.McCrea Y.Miyoshi J.Rae L.Ren F.Sigernes E.Spanswick K.Sterne A.Steuwer T.Sun M.-T.Walach B.Walsh C.Wang J.Weygand J.Wild J.Yan J.Zhang Q.-H.Zhang 《Earth and Planetary Physics》 EI CSCD 2024年第1期275-298,共24页
The joint European Space Agency and Chinese Academy of Sciences Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission will explore global dynamics of the magnetosphere under varying solar wind and interplane... The joint European Space Agency and Chinese Academy of Sciences Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field conditions,and simultaneously monitor the auroral response of the Northern Hemisphere ionosphere.Combining these large-scale responses with medium and fine-scale measurements at a variety of cadences by additional ground-based and space-based instruments will enable a much greater scientific impact beyond the original goals of the SMILE mission.Here,we describe current community efforts to prepare for SMILE,and the benefits and context various experiments that have explicitly expressed support for SMILE can offer.A dedicated group of international scientists representing many different experiment types and geographical locations,the Ground-based and Additional Science Working Group,is facilitating these efforts.Preparations include constructing an online SMILE Data Fusion Facility,the discussion of particular or special modes for experiments such as coherent and incoherent scatter radar,and the consideration of particular observing strategies and spacecraft conjunctions.We anticipate growing interest and community engagement with the SMILE mission,and we welcome novel ideas and insights from the solar-terrestrial community. 展开更多
关键词 MAGNETOSPHERE IONOSPHERE magnetosphere-ionosphere coupling ground-based experimentation SMILE CONJUNCTIONS MISSIONS
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Improving Satellite-Retrieved Cloud Base Height with Ground-Based Cloud Radar Measurements 被引量:1
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作者 Zhonghui TAN Ju WANG +3 位作者 Jianping GUO Chao LIU Miao ZHANG Shuo MA 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第11期2131-2140,共10页
Cloud base height(CBH) is a crucial parameter for cloud radiative effect estimates, climate change simulations, and aviation guidance. However, due to the limited information on cloud vertical structures included in p... Cloud base height(CBH) is a crucial parameter for cloud radiative effect estimates, climate change simulations, and aviation guidance. However, due to the limited information on cloud vertical structures included in passive satellite radiometer observations, few operational satellite CBH products are currently available. This study presents a new method for retrieving CBH from satellite radiometers. The method first uses the combined measurements of satellite radiometers and ground-based cloud radars to develop a lookup table(LUT) of effective cloud water content(ECWC), representing the vertically varying cloud water content. This LUT allows for the conversion of cloud water path to cloud geometric thickness(CGT), enabling the estimation of CBH as the difference between cloud top height and CGT. Detailed comparative analysis of CBH estimates from the state-of-the-art ECWC LUT are conducted against four ground-based millimeter-wave cloud radar(MMCR) measurements, and results show that the mean bias(correlation coefficient) is0.18±1.79 km(0.73), which is lower(higher) than 0.23±2.11 km(0.67) as derived from the combined measurements of satellite radiometers and satellite radar-lidar(i.e., Cloud Sat and CALIPSO). Furthermore, the percentages of the CBH biases within 250 m increase by 5% to 10%, which varies by location. This indicates that the CBH estimates from our algorithm are more consistent with ground-based MMCR measurements. Therefore, this algorithm shows great potential for further improvement of the CBH retrievals as ground-based MMCR are being increasingly included in global surface meteorological observing networks, and the improved CBH retrievals will contribute to better cloud radiative effect estimates. 展开更多
关键词 cloud base height passive radiometer ground-based cloud radar remote sensing
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Solar-and/or Radiative Cooling-Driven Thermoelectric Generators:A Critical Review 被引量:1
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作者 Jinglong Wang Lin Lu Kai Jiao 《Energy Engineering》 EI 2024年第10期2681-2718,共38页
