Capable and accurate predictions of some effects of strongly nonlinear interaction wave-ship associated with hydroelastic behaviors are very required for simulation tool in naval architect and ocean engineering. It ca...Capable and accurate predictions of some effects of strongly nonlinear interaction wave-ship associated with hydroelastic behaviors are very required for simulation tool in naval architect and ocean engineering. It can guarantee ship safety at the sea state by producing proper design. Therefore, we have developed a hybrid scheme based on both grid and particle method. In order to clarify hydroelastic behaviors of a ship, a dropping test of a ship with elastic motion has been performed firstly. The developed scheme has been then validated on ship dropping case under the same conditions with experiment. The comparisons showed consistently in good agreement. Furthermore, evaluation on hydroelastic behaviors of ship motion under slamming, the impact pressure tends to increase in increasing Froude number. （Fn） The bending moment and torque defined at the centre gravity due to hogging and sagging events can be predicted well, and their effects on the ship increase in increasing wave length even though the impact pressure decreases in increasing wave length after wave length λ/L, where L is ship length, is equal to 1.0. Moreover, hydroelastie behaviors affect the large heave and pitch amplitudes. Finally, the developed scheme can predict simultaneously hydrodynamic and hydroelastic with a strongly nonlinear interaction between wave and ship.展开更多
Tropical forest cover change along with increasing fragmentation has detrimental effects on the global biodiversity.In the current study change in both forest cover and fragmentation of Koraput district have been asse...Tropical forest cover change along with increasing fragmentation has detrimental effects on the global biodiversity.In the current study change in both forest cover and fragmentation of Koraput district have been assessed in the past three decades(1987-2017)and future decade(2017-2027),which has been modelled using logistic regression showing a gradual decrease in the forest cover and increase in fragmentation.The long term deforestation rates from 1987 to 2017(current period)and from 1987 to 2027(predicted period)were found to be-0.018 and-0.012,respectively.Out of the total geographical area,2027 number of grids(1 km^(2))out of 8856 grids were found to have shown extinction of forest in the study period.The conversion of forested lands into other land uses has been one of the major causes of deforestation in Koraput,especially because of the increasing mining activities and establishment of three major industries namely National Aluminium Company(NALCO),Damanjodi,Hindustan Aeronautics Limited(HAL),Sunabeda and Ballarpur Industries Limited(BILT).The forest fragmentation reveals a negative trend,recording highest conversion from large core fragments to edge(191.33 km2)and the predicted period has also shown the same trend of negative change,which poses serious danger to the structure of the forests.Out of all the landscape matrices calculated,number of patches will increase to 214 in 2027 from 93 in 1987.In the test between geographically weighted regression(GWR)and ordinary least square regression(OLS),GWR was the better fit model for drawing a spatial relationship between forest cover and fragmentation changes.The study confirmed that the forest cover change has impacted the forest fragmentation in the study area.The programmes like REDD+should be implemented along with the experiences of Community Forest Management and the joint forest management should be intensified at community level in order to develop better management practices to conserve habitats in biodiversity rich areas.展开更多
Objective： To understand the druggability of the bioactive compounds from traditional herbal formulations ＂Nilavembu Kudineer＂ and ＂Swasthya Raksha Amruta Peya＂ to heal chikungunya virus （CHIKV） infection. Meth...Objective： To understand the druggability of the bioactive compounds from traditional herbal formulations ＂Nilavembu Kudineer＂ and ＂Swasthya Raksha Amruta Peya＂ to heal chikungunya virus （CHIKV） infection. Methods： The efficiency of twenty novel chemical entities from ＂Nilavembu Kudineer＂ and ＂Swasthya Raksha Amruta Peya＂ to inhibit CHIKV infection in silico were evaluated. Ligands were prepared using Ligprep module of Schr0dinger. Active site was identified using SiteMap program. Grid box was generated using receptor grid generation wizard. Molecular docking was carried out using Grid Based Ligand Docking with Energetics （GLIDE） program. Results： Molecular docking studies showed that among twenty compounds, andrographoside, deoxyandrographoside, neoandrographolide, 14-deoxy-11-oxoandrographolide, butoxone and oleanolic acid showed GLIDE extra precision （XP） score of-9.10,-8.72, -8.25,-7.38,-7.28 and -7.01, respectively which were greater than or comparable with chloroquine （reference compound） XP score （-7.08） and were found to interact with the key residues GLLI 1043, LYS 1045, GLY 1176, LEU 1203, HIS 1222 and LYS 1239 which were characteristic functional unit crucial for replication of CHIKV. Conclusion： The binding affinity and the binding mode of chemical entities taken from herbal formulations with non-structural protein 2 protease were understood and our study provided a novel strategy in the development and design of drugs for CHIKV infection.展开更多
文摘Capable and accurate predictions of some effects of strongly nonlinear interaction wave-ship associated with hydroelastic behaviors are very required for simulation tool in naval architect and ocean engineering. It can guarantee ship safety at the sea state by producing proper design. Therefore, we have developed a hybrid scheme based on both grid and particle method. In order to clarify hydroelastic behaviors of a ship, a dropping test of a ship with elastic motion has been performed firstly. The developed scheme has been then validated on ship dropping case under the same conditions with experiment. The comparisons showed consistently in good agreement. Furthermore, evaluation on hydroelastic behaviors of ship motion under slamming, the impact pressure tends to increase in increasing Froude number. （Fn） The bending moment and torque defined at the centre gravity due to hogging and sagging events can be predicted well, and their effects on the ship increase in increasing wave length even though the impact pressure decreases in increasing wave length after wave length λ/L, where L is ship length, is equal to 1.0. Moreover, hydroelastie behaviors affect the large heave and pitch amplitudes. Finally, the developed scheme can predict simultaneously hydrodynamic and hydroelastic with a strongly nonlinear interaction between wave and ship.