Thermoelectric generators(TEGs)play a critical role in collecting renewable energy fromthe sun and deep space to generate clean electricity.With their environmentally friendly,reliable,and noise-free operation,TEGs of... Thermoelectric generators(TEGs)play a critical role in collecting renewable energy fromthe sun and deep space to generate clean electricity.With their environmentally friendly,reliable,and noise-free operation,TEGs offer diverse applications,including areas with limited power infrastructure,microelectronic devices,and wearable technology.The review thoroughly analyses TEG system configurations,performance,and applications driven by solar and/or radiative cooling,covering non-concentrating,concentrating,radiative cooling-driven,and dual-mode TEGs.Materials for solar absorbers and radiative coolers,simulation techniques,energy storage management,and thermal management strategies are explored.The integration of TEGs with combined heat and power systems is identified as a promising application.Additionally,TEGs hold potential as charging sources for electronic devices.This comprehensive review provides valuable insights into this energy collection approach,facilitating improved efficiency,reduced costs,and expanded applications.It also highlights current limitations and knowledge gaps,emphasizing the importance of further research and development in unlocking the full potential of TEGs for a sustainable and efficient energy future. 展开更多
关键词 Thermoelectric generators solar energy radiative sky cooling applications
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Numerical Study on the Effect of Vortex Generators on the Aerodynamic Drag of a High-Speed Train
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作者 Tian Li Hao Liang +1 位作者 Zerui Xiang Jiye Zhang 《Fluid Dynamics & Materials Processing》 EI 2024年第2期463-473,共11页
A relatively high aerodynamic drag is an important factor that hinders the further acceleration of high-speed trains.Using the shear stress transport(SST)k-ωturbulence model,the effect of various vortex generator typ... A relatively high aerodynamic drag is an important factor that hinders the further acceleration of high-speed trains.Using the shear stress transport(SST)k-ωturbulence model,the effect of various vortex generator types on the aerodynamic characteristics of an ICE2(Inter-city Electricity)train has been investigated.The results indi-cate that the vortex generators with wider triangle,trapezoid,and micro-ramp arranged on the surface of the tail car can significantly change the distribution of surface pressure and affect the vorticity intensity in the wake.This alteration effectively reduces the resistance of the tail car.Meanwhile,the micro-ramp vortex generator with its convergent structure at the rear exhibits enhancedflow-guiding capabilities,resulting in a 15.4%reduction in the drag of the tail car. 展开更多
关键词 Vortex generator aerodynamic drag REDUCTION numerical simulation
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Analysis of pseudo-random number generators in QMC-SSE method
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作者 刘东旭 徐维 张学锋 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期75-79,共5页
In the quantum Monte Carlo(QMC)method,the pseudo-random number generator(PRNG)plays a crucial role in determining the computation time.However,the hidden structure of the PRNG may lead to serious issues such as the br... In the quantum Monte Carlo(QMC)method,the pseudo-random number generator(PRNG)plays a crucial role in determining the computation time.However,the hidden structure of the PRNG may lead to serious issues such as the breakdown of the Markov process.Here,we systematically analyze the performance of different PRNGs on the widely used QMC method known as the stochastic series expansion(SSE)algorithm.To quantitatively compare them,we introduce a quantity called QMC efficiency that can effectively reflect the efficiency of the algorithms.After testing several representative observables of the Heisenberg model in one and two dimensions,we recommend the linear congruential generator as the best choice of PRNG.Our work not only helps improve the performance of the SSE method but also sheds light on the other Markov-chain-based numerical algorithms. 展开更多
关键词 stochastic series expansion quantum Monte Carlo pseudo-random number generator
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Recovery of Solid Oxide Fuel CellWaste Heat by Thermoelectric Generators and AlkaliMetal Thermoelectric Converters
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作者 Wenxia Zhu Baishu Chen +1 位作者 Lexin Wang Chunxiang Wang 《Frontiers in Heat and Mass Transfer》 EI 2024年第5期1559-1573,共15页
A Solid Oxide Fuel Cell(SOFC)is an electrochemical device that converts the chemical energy of a substance into electrical energy through an oxidation-reduction mechanism.The electrochemical reaction of a solid oxide ... A Solid Oxide Fuel Cell(SOFC)is an electrochemical device that converts the chemical energy of a substance into electrical energy through an oxidation-reduction mechanism.The electrochemical reaction of a solid oxide fuel cell(SOFC)generates heat,and this heat can be recovered and put to use in a waste heat recovery system.In addition to preheating the fuel and oxidant,producing steam for industrial use,and heating and cooling enclosed rooms,this waste heat can be used for many more productive uses.The large waste heat produced by SOFCs is a worry that must be managed if they are to be adopted as a viable option in the power generation business.In light of these findings,a novel approach to SOFC waste heat recovery is proposed.The SOFC is combined with a“Thermoelectric Generator and an Alkali Metal Thermoelectric Converter(TG-AMTC)”to transform the excess heat generated by both the SOFC and the TG-AMTC.The proposed TG-AMTC is evaluated using a number of performance indicators including power density,operating temperature,heat recovery rate,exergetic efficiency,energy efficiency,and recovery time.The experimental results state that TG-AMTC has provided an exergetic efficiency,energetic efficiency,and recovery time of 97%,98%,and 23%,respectively.The study proves that the proposed TG-AMTC for SOFC is an efficient method of recovering waste heat. 展开更多