基金the Department of Science and Technology,Govt.of India,DST-INSPIRE for providing fellowship(Sanction No.DST/INSPIRE Fellowship/2015/IF150127 dated 10.04.2015)during the tenure of the research work。
文摘Tropical forest cover change along with increasing fragmentation has detrimental effects on the global biodiversity.In the current study change in both forest cover and fragmentation of Koraput district have been assessed in the past three decades(1987-2017)and future decade(2017-2027),which has been modelled using logistic regression showing a gradual decrease in the forest cover and increase in fragmentation.The long term deforestation rates from 1987 to 2017(current period)and from 1987 to 2027(predicted period)were found to be-0.018 and-0.012,respectively.Out of the total geographical area,2027 number of grids(1 km^(2))out of 8856 grids were found to have shown extinction of forest in the study period.The conversion of forested lands into other land uses has been one of the major causes of deforestation in Koraput,especially because of the increasing mining activities and establishment of three major industries namely National Aluminium Company(NALCO),Damanjodi,Hindustan Aeronautics Limited(HAL),Sunabeda and Ballarpur Industries Limited(BILT).The forest fragmentation reveals a negative trend,recording highest conversion from large core fragments to edge(191.33 km2)and the predicted period has also shown the same trend of negative change,which poses serious danger to the structure of the forests.Out of all the landscape matrices calculated,number of patches will increase to 214 in 2027 from 93 in 1987.In the test between geographically weighted regression(GWR)and ordinary least square regression(OLS),GWR was the better fit model for drawing a spatial relationship between forest cover and fragmentation changes.The study confirmed that the forest cover change has impacted the forest fragmentation in the study area.The programmes like REDD+should be implemented along with the experiences of Community Forest Management and the joint forest management should be intensified at community level in order to develop better management practices to conserve habitats in biodiversity rich areas.
基金Supported by Shanmuga Arts Science Technology Research Academy University Fund(Feb 2012 Scheme)Junior Research Fellowship from Department of Science and Technology,Government of India
文摘Objective： To understand the druggability of the bioactive compounds from traditional herbal formulations ＂Nilavembu Kudineer＂ and ＂Swasthya Raksha Amruta Peya＂ to heal chikungunya virus （CHIKV） infection. Methods： The efficiency of twenty novel chemical entities from ＂Nilavembu Kudineer＂ and ＂Swasthya Raksha Amruta Peya＂ to inhibit CHIKV infection in silico were evaluated. Ligands were prepared using Ligprep module of Schr0dinger. Active site was identified using SiteMap program. Grid box was generated using receptor grid generation wizard. Molecular docking was carried out using Grid Based Ligand Docking with Energetics （GLIDE） program. Results： Molecular docking studies showed that among twenty compounds, andrographoside, deoxyandrographoside, neoandrographolide, 14-deoxy-11-oxoandrographolide, butoxone and oleanolic acid showed GLIDE extra precision （XP） score of-9.10,-8.72, -8.25,-7.38,-7.28 and -7.01, respectively which were greater than or comparable with chloroquine （reference compound） XP score （-7.08） and were found to interact with the key residues GLLI 1043, LYS 1045, GLY 1176, LEU 1203, HIS 1222 and LYS 1239 which were characteristic functional unit crucial for replication of CHIKV. Conclusion： The binding affinity and the binding mode of chemical entities taken from herbal formulations with non-structural protein 2 protease were understood and our study provided a novel strategy in the development and design of drugs for CHIKV infection.