关键词 Alkali metal thermoelectric converters waste heat thermoelectric generators solid oxide fuel cell
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A Represent of Generators of the Cyclic Group of Higher Even, Odd and Prime Order for Composition Being Multiplication
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作者 Faruque Hossain Mozumder Md. Sahidul Islam +1 位作者 Md. Mehedi Hasan Modern Md. Abdul Mannan 《Journal of Applied Mathematics and Physics》 2024年第12期4198-4205,共8页
This paper aims to treat a study of generators of the cyclic group of higher even, odd, and prime order for composition being multiplication. In fact we developed order of a group, order of element of a group and gene... This paper aims to treat a study of generators of the cyclic group of higher even, odd, and prime order for composition being multiplication. In fact we developed order of a group, order of element of a group and generators of the cyclic group in real numbers. Also we express cyclic and generators of the group for composition in real numbers. Here we discuss the higher order of groups in different types of order, and generators of the cyclic group which will give us practical knowledge to see the applications of the composition. In order to find out the order of an element am∈Gin which an=e= identity element, then find Highest Common Factor i.e. (H.C.F) of mand n. When Gis a finite group, every element must have finite order but the converse is false. There are infinite groups where each element has a finite order. There may be more than one generator of a cyclic group. Also every cyclic group is necessarily abelian. But show that every infinite cyclic group contains only two generators. Finally, we find out the generators of the cyclic group of higher even, odd and prime order in different types of the group for composition being multiplication. 展开更多
关键词 Order of Element of a Group Multiplication Composition Highest Common Factor generator
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Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease
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作者 Leyre Ayerra Maria S.Aymerich 《Neural Regeneration Research》 SCIE CAS 2025年第10期2917-2918,共2页
Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss o... Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons.Neuroinflammation has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be determined.Human leukocyte antigen. 展开更多
关键词 inflammation LEUKOCYTE generating
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Diffusion-based generative drug-like molecular editing with chemical natural language 被引量:1
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作者 Jianmin Wang Peng Zhou +6 位作者 Zixu Wang Wei Long Yangyang Chen Kyoung Tai No Dongsheng Ouyang Jiashun Mao Xiangxiang Zeng 《Journal of Pharmaceutical Analysis》 2025年第6期1215-1225,共11页
Recently,diffusion models have emerged as a promising paradigm for molecular design and optimization.However,most diffusion-based molecular generative models focus on modeling 2D graphs or 3D geom-etries,with limited ... Recently,diffusion models have emerged as a promising paradigm for molecular design and optimization.However,most diffusion-based molecular generative models focus on modeling 2D graphs or 3D geom-etries,with limited research on molecular sequence diffusion models.The International Union of Pure and Applied Chemistry(IUPAC)names are more akin to chemical natural language than the simplified molecular input line entry system(SMILES)for organic compounds.In this work,we apply an IUPAC-guided conditional diffusion model to facilitate molecular editing from chemical natural language to chemical language(SMILES)and explore whether the pre-trained generative performance of diffusion models can be transferred to chemical natural language.We propose DiffIUPAC,a controllable molecular editing diffusion model that converts IUPAC names to SMILES strings.Evaluation results demonstrate that our model out-performs existing methods and successfully captures the semantic rules of both chemical languages.Chemical space and scaffold analysis show that the model can generate similar compounds with diverse scaffolds within the specified constraints.Additionally,to illustrate the model’s applicability in drug design,we conducted case studies in functional group editing,analogue design and linker design. 展开更多
关键词 Diffusion model IUPAC Molecular generative model Chemical natural language Transformer
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Generative Artificial Intelligence and Its Applications in Cartography and GIS:an Exploratory Review 被引量:1
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作者 SUN Chenzhen LAN Tian +3 位作者 WU Zhiwei SHI Xing CHENG Donglin JIANG Songlin 《Journal of Geodesy and Geoinformation Science》 2025年第2期74-89,共16页
Since the release of ChatGPT in late 2022,Generative Artificial Intelligence(GAI)has gained widespread attention because of its impressive capabilities in language comprehension,reasoning,and generation.GAI has been s... Since the release of ChatGPT in late 2022,Generative Artificial Intelligence(GAI)has gained widespread attention because of its impressive capabilities in language comprehension,reasoning,and generation.GAI has been successfully applied across various aspects(e.g.,creative writing,code generation,translation,and information retrieval).In cartography and GIS,researchers have employed GAI to handle some specific tasks,such as map generation,geographic question answering,and spatiotemporal data analysis,yielding a series of remarkable results.Although GAI-based techniques are developing rapidly,literature reviews of their applications in cartography and GIS remain relatively limited.This paper reviews recent GAI-related research in cartography and GIS,focusing on three aspects:①map generation,②geographical analysis,and③evaluation of GAI’s spatial cognition abilities.In addition,the paper analyzes current challenges and proposes future research directions. 展开更多
关键词 generative artificial intelligence CARTOGRAPHY map generation geographical analysis spatial cognition
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Generation of SARS-CoV-2 dual-target candidate inhibitors through 3D equivariant conditional generative neural networks 被引量:1
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作者 Zhong-Xing Zhou Hong-Xing Zhang Qingchuan Zheng 《Journal of Pharmaceutical Analysis》 2025年第6期1291-1310,共20页
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)mutations are influenced by random and uncontrollable factors,and the risk of the next widespread epidemic remains.Dual-target drugs that synergistically act ... Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)mutations are influenced by random and uncontrollable factors,and the risk of the next widespread epidemic remains.Dual-target drugs that synergistically act on two targets exhibit strong therapeutic effects and advantages against mutations.In this study,a novel computational workflow was developed to design dual-target SARS-CoV-2 candidate inhibitors with the Envelope protein and Main protease selected as the two target proteins.The drug-like molecules of our self-constructed 3D scaffold database were used as high-throughput molecular docking probes for feature extraction of two target protein pockets.A multi-layer perceptron(MLP)was employed to embed the binding affinities into a latent space as conditional vectors to control conditional distribution.Utilizing a conditional generative neural network,cG-SchNet,with 3D Euclidean group(E3)symmetries,the conditional probability distributions of molecular 3D structures were acquired and a set of novel SARS-CoV-2 dual-target candidate inhibitors were generated.The 1D probability,2D joint probability,and 2D cumulative probability distribution results indicate that the generated sets are significantly enhanced compared to the training set in the high binding affinity area.Among the 201 generated molecules,42 molecules exhibited a sum binding affinity exceeding 17.0 kcal/mol while 9 of them having a sum binding affinity exceeding 19.0 kcal/mol,demonstrating structure diversity along with strong dual-target affinities,good absorption,distribution,metabolism,excretion,and toxicity(ADMET)properties,and ease of synthesis.Dual-target drugs are rare and difficult to find,and our“high-throughput docking-multi-conditional generation”workflow offers a wide range of options for designing or optimizing potent dual-target SARS-CoV-2 inhibitors. 展开更多
关键词 SARS-CoV-2 Dual-target drug 3D generative neural networks Drug design
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Application of Fractal Technology in the Generative Design of Chaoshan Drawnwork Patterns
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作者 CHEN Jia-jun ZHANG Ya CHEN Zhao-yang 《印刷与数字媒体技术研究》 北大核心 2025年第5期179-194,共16页
Chaoshan drawnwork handkerchief design exhibits self-similarity and fractal characteristics due to their grid-based structure,overall symmetry,and the way local motifs reflect the whole pattern.To explore the potentia... Chaoshan drawnwork handkerchief design exhibits self-similarity and fractal characteristics due to their grid-based structure,overall symmetry,and the way local motifs reflect the whole pattern.To explore the potential of fractals in traditional textile design,a fractal-based generative framework was proposed for efficiently creating drawnwork patterns suitable for practical handicraft production.The research was initiated with an analysis of the structural composition of center,skeleton,and filler motifs extracted from a pattern sample library.Based on this hierarchical classification,the box-counting method was employed to calculate their respective fractal dimensions.Building on fractal art theory,generative algorithms,and studies on the application of Ultra Fractal,a Chaoshan drawnwork fractal design model was established.Using this model,51 drawnwork fractal patterns and 153 handkerchief patterns were generated.These patterns were subsequently applied in real-world production to validate the feasibility and value of fractal techniques in textile design. 展开更多
关键词 Chaoshan drawnwork Fractal pattern generative design Cultural heritage
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Ramsey numbers of edge-critical graphs versus large generalized fans
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作者 Taiping Jiang Xinmin Hou 《中国科学技术大学学报》 北大核心 2025年第5期62-66,61,I0002,共7页
Given two graphs G and H,the Ramsey number R(G,H)is the smallest positive integer N such that every 2-coloring of the edges of K_(N)contains either a red G or a blue H.Let K_(N-1)■K_(1,k)be the graph obtained from K_... Given two graphs G and H,the Ramsey number R(G,H)is the smallest positive integer N such that every 2-coloring of the edges of K_(N)contains either a red G or a blue H.Let K_(N-1)■K_(1,k)be the graph obtained from K_(N-1)by adding anew vertexνconnecting k vertices of K_(N-1).A graph G withχ(G)=k+1 is called edge-critical if G contains an edge e such thatχ(G-e)=k.A considerable amount of research has been conducted by previous scholars on Ramsey numbers ofgraphs.In this study,we show that for an edge-critical graph G with x(G)=k+1,when k≥2,1≥2,and n is sufficiently large,R(G,K_(1)+nK_(t))=knt+1 and r,(G,K_(1)+nK_(t))=(k-1)nt+1. 展开更多
关键词 Ramsey number color critical graph generalized fan
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5DGWO-GAN:A Novel Five-Dimensional Gray Wolf Optimizer for Generative Adversarial Network-Enabled Intrusion Detection in IoT Systems
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作者 Sarvenaz Sadat Khatami Mehrdad Shoeibi +2 位作者 Anita Ershadi Oskouei Diego Martín Maral Keramat Dashliboroun 《Computers, Materials & Continua》 SCIE EI 2025年第1期881-911,共31页
The Internet of Things(IoT)is integral to modern infrastructure,enabling connectivity among a wide range of devices from home automation to industrial control systems.With the exponential increase in data generated by... The Internet of Things(IoT)is integral to modern infrastructure,enabling connectivity among a wide range of devices from home automation to industrial control systems.With the exponential increase in data generated by these interconnected devices,robust anomaly detection mechanisms are essential.Anomaly detection in this dynamic environment necessitates methods that can accurately distinguish between normal and anomalous behavior by learning intricate patterns.This paper presents a novel approach utilizing generative adversarial networks(GANs)for anomaly detection in IoT systems.However,optimizing GANs involves tuning hyper-parameters such as learning rate,batch size,and optimization algorithms,which can be challenging due to the non-convex nature of GAN loss functions.To address this,we propose a five-dimensional Gray wolf optimizer(5DGWO)to optimize GAN hyper-parameters.The 5DGWO introduces two new types of wolves:gamma(γ)for improved exploitation and convergence,and theta(θ)for enhanced exploration and escaping local minima.The proposed system framework comprises four key stages:1)preprocessing,2)generative model training,3)autoencoder(AE)training,and 4)predictive model training.The generative models are utilized to assist the AE training,and the final predictive models(including convolutional neural network(CNN),deep belief network(DBN),recurrent neural network(RNN),random forest(RF),and extreme gradient boosting(XGBoost))are trained using the generated data and AE-encoded features.We evaluated the system on three benchmark datasets:NSL-KDD,UNSW-NB15,and IoT-23.Experiments conducted on diverse IoT datasets show that our method outperforms existing anomaly detection strategies and significantly reduces false positives.The 5DGWO-GAN-CNNAE exhibits superior performance in various metrics,including accuracy,recall,precision,root mean square error(RMSE),and convergence trend.The proposed 5DGWO-GAN-CNNAE achieved the lowest RMSE values across the NSL-KDD,UNSW-NB15,and IoT-23 datasets,with values of 0.24,1.10,and 0.09,respectively.Additionally,it attained the highest accuracy,ranging from 94%to 100%.These results suggest a promising direction for future IoT security frameworks,offering a scalable and efficient solution to safeguard against evolving cyber threats. 展开更多
关键词 Internet of things intrusion detection generative adversarial networks five-dimensional binary gray wolf optimizer deep learning
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